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| 1 | 成人自发性脑出血处理指南——2007年更新版:美国心脏协会/美国卒中协会卒中委员会、高血压研究委员会、医疗质量和转归研究跨学科工作组指南:美国神经病学学会确认本指南作为神经科医生教学工具的价值显示文摘目的:本指南旨在为急性自发性脑出血的诊断和治疗提供最新的综合性推荐意见。方法:通过Medline正式检索截止2006年8月的相关文献,并将撰写委员会已知相关问题的其他论文作为补充,用证据表合并资料。采用美国心脏协会卒中委员会的证据水平分级标准对每项推荐意见进行分级。由5位同行评议专家和卒中委员会领导委员会成员对指南草案进行发表前审阅。预期本指南在3年内完全更新。结果:本文陈述了脑出血的诊断、动脉血压和颅内压增高的处理、脑出血内科并发症的治疗以及复发性脑出血的预防等方面的循证指南。对重组Ⅶ因子延缓早期出血的近期试验进行了讨论。对自发性脑出血治疗的各种外科手术方法提出了推荐意见。最后,对脑出血患者的撤销治疗和临终问题进行了分析。 | Joseph Broderick Sander Connolly Edward Feldmann Daniel Hanley Carlos Kase Derk Krieger Marc Mayberg Lewis Morgenstern Christopher S. Ogilvy Paul Vespa Mario Zuccarello 王玉洁(译) 刘娟(译) 白璇(译) 李新辉 孙虹(译) 姚志成(译) 张慧(译) 牛英翔(译) | 2007 | 国际脑血管病杂志2007，15，7： | 234 |
| 2 | 成人自发性脑出血处理指南——2007年更新版 美国心脏协会/美国卒中协会卒中委员会、高血压研究委员会、医疗质量和转归研究跨学科工作组指南 美国神经病学学会确认本指南作为神经科医生教学工具的价值显示文摘目的:本指南旨在为急性自发性脑出血的诊断和治疗提供最新的综合性推荐意见。方法:通过Medline正式检索截止2006年8月的相关文献,并将撰写委员会已知相关问题的其他论文作为补充,用证据表合并资料。采用美国心脏协会卒中委员会的证据水平分级标准对每项推荐意见进行分级。由5位同行评议专家和卒中委员会领导委员会成员对指南草案进行发表前审阅。预期本指南在3年内完全更新。结果:本文陈述了脑出血的诊断、动脉血压和颅内压增高的处理、脑出血内科并发症的治疗以及复发性脑出血的预防等方面的循证指南。对重组Ⅶ因子延缓早期出血的近期试验进行了讨论。对自发性脑出血治疗的各种外科手术方法提出了推荐意见。最后,对脑出血患者的撤销治疗和临终问题进行了分析。 | Joseph Broderick Sander Connolly Edward Feldmann Daniel Hanley Carlos Kase Derk Krieger Marc Mayberg Lewis Morgenstern Christopher S.Ogilvy Paul Vespa Mario Zuccarello 王玉洁 刘娟 白璇 李新辉 孙虹 姚志成 张慧 牛英翔 | 2008 | 中华脑血管病杂志(电子版)2008，2，1： | 29 |
| 3 | Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial显示文摘 | Axel Grothey Eric Van Cutsem Alberto Sobrero Salvatore Siena Alfredo Falcone Marc Ychou Yves Humblet Olivier Bouché Laurent Mineur Carlo Barone Antoine Adenis Josep Tabernero Takayuki Yoshino Heinz-Josef Lenz Richard M Goldberg Daniel J Sargent Frank Ciho | 2012 | The Lancet2012，，： | 10 |
| 4 | The importance of shale composition and pore structure upon gas storage potential of shale gas reservoirs显示文摘 | Daniel J.K. Ross R. Marc Bustin | 2008 | Marine and Petroleum Geology2008，，6： | 9 |
| 5 | Peroxisome proliferator-activated receptor γ agonist reduces the severity of post-ERCP pancreatitis in rats显示文摘AIM: To determine the effects of prophylactic peroxi-some proliferator-activated receptor (PPARγ) agonist administration in an experimental model of post-endoscopic retrograde cholangiopancreatography (post-ERCP) acute pancreatitis.METHODS: Post-ERCP pancreatitis was induced in male Wistar rats by infusion of contrast medium into the pancreatic duct. In additional group, rosiglitazone, a PPARγ agonist, was administered 1 h before infusion of contrast medium. Plasma and pancreas samples were obtained 6 h after the infusion.RESULTS: Infusion of contrast medium into the pan-creatic duct resulted in an inflammatory process characterized by increased lipase levels in plasma, and edema and myeloperoxidase activity (MPO) in pancreas. This result correlated with the activation of nuclear factor κB (NFκB) and the inducible NO synthase (iNOS) expression in pancreatic cells. Rosiglitazone reduced the increase in lipase and the level of edema and the increase in myeloperoxidase as well as the activation of NFκB and iNOS expression.CONCLUSION: A single oral dose of rosiglitazone, given 1 h before post-ERCP pancreatitis induction is effective in reducing the severity of the subsequent inflammatory process. The protective effect of rosiglitazone was associated with NFκB inhibition and the blockage of leukocyte infiltration in pancreas. | Emma Folch-Puy Susana Granell Juan L Iovanna Marc Barthet Daniel Closa | 2006 | World Journal of Gastroenterology2006，12，40： | 6 |
