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| 1 | Selenium and the Thioredoxin and Glutaredoxin Systems显示文摘Thioredoxin (Trx) is a small ubiquitous dithiol protein which together with the FADcontaining enzyme thioredoxin reductase (TR) and NADPH (the Trx system) is a hydrogen donor for ribonucleotide reductase essential for DNA synthesis and a general protein disulfide reductase involved in redox regulation. Selenite, selenodiglutathione (GS-Se-SG) and selenocystine are efficiently reduced by thioredoxins and also directly by NADPH and mammalian TR but not by the E. coli enzyme. Incubation of selenite or GS-Se-SG with the Trx system or with mammalian TR results in a rapid formation of selenide, which by redox cycling with oxygen may cause a large non-stoichiometric oxidation of NADPH. Selenocystine is efficiently reduced into two molecules of the selenol amino acid selenocysteine by mammalian TR with a Km-value (6μmol·L-1 ) and a high turnover number (kcat, 3200 min-1) almost identical to the natural substrate Trx-S2. TR also directly reduces lipid hydroperoxides and this peroxidase reaction is strongly stimulated by the presence of catalytic amounts of free selenocysteine. Glutaredoxin (Grx) which catalyzes GSH dependent disulfide reduction also via a redox-active disulfide and Trx are both efficient electron donors to the hut-nan plasrna glutathione peroxidase providing a mechanism by which human plasma glutathione peroxidase may reduce hydroperoxides in an environment almost free from glutathione. Selenate is reduced by Grx and Trx in the presence of GSH. The DNA-binding of the transcription factor AP-1 is strongly inhibited by GS-Se-SG and selenite. Furtherrnore, selenide formed by TR-mediated reduction of selenite and GS-Se-SG inhibits lipoxygenase and changes the electron spin resonance spectrum of the active site iron. Mammalian TR with two subunits of 57 kDa has recently been cloned and shown to be homologous to glutathione reductase. The rat enzyme contains a selenocysteine residue in a unique Cterminal position and a conserved SEClS sequence directing insertion of the selenocysteine. The discovery of selenocysteine in mammalian TR may explain the broad substrate specificity of the enzyme and the requirement of seleflium for cell | MIKAEL BJORNSTEDT SUSHIL KUMAR LINDA BJ■RKHEM GIANNIS SPYROU AND ARNE HOLMGREN(The Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institute, S-171 77 Stockholm, Sweden Department of Bioscience, | 1997 | Biomedical and Environmental Sciences1997，10，2： | 4 |
| 2 | An emerging threat Fileless malware:a survey and research challenges显示文摘With the evolution of cybersecurity countermeasures,the threat landscape has also evolved,especially in malware from traditional file-based malware to sophisticated and multifarious fileless malware.Fileless malware does not use traditional executables to carry-out its activities.So,it does not use the file system,thereby evading signature-based detection system.The fileless malware attack is catastrophic for any enterprise because of its persistence,and power to evade any anti-virus solutions.The malware leverages the power of operating systems,trusted tools to accomplish its malicious intent.To analyze such malware,security professionals use forensic tools to trace the attacker,whereas the attacker might use anti-forensics tools to erase their traces.This survey makes a comprehensive analysis of fileless malware and their detection techniques that are available in the literature.We present a process model to handle fileless malware attacks in the incident response process.In the end,the specific research gaps present in the proposed process model are identified,and associated challenges are highlighted. | Sudhakar Sushil Kumar | 2020 | Cybersecurity2020，3，1： | 4 |
| 3 | Molecular docking studies of anti-cancerous candidates in Hippophae rhamnoides and Hippophae salicifolia显示文摘Actinorhizal plants contain numerous antioxidants that may play a crucial role in preventing the formation of tumors.H-Ras p21,a member of the Ras-GTPase family,is a promising target to treat various kinds of cancers.An in silico docking study was carried out to identify the inhibitory potential of compounds of these plants against H-Ras by using Discovery Studio 3.5 and by using Autodock 4.2.Docking studies revealed that four compounds,isorhamnetin-7-rhamnoside,quercetin-3-glucoside-7-rhamnoside(present in H.rhamnoides),zeaxanthin,and translutein(present in H.salicifolia) significantly bind with binding energies-17.1534,-14.7936,-10.2105 and-17.2217 Kcal/mol,respectively,even though they slightly deviate from Lipinski's rule.Absorption,distribution,metabolism,excretion and toxicity(ADME/tox) analyses of these compounds and their stereoisomers showed that they were less toxic and non-mutagenic.Amongst them,isorhamntein-7-rhamnoside showed hepatotoxicity.Hence,these compounds can be further investigated in vivo to optimize their formulation and concentration and to develop potential chemical entities for the prevention and treatment of cancers. | Talambedu Usha Sushil Kumar Middha Arvind Kumar Goyal Mahesh Karthik DA Manoj Syed Faizan Peyush Goyal HP Prashanth Veena Pande | 2014 | The Journal of Biomedical Research2014，28，5： | 3 |
