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| 1 | MicroRNAs as a potential prognostic factor in gastric cancer显示文摘AIM:To compare the microRNA (miR) profiles in the primary tumor of patients with recurrent and non-recurrent gastric cancer.METHODS:The study group included 45 patients who underwent curative gastrectomies from 1995 to 2005 without adjuvant or neoadjuvant therapy and for whom adequate tumor content was available.Total RNA was extracted from formalin-fixed paraffin-embedded tumor samples,preserving the small RNA fraction.Initial profiling using miR microarrays was performed to identify potential biomarkers of recurrence after resection.The expression of the differential miRs was later verified by quantitative real-time polymerase chain reaction (qRT-PCR).Findings were compared between patients who had a recurrence within 36 mo of surgery (bad-prognosis group,n=14,31%) and those who did not (good-prognosis group,n=31,69%).RESULTS:Three miRs,miR-451,miR-199a-3p and miR-195 were found to be differentially expressed in tumors from patients with good prognosis vs patients with bad prognosis (P<0.0002,0.0027 and 0.0046 respectively).High expression of each miR was associated with poorer prognosis for both recurrence and survival.Using miR-451,the positive predictive value for non-recurrence was 100% (13/13).The expression of the differential miRs was verified by qRT-PCR,showing high correlation to the microarray data and similar separation into prognosis groups.CONCLUSION:This study identified three miRs,miR-451,miR-199a-3p and miR-195 to be predictive of recurrence of gastric cancer.Of these,miR-451 had the strongest prognostic impact. | Baruch Brenner Moshe B Hoshen Ofer Purim Miriam Ben David Karin Ashkenazi Gideon Marshak Yulia Kundel Ronen Brenner Sara Morgenstern Marisa Halpern Nitzan Rosenfeld Ayelet Chajut Yaron Niv Michal Kushnir | 2011 | World Journal of Gastroenterology2011，17，35： | 31 |
| 2 | Tumor microRNA-29a expression and the risk of recurrence in stage IIcolon cancer显示文摘 | Alina Weissmann-Brenner Michal Kushnir Gila Lithwick Yanai Ranit Aharonov Hadas Gibori Ofer Purim Yulia Kundel Sara Morgenstern Marissa Halperin Yaron Niv Baruch Brenner | 2012 | International Journal of Oncology2012，，： | 2 |
| 3 | ls local excision after complete pathological response to neoadjuvant chemoradiation for rectal cancer an acceptable treatment option? 显示文摘 | Kundel Y Brenner R Purim O | 2010 | Dis Co Ion Rectum2010，53，12： | 1 |
| 4 | Is local excision after complete pathological response to neoadjuvant chemoradiation for rectal cancer an acceptable treatment option? 显示文摘 | Kundel Y Brenner R Purim O | 2010 | Dis Colon Rectum2010，53，12： | 1 |
| 5 | Preoperative ehemoradiation and cetuximab for resectable,locally advanced esophageal cancer: Preliminary results of a prospective phase I b/II trial 显示文摘 | Brenner B Kundel Y Purim O | 2012 | J Clin Oncol2012，，14： | 1 |
| 6 | Is local excision after complete pathological response to neoadjuvant chemoradiation for rectal cancer an acceptable treatment option? 显示文摘 | Kundel Y Brenner R Purim O | 2010 | Dis Colon Rectum2010，53，12： | 1 |
| 7 | Is local excision after complete pathological response to neoadjuvant chemoradiation for rectal cancer an acceptable treatment option 显示文摘 | Kundel Y Brenner R Purim O | 2010 | Dis Colon Rectum2010，53，12： | 1 |
| 8 | Itraconazole in thetreatment of chromoblastomycosis due to Fonsecaea pedrosoi显示文摘 | Queiroz-Telles F Purim KS Fillus JN | 1992 | Int J Dermatol1992，31，11： | 1 |
| 9 | Expression of estrogen receptor β1 in colorectal cancer: correlation with clinicopathological variables 显示文摘 | Rath-Wolfson L Purim O Ram E | 2012 | Oncol Rep2012，27，6： | 1 |
