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| 1 | SWEET as Sugar: New Sucrose Effluxers in Plants显示文摘 | R. Frank Baker Kristen A. Leach David M. Braun | 2012 | Molecular Plant2012，5，4： | 29 |
| 2 | 12味止血中药对脂多糖诱导小鼠巨噬细胞产生一氧化氮的抑制作用显示文摘目的:研究12味止血中药对脂多糖(LPS)诱导小鼠巨噬细胞产生一氧化氮(NO)的抑制作用,并探讨其止血机制。方法:以1μg.mL-1LPS刺激小鼠巨噬细胞RAW264.7,22h后以Griess法测定NO的终产物亚硝酸盐的含量,观察LPS对NO生成的影响。结果:12味止血药均可抑制LPS诱导小鼠巨噬细胞RAW264.7中NO的生成。三七、地榆、仙鹤草、槐花、艾叶、蒲黄、侧柏叶及白茅根的抑制作用显著(P<0.05)。结论:本实验为12味止血中药对脂多糖诱导小鼠巨噬细胞产生NO的抑制作用提供了一定的理论依据。 | 廖晖 Linda K Banbury David N Leach | 2007 | 中国药房2007，18，9： | 27 |
| 3 | 滇西北兰坪金顶可能的古油气藏及对铅锌大规模成矿的作用显示文摘滇西北兰坪中—新生代沉积盆地产有中国最大的铅锌矿床,巨量铅锌矿石集中产在金顶穹窿内,矿石中不同产状的干酪根、轻质原油、重油、烃类气、沥青等多种成熟形式的有机物质丰富。对矿区有机物质进行了岩相学、生物标志化合物、碳同位素及铅同位素分析,结果显示:有机物质中氯仿沥青“A”的质量分数为(72~395 415.42)×10^-6,w(饱和烃)/w(芳香烃)普遍大于1,饱和烃中检测出丰度较高的正构烷烃、Pr、Ph和iC18等生物标志化合物,烃源母质为藻类生物Ⅰ型有机质;相对于区域岩石,矿石中有机物质的有机转化率较低(0.5%~7.2%,平均为3.05%),已明显受热而成熟;透射全色光和紫外光显微镜在矿石光薄片样品中鉴别出较多原油和烃类气体包裹体。研究表明:金顶穹窿具有油气成藏“生、运、储、盖、闭”等配套发育的良好条件,矿区油气显示和古油气藏遗迹明显,铅锌成矿前或成矿中可能已形成油气藏;这个可能的油气藏以富含原油、烃类和H2S等还原性气体为成分特征;金顶古油气藏中H2S等还原性气体的聚集及其导致铅锌硫化物快速集中沉淀是大规模成矿的关键,成藏—成矿是金顶穹窿中一个连续发生、发展的动力学过程,成藏是成矿的前提。 | 薛春纪 高永宝 CHI Guo-xiang David L Leach | 2009 | 地球科学与环境学报2009，31，3： | 27 |
| 4 | EMT and Dissemination Precede Pancreatic Tumor Formation显示文摘 | Andrew D. Rhim Emily T. Mirek Nicole M. Aiello Anirban Maitra Jennifer M. Bailey Florencia McAllister Maximilian Reichert Gregory L. Beatty Anil K. Rustgi Robert H. Vonderheide Steven D. Leach Ben Z. Stanger | 2012 | Cell2012，，1： | 13 |
| 5 | 小柴胡汤对体外培养人肝癌细胞株HepG2增殖的影响显示文摘目的探讨小柴胡汤45%乙醇提取物对体外培养人肝癌细胞株HepG2增殖的影响及其可能的机理。方法采用ATP-Lite法测定不同浓度小柴胡汤对体外培养的HepG2增殖的作用,同时利用氧自由基清除能(ORAC)法测定样品的抗氧化活性;以LPS刺激小鼠巨噬细胞RAW264.7产生一氧化氮(NO),Griess法测定NO的终产物亚硝酸盐的含量,观察样品对NO生成的影响。结果小柴胡汤在62.5~500mg/L浓度范围内可以显著抑制HepG2增殖,抑制作用呈剂量相关性,计算半数抑制浓度(IC50)为(90.7±23.7)mg/L。小柴胡汤提取物具有一定的抗氧化活性,其抗氧化能力为阳性对照维生素C的1.3倍。小柴胡汤在3.125~50mg/L浓度范围内均可以显著抑制NO的生成(P<0.05,P<0.01)。结论小柴胡汤具有体外抑制人肝癌细胞株HepG2增殖的作用,其抑制作用可能与其抗氧化活性及抑制NO生成有关。 | 廖晖 David J de Vries Linda K Banbury David N Leach | 2010 | 中国中医药信息杂志2010，17，11： | 7 |
| 6 | Cancer treatment and survivorship statistics, 2012显示文摘 | Rebecca Siegel Carol DeSantis Katherine Virgo Kevin Stein Angela Mariotto Tenbroeck Smith Dexter Cooper Ted Gansler Catherine Lerro Stacey Fedewa Chunchieh Lin Corinne Leach Rachel Spillers Cannady Hyunsoon Cho Steve Scoppa Mark Hachey Rebecca Kirch Ahmed | 2012 | CA: A Cancer Journal for Clinicians2012，，4： | 6 |
| 7 | 16味中药炮制前后抗氧化活性的比较研究显示文摘目的:比较16味中药炮制前后的抗氧化活性。方法:采用氧自由基清除能力(ORAC)法测定样品的抗氧化活性。荧光素(FL)为荧光探针。2,2-偶氮-2-氨基氢氯化丙烷在37℃时以稳定的速率产生过氧化氢(H2O2),H2O2氧化FL从而造成其荧光衰减。抗氧化剂的存在可以清除H2O2,延迟FL的荧光衰减,动态记录样品35min内的荧光变化。以水溶性维生素E为标准品绘制标准方程,根据Trolox标准方程计算样品的ORAC值。表儿茶素为阳性对照。结果:16味中药炮制前、后均具有一定的ORAC值,酒黄芩的ORAC值最高,为4241μmol TE·g-1;炒薏苡仁的ORAC值最低,为17μmol TE·g-1。10味中药炮制品的ORAC值低于生品,其中7味有显著性差异(P<0.05);6味炮制品的ORAC值高于生品,其中3味有显著性差异(P<0.05)。结论:16味中药炮制前、后抗氧化活性的变化可能与其所含的化学成分含量改变有关。 | 廖晖 王孝敏 Linda K Banbury David N Leach | 2010 | 中国药房2010，21，47： | 5 |
