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| 1 | Parkinson's disease therapy: treatment of early and late disease显示文摘Purpose To summarize the current strategies for the treatment of early and late Parkinson’s disease (PD) Data sources The presented guidelines are based on the review of the literature as well as the author’s extensive experience with the treatment of 7000 patients with PD over the past 25 years Results An analysis of reported data as well as personal experience suggest that while young patients seem to have a slower progression of the disease, they are at a higher risk for developing levodopa induced complications, such as motor fluctuations and dyskinesias It is, therefore, prudent practice to delay levodopa therapy, particularly in younger patients, until the PD symptoms become troublesome and interfere with social or occupational functioning Other strategies, such as the use of deprenyl, amantadine, trihexyphenidyl and dopamine agonists, should be employed before instituting levodopa therapy Entacopone and dopamine agonists are useful in smoothing out levodopa related motor fluctuations Surgical interventions, such as pallidotomy and pallidal or subthalamic deep brain stimulation, are effective therapeutic strategies, but should be reserved only for patients in whom optimal medical therapy fails to provide satisfactory control of symptoms Conclusion The medical and surgical treatment of patients with PD must be individualized and tailored to the needs of the individual | Joseph Jankovic | 2001 | Chinese Medical Journal2001，，3： | 4 |
| 2 | TECTONIC SETTING AND METALLOGENESIS OF THE PRINCIPAL SECTORS OF THE TETHYAN EURASIAN METALLOGENIC BELT显示文摘Three global metallogenic belts were formed in the world during Mesozoic and post Mesozoic times. Two of them are situated along the western and eastern Pacific margins, and the third one——the Tethyan Eurasian metallogenic belt (TEMB) is related to the domain of Eurasian plate and flanked on the south by the Afro Arabian and Indian plates.The general tectonic evolution of the realm where the TEMB was formed is closely connected with the history of Tethys. The emplacement of ore deposits and the development of regional metallogenic units are related to a definitive time interval and to specific tectonic settings such as: (1) Intracontinental rifting along the northern margin of Gondwana and/or fragments already separated; (2) Oceanic environments (i.e. ophiolite complexes and ocean floor sediments) host podiform chromite deposits, volcano sedimentary cupriferous pyrite deposits (Cyprus type), stratiform manganese deposits, and sporadically PGE deposits; (3) Subduction related settings involve mainly porphyry copper deposits, hydrothermal massive sulphide polymetallic deposits, and epithermal deposits. So far identified mineralization of porphyry copper exceeds in the TEMB over 100 million tons of copper metal; and (4) Collision and post collision continent continent setting includes deposits of lead zinc, antimony, gold, in some sectors tin deposits, as well. The giant deposits of Li pegmatite occur sporadically. The TEMB is almost a continuously mineralized belt, but within it, some sectors display specific features of tectonic settings, association of elements, minerals and morphogenetic types of mineralization. | Slobodan Jankovic (Dept. of Mineral Exploration, Faculty of Mining and Geology, Djusina 7, 11000 Belgrade, Yogoslavia) | 2001 | Geotectonica et Metallogenia2001，25，1： | 4 |
| 3 | Evaluation of survivin expression and its prognostic value in papillary thyroid carcinoma显示文摘 | Sonja Selemetjev Tijana Isic Dencic Ilona Marecko Jelena Jankovic Ivan Paunovic Svetlana Savin Dubravka Cvejic | 2013 | Pathology - Research and Practice2013，，： | 2 |
