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| 1 | In vivo subsurface morphological and functional cellular and subcellular imaging of the gastrointestinal tract with confocal mini-microscopy显示文摘瞄准:为在活体内评估一根最新发达的手持的共焦的探针在啮齿类动物的完全的胃肠道的显微镜的成像。方法:一根新奇僵硬共焦的探针(直径 7 公里) 为 fluorophore 刺激用 488 nm 单身者线激光在人为使用与类似于灵活 endomicroscopy 系统的光特征被设计。轻排放在 505 ~ 750 nm 被检测。看法的地多样地是 475 妈妈 475 妈妈。光片厚度是有 0.7 妈妈的侧面的分辨率的 7 妈妈。在不同深度(到 250 妈妈的表面) 的表面下的连续图象多样地在 1024 点在实时被产生由在轻轻的、稳定的接触把探查放到织物上的 1024 个象素(0.8 frames/s ) 。织物标本为组织病理学说的关联被取样。结果:食管,胃,小并且大肠和中央,肝,胰和胆囊是在在 n = 的高分辨率的视觉 ised 在活体内 48 个鼠标。有共焦的微型显微镜学探查的实时显微镜的成像是容易的完成。不同染色协议(荧光黄,吖啶黄,标记 FITC 的葡聚糖和 L。可食用嗯植物凝血素) 织物的每个加亮的特定的方面,和在活体内成像与常规组织学最优地相关。在活体内血流监视把功能的质量加到词法成像。结论:共焦的显微镜学是在甚至表面下的织物结构的高分辨率允许完全的官方补给的道的可视化的可行在活体内。在这研究评估的新共焦的探查设计与腹腔镜检查兼容并且显著地扩展可能的应用的地到 intra 腹的机关。它允许新在活体内染色和申请选择的立即的测试因此在病人从动物研究允许快速的转移到临床的使用。 | Martin Goetz Beena Memadathil Stefan Biesterfeld Constantin Schneider Sebastian Gregor Peter R Galle Markus F Neurath Ralf Kiesslich | 2007 | World Journal of Gastroenterology2007，13，15： | 6 |
| 2 | Efficacy of SpyGlass^(TM)-directed biopsy compared to brush cytology in obtaining adequate tissue for diagnosis in patients with biliary strictures显示文摘AIM: To evaluate the diagnostic yield(inflammatory activity) and efficiency(size of the biopsy specimen) of SpyGlassTM-guided biopsy vs standard brush cytology in patients with and without primary sclerosing cholangitis(PSC).METHODS: At the University Medical Center Mainz, Germany, 35 consecutive patients with unclear biliarylesions(16 patients) or long-standing PSC(19 patients) were screened for the study. All patients underwent a physical examination, lab analyses, and abdominal ultrasound. Thirty-one patients with non-PSC strictures or with PSC were scheduled to undergo endoscopic retrograde cholangiography(ERC) and subsequent per-oral cholangioscopy(POC). Standard ERC was initially performed, and any lesions or strictures were localized. POC was performed later during the same session. The Boston Scientific SpyGlass SystemTM(Natick, MA, United States) was used for choledochoscopy. The biliary tree was visualized, and suspected lesions or strictures were biopsied, followed by brush cytology of the same area. The study endpoints(for both techniques) were the degree of inflammation, tissue specimen size, and the patient populations(PSC vs non-PSC). Inflammatory changes were divided into three categories: none, low activity, and high activity. The specimen quantity was rated as low, moderate, or sufficient.RESULTS: SpyGlassTM imaging and brush cytology with material retrieval were performed in 29 of 31(93.5%) patients(23 of the 29 patients were male). The median patient age was 45 years(min, 20 years; max, 76 years). Nineteen patients had known PSC, and 10 showed non-PSC strictures. No procedure-related complications were encountered. However, for both methods, tissues could only be retrieved from 29 pa-tients. In cases of inflammation of the biliary tract, the diagnostic yield of the SpyGlassTM-directed biopsies was greater than that using brush cytology. More tissue material was obtained for the biopsy method than for the brush cytology method(P = 0.021). The biopsies showed significantly more inflammatory characteristics and greater inflammatory activity compared to the cy-tological investigation(P = 0.014). The greater quantity of tissue samples proved useful for both PSC and non-PSC patients.CONCLUSION: SpyGlassTM imaging can be recom-mended for proper inflammatory diagnosis in PSC pa-tients. However, its value in diagnosing dysplasia wasnot addressed in this study and requires further investi-gation. | Johannes Wilhelm Rey Torsten Hansen Sebastian Dümcke Achim Tresch Katja Kramer Peter Robert Galle Martin Goetz Marcus Schuchmann Ralf Kiesslich Arthur Hoffman | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，4： | 2 |
