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| 1 | Comparative clinical trial of S-pantoprazole versus racemic pantoprazole in the treatment of gastro-esophageal reflux disease显示文摘AIM: To compare the effi cacy and tolerability of S-pan- toprazole (20 mg once a day) versus racemic Panto- prazole (40 mg once a day) in the treatment of gastro- esophageal reflux disease (GERD). METHODS: This multi-centre, randomized, double-blind clinical trial consisted of 369 patients of either sex suf- fering from GERD. Patients were randomly assigned to receive either one tablet (20 mg) of S-pantoprazole once a day (test group) or 40 mg racemic pantoprazole once a day (reference group) for 28 d. Patients were evaluated for reduction in baseline on d 0, GERD symptom score on d 14 and 28, occurrence of any adverse effect during the course of therapy. Gastrointestinal (GI) endoscopy was performed in 54 patients enrolled at one of the study centers at baseline and on d 28. RESULTS: Signifi cant reduction in the scores (mean and median) for heart burn (P < 0.0001), acid regurgitation (P < 0.0001), bloating (P < 0.0001), nausea (P < 0.0001) and dysphagia (P < 0.001) was achieved in both groups on d 14 with further reduction on continuing the therapy till 28 d. There was a statistically signifi cant difference in the proportion of patients showing improvement in acid regurgitation and bloating on d 14 and 28 (P = 0.004 for acid regurgitation; P = 0.03 for bloating) and heart burn on d 28 (P = 0.01) between the two groups, with a higher proportion in the test group than in the refer- ence group. Absolute risk reductions for heartburn/acid regurgitation/bloating were approximately 15% on d 14 and 10% on d 28. The relative risk reductions were 26%-33% on d 14 and 15% on d 28. GI endoscopy showed no signifi cant difference in healing of esophagitis (P = 1) and gastric erosions (P = 0.27) between the two groups. None of the patients in either group reported any adverse effect during the course of therapy.CONCLUSION: In GERD, S-pantoprazole (20 mg) is more effective than racemic pantoprazole (40 mg) in improving symptoms of heartburn, acid regurgitation, bloating and equally effective in healing esophagitis and gastric erosions. The relative risk reduction is 15%-33%. Both drugs are safe and well tolerated. | Vikas G Pai Nitin V Pai Hemant P Thacker Jaisingh K Shinde Vijay P Mandora Subhash S Erram | 2006 | World Journal of Gastroenterology2006，12，37： | 19 |
| 2 | Randomized, double-blind, comparative study of dexrabeprazole 10 mg versus rabeprazole 20 mg in the treatment of gastroesophageal reflux disease显示文摘AIM: To compare the efficacy and safety of dexrabe- prazole 10 mg versus rabeprazole 20 mg in the treatment of gastroesophageal reflux disease (GERD). METHODS: This was a randomized, double-blind clinical study. Fifty patients with GERD were randomly assigned to receive dexrabeprazole 10 mg or rabeprazole 20 mg once daily. Efficacy was assessed by evaluating improvement in visual analog scale (VAS) scores of heart-burn and regurgitation and safety was assessed by recording incidence of any adverse drug reactions. Laboratory investigations and upper gastro-intestinal endoscopy was conducted at baseline and after 28 d of therapy. RESULTS: A total of 50 patients (n = 25 in dexrabeprazole group and rabeprazole group each) completed the study. There were no significant differences in the baseline characteristics between the two groups. The VAS score (mean ± SD) of heartburn and regurgitation in dexrabeprazole (64.8 ± 5.1 and 64 ± 8.1, respectively) and rabeprazole (64.4 ± 8.7 and 57.6 ± 9.7, respectively) groups significantly reduced (P < 0.0001) to 30 ± 11.5, 24 ± 10 and 32 ± 9.5, 29.2 ± 11.9, respectively on d 28. A significantly higher (P = 0.002) proportion of patients showed ≥ 50% improvement in regurgitation with dexrabeprazole 10 mg (96%) compared to rabeprazole 20 mg (60%). Onset of symptom improvement was significantly earlier with dexrabeprazole than with rabeprazole (1.8 ± 0.8 d vs 2.6 ± 1.4 d; P <0.05). The incidences of esophagitis in the dexrabeprazole group and rabeprazole group before therapy were 84% and 92%, respectively (P = 0.38). The incidence of improvement/healing of esophagitis after therapy was more (P = 0.036) in the dexrabeprazole group (95.2%) compared to the rabeprazole group (65.2%). No adverse drug reaction was seen in either group.CONCLUSION: In the treatment of GERD, efficacy of dexrabeprazole 10 mg is better than rabeprazole 20 mg, with regards to improvement/healing of endoscopic lesions and relief from symptoms of regurgitation. | Vikas Pai Nitin Pai | 2007 | World Journal of Gastroenterology2007，13，30： | 18 |
| 3 | Nanodendrites of platinum-group metals for electrocatalytic applications显示文摘Developing highly efficient and durable catalysts for future electrochemical and energy applications is one of the main subjects of current studies in renewable energy generation.In the past several years,researchers have developed Pt-based ,alloy electrocatalyst nanomaterials that exhibit promising electrocatalytic properties for various electrochemical applications.The efficient structural and morphological control of Pt-based alloy materials plays a decisive role in achieving these enhanced electrocatalytic properties.The present review article emphasizes the recent progress and important developments in the synthesis and electrocatalytic applications of Pt-group-based nanodendrite materials.The following review will help the exploration and development of better catalysts for practical applications and aims to elucidate the nanodendrite structure of Pt-group metals. | Nitin K.Chaudhari Jinwhan Joo Hyuk-bu Kwon Byeongyoon Kim Ho Young Kim Sang Hoon Joo Kwangyeol Lee | 2018 | Nano Research2018，11，12： | 10 |
| 4 | 员工激励的“四力模型”显示文摘如何让员工做出最好的成绩,尤其是在艰难的环境下如何做到这一点,这是管理者面临的最棘手的长久挑战。可是,到底什么东西能够激励我们?几个世纪以来,人们一直试图破解这个难题。一些大思想家,包括亚里士多德(Aristotle)、亚当·斯密(Adam Smith)、西格蒙德·弗洛伊德(Sigmund Freud)、亚伯拉罕·马斯洛(Abraham Maslow)等,都曾努力理解人类行为的种种微妙特征,给了人们许多启发。 | 尼廷·诺里亚(Nitin Nohria) 鲍里斯·格鲁斯伯格(Boris Groysberg) 琳达-埃琳·李(Linda-Eling Lee) 詹正茂(翻译) | 2008 | 商业评论2008，，8： | 8 |
| 5 | Endoscopic therapy for weight loss: Gastroplasty, duodenal sleeves, intragastric balloons, and aspiration显示文摘A new paradigm in the treatment of obesity and metabolic disease is developing. The global obesity epidemic continues to expand despite the availability of diet and lifestyle counseling, pharmacologic therapy, and weight loss surgery. Endoscopic procedures have the potential to bridge the gap between medical therapy and surgery. Current primary endoscopic bariatric therapies can be classified as restrictive, bypass, spaceoccupying, or aspiration therapy. Restrictive procedures include the USGI Primary Obesity Surgery Endolumenal procedure, endoscopic sleeve gastroplasty using Apollo Over Stitch, Trans Oral GAstroplasty, gastric volume reduction using the ACE stapler, and insertion of the TERIS restrictive device. Intestinal bypass has been reported using the EndoB arrier duodenal-jejunal bypass liner. A number of space-occupying devices have been studied or are in use, including intragastric balloons(Orbera, Reshape Duo, Heliosphere BAG, Obalon), Transpyloric Shuttle, and Sati Sphere. The Aspire Assist aspiration system has demonstrated efficacy. Finally, endoscopic revision of gastric bypass to address weight regain has been studied using Apollo Over Stitch, the USGI Incisionless Operating Platform Revision Obesity Surgery Endolumenal procedure, Stomaphyx, and endoscopic sclerotherapy. Endoscopic therapies for weight loss are potentially reversible, repeatable, less invasive, and lower cost than various medical and surgical alternatives. Given the variety of devices under development, in clinical trials, and currently in use, patients will have multiple endoscopic options with greater efficacy than medical therapy, and with lower invasiveness and greater accessibility than surgery. | Nitin Kumar | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，9： | 7 |