| 8 | Crohn’s and colitis in children and adolescents显示文摘Crohn's disease and ulcerative colitis can be grouped as the inflammatory bowel diseases(IBD).These conditions have become increasingly common in recent years,including in children and young people.Although much is known about aspects of the pathogenesis of these diseases,the precise aetiology is not yet understood,and there remains no cure.Recent data has illustrated the importance of a number of genes-several of these are important in the onset of IBD in early life,including in infancy.Pain,diarrhoea and weight loss are typical symptoms of paediatric Crohn's disease whereas bloody diarrhoea is more typical of colitis in children.However,atypical symptoms may occur in both conditions:these include isolated impairment of linear growth or presentation with extra-intestinal manifestations such as erythema nodosum.Growth and nutrition are commonly compromised at diagnosis in both Crohn's disease and colitis.Consideration of possible IBD and completion of appropriate investi-gations are essential to ensure prompt diagnosis,thereby avoiding the consequences of diagnostic delay.Patterns of disease including location and progression of IBD in childhood differ substantially from adultonset disease.Various treatment options are available for children and adolescents with IBD.Exclusive enteral nutrition plays a central role in the induction of remission of active Crohn's disease.Medical and surgical therapies need to considered within the context of a growing and developing child.The overall management of these chronic conditions in children should include multi-disciplinary expertise,with focus upon maintaining control of gut inflammation,optimising nutrition,growth and quality of life,whilst preventing disease or treatment-related complications. | Andrew S Day Oren Ledder Steven T Leach Daniel A Lemberg | 2012 | World Journal of Gastroenterology2012，18，41： | 4 |
| 9 | MRI定量肝灌注指数图:一种可能对抗肿瘤血管生成复合物BIBF1120(一种有效三联血管激酶抑制剂)治疗肿瘤效果可重复评估的方法显示文摘肝转移灶由肝动脉供血,造成肝灌注指数(HPI)增高。本研究的目的是用动态增强MRI定量分析肝转移灶在接受一种抗血管生成新药治疗前后的灌注指数。10例已知肝转移瘤的病人接受了动态增强MR成像检查。转移灶及全肝的HPI均由感兴趣区(ROI)获取,并以像素对像素的方式定量计算钆喷酸葡胺(Gd—DTPA)的浓度改变。治疗前HPI测量误差用Bland—Ahman法分析,在应用抗血管生成药物BIBF1120治疗前后中位HPI的比较应用Wilcoxon秩和检验。治疗前, | K. Miyazaki D.J. Collins S. Walker-Samuel J.N. Taylor A.R. Padhani M.O. Leach 赵艳萍(译) 刘文亚(校) 唐光健(校) | 2008 | 国际医学放射学杂志2008，31，5： | 4 |
| 10 | RF characteristics of wireless capsule endoscopy in human body显示文摘The wireless capsule endoscope,as a small electronic device,has conquered some limitations of traditional wired diagnosing tools,such as the uncomfortableness of the cables for the patient and the inability to examine the very convoluted small intestine section.However,this technique is still encountering a lot of practical challenges and is looking for feasible improvements.This work investigates the RF performance of the wireless capsule endoscope system by studying