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| 1 | Role of diet on non-alcoholic fatty liver disease: An updated narrative review显示文摘The purpose of this article review is to update what is known about the role of diet on non-alcoholic fatty liver disease(NAFLD). NAFLD is the most common cause of chronic liver disease in the developed world and is considered to be a spectrum, ranging from fatty infiltration of the liver alone(steatosis), which may lead to fatty infiltration with inflammation known as non alcoholic steatohepatitis While the majority of individualswith risk factors like obesity and insulin resistance have steatosis, only few people may develop steatohepatitis. Current treatment relies on weight loss and exercise, although various insulin-sensitizing medications appear promising. Weight loss alone by dietary changes has been shown to lead to histological improvement in fatty liver making nutrition therapy to become a cornerstone of treatment for NAFLD. Supplementation of vitamin E, C and omega 3 fatty acids are under consideration with some conflicting data. Moreover, research has been showed that saturated fat, trans-fatty acid, carbohydrate, and simple sugars(fructose and sucrose) may play significant role in the intrahepatic fat accumulation. However, true associations with specific nutrients yet to be clarified. | Dimitrios Papandreou Eleni Andreou | 2015 | World Journal of Hepatology2015，7，3： | 9 |
| 2 | Matched-pair analysis of postoperative morbidity and mortality for pancreaticogastrostomy and pancreaticojejunostomy using mattress sutures in soft pancreatic tissue remnants显示文摘BACKGROUND:After pancreaticoduodenectomy,the incidence of postoperative pancreatic fistula remains high,especially in patients with 'soft' pancreatic tissue remnants.No 'gold standard' surgical technique for pancreaticoenteric anastomosis has been established.This study aimed to compare the postoperative morbidity and mortality of pancreaticogastrostomy and pancreaticojejunostomy for 'soft' pancreatic tissue remnants using modified mattress sutures.METHODS:Seventy-five patients who had undergone pancreaticogastrostomy and 75 who had undergone pancreaticojejunostomy after pancreaticoduodenectomy between 2002 and 2008 were retrospectively compared using matched-pair analysis.A modified mattress suture technique was used for the pancreaticoenteric anastomosis.Patients with an underlying 'hard' pancreatic tissue remnant,as in chronic pancreatitis,were excluded.Both groups were homogeneous for age,gender,and underlying disease.Postoperative morbidity,mortality,and preoperative and operative data were analyzed.RESULTS:There were no significant differences between the groups for the incidence of postoperative pancreatic fistula (10.7% in both).Postoperative morbidity and mortality,median operation time,median length of hospital stay,intraoperative blood loss,and the amount of intraoperatively transfused erythrocyte concentrates also did not significantly differ between the groups.Patient age >65 years (P=0.017),operation time >350minutes (P=0.001),and intraoperative transfusion of erythrocyte concentrates (P=0.038) were identified as risk factors for postoperative morbidity.CONCLUSIONS:Our results showed no significant differences between the groups in the pancreaticogastrostomy and pancreaticojejunostomy anastomosis techniques using mattress sutures for 'soft' pancreatic tissue remnants.In our experience,the mattress sutures are safe and simple to use,and pancreaticogastrostomy in particular is feasible and easy to learn,with good endoscopic accessibility to the anastomosis region.However,the location of the anastomosis and the surgical technique need to be individually evaluated to further reduce the incidence of postoperative pancreatic fistula. | Fritz Klein Marcus Bahra Matthias Glanemann Wladimir Faber Peter Warnick Andreas Andreou Safak Gül Dietmar Jacob | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，1： | 9 |