| 6 | Towards maximized utilization of iridium for the acidic oxygen evolution reaction显示文摘The reduction in noble metal content for efficient oxygen evolution catalysis is a crucial aspect towards the large scale commercialisation of polymer electrolyte membrane electrolyzers.Since catalytic stability and activity are inversely related,long service lifetime still demands large amounts of low-abundant and expensive iridium.In this manuscript we elaborate on the concept of maximizing the utilisation of iridium for the oxygen evolution reaction.By combining different tin oxide based support materials with liquid atomic layer deposition of iridium oxide,new possibilities are opened up to grow thin layers of iridium oxide with tuneable noble metal amounts.In-situ,time-and potential-resolved dissolution experiments reveal how the stability of the substrate and the catalyst layer thickness directly affect the activity and stability of deposited iridium oxide.Based on our results,we elaborate on strategies how to obtain stable and active catalysts with maximized iridium utilisation for the oxygen evolution reaction and demonstrate how the activity and durability can be tailored correspondingly.Our results highlight the potential of utilizing thin noble metal films with earth abundant support.materials for future catalytic applications in the energy sector. | Marc Ledendecker Simon Geiger Katharina Hengge Joohyun Lim Serhiy Cherevko Andrea M. Mingers Daniel Gohl Guilherme V. Fortunato Daniel Jalalpoor Ferdi Schuth Christina Scheu Karl J. J. Mayrhofer | 2019 | Nano Research2019，12，9： | 6 |
| 7 | Treating Clostridium difficile Infection With Fecal Microbiota Transplantation显示文摘 | Johan S. Bakken Thomas Borody Lawrence J. Brandt Joel V. Brill Daniel C. Demarco Marc Alaric Franzos Colleen Kelly Alexander Khoruts Thomas Louie Lawrence P. Martinelli Thomas A. Moore George Russell Christina Surawicz | 2011 | Clinical Gastroenterology and Hepatology2011，，12： | 5 |
| 8 | Comparison of inhaled milrinone, nitric oxide and prostacyclin in acute respiratory distress syndrome显示文摘AIM To evaluate the safety and efficacy of inhaled milrinone in acute respiratory distress syndrome(ARDS).METHODS Open-label prospective cross-over pilot study where fifteen adult patients with hypoxemic failure meeting standard ARDS criteria and monitored with a pulmonary artery catheter were recruited in an academic 24-bed medico-surgical intensive care unit. Random sequential administration of i NO(20 ppm) or nebulized epoprostenol(10 μg/mL) was done in all patients. Thereafter, inhaled milrinone(1 mg/mL) alone followed by inhaled milrinone in association with inhaled nitric oxide(iN O) was administered. A jet nebulization device synchronized with the mechanical ventilation was use to administrate the epoprostenol and the milrinone. Hemodynamic measurements and partial pressure of arterial oxygen(PaO_2) were recorded before and after each inhaled therapyadministration.RESULTS The majority of ARDS were of pulmonary cause(n = 13) and pneumonia(n = 7) was the leading underlying initial disease. Other pulmonary causes of ARDS were: Post cardiopulmonary bypass(n = 2), smoke inhalation injury(n = 1), thoracic trauma and pulmonary