| 6 | 溶液注入热等离子体中直接制备纳米结构热障涂层显示文摘采用一种新的方法,将Y2O3稳定的ZrO2前驱体溶液雾化注入直流等离子体中直接制备热障涂层.扫描电镜、透射电镜、X射线衍射分析、激光闪烁法分别观察分析了涂层的显微组织、纳米晶粒、相结构和热导率,排水法、冷热冲击法分别检测了涂层密度和热循环性能.实验结果显示:等离子体喷涂液体制备出来的热障涂层不具有层状组织,晶粒尺寸小于100nm,组成相为四方相,硬度为350左右,热导率在1.2~1.5 W/m·K范围,涂层中存在16%左右的孔隙率,具有比常规微米结构热障涂层更优越的热循环性能.分析结果表明:液体注入热等离子体中的雾化沉积既区别于物理化学气相沉积,又区别于粉末注入热等离子体中的熔化沉积,属于表面工程技术下的交叉领域. | 蒋显亮 Nitin PADTURE Maurice GELL Danny XIAO | 2004 | 功能材料2004，35，z1： | 6 |
| 7 | Three-dimensional bio-printing: A new frontier in oncology research显示文摘Current research in oncology deploys methods that rely principally on two-dimensional(2D) mono-cell cultures and animal models.Although these methodologies have led to significant advancement in the development of novel experimental therapeutic agents with promising anticancer activity in the laboratory, clinicians still struggle to manage cancer in the clinical setting.The disappointing translational success is attributable mainly to poor representation and recreation of the cancer microenvironment present in human neoplasia.Threedimensional(3D) bio-printed models could help to simulate this micro-environment, with recent bio-printing of live human cells demonstrating that effective in vitro replication is achievable.This literature review outlines up-to-date advancements and developments in the use of 3D bio-printed models currently being used in oncology research.These innovative advancements in 3D bio-printing open up a new frontier for oncology research and could herald an era of progressive clinical cancer therapeutics. | Nitin Charbe Paul A McCarron Murtaza M Tambuwala | 2017 | World Journal of Clinical Oncology2017，8，1： | 6 |
| 8 | Magnesium:pathophysiological mechanisms and potential therapeutic roles in intracerebral hemorrhage显示文摘Intracerebral hemorrhage(ICH) remains the second-most common form of stroke with high morbidity and mortality.ICH can be divided into two pathophysiological stages:an acute primary phase,including hematoma volume expansion,and a subacute secondary phase consisting of blood-brain barrier disruption and perihematomal edema expansion.To date,all major trials for ICH have targeted the primary phase with therapies designed to reduce hematoma expansion through blood pressure control,surgical evacuation,and hemostasis.However,none of these trials has resulted in improved clinical outcomes.Magnesium is a ubiquitous element that also plays roles in vasodilation,hemostasis,and blood-brain barrier preservation.Animal models have highlighted potential therapeutic roles for magnesium in neurological diseases specifically targeting these pathophysiological mechanisms.Retrospective studies have also demonstrated inverse associations between admission magnesium levels and hematoma volume,hematoma expansion,and clinical outcome in patients with ICH.These associations,coupled with the multifactorial role of magnesium that targets both primary and secondary phases of ICH,suggest that magnesium may be a viable target of study in future ICH studies. | Jason J.Chang Rocco Armonda Nitin Goyal Adam S.Arthur | 2019 | Neural Regeneration Research2019，14，7： | 6 |
| 9 | Current therapeutic strategies for inflammation following traumatic spinal cord injury显示文摘Damage from spinal cord injury occurs in two phases-the trauma of the initial mechanical insult and a secondary injury to nervous tissue spared by the primary insult.Apart from damage sustained as a result of direct trauma to the spinal cord,the post-traumatic inflammatory response contributes significantly to functional motor deficits exacerbated by the secondary injury.Attenuating the detrimental aspects of the inflammatory response is a promising strategy to potentially ameliorate the secondary injury,and promote significant functional recovery.This review details how the inflammatory component of secondary injury to the spinal cord can be treated currently and in the foreseeable future. | Priyanka L.Singh Nitin Agarwal James C.Barrese Robert F.Heary | 2012 | Neural Regeneration Research2012，7，23： | 5 |