| 3 | 分娩所致Valsalva视网膜病变治疗方法的探讨(英文)显示文摘目的:讨论孕妇Valsalva视网膜病变保守或手术治疗方法的选择。方法:一健康孕妇在自然阴道分娩时,右眼底发生黄斑前玻璃体后界膜下出血,本文报道其保守治疗的效果。结果:右眼发病3wk时积血收缩,视力为眼前手动,但病程6mo时,积血溶解,视力恢复至6/5。结论:大多数Valsalva视网膜病变能够自愈。对一些难治性病例,采用Nd:YAG激光行内界膜切开具有一定的效果。而早期玻璃体切除术的增殖膜切除,对预防眼底新生血管膜的发生也具有一定的效果。 | Konstantinos I Papageorgiou Rashmi G Mathew AlexanderS Ioannidis Ajay Sinha Petros S Andreou | 2007 | 国际眼科杂志2007，7，3： | 3 |
| 4 | Measurement reproducibility of perfusion fraction and pseudodiffusion coefficient derived by intravoxel incoherent motion diffusion-weighted MR imaging in normal liver and metastases显示文摘 | A. Andreou D. M. Koh D. J. Collins M. Blackledge T. Wallace M. O. Leach M. R. Orton | 2013 | European Radiology2013，，： | 2 |
| 5 | Infected Completely Isolated Enteric Duplication Cyst Management with Percutaneous Drainage and Surgical Excision after Retreat of Infection: A Case Report显示文摘 | Neofytou Kyriakos Chysochos Andreas Sammouti Elena Andreou Charalampos Georgiou Chrisanthos C. Barnett F. Marchal B. Tokar | 2013 | Case Reports in Surgery2013，，： | 2 |
| 6 | The prognostic significance of MRI-detected extramural venous invasion in rectal carcinoma显示文摘 | W.G. Bugg A.K. Andreou D. Biswas A.P. Toms S.M. Williams | 2014 | Clinical Radiology2014，，： | 2 |
| 7 | Warm HTK donor pretreatment reduces liver injury during static cold storage in experimental rat liver transplantation显示文摘BACKGROUND: Organ shortage has led to an increased number of transplantations from extended criteria donors. These organs are more vulnerable to ischemia-reperfusion injury. Thus,improvement of organ preservation is needed. HTK is a widely used preservation solution for static cold storage in liver transplantation. The present study was to investigate the beneficial effect of warm HTK donor pretreatment on liver preservation.METHODS: Male inbred Wistar rats(weighing 230-260 g) served as donors and recipients(n=6/group). Donors of treatment groups received i.v. 0.01 m L/g body weight(BW) warm(21 ℃) HTK systemically 15 minutes prior to cold perfusion. Control groups received 0.01 m L/g BW warm(21 ℃) Na Cl 0.9%. Following pretreatment,donors were flushed with 4 ℃ cold HTK,livers were explanted and stored in 4 ℃ HTK for six hours. Thereafter orthotopic liver transplantation was performed. Recipients were harvested four hours,two and five days after reperfusion and blood and liver tissue samples were obtained. Blood samples were analyzed for AST,ALT,lactate dehydrogenase and bilirubin. Liver histological analysis as well as tissue analysis for pro-MMP2,MMP2 and pro-MMP9 using zymography was conducted.RESULTS: Treatment groups showed significantly lower ALT and lactate dehydrogenase levels as well as significantly lower activities of pro-MMP2,MMP2 and pro-MMP9. Histological analysis revealed only minor damage in all groups.CONCLUSIONS: The new concept of warm HTK pretreatment significantly reduced ischemia-reperfusion injury. The reduced ischemia-reperfusion injury was due to MMP inhibition. Warm HTK donor pretreatment is easy to handle and could further improve HTK's potency in liver preservation. | Wenzel Schoening Veeravorn Ariyakhagorn Thomas Schubert Peter Olschewski Andreas Andreou Peter Neuhaus Johann Pratschke Gero Puhl | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，6： | 2 |
| 8 | Monitoring disruptions in financial markets显示文摘 | Andreou E Ghysels E | 2006 | Journal of Econometrics2006，135，： | 1 |
| 9 | Periodontitis and sys- temic inflammation: control of the local infection is associated with a reduction in serum inflammatory markers 显示文摘 | D' Aiuto F Parkar M Andreou G | 2004 | Den Res2004，8，3： | 1 |
| 10 | Follow-up in head and neck cancer: patients perspective 显示文摘 | Trinidade A Kothari P Andreou Z | 2012 | Int J Health Care Qual Assur2012，25，2： | 1 |
| 11 | Novel fiber-optic biosensor based on immobilized glutathione S-trans-ferase and sol-gel entrapped bromcresol green for the determination of atrazine显示文摘 | ANDREOU V G CLONIS Y D | 2002 | Analytica Chimica Acta2002，460，2： | 1 |
| 12 | Differences in clinical presentation of deep vein thrombosis in men and women 显示文摘 | Andreou ER Koru-Sengul T Linkins L | 2008 | J Thromb Haemost2008，6，10： | 1 |