contusions(n = 2) and aspiration(n = 1). Two patients had an extra pulmonary cause of ARDS: A polytrauma patient and an intra-abdominal abscess Inhaled nitric oxide, epoprostenol, inhaled milrinone and the combination of inhaled milrinone and i NO had no impact on systemic hemodynamics. No significant adverse events related to study medications were observed. The median increase of PaO 2 from baseline was 8.8 mmH g [interquartile range(IQR) = 16.3], 6.0 mm Hg(IQR = 18.4), 6 mm Hg(IQR = 15.8) and 9.2 mm Hg(IQR = 20.2) respectively with i NO, epoprostenol, inhaled milrinone, and i NO added to milrinone. Only i NO and the combination of inhaled milrinone and i NO had a statistically significant effect on PaO 2. CONCLUSION When comparing the effects of inhaled NO, milrinone and epoprostenol, only NO significantly improved oxygenation. Inhaled milrinone appeared safe but failed to improve oxygenation in ARDS. | Martin Albert Daniel Corsilli David R Williamson Marc Brosseau Patrick Bellemare Stéphane Delisle Anne QN Nguyen France Varin | 2017 | World Journal of Critical Care Medicine2017，6，1： | 4 |
| 9 | AHA/ACC Guidelines for Secondary Prevention for Patients With Coronary and Other Atherosclerotic Vascular Disease: 2006 Update: Endorsed by the National Heart, Lung, and Blood Institute显示文摘 | Sidney C. Smith Jerilyn Allen Steven N. Blair Robert O. Bonow Lawrence M. Brass Gregg C. Fonarow Scott M. Grundy Loren Hiratzka Daniel Jones Harlan M. Krumholz Lori Mosca Richard C. Pasternak Thomas Pearson Marc A. Pfeffer Kathryn A. Taubert | 2006 | Circulation2006，，19： | 4 |
| 10 | Cholesterol Efflux and Atheroprotection: Advancing the Concept of Reverse Cholesterol Transport显示文摘 | Robert S. Rosenson H. Bryan Brewer W. Sean Davidson Zahi A. Fayad Valentin Fuster James Goldstein Marc Hellerstein Xian-Cheng Jiang Michael C. Phillips Daniel J. Rader Alan T. Remaley George H. Rothblat Alan R. Tall Laurent Yvan-Charvet | 2012 | Circulation2012，，15： | 4 |
| 11 | Characterization of two rat models of cystic fibrosis—KO and F508del CFTR—Generated by Crispr-Cas9显示文摘Background: Genetically engineered animals are essential for gaining a proper understanding of the disease mechanisms of cystic fibrosis(CF). The rat is a relevant laboratory model for CF because of its zootechnical capacity, size, and airway characteristics, including the presence of submucosal glands.Methods: We describe the generation of a CF rat model(F508 del) homozygous for the p.Phe508 del mutation in the transmembrane conductance regulator(Cftr) gene. This model was compared to new Cftr-/-rats(CFTR KO). Target organs in CF were examined by histological staining of tissue sections and tooth enamel was quantified by micro-computed tomography. The activity of CFTR was evaluated by nasal potential difference(NPD) and short-circuit current measurements. The effect of VX-809 and VX-770 was analyzed on nasal epithelial primary cell cultures from F508 del rats.Results: Both newborn F508 del and Knock out(KO) animals developed intestinal obstruction that could be partly compensated by special diet combined with an osmotic laxative. The two rat models exhibited CF phenotypic anomalies such as vas deferens agenesis and tooth enamel defects. Histology of the intestine, pancreas, liver, and lungs was normal. Absence of CFTR function in KO rats was confirmed ex vivo by short-circuit current measurements on