| 10 | Snapshot of HIV pathogenesis in China显示文摘Several reviews have focused on the nature of HIV infection and its spread in various geographical regions of China. In contrast, this review provides a comprehensive update on the prevalence of multiple HIV-1 subtypes, consequent emergence of recombinant and novel forms of HIV-1 in China, and the implications this may have on HIV diversity and the development of effective vaccines. In addition it also examines the dissemination of primary drug resistance in therapy na?ve patients, as well as co-infections with two other important viruses-hepatitis B and C. The main purpose of this review is to provide a current snapshot of HIV-1 pathogenesis in China and possibly shed some light on the future of HIV evolution, and potential challenges for future vaccine and anti-retroviral therapeutics against HIV strains in this area. | Nitin K SAKSENA Bin WANG Megan STEAIN Rong Ge YANG Lin Qi ZHANG | 2005 | Cell Research2005，15，11： | 4 |
| 11 | 优化快速成膜工艺中的前驱体组分以制备致密、稳定的钙钛矿薄膜(英文)显示文摘快速成膜工艺提供了一种简单、高产率、无铅释放的钙钛矿薄膜制备方法.在这一方法中,低浓度的钙钛矿前驱体溶液被滴到240℃的热衬底上,伴随着溶剂在高温条件下的迅速挥发,钙钛矿在衬底表面迅速结晶,生长成一层薄膜.在此过程中,所有含铅的原材料都被沉积到钙钛矿薄膜中,含铅原材料的浪费和铅释放导致的污染都被显著降低.这种方法制备的钙钛矿薄膜的性质可以由前驱体溶液的组分调节.CH_3NH_3Cl(MACl)可以调节结晶过程,有助于提高薄膜表面覆盖率.CH(NH_2)_2I(FAI)有助于提高钙钛矿薄膜的热稳定性.当前驱体组分为PbI_2·(1-x)FAI·xMACl,x=0.75时,快速成膜工艺制备的钙钛矿膜达到最优化性质,由此制备的平面结太阳电池可以实现超过15%的能量转换效率,迟滞现象很小,并且重复性良好. | 刘堂昊 周圆圆 胡芹 陈科 张翼飞 杨文强 吴疆 叶冯俊 罗德映 朱凯 Nitin P.Padture 刘锋 Thomas Russell 朱瑞 龚旗煌 | 2017 | Science China Materials2017，60，7： | 4 |
| 12 | Management of pregnancy in Crigler Najjar syndrome type 2显示文摘Crigler Najjar syndrome is associated with indirect hyperbilirubinemia due to a deficiency of enzyme Uridine Di Phospho Glucoronosyl Transferase(UDPGT).Presented here is a case of a female in the first trimester of pregnancy,who was diagnosed to have type 2 Crigler Najjar syndrome.We also discuss the management of this rare disease especially in pregnancy.Unconjugated bilirubin can cross the placental barrier causing neuro-logical damage in the newborn.Patient was carefully monitored during pregnancy and treatment with pheno-barbitone in low doses was adjusted such that the serum bilirubin levels were below 10 mg/d L.Crigler Najjar syndrome being rare needs to be diagnosed early in pregnancy to avoid adverse fetal outcomes.Phenobarbitone being an inducer of enzyme UDPGT is used as the first line of treatment and is not teratogenic in the low doses used.Treatment protocol followed was on the basis of previous reported cases and successful perinatal outcome was achieved. | Alisha Nitin Chaubal Ruchir Patel Dhaval Choksi Kaivan Shah Meghraj Ingle Prabha Sawant | 2016 | World Journal of Hepatology2016，8，11： | 4 |
| 13 | Pedotransfer Functions for Estimating Soil Hydraulic Properties: A Review显示文摘Characterization of soil hydraulic properties is important to environment management; however, it is well recognized that it is laborious, time-consuming and expensive to directly measure soil hydraulic properties. This paper reviews the development of pedotransfer functions(PTFs) used as an alternative tool to estimate soil hydraulic properties during the last two decades. Modern soil survey techniques like satellite imagery/remote sensing has been used in developing PTFs. Compared to mechanistic approaches,empirical relationships between physical properties and hydraulic properties have received wide preference for predicting soil hydraulic properties. Many PTFs based on different parametric functions can be found in the literature. A number of researchers have pursued a universal function that can describe water retention characteristics of all types of soils, but no single function can be termed generic though van Genuchten(VG) function has been the most widely adopted. Most of the reported parametric PTFs focus on estimation of VG parameters to obtain water retention curve(WRC). A number of physical, morphological and chemical properties have been used as predictor variables in PTFs. Conventionally, regression