|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Extramural vascular invasion and response to neoadjuvant chemoradiotherapy in rectal cancer: influence of the CpG island methylator phenotype显示文摘AIM To identify whether Cp G island methylator phenotype(CIMP) is predictive of response to neoadjuvant chemoradiotherapy(NACRT) and outcomes in rectal cancer.METHODS Patients undergoing NACRT and surgical resection for rectal cancer in a tertiary referral centre between 2002-2011 were identified. Pre-treatment tumour biopsies were analysed for CIMP status(high, intermediate or low) using methylation specific PCR. KRAS and BRAF status were also determined using pyrosequencing analysis. Clinical information was extracted from case records and cancer services databases. Response to radiotherapy was measured by tumour regression scores determined uponhistological examination of the resected specimen. The relationship between these molecular features, response to NACRT and oncological outcomes were analysed.RESULTS There were 160 patients analysed with a median followup time of 46.4 mo. Twenty-one(13%) patients demonstrated high levels of CIMP methylation(CIMP-H) and this was significantly associated with increased risk of extramural vascular invasion(EMVI) compared with CIMP-L [8/21(38%) vs 15/99(15%), P = 0.028]. CIMP status was not related to tumour regression after radiotherapy or survival, however EMVI was significantly associated with adverse survival(P < 0.001). Intermediate CIMP status was significantly associated with KRAS mutation(P = 0.01). There were 14(9%) patients with a pathological complete response(pC R) compared to 116(73%) patients having no or minimal regression after neoadjuvant chemoradiotherapy. Those patients with pC R had median survival of 106 mo compared to 65.8 mo with minimal regression, although this was not statistically significant(P = 0.26). Binary logistic regression analysis of the relationship between EMVI and other prognostic features revealed, EMVI positivity was associated with poor overall survival, advanced 'T' stage and CIMP-H but not nodal status, age, sex, KRAS mutation status and presence of local or systemic recurrence.CONCLUSION We report a novel association of pre-treatment characterisation of CIMP-H with EMVI status which has prognostic implications and is not readily detectable on pre-treatment histological examination. | Jeremy Stuart Williamson Huw Geraint Jones Namor Williams Anthony Paul Griffiths Gareth Jenkins John Beynon Dean Anthony Harris | 2017 | World Journal of Gastrointestinal Oncology2017，9，5： | 4 |
| 2 | A randomised controlled trial of a new 2 litre polyethylene glycol solution versus sodium picosulphate + magnesium citrate solution for bowel cleansing prior to colonoscopy*显示文摘 | J. Worthington M. Thyssen G. Chapman R. Chapman M. Geraint | 2008 | Current Medical Research and Opinion?2008，，2： | 3 |
| 3 | Suppression of tumour-specific CD4+ T cells by regulatory T cells is associated with progression of human colorectal cancer显示文摘 | Gareth Betts Emma Jones Syed Junaid Tariq El-Shanawany Martin Scurr Paul Mizen Mayur Kumar Sion Jones Brian Rees Geraint Williams Awen Gallimore Andrew Godkin | 2012 | Gut2012，，8： | 3 |
| 4 | 高等教育定价:2004年英格兰高等教育法案对大学的政策意义显示文摘2004年英格兰高等教育法案确定了不同学校、不同学科可以收取不同学费的差异收费原则。文章根据这一政策,运用博弈论的方法,提出了一个高等教育定价模型。在对模型解释的基础上,从一般意义上探讨了高等教育法案对于大学的政策意义。 | Geraint Johnes 杜育红 周雪飞 | 2005 | 教育与经济2005，21，2： | 3 |
| 5 | Seize the state, seize the day: state capture and influence in transition economies显示文摘 | Joel S Hellman Geraint Jones Daniel Kaufmann | 2003 | Journal of Comparative Economics2003，，4： | 2 |
| 6 | A novelspherical permanent magnet actuator with three degrees-of-freedom显示文摘 | Wang J B Wang W Y Geraint W | 1998 | IEEE Transactions on Magnetics1998，34，4： | 1 |
| 7 | Measuring the Research Performance of UK Economics Departments:An Application of Data Envelopment Analysis显示文摘 | Geraint Johnes and Jill Johnes | 1993 | Oxford Economic Paper1993，45，： | 1 |
| 8 | Stochastic Frontier Estimation of a CES Cost Function:The Case of Higher Education in Britain 显示文摘 | IZADI HOOSHANG JOHNES GERAINT OSKRO CHI REZA | 2002 | Economics of Education Review2002，21，1： | 1 |
| 9 | Inhibition of aluminium alloy AA2024-T3 pitting corrosion by copper complexing compounds 显示文摘 | Geraint Williams Andrew J Coleman H Neil McMurray | 2010 | Eleetrochimiea Ae- ta2010，55，： | 1 |
| 10 | The influence of magnetization pattern on the performance of a cylindri- cal moving-magnet linear actuator显示文摘 | Richard E C David H Geraint W J | 2000 | IEEE Transac- tions on Magnetics2000，36，5： | 1 |
| 11 | The future of the TNM staging system in colorectal cancer: time for a debate?显示文摘 | Philip Quirke Geraint T Williams Nadine Ectors Arzu Ensari Fran?oise Piard Iris Nagtegaal | 2007 | Lancet Oncology2007，，7： | 1 |
| 12 | Processing of irrelevant visual motion during performance of an auditory attention task显示文摘 | Rees Geraint Frith Chris Lavie Nilli | 2001 | Neuropsychologia2001，39，9： | 1 |
| 13 | Apples and oranges: The aggregation problem in publications analysis显示文摘 | Geraint Johnes Jill Johnes | 1992 | Scientometrics1992，，2： | 1 |
| 14 | A novel spherical permanent actuator with three degrees-of-freedom显示文摘 | Jiabin Wang Weiya Wang Geraint W | 1998 | IEEE Transactions on Magnetics1998，34，4： | 1 |
| 15 | Latent fingermark visualisation using a scanning Kelvin probe 显示文摘 | Geraint Williams Neil McMurray | 2007 | Forensic Science International2007，167，： | 1 |
| 16 | Measuring the Research Performance of UK Economics Departments: an Application of Data Envelop- ment Analysis 显示文摘 | Geraint Johnes Jill Johnes | 1993 | Oxford Economics Papers1993，45，： | 1 |
| 17 | Product Liability for Nanotechnology显示文摘 | Geraint Howells | 2009 | Journal of Consumer Policy2009，，4： | 1 |
| 18 | Extensive Telomere Erosion in the Initiation of Colorectal Adenomas and Its Association With Chromosomal Instability显示文摘 | Laureline Roger Rhiannon E. Jones Nicole H. Heppel Geraint T. Williams Julian R. Sampson Duncan M. Baird | 2013 | JNCI Journal of the National Cancer Institute2013，，16： | 1 |
| 19 | Indoor GPS: system functionality and initial performance evaluation显示文摘 | Domenico A. Maisano Jafar Jamshidi Fiorenzo Franceschini Paul G. Maropoulos Luca Mastrogiacomo Antony R. Mileham Geraint W. Owen | 2008 | Int. J. of Manufacturing Research2008，，3： | 1 |
| 20 | Review of the pathological results of 2660 appendicectomy specimens显示文摘 | Ravi Marudanayagam Geraint T Williams Brian I Rees | 2006 | Journal of Gastroenterology2006，，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员