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| 1 | MicroRNAs as a potential prognostic factor in gastric cancer显示文摘AIM:To compare the microRNA (miR) profiles in the primary tumor of patients with recurrent and non-recurrent gastric cancer.METHODS:The study group included 45 patients who underwent curative gastrectomies from 1995 to 2005 without adjuvant or neoadjuvant therapy and for whom adequate tumor content was available.Total RNA was extracted from formalin-fixed paraffin-embedded tumor samples,preserving the small RNA fraction.Initial profiling using miR microarrays was performed to identify potential biomarkers of recurrence after resection.The expression of the differential miRs was later verified by quantitative real-time polymerase chain reaction (qRT-PCR).Findings were compared between patients who had a recurrence within 36 mo of surgery (bad-prognosis group,n=14,31%) and those who did not (good-prognosis group,n=31,69%).RESULTS:Three miRs,miR-451,miR-199a-3p and miR-195 were found to be differentially expressed in tumors from patients with good prognosis vs patients with bad prognosis (P<0.0002,0.0027 and 0.0046 respectively).High expression of each miR was associated with poorer prognosis for both recurrence and survival.Using miR-451,the positive predictive value for non-recurrence was 100% (13/13).The expression of the differential miRs was verified by qRT-PCR,showing high correlation to the microarray data and similar separation into prognosis groups.CONCLUSION:This study identified three miRs,miR-451,miR-199a-3p and miR-195 to be predictive of recurrence of gastric cancer.Of these,miR-451 had the strongest prognostic impact. | Baruch Brenner Moshe B Hoshen Ofer Purim Miriam Ben David Karin Ashkenazi Gideon Marshak Yulia Kundel Ronen Brenner Sara Morgenstern Marisa Halpern Nitzan Rosenfeld Ayelet Chajut Yaron Niv Michal Kushnir | 2011 | World Journal of Gastroenterology2011，17，35： | 31 |
| 2 | H pylori recurrence after successful eradication显示文摘Recurrence of H pylori after eradication is rare in developed countries and more frequent in developing countries. Recrudescence (recolonization of the same strain within 12 mo after eradication) rather than reinfection (colonization with a new strain, more than 12 mo after eradication) is considered to be responsible for most of the cases. This observation was confirmed only in developed countries, while in developing countries a recent meta-analysis demonstrated a high rate of reinfection. The proportion of H pylori annual recurrence was 2.67% and 13.00% in developed and developing countries, respectively. Nested meta-analysis (only cases with a longer follow-up and a negative 13CUBT a year after eradication) revealed annual recurrence rate of 1.45% [relative risk (RR), 0.54] and 12.00% (RR, 0.92) in developed and developing countries, respectively. These findings support the notion that in developed countries many cases of recurrence are due to recrudescence within the first year after eradication, with a 46% drop in the recurrence rate after the first year post eradication, while in developing countries reinfection is more pronounced, and continue at the same rate since eradication. A different approach for follow-up after H pylori eradication is probably needed in patients of developing countries, since reinfection is highly prevalent. | Yaron Niv | 2008 | World Journal of Gastroenterology2008，14，10： | 14 |