algorithms/techniques(statistical/neural regression) have been used for calibrating PTFs. However, there are reports of utilizing data mining techniques, e.g., pattern recognition and genetic algorithm.It is inferred that it is critical to refine the data used for calibration to improve the accuracy and reliability of the PTFs. Many statistical indices, including root mean square error(RMSE), index of agreement(d), maximum absolute error(ME), mean absolute error(MAE), coefficient of determination(r^2) and correlation coefficient(r), have been used by different researchers to evaluate and validate PTFs. It is argued that being location specific, research interest in PTFs will continue till generic PTFs are developed and validated. In future studies, improved methods will be required to extract information from the existing database. | Nitin Gorakh PATIL Surendra Kumar SINGH | 2016 | Pedosphere2016，26，4： | 4 |
| 14 | Development of an HPLC–UV assay method for the simultaneous quantification of nine antiretroviral agents in the plasma of HIV-infected patients显示文摘A new method using high-performance liquid chromatography coupled with ultra violet detection(HPLC–UV)was developed and validated for the simultaneous quantification of atazanavir,dolutegravir,darunavir,efavirenz,etravirine lopinavir,raltegravir,rilpivirine and tipranavir in human plasma.For the first time we reported here the development and validation of an HPLC–UV assay to quantify the frequently administered 9antiretroviral compounds including dolutegravir and rilpivirine.A simple solid phase extraction procedure was applied to 500 μL aliquots of plasma.The chromatographic separation of the drugs and internal standard(quinoxaline) was achieved with a gradient of acetonitrile and sodium acetate buffer on a C_(18) reverse-phase analytical column with a 25 min analytical run time.Calibration curves were optimised according to the therapeutic range of drug concentrations in patients,and the coefficient of determination(r^2) was higher than0.99 for all analytes.Mean intraday and interday precisions(RSD) for all compounds were less than 15.0%,and the mean accuracy(% deviation from nominal concentration) was also found to be less than 15.0%.Extraction recovery range was between 80% and 120% for all drugs analysed.The solid phase extraction and HPLC–UV method enable a specific,sensitive,and reliable simultaneous determination of nine antiretroviral agents in plasma.Good extraction efficiency and low limit of HPLC–UV quantification make this method suitable for use in clinical trials and therapeutic drug monitoring. | Nitin Charbe Sara Baldelli Valeria Cozzi Simone Castoldi Dario Cattaneo Emilio Clementi | 2016 | Journal of Pharmaceutical Analysis2016，6，6： | 4 |
| 15 | Bone graft substitutes for spine fusion: A brief review显示文摘Bone graft substitutes are widely used in the field of orthopedics and are extensively used to promote vertebral fusion. Fusion is the most common technique in spine surgery and is used to treat morbidities and relieve discomfort. Allograft and autograft bone substitutes are currently the most commonly used bone grafts to promote fusion. These approaches pose limitations and present complications to the patient. Numerous alternative bone graft substitutes are on the market or have been developed and proposed for application. These options have attempted to promote spine fusion by enhancing osteogenic properties. In this review, we reviewed biology of spine fusion and the current advances in biomedical materials and biological strategies for application in surgical spine fusion. Our findings illustrate that, while many bone graft substitutes perform well as bone graft extenders, only osteoinductive proteins(recombinant bone morphogenetic proteins-2 and osteogenic protein-1) provide evidence for use as both bone enhancers and bone substitutes for specific types of spinal fusion. Tissue engineered hydrogels, synthetic polymer composites and viral based gene therapy also holds the potential to be used for spine fusion in future, though warrants further investigation to be used in clinical practice. | Ashim Gupta Nitin Kukkar Kevin Sharif Benjamin J Main Christine E Albers Saadiq F El-Amin Ⅲ | 2015 | World Journal of Orthopedics2015，6，6： | 4 |
