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9篇 您的检索式：作者名="Marc Chanson"

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		题名	作者	年代	出处	被引量
	1	Characterization of two rat models of cystic fibrosis—KO and F508del CFTR—Generated by Crispr-Cas9显示文摘Background: Genetically engineered animals are essential for gaining a proper understanding of the disease mechanisms of cystic fibrosis(CF). The rat is a relevant laboratory model for CF because of its zootechnical capacity, size, and airway characteristics, including the presence of submucosal glands.Methods: We describe the generation of a CF rat model(F508 del) homozygous for the p.Phe508 del mutation in the transmembrane conductance regulator(Cftr) gene. This model was compared to new Cftr-/-rats(CFTR KO). Target organs in CF were examined by histological staining of tissue sections and tooth enamel was quantified by micro-computed tomography. The activity of CFTR was evaluated by nasal potential difference(NPD) and short-circuit current measurements. The effect of VX-809 and VX-770 was analyzed on nasal epithelial primary cell cultures from F508 del rats.Results: Both newborn F508 del and Knock out(KO) animals developed intestinal obstruction that could be partly compensated by special diet combined with an osmotic laxative. The two rat models exhibited CF phenotypic anomalies such as vas deferens agenesis and tooth enamel defects. Histology of the intestine, pancreas, liver, and lungs was normal. Absence of CFTR function in KO rats was confirmed ex vivo by short-circuit current measurements on colon mucosae and in vivo by NPD, whereas residual CFTR activity was observed in F508 del rats. Exposure of F508 del CFTR nasal primary cultures to a combination of VX-809 and VX-770 improved CFTR-mediated Cl-transport.Conclusions: The F508 del rats reproduce the phenotypes observed in CFTR KO animals and represent a novel resource to advance the development of CF therapeutics.	Elise Dreano Marc Bacchetta Juliette Simonin Louise Galmiche Claire Usal Lotfi Slimani Jérémy Sadoine Laurent Tesson Ignacio Anegon Jean-Paul Concordet Aurélie Hatton Lucile Vignaud Danielle Tondelier Isabelle Sermet-Gaudelus Marc Chanson Charles-Henry Cottart	2019	Animal Models and Experimental Medicine2019，2，4：	3
	2	Connexin37: a potential modifier gene of inflammatory disease显示文摘	Marc Chanson Brenda R. Kwak	2007	Journal of Molecular Medicine2007，，8：	1
	3	Reduced Connexin43 Expression Inhibits Atherosclerotic Lesion Formation in Low-Density Lipoprotein Receptor–Deficient Mice显示文摘	Brenda R. Kwak Niels Veillard Graziano Pelli Flore Mulhaupt Richard W. James Marc Chanson Fran?ois Mach	2003	Circulation: Journal of the American Heart Association2003，，7：	1
	4	Reduced Connexin43 Expression Limits Neointima Formation After Balloon Distension Injury in Hypercholesterolemic Mice显示文摘	Christos E. Chadjichristos Christian M. Matter Isabelle Roth Esther Sutter Graziano Pelli Thomas F. Lüscher Marc Chanson Brenda R. Kwak	2006	Circulation2006，，24：	1
	5	Reduced Connexin43 Expression Inhibits Atherosclerotic Lesion Formation in Low-Density Lipoprotein Receptor–Deficient Mice显示文摘	Brenda R. Kwak Niels Veillard Graziano Pelli Flore Mulhaupt Richard W. James Marc Chanson Fran?ois Mach	2003	Circulation: Journal of the American Heart Association2003，，7：	1
	6	Role of Toll-like receptor 4 on pancreatic and pulmonary injury in a mice model of acute pancreatitis associated with endotoxemia显示文摘	Catherine M. Pastor Jér?me Pugin Brenda Kwak Marc Chanson Fran?ois Mach Antoine Hadengue Jean Louis Frossard	2004	Critical Care Medicine2004，，8：	1
	7	Severe acute pancreatitis and reduced acinar cell apoptosis in the exocrine pancreas of mice deficient for the Cx32 gene显示文摘	Jean–Louis Frossard Laura Rubbia–Brandt Matthew A. Wallig Messod Benathan Thomas Ott Philippe Morel Antoine Hadengue Susanne Suter Klaus Willecke Marc Chanson	2003	Gastroenterology2003，，2：	1
	8	Role of Toll-like receptor 4 on pancreatic and pulmonary injury in a mice model of acute pancreatitis associated with endotoxemia显示文摘	Catherine M. Pastor Jér?me Pugin Brenda Kwak Marc Chanson Fran?ois Mach Antoine Hadengue Jean Louis Frossard	2004	Critical Care Medicine2004，，8：	1
	9	Hypoxic pulmonary vasoconstriction requires connexin 40-mediated endothelial signal conduction显示文摘	Wang Liming Yin Jun Nickles Hannah T Ranke Hannes Tabuchi Arata Hoffmann Julia Tabeling Christoph Barbosa-Sicard Eduardo Chanson Marc Kwak Brenda R Shin Hee-Sup Wu Songwei Isakson Brant E Witzenrath Martin de Wit Cor Fleming Ingrid Kuppe	2012	EN2012，，11：	1

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