| 3 | Efficiency of bowel preparation for capsule endoscopy examination:A meta-analysis显示文摘Good preparation before endoscopic procedures is essential for successful visualization. The small bowel is difficult to evaluate because of its length and complex configuration. A meta-analysis was conducted of studies comparing small bowel visualization by capsule endoscopy with and without preparation. Medical data bases were searched for all studies investigating the preparation for capsule endoscopy of the small bowel up to July 31, 2007. Studies that scored bowel cleanness and measured gastric and small bowel transit time and rate of cecum visualization were included. The primary endpoint was the quality of bowel visualization. The secondary endpoints were transit times and proportion of examinations that demonstrated the cecum, with and without preparation. Meta-analysis was performed with StatDirect Statistical software, version 2.6.1 (http:// statsdirect.com). Eight studies met the inclusion criteria. Bowel visualization was scored as 'good' in 78% of the examinations performed with preparation and 49% performed without (P < 0.0001). There were no significant differences in transit times or in the proportion of examinations that demonstrated the cecum with and without preparation. Capsule endoscopy preparation improves the quality of small bowel visualization, but has no effect on transit times, or demonstration of the cecum. | Yaron Niv | 2008 | World Journal of Gastroenterology2008，14，9： | 13 |
| 4 | Effect of erythromycin on image quality and transit time of capsule endoscopy: A two-center study显示文摘AIM: To compare the effect of oral erythromycin vs no preparation with prokinetics on the transit time and the image quality of capsule endoscopy (CE) in evaluating small bowel (SB) pathology. METHODS: We conducted a retrospective, blinded (to the type of preparation) review of 100 CE studies, 50 with no preparation with prokinetics from one medical center (Group A) and 50 from another center with administration of a single dose of 200 mg oral erythromycin 1 h prior to CE (Group B). Gastric, SB and total transit times were calculated, the presence of bile in the duodenum was scored, as was cleanliness within the proximal, middle and distal intestine. RESULTS: The erythromycin group had a slightly shorter gastric transit time (21 min vs 28 min, with no statistical significance). SB transit time was similar for both groups (all P > 0.05). Total transit time was almost identical in both groups. The rate of incomplete examination was 16% for Group A and 10% for Group B (P = 0.37). Bile and cleanliness scores in different parts of the intestine were similar for the two groups (P > 0.05). CONCLUSION: Preparation for capsule endoscopy with erythromycin does not affect SB or total transit time. It tends to reduce gastric transit time, but it does not increase the cecum-reaching rate. Erythromycin does not adversely affect image quality. We consider the routine use of oral erythromycin preparation as being unjustified, although it might be considered in patients with known prolonged gastric emptying time. | Eva Niv Ido Bogner Olga Barkey Zamir Halpern Elisabeth Mahajna Roman Depsames Yael Kopelman Zvi Fireman | 2008 | World Journal of Gastroenterology2008，14，16： | 10 |
| 5 | Microsatellite instability and MLH1 promoter hypermethylation in colorectal cancer显示文摘Colorectal cancer (CRC) is caused by a series of genetic or epigenetic changes, and in the last decade there has been an increased awareness that there are multiple forms of colorectal cancer that develop through different pathways. Microsatellite instability is involved in the genesis of about 15% of sporadic colorectal cancers and most of hereditary nonpolyposis cancers. Tumors with a high frequency of microsatellite instability tend to be diploid, to possess a mucinous histology, and to have a surrounding lymphoid reaction. They are more prevalent in the proximal colon and have a fast pass from polyp to cancer. Nevertheless, they are associated with longer survival than stage-matched tumors with microsatellite stability. Resistance of colorectal cancers with a high frequency of microsatellite instability to 5-fluorouracil-based chemotherapy is well established. Silencing the MLH1 gene expression by its promoter methylation stops the formation of MLH1 protein, and prevents the normal activation of the DNA repair gene. This is an important cause for genomic instability and cell proliferation to the point of colorectal cancer formation. Better knowledge of this process will have a huge impact on colorectal cancer management, prevention, treatment and prognosis. | Yaron Niv | 2007 | World Journal of Gastroenterology2007，13，12： | 7 |