colon mucosae and in vivo by NPD, whereas residual CFTR activity was observed in F508 del rats. Exposure of F508 del CFTR nasal primary cultures to a combination of VX-809 and VX-770 improved CFTR-mediated Cl-transport.Conclusions: The F508 del rats reproduce the phenotypes observed in CFTR KO animals and represent a novel resource to advance the development of CF therapeutics. | Elise Dreano Marc Bacchetta Juliette Simonin Louise Galmiche Claire Usal Lotfi Slimani Jérémy Sadoine Laurent Tesson Ignacio Anegon Jean-Paul Concordet Aurélie Hatton Lucile Vignaud Danielle Tondelier Isabelle Sermet-Gaudelus Marc Chanson Charles-Henry Cottart | 2019 | Animal Models and Experimental Medicine2019，2，4： | 3 |
| 12 | Impact of mass balance calculations on adsorption capacities in microporous shale gas reservoirs显示文摘 | Daniel J.K. Ross R. Marc Bustin | 2007 | Fuel2007，，17： | 3 |
| 13 | Surveillance for Hepatocellular Carcinoma in Patients with Cirrhosis Improves Outcome显示文摘 | Richard Todd Stravitz Douglas M. Heuman Nisha Chand Richard K. Sterling Mitchell L. Shiffman Velimir A. Luketic Arun J. Sanyal Adil Habib Anastasios A. Mihas Ho-Chong S. Giles Daniel G. Maluf Adrian H. Cotterell Marc P. Posner Robert A. Fisher | 2008 | The American Journal of Medicine2008，，2： | 3 |
| 14 | Developing Predictive Models of Health Literacy显示文摘 | Laurie T. Martin Teague Ruder José J. Escarce Bonnie Ghosh-Dastidar Daniel Sherman Marc Elliott Chloe E. Bird Allen Fremont Charles Gasper Arthur Culbert Nicole Lurie | 2009 | Journal of General Internal Medicine2009，，11： | 3 |
| 15 | Lgr5 +ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro显示文摘 | Nick Barker Meritxell Huch Pekka Kujala Marc van de Wetering Hugo J. Snippert Johan H. van Es Toshiro Sato Daniel E. Stange Harry Begthel Maaike van den Born Esther Danenberg Stieneke van den Brink Jeroen Korving Arie Abo Peter J. Peters Nick Wright Richa | 2010 | Cell Stem Cell2010，，1： | 2 |
| 16 | Quantitative dynamic contrast-enhanced MR imaging analysis of complex adnexal masses: a preliminary study显示文摘 | Isabelle Thomassin-Naggara Daniel Balvay Emilie Aubert Emile Dara? Roman Rouzier Charles A. Cuenod Marc Bazot | 2012 | European Radiology2012，，4： | 2 |
| 17 | Efficacy of Endoscopic Closure of Acute Perforations of the Gastrointestinal Tract显示文摘 | Rogier P. Voermans Olivier Le Moine Daniel von Renteln Thierry Ponchon Marc Giovannini Marco Bruno Bas Weusten Stefan Seewald Guido Costamagna Pierre Deprez Paul Fockens | 2012 | Clinical Gastroenterology and Hepatology2012，，6： | 2 |
| 18 | Impending Pollution of Betare Oya Opencast Mining Environment (Eastern Cameroon)显示文摘 | Tehna Natanael Nguene Feudoung Daniel Etame Jacques Medza Ekodo Jean Marc Noa Tang Sylvie Sub Emmanuel Cheo Bilong Paul | 2015 | Journal of Environmental Science and Engineering(B)2015，4，1： | 2 |
| 19 | Preoperative Cognitive Dysfunction Is Related to Adverse Postoperative Outcomes in the Elderly显示文摘 | Thomas N. Robinson Daniel S. Wu Lauren F. Pointer Christina L. Dunn Marc Moss | 2012 | Journal of the American College of Surgeons2012，，： | 2 |
| 20 | Small renal masses progressing to metastases under active surveillance显示文摘 | Marc C.Smaldone AlexanderKutikov Brian L.Egleston Daniel J.Canter RosaliaViterbo David Y. T.Chen Michael A.Jewett Richard E.Greenberg Robert G.Uzzo | 2012 | Cancer2012，，： | 2 |
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