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3篇 您的检索式:作者名="Navin Sheth"
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1Self nano-emulsifying drug delivery system for Embelin:Design,characterization and in-vitro studies显示文摘CThe objective of the present study was to prepare solid self-nanoemulsifying drug delivery system(S-SNEDDS)containing Capryol-90 as oil phase for the delivery of Embelin,a poorly water soluble herbal active ingredient.Box-Behnken experimental design was employed to optimise the formulation variables,X1(amount of oil;Capryol 90),X2(amount of surfactant;Acrysol EL 135)and X3(amount of co-surfactant;PEG 400).Systems were appraised for visual characteristics for self emulsifying time,globule size and drug release.Optimised liquid formulations were formulated into free flowing granules(S-SNEDDS)by adsorption on the porous materials like Aerosil 200 and Neusilin and thereby compressed into tablet.In vitro dissolution studies of SNEDDS revealed increased in the dissolution rate of the drug.FT-IR data revealed no physicochemical interaction between drug and excipients.Solid state characterization of S-SNEDDS by DSC and Powder XRD confirmed reduction in drug crystallinity which further supports the results of dissolution studies.TEM analysis exhibited spherical globules.Further,the accelerated stability studies for 6 months revealed that S-SNEDDS of Embelin are found to be stable without any significant change in physicochemical properties.Thus,the present studies demonstrated dissolution enhancement potential of porous carrier based S-SNEDDS for poorly water soluble herbal active ingredient,Embelin.Komal Parmar Jayvadan Patel Navin Sheth 2015Asian Journal of Pharmaceutical Sciences2015,10,5:2
2Neuroprotective activity of Cymbopogon martinii against cerebral ischemia/reperfusion-induced oxidative stress in rats显示文摘Prakruti Buch Vishal Patel Vishavas Ranpariya Navin Sheth Sachin Parmar 2012Journal of Ethnopharmacology2012,,1:1
3Neuroprotective activity of Cymbopogon martinii against cerebral ischemia/reperfusion-induced oxidative stress in rats显示文摘Prakruti Buch Vishal Patel Vishavas Ranpariya Navin Sheth Sachin Parmar 2012Journal of Ethnopharmacology2012,,1:1
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