| 6 | Incidence and management of colonoscopic perforations: 8 years' experience显示文摘瞄准:与诊断、治疗学的 colonoscopies 考察一个主要医药教学中心的经验并且估计相关结肠的穿孔的发生和管理。方法:所有 colonoscopies 在 1994 年 1 月之间表现了, 2001 年 12 月被学习。病人, colonoscopic 报告和过程相关的复杂并发症上的数据从部的计算机化的数据库被收集。有柱子的病人的医药记录程序的结肠的穿孔被考察。结果:120067 colonoscopies 的一个总数在学习的 8 年期间被执行。七个 colonoscopic 穿孔(4 女性, 3 男性) 被诊断(0.058%) 。五发生了在期间诊断并且二在治疗学的结肠镜检查期间。六在结肠镜检查以后被怀疑在期间或立即。除了都,一有弥漫的温柔的符号并且经历了立即的操作,主要修理在 4 个病人做。没有死亡被报导。结论:穿孔率在结肠镜检查期间是低的。不过,它是严肃的复杂并发症和它的早识别,治疗是必要的优化结果。在有早起作用的弥漫的腹膜炎的病人,干预使主要修理成为一种安全选择。 | Hagit Tulchinsky Osnat Madhala-Givon Nir Wasserberg Shiomo Lelcuk Yaron Niv | 2006 | World Journal of Gastroenterology2006，12，26： | 6 |
| 7 | Gastric mucin expression in Helicobacter pylori-related, nonsteroidal anti-inflammatory drug-related and idiopathic ulcers显示文摘AIM: To determine the pattern of secreted mucin expression in Helicobacter pylori (H. pylori)-related, nonsteroidal anti-inflammatory drug (NSAID)-related and idiopathic gastric ulcers. METHODS: We randomly selected 92 patients with H. pylori-associated (n = 30), NSAID-associated (n = 18), combined H. pylori and NSAID-associated gastric ulcers (n = 24), and patients with idiopathic gastric ulcers (n = 20). Immunohistochemistry for T-cell CD4/CD8, andfor mucin 5AC (MUC5AC) and mucin 6 (MUC6), was performed on sections of the mucosa from the ulcer margin. Inflammation score was assessed according to the Sydney system. RESULTS: MUC5AC was expressed on the surface epithelium (98.9%) and neck glands (98.9%) with minimal expression in the deep glands (6.5%). MUC6 was strongly expressed in the deep glands (97.8%), variable in the neck glands (19.6%) and absent in the surface epithelium (0%). The pattern of mucin expression in idiopathic ulcer margins was not different from the expression in ulcers associated with H. pylori, NSAIDs, or combined H. pylori and NSAIDs. CD4/CD8 ratio was higher in H. pylori-positive patients (P = 0.009). Idiopathic ulcers are associated with hospitalized patients and have higher bleeding and mortality rates. CONCLUSION: Idiopathic ulcers have a unique clinical profile. Gastric mucin expression in idiopathic gastric ulcers is unchanged compared with H. pylori and/or NSAID-associated ulcers. | Doron Boltin Marisa Halpern Zohar Levi Alex Vilkin Sara Morgenstern Samuel B Ho Yaron Niv | 2012 | World Journal of Gastroenterology2012，18，33： | 5 |
| 8 | MUC1 and colorectal cancer pathophysiology considerations显示文摘Several lines of evidence point towards a biological role of mucin and particularly MUC1 in colorectal cancer. A positive correlation was described between mucin secretion, proliferation, invasiveness, metastasis and bad prognosis. But, the role of MUC1 in cancer progression is still controversial and somewhat confusing. While Mukherjee and colleagues developed MUC1-specific immune therapy in a CRC model, Lillehoj and coinvestigators showed recently that MUC1 inhibits cell proliferation by a β-catenin-dependent mechanism. In carcinoma cells the polarization of MUC1 is lost and the protein is over expressed at high levels over the entire cell surface. A competitive interaction between MUC1 and E-cadherin, through β-catenin binding, disrupts E-cadherin-mediated cell-cell interactions at sites of MUC1 expression. In addition, the complex of MUC1-β-catenin enters the nucleus and activates T-cell factor/leukocyte enhancing factor 1 transcription factors and activates gene expression. This mechanism may be similar to that just described for DCC and UNC5H, which induced apoptosis when not engaged with their ligand netrin, but mediate signals for proliferation, differentiation or migration when ligand bound. | Yaron Niv | 2008 | World Journal of Gastroenterology2008，14，14： | 5 |
