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| 1 | Efficacy of SpyGlass^(TM)-directed biopsy compared to brush cytology in obtaining adequate tissue for diagnosis in patients with biliary strictures显示文摘AIM: To evaluate the diagnostic yield(inflammatory activity) and efficiency(size of the biopsy specimen) of SpyGlassTM-guided biopsy vs standard brush cytology in patients with and without primary sclerosing cholangitis(PSC).METHODS: At the University Medical Center Mainz, Germany, 35 consecutive patients with unclear biliarylesions(16 patients) or long-standing PSC(19 patients) were screened for the study. All patients underwent a physical examination, lab analyses, and abdominal ultrasound. Thirty-one patients with non-PSC strictures or with PSC were scheduled to undergo endoscopic retrograde cholangiography(ERC) and subsequent per-oral cholangioscopy(POC). Standard ERC was initially performed, and any lesions or strictures were localized. POC was performed later during the same session. The Boston Scientific SpyGlass SystemTM(Natick, MA, United States) was used for choledochoscopy. The biliary tree was visualized, and suspected lesions or strictures were biopsied, followed by brush cytology of the same area. The study endpoints(for both techniques) were the degree of inflammation, tissue specimen size, and the patient populations(PSC vs non-PSC). Inflammatory changes were divided into three categories: none, low activity, and high activity. The specimen quantity was rated as low, moderate, or sufficient.RESULTS: SpyGlassTM imaging and brush cytology with material retrieval were performed in 29 of 31(93.5%) patients(23 of the 29 patients were male). The median patient age was 45 years(min, 20 years; max, 76 years). Nineteen patients had known PSC, and 10 showed non-PSC strictures. No procedure-related complications were encountered. However, for both methods, tissues could only be retrieved from 29 pa-tients. In cases of inflammation of the biliary tract, the diagnostic yield of the SpyGlassTM-directed biopsies was greater than that using brush cytology. More tissue material was obtained for the biopsy method than for the brush cytology method(P = 0.021). The biopsies showed significantly more inflammatory characteristics and greater inflammatory activity compared to the cy-tological investigation(P = 0.014). The greater quantity of tissue samples proved useful for both PSC and non-PSC patients.CONCLUSION: SpyGlassTM imaging can be recom-mended for proper inflammatory diagnosis in PSC pa-tients. However, its value in diagnosing dysplasia wasnot addressed in this study and requires further investi-gation. | Johannes Wilhelm Rey Torsten Hansen Sebastian Dümcke Achim Tresch Katja Kramer Peter Robert Galle Martin Goetz Marcus Schuchmann Ralf Kiesslich Arthur Hoffman | 2014 | World Journal of Gastrointestinal Endoscopy2014,6,4: | 2 |
| 2 | An iron delivery pathway mediated by a lipocalin 显示文摘 | Yang J Goetz D Li JY | 2002 | Mol Cell2002,10,5: | 1 |
| 3 | Integratedpowertrain control of gearshifts on twin clutchtransmissions显示文摘 | Goetz M Levesley M C Crolla D A | 2004 | Transmission and DrivelineSymposium2004,,1: | 1 |
| 4 | Diagnostic procedures for Parkin- son' s disease dementia : recommendations from the Movement Disor- der Society Task Force 显示文摘 | Dubois B Burn D Goetz C | 2007 | Mov Disord2007,22,16: | 1 |
| 5 | The dynamics of spatial pollution:The case of phosphorus runoff from agricultural land显示文摘 | Renan U Goetz Zilberman D | 2000 | Journal of Economic Dynamics & Control2000,24,1: | 1 |
| 6 | Diagnostic procedures for Parkinson's disease dementia: recommendations from the movement disorder society task force显示文摘 | Dubois B Burn D Goetz C | 2007 | Mov Disord2007,22,16: | 1 |
| 7 | Induction of male sterility in plants by metabolic engineering of the carbohydrate supply显示文摘 | Goetz M Godt D Gvivarch A | 2001 | Proc Natl Acad Sci USA2001,98,11: | 1 |
| 8 | Occupational asthma in a seafood restaurant worker: cross-reactivity of shrimp and scallops 显示文摘 | Goetz D W Whisman B A | 2000 | Ann Allergy Asthma Immunol2000,85,6: | 1 |
| 9 | Hyaluro- nan microspheres for sustained gene delivery and site-specific targeting 显示文摘 | YUN Y H GOETZ D J YELLEN P | 2004 | Biomaterials2004,25,1: | 1 |
| 10 | Pediatric adenoidal hypertrophy and nasal airway obstruction:reduction with aqueous nasal beclomethasone显示文摘 | Demain J G Goetz D W | 1995 | Pediatrics1995,95,3: | 1 |
| 11 | Using the SLEUTH urban growth model to simulate the impacts of future policy scenario on urban land use in the Baltimore-Washington metropolitan area 显示文摘 | Jantz C A Geog D Goetz S J | 2004 | Environment and Planning B: Planning and Design2004,31,2: | 1 |
| 12 | An iron delivery pathway mediated by a lipocalin 显示文摘 | Yang J Goetz D Li JY | 2002 | Mol Ce112002,10,5: | 1 |
| 13 | An iron delivery pathway mediated by a lipocalin显示文摘 | YANG J GOETZ D Li JY | 2002 | Mol Cell2002,10,5: | 1 |
| 14 | Detection of seasonal variability in microclimatic borders and ecotones between forest and savanna显示文摘 | Hennenberg K J Goetze D Szarzynski J | 2008 | Basic and Applied Ecology2008,9,3: | 1 |
| 15 | Identifica- tion of differentially expressed ovarian genes during primary and early secondary oocyte growth in coho sal- mon, Oncorhynchus kisutch 显示文摘 | Luckenbach J A Iliev D B Goetz F W | 2008 | Reproductive Biology and Endocrinology2008,6,1: | 1 |
| 16 | Determination of self-accelerating decomposition temperatures using the accelerating rate calorimeter显示文摘 | Fisher H G Goetz D D | 1991 | Journal of Loss Prevention in the Process Industries1991,4,: | 1 |
| 17 | Inhibition of autoimmune encephalomyelitis by a tetracycline显示文摘 | POPOVIC N SCHUBART A GOETZ B D | 2002 | Ann Neurol2002,51,2: | 1 |
| 18 | Validation of MODIS FAPAR products in boreal forests of Alaska显示文摘 | Steinberg D C Goetz S J Hyer E | 2006 | IEEE Transactions on Geoscience and Remote Sensing2006,44,7: | 1 |
| 19 | An iron delivery pathway mediated by a lipocalin显示文摘 | Yang J Goetz D Li J Y | 2002 | Mol Cell2002,10,5: | 1 |
| 20 | Incidence, timing, and follow-up of periventricular ieukomalaeia 显示文摘 | Goetz MC Gretebeck RJ Oh KS Shaffer D Hermansen MC | 1995 | Am J Perinatol1995,12,5: | 1 |