|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | MicroRNAs as a potential prognostic factor in gastric cancer显示文摘AIM:To compare the microRNA (miR) profiles in the primary tumor of patients with recurrent and non-recurrent gastric cancer.METHODS:The study group included 45 patients who underwent curative gastrectomies from 1995 to 2005 without adjuvant or neoadjuvant therapy and for whom adequate tumor content was available.Total RNA was extracted from formalin-fixed paraffin-embedded tumor samples,preserving the small RNA fraction.Initial profiling using miR microarrays was performed to identify potential biomarkers of recurrence after resection.The expression of the differential miRs was later verified by quantitative real-time polymerase chain reaction (qRT-PCR).Findings were compared between patients who had a recurrence within 36 mo of surgery (bad-prognosis group,n=14,31%) and those who did not (good-prognosis group,n=31,69%).RESULTS:Three miRs,miR-451,miR-199a-3p and miR-195 were found to be differentially expressed in tumors from patients with good prognosis vs patients with bad prognosis (P<0.0002,0.0027 and 0.0046 respectively).High expression of each miR was associated with poorer prognosis for both recurrence and survival.Using miR-451,the positive predictive value for non-recurrence was 100% (13/13).The expression of the differential miRs was verified by qRT-PCR,showing high correlation to the microarray data and similar separation into prognosis groups.CONCLUSION:This study identified three miRs,miR-451,miR-199a-3p and miR-195 to be predictive of recurrence of gastric cancer.Of these,miR-451 had the strongest prognostic impact. | Baruch Brenner Moshe B Hoshen Ofer Purim Miriam Ben David Karin Ashkenazi Gideon Marshak Yulia Kundel Ronen Brenner Sara Morgenstern Marisa Halpern Nitzan Rosenfeld Ayelet Chajut Yaron Niv Michal Kushnir | 2011 | World Journal of Gastroenterology2011，17，35： | 31 |
| 2 | Beam dynamics studies on the 100 MeV/100 kW electron linear accelerator for NSC KIPT neutron source显示文摘We designed a 100 MeV/100 kW electron linear accelerator for NSC KIPT, which will be used to drive a neutron source on the basis of subcritical assembly. Beam dynamics studies have been conducted to reach the design requirements (E=100 MeV, P =100 kW, dE/E <1% for 99% particles). In this paper, we will present the progress of the design and the dynamic simulation results. For high intensity and long beam pulse linear accelerators, the BBU effect is one big issue; special care has been taken in the accelerating structure design. To satisfy the energy spread requirement at the linac exit, the particles with large energy difference from the synchronous particle should be eliminated at a low energy stage to ease the design of the collimation system and radiation shielding. A dispersion free chicane with 4 bending magnets is introduced downstream of the 1st accelerating section; the unwanted particles will be collimated there. | 裴士伦 池云龙 王书鸿 裴国玺 周祖圣 侯汨 Mykola Ayzatskiy Ivan Karnaukhov Volodymyr Kushnir Viktor Mytrochenko Andrey Zelinsky | 2012 | Chinese Physics C2012，36，7： | 2 |
| 3 | Tumor microRNA-29a expression and the risk of recurrence in stage IIcolon cancer显示文摘 | Alina Weissmann-Brenner Michal Kushnir Gila Lithwick Yanai Ranit Aharonov Hadas Gibori Ofer Purim Yulia Kundel Sara Morgenstern Marissa Halperin Yaron Niv Baruch Brenner | 2012 | International Journal of Oncology2012，，： | 2 |
| 4 | Stress and social facilitation:The effects of the presence of an instructor on student nurses'behaviour显示文摘 | Kushnir T | 1986 | Journal of Advanced Nursing1986，11，： | 1 |
| 5 | The Time Dimension and Lithium Resource Constraints for Electric Vehicles 显示文摘 | Kushnir D Sand~n B A | 2012 | Resources Policy2012，37，1： | 1 |
| 6 | The heat-shock element is a functional component of the Arabidopsis APX1 gene promoter显示文摘 | Storozhenko S De Pauw P Van Montagu M Inzé D Kushnir S | | 0，，03： | 1 |
| 7 | Molecular characterization of a putative Arabidopsis thaliana copper transporter and its yeast homologue显示文摘 | Kampfenkel K Kushnir S Babiychuk E | 1995 | Journal of Biological Chemistry1995，270，28： | 1 |
| 8 | Analysis of Current Unbalance in Transmission Systems With Short Lines显示文摘 | KALYUZHNY A KUSHNIR G | | 0，，02： | 1 |
| 9 | AtATM3 is involved in heavy metal resistance in Arabidopsis显示文摘 | KIM D Y BOVET L KUSHNIR S | 2006 | Plant Physiology2006，140，： | 1 |
| 10 | Clinical develop- ment of plantproducedrecombinant pharmaceuticals : vac-cines, antibodies andbeyond显示文摘 | Yusibov V Streatfield S J Kushnir N | 2011 | Hum Vaccin2011，7，3： | 1 |
| 11 | Job stmc-ture and burnout among primary care pediatricians显示文摘 | Kushnir T Cohen A H | 2006 | Work2006，27，1： | 1 |
| 12 | Assessment of upper esophageal sphincter function on high-resolution manometry: identification of predictors of globus symptoms 显示文摘 | Peng L Patel A Kushnir V | 2015 | J Clin Gastroenterol2015，49，2： | 1 |
| 13 | A mutation of the mitochondrial ABC transporter Stal leads to dwarfism and chlorosis in the Arabidopsis mutant starik显示文摘 | KUSHNIR S BABIYCHUK E STOROZHENKO S | 2001 | The Plant Cell2001，，3： | 1 |
| 14 | Improvement of the hydrogenation teehnologe of colophony显示文摘 | Savinykh V I Kushnir S R Gidroliz lesokhim | 1992 | Promst1992，，3： | 1 |
| 15 | Antidotal therapy of severe achte organophosphate poisoning: amultihospital study显示文摘 | Finkelsteein Y Kushnir A Raikhlirreisenkraft B | 1989 | Neurotoxicol Teratol1989，11，： | 1 |
| 16 | Quaternary ammonium compounds based on resin acids and rosin and their colloidal- chemical and bioeidal properties 显示文摘 | RADBIL B A KUSHNIR S R RADBIL' A B | 2008 | Russian Journal of Applied Chemistry2008，81，5： | 1 |
| 17 | Comparison of renal effects of ibuprofen versus indomethacin during treatment of patent ductus arteriosus in contiguous historical cohorts 显示文摘 | Kushnir A Pinheiro JM | 2011 | BMC Clin Pharmacol2011，11，： | 1 |
| 18 | Tumor microRNA expression patterns associated with resistance to platinum based chemotherapy and survival in ovarian cancer patients显示文摘 | Eitan R Kushnir M Lithwick-Yanai G | 2009 | Gynecol Oncol2009，114，2： | 1 |
| 19 | Liquid chromatography tandem mass spectrometry for analysis of steroids in clinical laboratories显示文摘 | Kushnir M M Rockwood A L Roberts W L | 2013 | ClinBiochem2013，12，44： | 1 |
| 20 | Upper abdominal cytoreduction and thoracoscopy for advanced epithelial ovarian cancer: unanswered questions and the impact on treatment显示文摘 | Fleury AC Kushnir CL Giuntoli RL 2nd | 2012 | B JOG2012，119，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员