| 9 | Membrane-bound mucins and mucin terminal glycans expression in idiopathic or Helicobacter pylori, NSAID associated peptic ulcers显示文摘AIM:To determine the expression of membrane-bound mucins and glycan side chain sialic acids in Helicobacter pylori(H.pylori)-associated,non-steroidal inflammatory drug(NSAID)-associated and idiopathic-gastric ulcers.METHODS:We studied a cohort of randomly selected patients with H.pylori(group 1,n=30),NSAID(group 2,n=18),combined H.pylori and NSAID associated gastric ulcers(group 3,n=24),and patients with idiopathic gastric ulcers(group 4,n=20).Immunohistochemistry for MUC1,MUC4,MUC17,and staining for Erythrina cristagalli agglutinin and Sambucus nigra agglutinin(SNA)lectins was performed on sections from the ulcer margins.RESULTS:Staining intensity of MUC17 was higher in H.pylori ulcers(group 1)than in idiopathic ulcers(group4),11.05±3.67 vs 6.93±4.00 for foveola cells,and10.29±4.67 vs 8.00±3.48 for gland cells,respectively(P<0.0001).In contrast,MUC1 expression was higher in group 4 compared group 1,9.89±4.17 vs 2.93±5.13 in foveola cells and 7.63±4.60 vs 2.57±4.50 for glands,respectively(P<0.0001).SNA lectin staining was increased in group 4,in parallel to elevated MUC1expression,indicating more abundantα2-6 sialylation in that group.CONCLUSION:Cytoplasmic MUC17 staining was sig-nificantly decreased in the cases with idiopathic ulcer.The opposite was observed for both MUC1 and SNA lectin.This observation may reflect important pathogenic mechanisms,since different mucins with altered sialylation patterns may differ in their protection efficiency against acid and pepsin. | Yaron Niv Doron Boltin Marisa Halpern Miriam Cohen Zohar Levi Alex Vilkin Sara Morgenstern Vahig Manugian Erica St Lawrence Pascal Gagneux Sukhwinder Kaur Poonam Sharma Surinder K Batra Samuel B Ho | 2014 | World Journal of Gastroenterology2014，20，40： | 5 |
| 10 | Mucin gene expression in bile of patients with and without gallstone disease,collected by endoscopic retrograde cholangiography显示文摘AIM:To investigate the pattern of mucin expression and concentration in bile obtained during endoscopic retrograde cholangiography(ERC) in relation to gallstone disease.METHODS:Bile samples obtained at ERC from 29 consecutive patients,17 with and 12 without gallstone disease were evaluated for mucin content by gel filtration on a Sepharose CL-4B column.Dot blot analysis for bile mucin apoproteins was performed with antibodies to Mucin 1(MUC1) ,MUC2,MUC3,MUC5AC,MUC5B and MUC6.Staining intensity score(0-3) was used as a measure of antigen expression.RESULTS:MUC1,MUC2,MUC3,MUC5AC,MUC5B and MUC6 were demonstrated in 34.4%,34.4%,51.7%,51.7%,55.1% and 27.5% of bile samples,respectively.The staining intensity scores were 0.62 ± 0.94,0.58 ± 0.90,0.79 ± 0.97,1.06 ± 1.22,1.20 ± 1.26 and 0.41 ± 0.73,respectively.Mean mucin concentration measured in bile by the Sepharose CL-4B method was 22.8 ± 24.0 mg/mL(range 3.4-89.0 mg/mL) .Mean protein concentration was 8.1 ± 4.8 mg/mL(range 1.7-23.2 mg/mL) .CONCLUSION:High levels of MUC3,MUC5AC and MUC5B are expressed in bile aspirated during ERC examination.A specific pattern of mucin gene expression or change in mucin concentration was not found in gallstone disease. | Alexander Vilkin Alex Geller Zohar Levi Yaron Niv | 2009 | World Journal of Gastroenterology2009，15，19： | 4 |
| 11 | Helicobacter pylori and gastric mucin expression: A systematic review and meta-analysis显示文摘AIM: To investigate the relationship between Helicobacter pylori(H. pylori) and mucin expression in gastric mucosa.METHODS: English Medical literature searches were conducted for gastric mucin expression in H. pylori infected people vs uninfected people. Searches wereperformed up to December 31 th 2014,using MEDLINE,Pub Med,EMBASE,Scopus,and CENTRAL. Studies comparing mucin expression in the gastric mucosa in patients positive and negative for H. pylori infection,were included. Meta-analysis was performed