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| 1 | 内镜下射频消融术治疗范围广泛的0-Ⅱb型早期食管鳞状细胞癌及癌前病变的临床效果显示文摘目的探讨内镜下应用HALO射频消融系统(Radiofrequency Ablation,RFA)治疗范围广泛的早期表浅平坦型(0-Ⅱb)食管鳞状细胞癌及癌前病变的治疗效果。方法对中国医学科学院肿瘤医院自2008年10月至2011年6月应用HALO射频消融系统治疗的33例早期食管鳞状细胞癌(early esophageal squamous cell cancer,EESCC)、重度不典型增生(high grade dysplasia,HGD)及中度不典型增生(middle grade dysplasia,MGD)患者的临床资料进行分析,观察治疗后1年病变组织学上完全缓解率(CR)及并发症情况。结果33例患者中,男26例,女7例,年龄平均61岁,MGD10例,HGD17例,EESCC6例,病变长度3~12(平均7.9)cm,治疗区域长度5~14(平均9.9)cm,累及食管周径平均11/12周。33例患者首次治疗手术时间11~57(平均30)min,平均住院时间3天。首次治疗后3个月内镜随访CR达69.7%(23/33),随访期间追加治疗1—4(平均2.7)次,12个月内镜随访时CR达93.9%(31/33)。4例(12%)术后出现重度狭窄,行内镜下水囊扩张术3—12(平均7)次,扩张后均缓解。无其他并发症发生。结论RFA治疗范围广泛的0-Ⅱb型早期食管鳞状细胞癌和癌前病变是安全的、有效的且是一项对于操作者技术要求较低的技术,扩大了内镜微创治疗的适应证。 | 张月明 贺舜 吕宁 薛丽燕 David E Fleischer Bas Weusten Sanford M Dawsey 窦利州 Jacques JGHM Bergman 王贵齐 | 2015 | 中华消化内镜杂志2015，32，9： | 8 |
| 2 | 内镜下射频消融术联合内镜黏膜切除术治疗大面积非表浅平坦型早期食管鳞状细胞癌和癌前病变疗效初探显示文摘目的:探讨内镜下联合应用射频消融系统(RFA)和内镜下黏膜切除术治疗范围广泛的非表浅平坦型早期食管鳞状细胞癌及癌前病变的治疗效果。方法北京协和医学院中国医学科学院肿瘤医院内镜科于2010年1月对经活检病理确诊的2例鳞状细胞癌、1例鳞状上皮中度不典型增生(MGIN)和1例鳞状上皮重度不典型增生(HGIN)患者予以内镜下RFA术联合内镜黏膜切除术治疗,总结分析术中、术后和随访情况。结果4例患者均顺利完成治疗,其中RFA时间为3~12(8.3) min,内镜下黏膜切除术时间6~20(10.3) min;所有病例均无出血和穿孔的发生。2例鳞状细胞癌患者病变长度分别为12和8 cm,非表浅平坦性病变长度分别为3和4 cm;MGIN患者的病变长度6 cm ,非表浅平坦性病变长度2 cm;HGIN患者的病变长度12 cm ,非表浅平坦型病变长度1 cm;术后病理与术前活检病理一致。4例术后均出现狭窄,其中2例为轻度狭窄,未予处理;2例为重度狭窄,行内镜下水囊扩张术均缓解。平均住院时间3d。3例经过3月及1年以上随访,治疗区域活检病理均达到完全缓解;余1例术后3月复查可见散在的碘染色阳性灶,活检病理为HGIN,分别追加RFA治疗后达到完全缓解。结论 RFA联合内镜下黏膜切除术治疗大面积非表浅平坦型早期食管鳞状细胞癌和癌前病变是安全有效的。 | 张月明 JacquesJGHMBergman 薛丽燕 贺舜 吕宁 David E Fleischer Bas Weusten Sanford M Dawsey 窦利州 王贵齐 | 2015 | 中华胃肠外科杂志2015，18，9： | 7 |
| 3 | Endoscopic Tri-Modal Imaging Is More Effective Than Standard Endoscopy in Identifying Early-Stage Neoplasia in Barrett’s Esophagus显示文摘 | Wouter L. Curvers Lorenza Alvarez Herrero Michael B. Wallace Louis–Michel Wong Kee Song Krish Ragunath Herbert C. Wolfsen Ganapathy A. Prasad Kenneth K. Wang Venkataraman Subramanian Bas L.A.M. Weusten Fiebo J. Ten Kate Jacques J.G.H.M. Bergman | 2010 | Gastroenterology2010，，4： | 6 |
| 4 | Efficacy of Endoscopic Closure of Acute Perforations of the Gastrointestinal Tract显示文摘 | Rogier P. Voermans Olivier Le Moine Daniel von Renteln Thierry Ponchon Marc Giovannini Marco Bruno Bas Weusten Stefan Seewald Guido Costamagna Pierre Deprez Paul Fockens | 2012 | Clinical Gastroenterology and Hepatology2012，，6： | 2 |
| 5 | Remission of Barrett’s Esophagus With Early Neoplasia 5 Years After Radiofrequency Ablation With Endoscopic Resection: A Netherlands Cohort Study显示文摘 | K. Nadine Phoa Roos E. Pouw Frederike G.I. van Vilsteren Carine M.T. Sondermeijer Fiebo J.W. Ten Kate Mike Visser Sybren L. Meijer Mark I. van Berge Henegouwen Bas L.A. M. Weusten Erik J. Schoon Rosalie C. Mallant–Hent Jacques J.G. H.M. Bergman | 2013 | Gastroenterology2013，，： | 2 |
| 6 | Double-peaked high-pressure zone at the esophagogastric junction in controls and in patients with a hiatal hernia:a study using high-resolution manometry显示文摘 | Bredenoord AJ Weusten BL Carmagnola S | 2004 | Dig Dis Sci2004，49，78： | 1 |
| 7 | Mathematic modeling of the risk of HBV, HCV,and HIV transmission by windowphase donations not detected by NAT 显示文摘 | Jos JA Weusten M Harry AJ | 2002 | Transfusion2002，42，3： | 1 |
| 8 | Randomized trial on endoscopic resection-cap versus multiband mucosectomy for piecemeal endoscopic resection of early Barrett’s neoplasia显示文摘 | Roos E. Pouw Frederike G.I. van Vilsteren Femke P. Peters Lorenza Alvarez Herrero Fiebo J.W. ten Kate Mike Visser Boudewijn E. Schenk Erik J. Schoon Frans T.M. Peters Martin Houben Raf Bisschops Bas L.A.M. Weusten Jacques J.G.H.M. Bergman | 2011 | Gastrointestinal Endoscopy2011，，： | 1 |
| 9 | Endoscopic radiofrequency ablation combined with endoscopic resection for early neoplasia in Barrett’s esophagus longer than 10 cm显示文摘 | Lorenza Alvarez Herrero Frederike G.I. van Vilsteren Roos E. Pouw Fiebo J.W. ten Kate Mike Visser Cornelis A. Seldenrijk Mark I. van Berge Henegouwen Paul Fockens Bas L.A.M. Weusten Jaques J.G.H.M. Bergman | 2011 | Gastrointestinal Endoscopy2011，，4： | 1 |