| 13 | Improved long-term survival after major resection for hepatocellular carcinoma : a mul- tieenter analysis based on a new definition of major hepatectomy 显示文摘 | Andreou A Vauthey J N Cherqui D | 2013 | J Gastrointest Surg2013，17，： | 1 |
| 14 | Polarization Camera Sensors显示文摘 | Wolff L B Andreou A G | 1995 | Image and Vision Computing1995，13，6： | 1 |
| 15 | A capital budgeting model for product-mix flexibility显示文摘 | Andreou SA | 1990 | Journal of Manufacturing and Operations Management1990，3，： | 1 |
| 16 | World health dilemmas: Orphan and rare diseases, orphan drugs and orphan patients显示文摘According to global annual estimates hunger/malnutrition is the major cause of death(36 of 62 million). Cardiovascular diseases and cancer(5.44 of 13.43 million) are the major causes of death in developed countries, while lower respiratory tract infections, human immunodeficiency virus infection/acquired immunodeficiency syndrome, diarrhoeal disease, malaria and tuberculosis(10.88 of 27.12 million) are the major causes of death in developing countries with more than 70% of deaths occurring in children. The majority of approximately 800 million people with other rare diseases, including 100000 children born with thalassaemia annually receive no treatment. There are major ethical dilemmas in dealing with global health issues such as poverty and the treatment of orphan and rare diseases. Of approximately 50000 drugs about 10% are orphan drugs, with annual sales of the latter approaching 100 billion USD. In comparison, the annual revenue in 2009 from the top 12 pharmaceutical companies in Western countrieswas 445 billion USD and the top drug, atorvastatin, reached 100 billion USD. In the same year, the total government expenditure for health in the developing countries was 410 billion USD with only 6%-7% having been received as aid from developed countries. Drugs cost the National Health Service in the United Kingdom more than 20 billion USD or 10% of the annual health budget. Uncontrollable drug prices and marketing policies affect global health budgets, clinical practice, patient safety and survival. Fines of 5.3 billion USD were imposed on two pharmaceutical companies in the United States, the regulatory authority in France was replaced and clinicians were charged with bribery in order to overcome recent illegal practises affecting patient care. High expenditure for drug development is mainly related to marketing costs. However, only 2 million USD was spent developing the drug deferiprone(L1) for thalassaemia up to the stage of multicentre clinical trials. The criteria for drug development, price levels and use needs to be readdressed to improve drug safety and minimise costs. New global health policies based on cheaper drugs can help the treatment of many categories of orphan and rare diseases and millions of orphan patients in developing and developed countries. | Christina N Kontoghiorghe Nicholas Andreou Katerina Constantinou George J Kontoghiorghes | 2014 | World Journal of Methodology2014，4，3： | 1 |
| 17 | Affecting Factors in Second Language Learning显示文摘 | G. Andreou F. Vlachos E. Andreou | 2005 | Journal of Psycholinguistic Research2005，，5： | 1 |
| 18 | Monitoring Disruptions in Finacial Markets显示文摘 | Andreou E Ghysels E | 2006 | Journal of Econometrics2006，135，1： | 1 |
| 19 | Effects of rosuvastatin and allopurinol on circulating endothelial progenitor cells in patients with congestive heart failure: The impact of inflammatory process and oxidative stress显示文摘 | Dimitris Tousoulis Ioannis Andreou Marinos Tsiatas Antigoni Miliou Costas Tentolouris Gerasimos Siasos Nikos Papageorgiou Christos A. Papadimitriou Meletios-Athanasios Dimopoulos Christodoulos Stefanadis | 2010 | Atherosclerosis2010，，1： | 1 |
| 20 | Infarction of the corpus callosum: computed tomography and magnetic resonance imaging显示文摘 | Hrysikopoulos H Andreou J Roussakis A | 1997 | Eur J Radiol1997，25，1： | 1 |
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