| 16 | 采用延性损伤模型和数值方法预测Ni-Cr基合金在温成形条件下的断裂极限显示文摘为了确定IN625合金的安全成形和断裂极限,在300和673 K下分别进行拉伸成形和深拉延成形实验。将实验获得的基于应力的断裂成形极限图(FFLD)转变为基于应力的σ-FFLD和有效塑性应变(EPS)跟三轴度(η)的关系曲线,以消除断裂极限对应变的过度依赖。为了预测断裂极限,校准7种不同的损伤模型。结果显示,Oh模型对断裂轨迹的预测能力最好,绝对误差最小。虽然实验得到的断裂极限仅用于数值分析,但没有一个损伤模型预测整个应力三轴度范围(0.33<η<0.66)的断裂应变。在不同的温度和润滑条件下深拉延成形圆柱杯,深拉延工艺窗口有助于确定起皱、安全和断裂区域。在润滑条件下,673 K时达到最大的拉延比2。利用Hill 1948各向异性屈服函数对拉伸成形和深拉延成形过程的数值预测结果均在可接受的误差范围内。 | Ayush MORCHHALE Anand BADRISH Nitin KOTKUNDE Swadesh Kumar SINGH Navneet KHANNA Ambuj SAXENA Chetan NIKHARE | 2021 | Transactions of Nonferrous Metals Society of China2021，31，8： | 3 |
| 17 | Reactive power compensation of an isolated hybrid power system with load interaction using ANFIS tuned STATCOM显示文摘 | Nitin SAXENA Ashwani KUMAR | 2014 | Frontiers in Energy2014，8，2： | 3 |
| 18 | A six months old neglected anterior shoulder dislocation managed by closed reduction and Latarjet procedure显示文摘忽视的肩膀脱臼是一个更稀罕的实体,仅仅很少案例在文学被报导。肩膀的前面的脱臼很少在诱拐和外部旋转作为与手足在场的病人被错过,对整形外科的外科医生很熟悉的态度。当时,偶尔,如此的案例被错过他们与近似肱骨的骨折在场或当他们从通常在农村区域练习的全然的专业人员接受治疗时。由于很少的报告,有文学的少量,没有标准治疗协议为肩膀的忽视的前面的脱臼存在,尽管最如此的长期的案例被开的减小管理。这份案例报告与重要的山 Sachs 损害描述六个月旧的忽视的前面的脱臼,它被关上的减小和 Latarjet 过程管理。 | Deepak Chaudhary Deepak Joshi Vineet Jain Mukul Mohindra Nitin Mehta | 2016 | Chinese Journal of Traumatology2016，19，5： | 3 |
| 19 | Prevalence of excessive internet use and its correlation with associated psychopathology in 11th and 12th grade students显示文摘Background Globally, the number of internet users has crossed the three-billion mark, while in India users grew over 17% in the first 6 months of 2015 to 354 million. This study presented a background on internet use and the existence of excessive internet use. Aim To study the extent of internet use in 11th and 12th grade students and the psychopathology, if any, associated with excessive internet use. Methods 426 students who met the inclusion criteria were recruited from 11 th and 12th grade classes from Kendriya Vidyalaya, New Delhi, India, and were assessed by Young's Internet Addiction Test and the Strength and Difficulties Questionnaire. Results Among the 426 students, the mean internet addiction total score was 36.63 (20.78), which indicated mild level of internet addiction. 1.41%(six students) was diagnosed as excessive internet users, while 30.28% and 23.94% were classified as moderate and mild internet users, respectively. The prevalence of internet addiction between gender was 58.22% in males and 41.78% in females. While both positive (prosocial) and negative (hyperactivity, emotional, conduct and peer problem) impacts of internet use were reported by students, in the current study excessive use of internet had a negative impact on students' lives as compared with positive impact, which was statistically significant (p<0.0001). Conclusion Excessive internet use led to abnormal behaviours which cause negative consequences to users. Early diagnosis of risk factors related to excessive internet use, provides education about responsible use and supervision of students by family members. | Nitin Kumar Arvind Kumar Subodh Kumar Mahto Manish Kandpal Smita Neelkanth Deshpande Parul Tanwar | 2019 | General Psychiatry2019，32，2： | 3 |
| 20 | 影像学评价腰椎不稳症:解剖与功能的定性与定位显示文摘背景:脊柱不稳经常被提及,但是很少有确切的定义,由于缺乏规整的临床经验或放射学准则的效果评价,所以仍然是一个有争议的概念。目的:对腰椎不稳症(尤其是退行性腰椎不稳症)的定义及诊断腰椎不稳症的影像学方法作一综述。方法:以'lumbar instability,traction spurs,ligament,disc space narrowing'等关键词在slide share、medlind和NCBI数据库筛选近30年的文献资料,语言种类为英文,最终纳入文章49篇。结果与结论:腰椎不稳症一方面可能是引起下腰痛和坐骨神经痛的病因,另一方面也常常被认为是决定脊柱融合和减压的一个重要条件。因其临床症状和体征无特异性,所以对此病的有效诊断和治疗也存在争议。功能性正侧位平片是腰椎不稳症影像学诊断使用最广泛最全面的一种方法。CT提供了更准确的脊柱退行性变和椎间关节方向的图像。磁共振通常被认为是诊断退行性脊椎改变最精确的成像方法,除了真空现象,常被用来诊断患者的慢性下腰痛。 | Nitin Tandra 祝晓 | 2014 | 中国组织工程研究2014，18，22： | 3 |
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