| 10 | Effect of proton-pump inhibitor treatment on symptoms and quality of life in GERD patients depends on the symptom-reflux association 显示文摘 | Aanen MC Weusten BL Numans ME | 2008 | J Clin Gastroentero12008，42，5： | 1 |
| 11 | Psychological factors affect the frequency of belching in patients with aerophagia显示文摘 | Bredenoord AJ Weusten BL Timmer R | 2006 | AmJ Gastroenterol2006，101，12： | 1 |
| 12 | Diagnostic value of the reflux disease questionnaire in general practice显示文摘 | Aanen MC Numans ME Weusten BL Smout AJ | 2006 | Digestion2006，74，34： | 1 |
| 13 | Pseudo-buried Barrett’s post radiofrequency ablation for Barrett’s esophagus, with or without prior endoscopic resection显示文摘 | Roos Pouw Mike Visser Robert Odze Carine Sondermeijer Fiebo Kate Bas Weusten Jacques Bergman | 2013 | Endoscopy2013，，： | 1 |
| 14 | Determinants of per-ception of heartburn and regurgitation 显示文摘 | Bredenoord AJ Weusten BL Curvers WL | 2005 | Gut2005，55，3： | 1 |
| 15 | 膈肌和食管下括约肌的间歇性空间分离促进酸性和轻度酸性反流显示文摘Background & Aims: In small hiatal hernias, the size of the hernia is variable. Intermittent complete reduction can be observed with high-resolution manometry as a transition from a doublepeak (hernia) to a single-peak (reduced) high-pressure zone. The aim of this study was to investigate whether intermittent separation of the diaphragm and lower esophageal sphincter (LES) favors the occurrence of gastroesophageal reflux. Methods: In 16 patients with a small hiatal hernia (3 cm), prolonged high-resolution manometry was performed. Acid and weakly acidic reflux episodes were detected with pH-impedance monitoring. Results: The single pressure peak profile (reduced hernia) was present for 814 minutes (56.5% of total time), and the double peak profile (unreduced hernia) was present for 626 minutes (43.5% of total time). In all patients, both pressure profiles were observed. The transition rate between the 2 profiles was 7.5 ± 0.9 per hour. More reflux occurred when the LES and diaphragm were separated versus the reduced hernia state (23.1 ± 5.1 vs 12.2 ± 2.4 episodes per hour, respectively; P < .05). The proportions of acidic reflux episodes during the single and double pressure peaks were similar (70% and 67% , respectively). In the two-pressure-zone state, there was an increase in all reflux mechanisms except transient LES relaxation. Conclusions: In patients with a small hiatal hernia, intermittent reduction of the hernia occurs frequently. Spatial separation of the diaphragm and LES in the nonreduced state results in a 2- fold increase in acidic and weakly acidic reflux due to mechanisms other than transient LES relaxation. | Bredenoord A. J. Weusten B. L A. M. Timmer R. Smout A. J. P.M. 赵天智(译) 张欣(校) | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，2，8： | 1 |
| 16 | Diagnostic value of the proton pump inhibitor test for gastro-oesophageal reflux disease in primary care显示文摘 | AANEN MC WEUSTEN BL NUMANS ME | 2006 | Aliment Pharmacol Ther2006，24，： | 1 |
| 17 | Endoscopic resection of early esophageal neoplasia in patients with esophageal varices: how to succeed while preventing the bleed显示文摘 | Hannah Künzli Bas Weusten | 2014 | Endoscopy2014，，： | 1 |
| 18 | SEMS and self ex- pandable plastic stents for the treatment of benign esophageal rup- tures and anastomotic leaks 显示文摘 | van Boeckel PG Dua KS Weusten BL | 2012 | BMC Gastroenterol2012，，12： | 1 |
| 19 | Fully covered self-expandable metal stents(SEMS),partially covered SEMS and self-expandable plastic stents for the treatment of benign esophageal ruptures and anastomotic leaks显示文摘 | van Boeckel PG Dua KS Weusten BL | | 0，，： | 1 |
| 20 | Reproducibility of multiehannel intraluminal electrical impedance monitoring of gastroesophageal reflux显示文摘 | Bredenoord AJ Weusten BL Tinat R | 2005 | Am J Gastroenterol2005，100，2： | 1 |
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