by using Comprehensive meta-analysis software(Version 3,Biostat Inc.,Englewood,NJ,United States). Pooled odds ratios(ORs) and 95% confidence intervals(CIs) were calculated compared mucin expression in individual studies by using the random effects model. Heterogeneity between studies was evaluated using the Cochran Q-test,and it was considered to be present if the Q-test P value was less than 0.10. I2 statistic was used to measure the proportion of inconsistency in individual studies,with I2 > 50% representing substantial heterogeneity. We also calculated a potential publication bias.RESULTS: Eleven studies,which represent 53 substudies of 15 different kinds of mucin expression,were selected according to the inclusion criteria. Every kind of mucin has been considered as one study. When a specific mucin has been studied in more than one paper,we combined the results in a nested metaanalysis of this particular mucin: MUC2,MUC6,STn,Paradoxical con A,Tn,T,Type 1 chain mucin,Le A,SLe A,Le B,AB-PAS,MUC1,and MUC5 AC. The odds ratio of mucin expression in random analysis was 2.33,95%CI: 1.230-4.411,P = 0.009,higher expression in H. pylori infected patients. Odds ratio for mucin expression in H. pylori positive patients was higher for MUC6(9.244,95%CI: 1.567-54.515,P = 0.014),and significantly lower for MUC5AC(0.447,95%CI: 0.211-0.949,P = 0.036). Thus,H. pylori infection may increase MUC6 expression and decrease MUC5 AC expression by 924% and 52%,respectively.CONCLUSION: H. pylori inhibits MUC5 AC expression in the gastric epithelium,and facilitates colonization. In contrast,increased MUC6 expression may help inhibiting colonization,using MUC6 antibiotics properties. | Yaron Niv | 2015 | World Journal of Gastroenterology2015，21，31： | 4 |
| 12 | Sequential capsule endoscopy of the small bowel for follow-up of patients with known Crohn’s disease显示文摘 | Eva Niv Sigal Fishman Helena Kachman Ruth Arnon Iris Dotan | 2014 | Journal of Crohn’s and Colitis2014，，： | 3 |
| 13 | Validation of the Capsule Endoscopy Crohn’s Disease Activity Index (CECDAI or Niv score): a multicenter prospective study显示文摘 | Y. Niv S. Ilani Z. Levi M. Hershkowitz E. Niv Z. Fireman S. O’Donnel C. O’Morain R. Eliakim E. Scapa N. Kalantzis C. Kalantzis P. Apostolopoulos E. Gal | 2012 | Endoscopy2012，，01： | 2 |
| 14 | 服用小剂量阿司匹林的无症状患者的内镜检查结果 | Niv Y Battler A Abuksis G 朱国栋 | 2005 | 世界核心医学期刊文摘(胃肠病学分册)2005，0，8： | 2 |
| 15 | European Society of Gastrointestinal Endoscopy (ESGE): Recommendations (2009) on clinical use of video capsule endoscopy to investigate small-bowel, esophageal and colonic diseases显示文摘 | S. Ladas K. Triantafyllou C. Spada M. Riccioni J.-F. Rey Y. Niv M. Delvaux R. de Franchis G. Costamagna | 2010 | Endoscopy2010，，03： | 2 |
| 16 | Tumor microRNA-29a expression and the risk of recurrence in stage IIcolon cancer显示文摘 | Alina Weissmann-Brenner Michal Kushnir Gila Lithwick Yanai Ranit Aharonov Hadas Gibori Ofer Purim Yulia Kundel Sara Morgenstern Marissa Halperin Yaron Niv Baruch Brenner | 2012 | International Journal of Oncology2012，，： | 2 |
| 17 | Assessment and Validation of the New Capsule Endoscopy Crohn’s Disease Activity Index (CECDAI)显示文摘 | Eyal Gal Alex Geller Gerald Fraser Zohar Levi Yaron Niv | 2008 | Digestive Diseases and Sciences2008，，7： | 2 |
| 18 | European Society of Gastrointestinal Endoscopy (ESGE): Recommendations (2009) on clinical use of video capsule endoscopy to investigate small-bowel, esophageal and colonic diseases显示文摘 | S. Ladas K. Triantafyllou C. Spada M. Riccioni J.-F. Rey Y. Niv M. Delvaux R. de Franchis G. Costamagna | 2010 | Endoscopy2010，，03： | 2 |
| 19 | H. pylori /NSAID – Negative peptic ulcer – The mucin theory显示文摘 | Yaron Niv | 2010 | Medical Hypotheses2010，，5： | 2 |
| 20 | Evaluation of a progressive treatment program for erectile dysfunction in patients with diabetes mellitus显示文摘 | Israilov S Shmuely J Niv E | 2005 | Int J Impot Res2005，，： | 1 |
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