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| 1 | Steps to consider in the approach and management of critically ill patient with spontaneous intracerebral hemorrhage显示文摘Spontaneous intracerebral hemorrhage is a type of stroke associated with poor outcomes. Mortality is elevated, especially in the acute phase. From a pathophysiological point of view the bleeding must traverse different stages dominated by the possibility of re-bleeding, edema, intracranial hypertension, inflammation and neurotoxicity due to blood degradation products, mainly hemoglobin and thrombin. Neurological deterioration and death are common in early hours, so it is a true neurologicalneurosurgical emergency. Time is brain so that action should be taken fast and accurately. The most significant prognostic factors are level of consciousness, location, volume and ventricular extension of the bleeding. Nihilism and early withdrawal of active therapy undoubtedly influence the final result. Although there are no proven therapeutic measures, treatment should be individualized and guided preferably by pathophysiology. The multidisciplinary teamwork is essential. Results of recently completed studies have birth to promising new strategies. For correct management it's important to establish an orderly and systematic strategy based on clinical stabilization, evaluation and establishment of prognosis, avoiding secondary insults and adoption of specific individualized therapies, including hemostatic therapy and intensive control of elevated blood pressure. Uncertainty continues regarding the role of surgery. | Daniel Agustin Godoy Gustavo Rene Pi?ero Patricia Koller Luca Masotti Mario Di Napoli | 2015 | World Journal of Critical Care Medicine2015，4，3： | 14 |
| 2 | Higher vitamin D serum concentration increases health related quality of life in patients with inflammatory bowel diseases显示文摘AIM: To investigate the effect of vitamin D(VD) concentrations and VD supplementation on health related quality of life in inflammatory bowel disease(IBD) patients. METHODS: A cohort of 220 IBD patients including 141 Crohn's disease(CD) and 79 ulcerative colitis(UC) patients was followed-up at a tertiary IBD center. A subgroup of the cohort(n = 26) took VD supplements for > 3 mo. Health related quality of life was assessed using the short IBD questionnaire(s IBDQ). VD serum concentration and s IBDQ score were assessed between August and October 2012(summer/autumn period) and between February and April 2013(winter/spring period). The mean VD serum concentration and its correlation with disease activity of CD were determined for each season separately. In a subgroup of patients, the effects of VD supplementation on winter VD serum concentration, change in VD serum concentration from summer to winter, and winter s IBDQ score were analyzed.RESULTS: During the summer/autumn and the winter/spring period, 28% and 42% of IBD patients were VD-deficient(< 20 ng/m L), respectively. In the winter/spring period, there was a significant correlation between s IBDQ score and VD serum concentration in UC patients(r = 0.35, P = 0.02), with a trend towards significance in CD patients(r = 0.17, P = 0.06). In the winter/spring period, VD-insufficient patients(< 30 ng/m L) had a significantly lower mean s IBDQ score than VD-sufficient patients; this was true of both UC(48.3 ± 2.3 vs 56.7 ± 3.4, P = 0.04) and CD(55.7 ± 1.25 vs 60.8 ± 2.14, P = 0.04) patients. In all analyzed scenarios(UC/CD, the summer/autumn period and the winter/spring period), health related quality of life was the highest in patients with VD serum concentrations of 50-59 ng/m L. Supplementation with a median of 800 IU/d VD day did not influence VD serum concentration or the s IBDQ score.CONCLUSION: VD serum concentration correlated with health related quality of life in UC and CD patients during the winter/spring period. | Tibor Hlavaty Anna Krajcovicova Tomas Koller Jozef Toth Monika Nevidanska Martin Huorka Juraj Payer | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 3 | Drug-induced liver injury in inflammatory bowel disease: 1-year prospective observational study显示文摘AIM To analyze 1-year liver injury burden in inflammatory bowel disease(IBD) patients. METHODS During a 6-mo inclusion period, consecutive IBD cases having a control visit at IBD center were included. Basic demographics, IBD phenotype and IBD treatment were recorded on entry. Aminotransferase(AT) activities of ALT, AST, ALP and gamma-glutamyl transpeptidase(GGT) were measured at baseline, 3 mo prior to study entry and prospectively every 3 mo for 1 year. Liver injury patterns were predefined as: Grade 1 in ALT 1-3 × upper limit of normal(ULN), grade 2 in ALT > 3 × ULN, hepatocellular injury in ALT > 2 × ULN, cholestatic injury in simultaneous GGT and ALP elevation > ULN.Persisting injury was reported when AT elevations were found on > 1 measurement. Risk factors for the patterns of liver injury were identified among demographic parameters, disease phenotype and IBD treatment in univariate and