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| 1 | Impact of hyperglycemia on autoimmune pancreatitis and regulatory T-cells显示文摘AIM To evaluate the influence of hyperglycemia on the progression of autoimmune pancreatitis.METHODS We induced hyperglycemia by repetitive intraperitoneal(ip) injection of 50 mg/kg streptozotocin in MRL/Mp J mice, which develop autoimmune pancreatitis due to a genetic predisposition. We compared the extent of inflammation(histological score, CD3^+ lymphocytes, CD8^+ T-cells, CD4^+ T-cells, Foxp3^+ T-helper cells) in the pancreas of hyperglycemic and normoglycemic mice. We also analyzed the number of leukocytes, lymphocytes, granulocytes and monocytes in the blood. In addition, we determined the percentage of CD3^+ lymphocytes, CD8^+ T-cells, CD4^+ T-cells, Foxp3^+ T-helper cells, Foxp3^+ CD25^+ T-helper and Foxp3^+T-helper cells in the spleen by flow cytometry.RESULTS Treatment with streptozotocin caused a strong induction of hyperglycemia and a reduction in body weight(P < 0.001). Severe hyperglycemia did not, however, lead to an aggravation, but rather to a slight attenuation of autoimmune pancreatitis. In the pancreas, both the histological score of the pancreas as well as the number of CD3+ lymphocytes(P < 0.053) were decreased by hyperglycemia. No major changes in the percentage of CD8^+ T-cells, CD4^+ T-cells, Foxp3^+ T-helper cells were observed between hyperglycemic and normoglycemic mice. Hyperglycemia increased the numbers of leukocytes(P < 0.001), lymphocytes(P = 0.016), granulocytes and monocytes(P = 0.001) in the blood. Hyperglycemia also moderately reduced the percentage of CD3^+ lymphocytes(P = 0.057), significantly increased the percentage of Foxp3^+ T-helper cells(P = 0.018) and Foxp3^+ CD25^+ T-helper cells(P = 0.021) and reduced the percentage of Foxp3^+T-helper cells(P = 0.034) in the spleen. CONCLUSION Hyperglycemia does not aggravate but moderately attenuates autoimmune pancreatitis, possibly by increasing the percentage of regulatory T-cells in the spleen. | Franz-Tassilo Müller-Graff Brit Fitzner Robert Jaster Brigitte Vollmar Dietmar Zechner | 2018 | World Journal of Gastroenterology2018，24，28： | 3 |
| 2 | Notch mediates TGFα-induced changes in epithelial differentiation during pancreatic tumorigenesis显示文摘 | Yoshiharu Miyamoto Anirban Maitra Bidyut Ghosh Ulrich Zechner Pedram Argani Christine A. Iacobuzio-Donahue Virote Sriuranpong Tatsuya Iso Ingrid M. Meszoely Michael S. Wolfe Ralph H. Hruban Douglas W. Ball Roland M. Schmid Steven D. Leach | 2003 | Cancer Cell2003，，6： | 3 |
| 3 | Lung ultrasound in acute and critical care medicine显示文摘 | Zechner PM Seibel A Aichinger G | | 0，，： | 1 |
| 4 | Bank Capital Regulation with Random Au- dits 显示文摘 | Sudipto Bhattacharya Manfred Plank Gunter Strobl Jo- sef Zechner | 2002 | Journal of Economic Dynamics and Control2002，26，7： | 1 |
| 5 | Gadd45alpha is highly expressed in pancreatic ductal adenocareinoma cells and required for tumor cell viability 显示文摘 | Schneider G Weber A Zechner U | 2006 | Int J Cancer2006，118，10： | 1 |
| 6 | IPO mechanisms,monitoring and ownership structure显示文摘 | Stoughton N M Zechner J | 1998 | Journal of Financial Economics1998，49，4： | 1 |
| 7 | Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores 显示文摘 | R Zechner P C Kienesberger G Haemmerle | 2009 | J LipidRes2009，50，1： | 1 |
| 8 | Methylation status of imprinted genes and repetitive elements in sperm DNA from infertile males显示文摘 | E1 Hajj N Zechner U Schneider E | 2011 | Sex Dev2011，5，2： | 1 |
| 9 | Gadd45alpha is highly expressed in pancreatic ductal adenocarcinoma cells and required for tumor cell viability显示文摘 | Schneider G Weber A Zechner U | 2006 | Int J Cancer2006，118，10： | 1 |
| 10 | Dynamic capital structure choice: Theory and tests 显示文摘 | Fischer Edwin O Robert Heinkel Josef Zechner | 1989 | Journal of Finance1989，，44： | 1 |
| 11 | FAT SIGNALS- lipases and lipolysis in lipid metabolism and signaling显示文摘 | Zechner R Zimmermann R Eiehmann TO | 2012 | Cell Metal)2012，15，3： | 1 |
| 12 | p38 mitogen-activated protein kinase mediates the transcriptional induction of the atrial natriuretic factor gene through a serum response element,a potential role for the transcription factor ATF6显示文摘 | THUERAUF D J ARNOLD N D ZECHNER D | 1998 | J Biol Chem1998，273，20： | 1 |
| 13 | The tissue-specific expression of lipoprotein lipase: implications for energy and lipoprotein metabolism 显示文摘 | Zechner R | 1997 | Curr Opin Lipidol1997，8，： | 1 |
| 14 | A role of the p38 mitogenactivated protein kinase pathway in myocardial cell growth, sareomeric organization, and cardiac-specific gene expression 显示文摘 | Zechner D Thuerauf DJ Hartford DS | 1997 | J Cell Biol1997，139，1： | 1 |
| 15 | Inbreeding, microsatel- lite heterozygosity, and morphological traits in Lipizzan horses显示文摘 | Curik I Zechner P Srlkner J | 2003 | J Hered2003，94，： | 1 |
| 16 | Tax Clienteles and Optimal Capital Structure under Uncertainty显示文摘 | Zechner Josef | 1990 | Journal of Business1990，64，04： | 1 |
| 17 | Cellular fatty acid metabolism and cancer显示文摘 | Currie Erin Schulze Almut Zechner Rudolf | 2013 | Cell metabolism2013，18，2： | 1 |
| 18 | The Role of Debt and Preferred Stock as a Solution to Adverse Investment Incentives显示文摘 | Heinkel R Zechner J | 1990 | Journal of Financial and Quantitative Analysis1990，，25： | 1 |
| 19 | IPO Mechanisms,Monito-ring and Ownership Structure 显示文摘 | Stoughton N and Zechner J | 1998 | Journal of Financial Eco-nomics1998，，49： | 1 |
| 20 | Dietary polyunsaturated fat of the w-6 and w-3 series reduce postprandial lipoprotein concentrations: acute and chronic effects of fat saturation postprandial lipoprotein metabolism 显示文摘 | Weintraub M S Zechner R Brown A | 1988 | Clin Invest1988，82，6： | 1 |
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