the electromagnetic(EM) wave propagation within the human body.A wireless capsule endoscopy transmission channel model is constructed to serve the purpose of investigating signal attenuations according to the relative position between the transmitter and the receiver.Within 300-500 MHz,the S_(21) results are regular and do not display any sudden changes,which allows a suitable expression to be derived for S_(21) in terms of frequency and offset.The results provide useful information for capsule localization. | 王璟琛 王炤 Mark Leach LEE Sanghyuk Eng Gee Lim HUANG Yi | 2016 | Journal of Central South University2016，23，5： | 4 |
| 11 | Pharmacokinetics and toxicology of therapeutic proteins:Advances and challenges显示文摘Significant progress has been made in understanding pharmacokinetics (PK),pharmacodynamics (PD),as well as toxicity profiles of therapeutic proteins in animals and humans,which have been in commercial development for more than three decades.However,in the PK arena,many fundamental questions remain to be resolved.Investigative and bioanalytical tools need to be established to improve the translation of PK data from animals to humans,and from in vitro assays to in vivo readouts,which would ultimately lead to a higher success rate in drug development.In toxicology,it is known,in general,what studies are needed to safely develop therapeutic proteins,and what studies do not provide relevant information.One of the major complicating factors in nonclinical and clinical programs for therapeutic proteins is the impact of immunogenicity.In this review,we will highlight the emerging science and technology,as well as the challenges around the pharmacokinetic-and safety-related issues in drug development of mAbs and other therapeutic proteins. | Yulia Vugmeyster Frank-Peter Theil Leslie A Khawli Michael W Leach | 2012 | World Journal of Biological Chemistry2012，3，4： | 3 |
| 12 | Notch mediates TGFα-induced changes in epithelial differentiation during pancreatic tumorigenesis显示文摘 | Yoshiharu Miyamoto Anirban Maitra Bidyut Ghosh Ulrich Zechner Pedram Argani Christine A. Iacobuzio-Donahue Virote Sriuranpong Tatsuya Iso Ingrid M. Meszoely Michael S. Wolfe Ralph H. Hruban Douglas W. Ball Roland M. Schmid Steven D. Leach | 2003 | Cancer Cell2003，，6： | 3 |
| 13 | Widespread use of gastric acid inhibitors in infants:Are they needed? Are they safe?显示文摘Gastroesophageal reflux is a common phenomenon in infants,but the differentiation between gastro-esophageal reflux and gastroesophageal reflux disease can be difficult.Symptoms are non-specific and there is increasing evidence that the majority of symptoms may not be acid-related.Despite this,gastric acid inhibitors such as proton pump inhibitors are widely and increasingly used,often without objective evidence or investigations to guide treatment.Several studies have shown that these medications are ineffective at treating symptoms