| 3 | The transjugular intrahepatic portosystemic Stent-Shunt (TIPSS): Results of a pilot study显示文摘 | Goetz M. Richter M.D. Gerd Noeldge Julio C. Palmaz Martin Roessle | 1990 | Cardiovascular and Interventional Radiology1990，，3： | 2 |
| 4 | Chromoscopy-Guided Endomicroscopy Increases the Diagnostic Yield of Intraepithelial Neoplasia in Ulcerative Colitis显示文摘 | Ralf Kiesslich Martin Goetz Katharina Lammersdorf Constantin Schneider Juergen Burg Manfred Stolte Michael Vieth Bernhard Nafe Peter R. Galle Markus F. Neurath | 2007 | Gastroenterology2007，，3： | 2 |
| 5 | Irritable bowel syndrome and organic diseases: A comparative analysis of esophageal motility显示文摘AIM:To assess the esophageal motility in patients with irritable bowel syndrome(IBS)and to compare those with patients with autoimmune disorders.METHODS:15 patients with IBS,22 with systemic lupus erythematosus(SLE)and 19 with systemic sclerosis(SSc)were prospectively selected from a total of 115patients at a single university centre and esophageal motility was analysed using standard manometry(Mui Scientific PIP-4-8SS).All patients underwent esophagogastro-duodenoscopy before entering the study so that only patients with normal endoscopic findings were included in the current study.All patients underwent a complete physical,blood biochemistry and urinary examination.The grade of dysphagia was determined for each patient in accordance to the intensity and frequency of the presented esophageal symptoms.Furthermore,disease activity scores(SLEDAI and modified Rodnan score)were obtained for patients with autoimmune diseases.Outcome parameter:A correlation coefficient was calculated between amplitudes,velocity and duration of the peristaltic waves throughout esophagus and patients’dysphagia for all three groups.RESULTS:There was no statistical difference in the standard blood biochemistry and urinary analysis in all three groups.Patients with IBS showed similar pathologic dysphagia scores compared to patients with SLE and SSc.The mean value of dysphagia score was in IBS group 7.3,in SLE group 6.73 and in SSc group7.56 with a P-value>0.05.However,the manometric patterns were different.IBS patients showed during esophageal manometry peristaltic amplitudes at the proximal part of esophagus greater than 60 mmHg in46%of the patients,which was significant higher in comparison to the SLE(11.8%)and SSc-Group(0%,P=0.003).Furthermore,IBS patients showed lower mean resting pressure of the distal esophagus sphincter(Lower esophageal sphincter,22 mmHg)when compared with SLE(28 mmHg,P=0.037)and SSc(26 mmHg,P=0.052).23.5%of patients with SLE showed amplitudes greater as 160 mmHg in the distal esophagus(IBS and SSc:0%)whereas 29.4%amplitudes greater as 100 mmHg in the middle one(IBS:16.7%,SSc:5.9%respectively,P=0.006).Patients with SSc demonstrated,as expected,in almost half of the cases reduced peristalsis or even aperistalsis in the lower two thirds of the esophagus.SSc patients demonstrated a negative correlation coefficient between dysphagia score,amplitude and velocity of peristaltic activity at middle and lower esophagus[r=-0.6,P | Thomas Thomaidis Martin Goetz Sebastian Paul Gregor Arthur Hoffman Elias Kouroumalis Markus Moehler Peter Robert Galle Andreas Schwarting Ralf Kiesslich | 2013 | World Journal of Gastroenterology2013，19，38： | 1 |
| 6 | Apolipoprotein E controls the risk and age at onset of Parkinson disease显示文摘 | Y.J. Li M.A. Hauser W.K. Scott E.R. Martin M.W. Booze X.J. Qin J.W. Walter M.A. Nance J.P. Hubble W.C. Koller R. Pahwa M.B. Stern B.C. Hiner J. Jankovic C.G. Goetz G.W. Small F. Mastaglia J.L. Haines M.A. Pericak-Vance J.M. Vance | 2004 | Neurology2004，，： | 1 |