| 10 | Fungal infection of the feet in soccer players and non-athlete individuals显示文摘 | Purim KS Bordignon GP Queiroz-Telles Fd | 2005 | Rev Iberoam Micol2005，22，1： | 1 |
| 11 | Cyclooxygenase -2 ex- pression in primary and metastatic Merkel cell carcinoma显示文摘 | Joachims Z Feinmesser R Purim O | 2008 | Appl Immunohistochem Mol Morphol2008，16，5： | 1 |
| 12 | Experimental system of free viewpoint television显示文摘 | Purim Na BANGCHANG Toshiaki FUJII Masayuki TANIMOTO | 2003 | SPIE2003，5006，： | 1 |
| 13 | VentureCapitalandtheProfessionalizationofStart-UpFirms:EmpiricalEvidence显示文摘 | HellmannT PuriM | 2002 | TheJournalofFinance2002，57，1： | 1 |
| 14 | Octogenarian patients with colorectal cancer: Characterizing an emerging clinical entity显示文摘AIM To characterize colorectal cancer(CRC) in octogenarians as compared with younger patients.METHODS A single-center, retrospective cohort study which included patients diagnosed with CRC at the age of 80 years or older between 2008-2013. A control group included consecutive patients younger than 80 years diagnosed with CRC during the same period. Clinicopathological characteristics, treatment and outcome were compared between the groups. Fisher's exact test was used for dichotomous variables and χ2 was used for variables with more than two categories. Overall survival was assessed by Kaplan-Meier survival analysis, with the log-rank test. Cancer specific survival(CSS) and disease-free survival were assessed by the Cox proportional hazards model, with the Fine and Gray correction for non-cancer death as a competing risk.RESULTS The study included 350 patients, 175 patients in each group. Median follow-up was 40.2 mo(range 1.8-97.5). Several significant differences were noted. Octogenarians had a higher proportion of Ashkenazi ethnicity(64.8% vs 47.9%, P < 0.001), a higher rate of personal history of other malignancies(22.4% vs 13.7%, P = 0.035) and lower rates of family history of any cancer(36.6% vs 64.6%, P < 0.001) and family history of CRC(14.4% vs 27.3%, P = 0.006). CRC diagnosis by screening was less frequent in octogenarians(5.7% vs 20%, P < 0.001) and presentation with performance status(PS) of 0-1 was less common in octogenarians(71% vs 93.9%, P < 0.001). Octogenarians were more likely to have tumors located in the right colon(45.7% vs 34.3%, P = 0.029) and had a lower prevalence of well differentiated histology(10.4% vs 19.3%, P = 0.025). They received less treatment and treatment was less aggressive, both in patients with metastatic and non-metastatic disease, regardless of PS. Their 5-year CSS was worse(63.4% vs 77.6%, P = 0.009), both for metastatic(21% vs 43%, P = 0.03) and for non-metastatic disease(76% vs 88%, P = 0.028).CONCLUSION Octogenarians presented with several distinct characteristics and had worse outcome. Further research is warranted to better define this growing population. | Hadar Goldvaser Noa Katz Shroitman Irit Ben-Aharon Ofer Purim Yulia Kundel Daniel Shepshelovich Tzippy Shochat Aaron Sulkes Baruch Brenner | 2017 | World Journal of Gastroenterology2017，23，8： | 1 |
| 15 | Cancer of the colon and rectum: potential effects of sex- age interactions on ineidenee and outcome显示文摘 | PURIM O GORDON N BRENNER B | 2013 | Med Sei Monit2013，19，： | 1 |
| 16 | Gastric cancer:biology and clinical manifestations in Israel显示文摘 | Dreznik A Purim O Idelevich E | 2012 | J Surg Oncol2012，105，3： | 1 |
| 17 | The combina- tion of docetaxel, cisplatin, and 5 - fluorouracil in ad- vanced gastric cancer: a single- institution experience 显示文摘 | Ben Aharon I Purim O Kundel Y | 2012 | Anticancer Drugs2012，23，3： | 1 |
| 18 | Itraconazole in the treatment of chromoblastomycosis due to Fonsecaea pedrosoi 显示文摘 | Queiroz- Telles F Purim KS Fillus JN | 1992 | Int J Dermatol1992，31，11： | 1 |
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