associated with reflux in the absence of endoscopically proven oesophagitis.With a lack of evidence for efficacy,attention is now being turned to the potential risks of gastric acid suppression.Previously assumed safety of these medications is being challenged with evidence of potential side effects including GI and respiratory infections,bacterial overgrowth,adverse bone health,food allergy and drug interactions. | Mark Safe Wei H Chan Steven T Leach Lee Sutton Kei Lui Usha Krishnan | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，4： | 2 |
| 14 | 燃用乙醇、汽油混合物和含水乙醇的GDI发动机运行(英文)显示文摘作为可再生燃料和改善能源安全的手段,乙醇被逐步推广使用。为研究含水的混合乙醇的燃烧性能以及水与乙醇一汽油的溶混性,试验了含乙醇0-100%的汽油、乙醇混合物,评价了混合物的喷雾特性、燃烧性能和颗粒物排放性能,进行了汽油、乙醇、水的三相图分析和试验。结果表明:在含水量不大于40%时,汽油乙醇混合物中水的存在,不妨碍混合物用作汽油直喷发动机燃料。向喷射汽油中加注乙醇,增大了喷射燃料的体积;以这种燃料注入并持续喷雾,尤其是在冷发动机情况下,降低了混合物均匀性,减少了燃烧稳定性,对于当量比混合物,还增加了颗粒物的排放。向喷射燃料的乙醇中加注水,在含水量不大于30%时,燃烧持续时间不明显增加,燃烧稳定性不明显减小。 | Richard STONE 陈龙飞 Nathan HINTON Felix LEACH 徐帆 | 2012 | 汽车安全与节能学报2012，3，3： | 2 |
| 15 | Imaging vascular function for early stage clinical trials using dynamic contrast-enhanced magnetic resonance imaging显示文摘 | M. Leach B. Morgan P. Tofts D. Buckley W. Huang M. Horsfield T. Chenevert D. Collins A. Jackson D. Lomas B. Whitcher L. Clarke R. Plummer I. Judson R. Jones R. Alonzi T. Brunner D. Koh P. Murphy J. Waterton G. Parker M. Graves T. Scheenen T. Redpath M. Or | 2012 | European Radiology2012，，7： | 2 |
| 16 | Rare presentation of actinomycosis as an abdominal mass显示文摘 | P. Meyer M.D. O. Nwariaku M.D. R. N. McCelland M.D. D. Gibbons M.D. F. Leach M.D. A. I. Sagalowsky M.D. C. Simmang M.D. Dr. D. R. Jeyarajah M.D | 2000 | Diseases of the Colon & Rectum2000，，6： | 2 |
| 17 | Human herpervirus-6 clinical implications of a recently discovered ubiquitous agent显示文摘 | Charles T Leach MD Ciro V | 1992 | J Pediatr1992，121，2： | 2 |
| 18 | Vedolizumab for the treatment of active ulcerative colitis: A randomized controlled phase 2 dose‐ranging study显示文摘 | Asit Parikh Timothy Leach Tim Wyant Catherine Scholz Serap Sankoh Diane R. Mould Terry Ponich Irving Fox Brian G. Feagan | 2011 | Inflamm Bowel Dis2011，，8： | 2 |
| 19 | Functional states of resident vascular stem cells and vascular remodeling显示文摘最近的证据显示脉管的干细胞(VSC ) 的不同类型住在动脉和静脉的墙壁的层以内。这些居民 VSC 的精确身份仍然是不清楚的;通常,出生后的 vasculature 包含 multilineage 干细胞和脉管的房间可以参予脉管的修理和损害形成的系特定的祖先 / 茎房间。然而,内在的机制遗体糟糕理解。在这评论,我们总结潜在的分子的机制,它可以控制居民 VSC 的静止和激活并且加亮居民 VSC 的微分状态直接被连接到脉管的修理或损害形成的一个观点。 | Desiree F. Leach Mitzi Nagarkatti Prakash Nagarkatti Taixing Cui | 2015 | Frontiers in Biology2015，10，5： | 2 |
| 20 | Measurement reproducibility of perfusion fraction and pseudodiffusion coefficient derived by intravoxel incoherent motion diffusion-weighted MR imaging in normal liver and metastases显示文摘 | A. Andreou D. M. Koh D. J. Collins M. Blackledge T. Wallace M. O. Leach M. R. Orton | 2013 | European Radiology2013，，： | 2 |
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