| 7 | Confocal Laser Endomicroscopy Image Interpretation: Interobserver Agreement Among Gastroenterologists and Pathologists显示文摘 | Kerry B. Dunbar Ralf Kiesslich Katja Deinert Martin Goetz Anirban Maitra Elizabeth A. Montgomery Michael Vieth Zhe Zhang Marcia I. Canto | 2007 | Gastrointestinal Endoscopy2007，，5： | 1 |
| 8 | Simultaneous confocal laser endomicroscopy and chromoendoscopy with topical cresyl violet显示文摘 | Martin Goetz Tanja Toermer Michael Vieth Kerry Dunbar Arthur Hoffman Peter R. Galle Markus F. Neurath Peter Delaney Ralf Kiesslich | 2009 | Gastrointestinal Endoscopy2009，，5： | 1 |
| 9 | Pseudoaneurysms of the Common Hepatic Artery Following Pancreaticoduodenectomy: Successful Emergency Embolization显示文摘 | Boris Radeleff Gerd Noeldge Tobias Heye Martin Schlieter Helmut Friess Goetz M. Richter Guenter W. Kauffmann | 2007 | CardioVascular and Interventional Radiology2007，，1： | 1 |
| 10 | Identification of Epithelial Gaps in Human Small and Large Intestine by Confocal Endomicroscopy显示文摘 | Ralf Kiesslich Martin Goetz Elizabeth M. Angus Qiuping Hu Yanfang Guan Chris Potten Terry Allen Markus F. Neurath Noah F. Shroyer Marshall H. Montrose Alastair J.M. Watson | 2007 | Gastroenterology2007，，6： | 1 |
| 11 | Chromoscopy-Guided Endomicroscopy Increases the Diagnostic Yield of Intraepithelial Neoplasia in Ulcerative Colitis显示文摘 | Ralf Kiesslich Martin Goetz Katharina Lammersdorf Constantin Schneider Juergen Burg Manfred Stolte Michael Vieth Bernhard Nafe Peter R. Galle Markus F. Neurath | 2007 | Gastroenterology2007，，3： | 1 |
| 12 | Dynamic biochemical tissue anal- ysis detects functional selectin ligands expressed on breast, colorec- tal,liver,lung, ovarian, pancreatic, prostate, and stomach cancer tis- sues显示文摘 | Martin E Malgor R Goetz D | 2014 | Cancer Research2014，74，19： | 1 |
| 13 | Novel Colonoscopic Imaging显示文摘 | Sanjay Murthy Martin Goetz Arthur Hoffman Ralf Kiesslich | 2012 | Clinical Gastroenterology and Hepatology2012，，9： | 1 |
| 14 | In Vivo Histology of Barrett’s Esophagus and Associated Neoplasia by Confocal Laser Endomicroscopy显示文摘 | Ralf Kiesslich Liebwin Gossner Martin Goetz Alexandra Dahlmann Michael Vieth Manfred Stolte Arthur Hoffman Michael Jung Bernhard Nafe Peter R. Galle Markus F. Neurath | 2006 | Clinical Gastroenterology and Hepatology2006，，： | 1 |
| 15 | Chromoscopy-Guided Endomicroscopy Increases the Diagnostic Yield of Intraepithelial Neoplasia in Ulcerative Colitis显示文摘 | Ralf Kiesslich Martin Goetz Katharina Lammersdorf Constantin Schneider Juergen Burg Manfred Stolte Michael Vieth Bernhard Nafe Peter R. Galle Markus F. Neurath | 2007 | Gastroenterology2007，，3： | 1 |
| 16 | Real-time Histology in Colonoscopy显示文摘 | Martin Goetz | 2013 | Gastroenterology Clinics of North America2013，，： | 1 |
| 17 | Molecular Imaging in Gastrointestinal Endoscopy显示文摘 | Martin Goetz Thomas D. Wang | 2010 | Gastroenterology2010，，3： | 1 |
| 18 | In Vivo Histology of Barrett’s Esophagus and Associated Neoplasia by Confocal Laser Endomicroscopy显示文摘 | Ralf Kiesslich Liebwin Gossner Martin Goetz Alexandra Dahlmann Michael Vieth Manfred Stolte Arthur Hoffman Michael Jung Bernhard Nafe Peter R. Galle Markus F. Neurath | 2006 | Clinical Gastroenterology and Hepatology2006，，8： | 1 |
| 19 | Novel Colonoscopic Imaging显示文摘 | Sanjay Murthy Martin Goetz Arthur Hoffman Ralf Kiesslich | 2012 | Clinical Gastroenterology and Hepatology2012，，9： | 1 |
| 20 | Diagnosing Helicobacter pylori In Vivo by Confocal Laser Endoscopy显示文摘 | Ralf Kiesslich Martin Goetz Juergen Burg Manfred Stolte Ekkehard Siegel Markus J. Maeurer Steven Thomas Dennis Strand Peter R. Galle Markus F. Neurath | 2005 | Gastroenterology2005，，7： | 1 |
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