multivariate analysis. Finally, implications for the change in IBD management were evaluated in cases with persisting hepatocellular or cholestatic injury.RESULTS Two hundred and fifty-one patients were included having 917 ALT and 895 ALP and GGT measurements. Over one year, grade 1 injury was found in 66(26.3%), grade 2 in 5(2%) and hepatocellular injury in 16 patients(6.4%). Persisting hepatocellular injury was found in 4 cases. Cholestasis appeared in 11 cases(4.4%) and persisted throughout the entire study period in 1 case. In multivariate analysis, hepatocellular injury was associated with BMI(OR = 1.13, 1.02-1.26), liver steatosis(OR = 10.61, 2.22-50.7), IBD duration(1.07, 1.00-1.15) and solo infliximab(OR = 4.57, 1.33-15.7). Cholestatic liver injury was associated with prior intestinal resection(OR = 32.7, 3.18-335), higher CRP(OR = 1.04, 1.00-1.08) and solo azathioprine(OR = 10.27, 1.46-72.3). In one case with transient hepatocellular injury azathioprine dose was decreased. In 4 cases with persisting hepatocellular injury, fatty liver or alcohol were most likely causes and IBD treatment was pursued without change. In the case with persisting cholestatic injury, no signs of portal hypertension were identified and treatment with infliximab continued.CONCLUSION Liver injury was frequent, mostly transient and rarely changed management. Infliximab or azathioprine were confirmed as its risk factors indicating the need for regular AT monitoring. | tomas koller martina galambosova simona filakovska michaela kubincova tibor hlavaty jozef toth anna krajcovicova juraj payer | 2017 | World Journal of Gastroenterology2017，23，22： | 5 |
| 4 | Age and duration of intra-oceanic arc volcanism built on a suprasubduction zone type oceanic crust in southern Neotethys,SE Anatolia显示文摘东南的古称包括象变形山岳, ophiolites,暴烈的弧单位和 granitoid 岩石那样的 tectono-magmatic/stratigraphic 单位的数字。所有为南部的 Neotethys 的迟了的白垩纪进化他们起重要作用。这些单位的空间、时间的关系建议同时代的 magmatism 的进步发展并且向北方在迟了的白垩纪期间推进 subduction/accretion。我们从普遍的暴烈的弧单位表演的 rhyolitic 岩石的新 U-Pb 锆石数据变老(83.1 ? | Fatih Karaoglan Osman Parlak Urs Kltzli Friedrich Koller Tamer Rizaoglu | 2013 | Geoscience Frontiers2013，4，4： | 4 |
| 5 | Effect of elevated growth hormone concentrations on the phenotype and functions of human lymphocytes and natural killer cells显示文摘 | Kotzmann H Koller M Czernin S | 1994 | Neuroendocrinology1994，60，6： | 2 |
| 6 | Model-based Object Tracking in Monocular Image Sequences of Road traffic Scenes 显示文摘 | Koller D Daniilidis K Nagel H | 1993 | International Journal of Computer Vision1993，10，93： | 1 |
| 7 | 显示文摘 | KOLLER H | 2004 | Stud Surf Sci Catal2004，149，： | 1 |
| 8 | Identification d fluoroquinolone antibiotics as the main source of human genotoxieity in native hospital waatewater显示文摘 | HARTMANN A ALDER A C KOLLER T | 1998 | Environmental Toxicololgy and Chemistry1998，17，： | 1 |
| 9 | Identification of fluoroquinolone antibiotics as the main source of genotoxicity in native hospital wastewater 显示文摘 | Hartmann A Alder A Koller T | 1998 | Environmental Toxicology and Chemistry1998，17，3： | 1 |
| 10 | NK and CD4 + T cell changes in blood after seizures in temporal lobe epilepsy 显示文摘 | Bauer S KOller M Cepok S Todorova-Rudolph A Nowak M Nockher WA | 2008 | Exp Neurol2008，211，2： | 1 |
| 11 | An algorithm (decision tree) for the management of Parkinson's disease (2001): Treat- mentGuidelines 显示文摘 | Olanow CW Watts RL Koller WC | 2001 | Neurology2001，56，5： | 1 |
| 12 | Localization of the gene for familial primary pulmonary hypertension to chromosome 2q31-32显示文摘 | Nichols WC Koller DL Slovis B | 1997 | Nat Genct1997，15，3： | 1 |
| 13 | Polynomial operators Stielties convolution and fractional calculus in hereditary mechanics显示文摘 | Koller R C | 1986 | Acta Mechanics1986，58，： | 1 |
| 14 | Real-time Continuous Level of Detail Rendering of Height Field显示文摘 | LINDSTROM P KOLLER D | 1996 | Computer Graphics( SIGGRAPH'' 96 Proceedings)1996，，8： | 1 |
| 15 | Increases in endothelial Ca(2+) activate K(Ca) channels and elicit EDHF-type arteriolar dilation via gap junctions显示文摘 | Ungvari Z Csiszar A Koller A | 2002 | Am J Physiol Heart Circ Physiol2002，282，5： | 1 |
| 16 | Comparison of selenium levels and glutathione peroxidase activity in bovine whole blood 显示文摘 | Koller L D | 1984 | Canadian Journal of Comparative Medicine1984，，4： | 1 |
| 17 | Molecular biology of the natriuretic peptides and their receptors显示文摘 | Koller K J Goeddel D V | 1992 | Circulation1992，86，： | 1 |
| 18 | Synthesis of novel 3 -amino and 29 - hydroxamic acid derivatives of glycyrrhetinic acid as selective 1115 - hydroxysteroid dehydrogenase 2 inhibitors 显示文摘 | Stanetty C Czollner L Koller l | 2010 | Bioorg Med Chem2010，18，21： | 1 |
| 19 | Proteomic survey of metabolic pathways in rice显示文摘 | Koller A Washburn M P Lange B M | 2002 | Proceedings of the National Academy of Sciences2002，99，11： | 1 |
| 20 | Proteomic survey of metabolic pathways in rice 显示文摘 | Koller A Washburn M P Lange B M | 2002 | Proc Natl Acad Sci USA2002，99，11： | 1 |
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