| 4 | Gender Differences in Acute Cadmium-Induced Systemic Inflammation in Rats显示文摘Objective To examine the presence of gender difierences in pro-inflammatory potential of cadmium in rats by comparing systemic inflammatory response to acute cadmium intoxication in animals of the two sexes.Methods Basic aspects of this response were evaluated,including plasma levels of inflammatory cytokines tumor necrosis factor(TNF)and interleukin-6(IL-6)and of major rat acute phase protein alpha 2-macroglobulin(alpha2-M),as soluble indicators of inflammation, and the number and activity of peripheral blood leukocytes.as cellular indicators of inflammation.Results Differential increases of IL-6 and alpha 2-M(higher in males than in females)in peripheral blood cell counts and types(leukocytosis and shift in the ratio of granulocytes to lymphocytes more pronounced in males vs females) and in levels of neutrophil priming (higher in males vs females)were noted.Conclusion The data document a more intense inflammatory response to cadmium administration in males The sex difierences in inflammatory effects of cadmium might be taken into consideration in studying the toxicity of this heavy metal. | MILENA KATARANOVSKI SRDJA JANKOVIC DRAGAN KATARANOVSKI JELENA STOIC DESA BOGOJEVIC | 2009 | Biomedical and Environmental Sciences2009，22，1： | 2 |
| 5 | Tics secondary to craniocerebral trauma显示文摘 | Jankovic J | 1997 | Mov Disord1997，12，5： | 1 |
| 6 | NOS- 2 mediates the protective anti - inflammatory and antifibrotic effects of the Th1 - inducing adjuvant,IL- 12,in a Th2 model of granulomatous disease显示文摘 | Cheever AW Jankovic D | 2000 | Am J Pathol2000，157，3： | 1 |
| 7 | Prevalence of cervical dystonia and spasmodic torticollis in the United States general populmion显示文摘 | JANKOVIC J TSUI J BERGERON C | 2007 | Parkinsionism Relat Disord2007，13，7： | 1 |
| 8 | Amiodarone induces apoptosis of human and rat alveolar epithelial cells in vitro显示文摘 | Bargout R Jankov A Dincer E | 2000 | Am J Physiol Lung Cell Mol Physiol2000，278，5： | 1 |
| 9 | Response and immunoresistance tobotulinum toxin injections显示文摘 | Jankovic J Schwartz KS | 1995 | Neurology1995，45，： | 1 |
| 10 | Outcome after stereotactic thalamotomy for dystonia and hemiballismus显示文摘 | Cardoso F Jankovic J Grossman RG | 1995 | Neurosurgery1995，36，3： | 1 |
| 11 | The long - term safety and efficacy of pramipexole in advanced Parkinson' s disease显示文摘 | Weiner WJ Factor SA Jankovic J | 2001 | Parkinsonism Relat Disord2001，7，2： | 1 |
| 12 | Botulinum toxin therapy for cervical dystonia显示文摘 | Jankovic J | 2006 | Neurotox Res2006，9，2： | 1 |
| 13 | Induced resistance in the human non small cell lung carcinoma (NCI-H460) cell line in vitro by anticancer drugs显示文摘 | Markovic JZ Jankovic D | 2006 | J Chemother2006，18，1： | 1 |
| 14 | The kinetic analysis of non-isothermal nickel oxide reduction in hydrogen atmosphere using the invariant kinetic parameters method显示文摘 | Jankovic B Adna B Mentus S | 2007 | Thermoehimica Acta2007，456，1： | 1 |
| 15 | Antioxidants as therapy in the newborn:some words of caution显示文摘 | Jankov RT Negus A Tans well AK | 2001 | Pediatr Res2001，50，6： | 1 |
| 16 | Sleep structure in epileptic patients with and without antiepileptic therapy显示文摘 | Jankovic SM Levic ZM Sokic DV | 1995 | Electroencephalogr Clin Neurophysio1995，97，： | 1 |
| 17 | An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection显示文摘 | Wynn TA Cheever AW Jankovic D | 1995 | Nature1995，376，6541： | 1 |
| 18 | Anote on mappings of extremally disconnected spaces 显示文摘 | JANKOVIC D S | 1985 | Acta Math Hungar1985，46，： | 1 |
| 19 | Neurologicpresentation of Wilson disease without Kayser-Fleischerrings显示文摘 | Demirkiran M Jankovic J Lewis R A | 1996 | Neurology1996，46，： | 1 |
| 20 | TORA example: Cascade-and passivity-based control designs 显示文摘 | Jankovic M Fontaine D Kokotovie P V | 1996 | IEEE Transactions on Control Systems Technology1996，4，3： | 1 |
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