| 4 | Silibinin and colorectal cancer chemoprevention:a comprehensive review on mechanisms and efficacy显示文摘Globally,the risk of colorectal cancer(CRC) as well as the incidence of mortality associated with CRC is increasing.Thus,it is imperative that we look at alternative approaches involving intake of non-toxic natural dietary/non-dietary agents,for the prevention of CRC.The ultimate goal of this approach is to reduce the incidence of pre-neoplastic adenomatous polyps and prevent their progression to more advanced forms of CRC,and use these natural agents as a safe intervention strategy during the clinical course of this deadly malignancy.Over the years,pre-clinical studies have shown that silibinin(a flavonolignan isolated from the seeds of milk thistle,Silybum marianum) has strong preventive and therapeutic efficacy against various epithelial cancers,including CRC.The focus of the present review is to provide a comprehensive tabular summary,categorically for an easy accessibility and referencing,pertaining to the efficacy and associated mechanisms of silibinin against CRC growth and progression. | Komal Raina Sushil Kumar Deepanshi Dhar Rajesh Agarwal | 2016 | The Journal of Biomedical Research2016，30，6： | 2 |
| 5 | Pediatric vs adult pulmonary tuberculosis:A retrospective computed tomography study显示文摘AIM: To compare the manifestations of chest tuberculosis(TB) in pediatric and adult patients based on contrast enhanced computed tomography of chest.METHODS: This was a retrospective study consisting of 152 patients of chest TB including 48 children and 104 adults who had undergone contrast enhanced computed tomography of chest prior to treatment. The patterns and severity of parenchymal, mediastinal and pleural manifestations were analyzed and compared among different age groups.RESULTS: Parenchymal changes observed include consolidation, air space nodules, miliary TB, cavitation, bronchiectasis and fibrosis and these were noted in 60% of children, 71% of adolescents and 76.9% of adults. These changes were more common in right upper lobe in all age groups. There was no significant difference in the frequency of these changes(except nodules) in different age groups. Centrilobular nodules were seen less commonly in children less than 10 years(P = 0.028). Pleural effusion was noted in 28(18.42%) patients and pericardial effusion in 8(5.3%) patients. No significant difference in the serosal involvement is seen among children and adults. Mediastinal adenopathy was seen 70% of children, 76.3% adolescents and 76.9% of adults and paratracheal nodes were seen most frequently. Nodes had similar features(except matting) among all age groups. Matting of nodes was seen more commonly in children(P = 0.014). CONCLUSION: Pediatric chest tuberculosis can have severe parenchymal lesions and nodal involvement similar to adults. The destructive lung changes observed in children needs immediate attention in view of the longer life span they have and hence in formulating optimal treatment strategies. | Prasad Thotton Veedu Ashu Seith Bhalla Sreenivas Vishnubhatla Sushil Kumar Kabra Arundeep Arora Divya Singh Arun Kumar Gupta | 2013 | World Journal of Clinical Pediatrics2013，2，4： | 2 |
| 6 | 克拉霉素治疗慢性鼻-鼻窦炎的临床效果及安全性评价显示文摘目的研究慢性鼻-鼻窦炎(CRS)患者行克拉霉素治疗的临床效果。方法选择2019年1月~2019年12月间襄阳市第一人民医院收治的84例CRS患者,采用随机数表法分为观察组(克拉霉素)与对照组(鼻用激素布地奈德)各42例,比较两组白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、血清总IgE(TIgE)、嗜酸粒细胞阳离子蛋白(ECP)水平及有效率。结果与对照组比较,观察组IL-6、TNF-α、TIgE及ECP值较低;观察组有效率高于对照组(P<0.05)。结论克拉霉素治疗CRS患者能提高整体疗效、稳定病情,缓解不适,值得临床应用。 | SAH SUSHIL KUMAR | 2021 | 中华养生保健2021，39，1： | 2 |
| 7 | Information and communication technologies (ICTs) and farmers’ decision-making across the agricultural supply chain显示文摘 | Jabir Ali Sushil Kumar | 2010 | International Journal of Information Management2010，，2： | 2 |
| 8 | Simuhaneous dyeing and finishing Of cotton fabric using reactive dyes and citric acid 显示文摘 | Malik S K Kumar Sushil | 2005 | Indian Journal of Fibre & Textile Research2005，30，4： | 1 |
| 9 | Band gap optimization of p–i–n layers of a-Si:H by computer aided simulation for development of efficient solar cell显示文摘 | Sukhbir Singh Sushil Kumar Neeraj Dwivedi | 2012 | Solar Energy2012，，5： | 1 |
| 10 | Establishment of artemisinin combination therapy as first line treatment for combating malaria:Artemisia annua cultivation in India needed for providing sustainable supply chain of artemisinin显示文摘 | Sushil Kumar Suchi Srivastava | 2005 | Current Sci2005，89，7： | 1 |
| 11 | Rapid Isolation of DNA from Dry and Fresh Samples of Plants Producing Large Amounts of Secondary Metabolites and Essential Oils显示文摘 | Suman P.S. Khanuja Ajit K. Shasany M.P. Darokar Sushil Kumar | 1999 | Plant Molecular Biology Reporter1999，，1： | 1 |
| 12 | Nonconvex economic load dispatch using an efficient real-coded genetic algorithm 显示文摘 | Sushil Kumar RN | 2009 | Ap- plied Soft Computing2009，9，1： | 1 |
| 13 | Qualitative and quantitative losses on some commercial varieties of mango due to Bactrocera correctus Bezzi ( Diptera : Tephritidae ) in South Gujarat 显示文摘 | Sushil Kumar Patel CB Bhatt RI | 1994 | Pest Management and Economic Zoology1994，2，1： | 1 |
| 14 | Terahertz quantum-cascade lasers显示文摘 | Benjamin S Williams Sushil Kumar Qi Qin | | 0，，05： | 1 |
| 15 | Analytic hierarchy process: An overview of applications显示文摘 | Omkarprasad S Vaidya Sushil Kumar | 2006 | European Journal of Operational Research2006，169，1： | 1 |
| 16 | Analytic Hierarchy Process: An Overview of Applications显示文摘 | Omkarprasad S Vaidya Sushil Kumar | 2006 | European Journal of Operational Research2006，169，1： | 1 |
| 17 | Stress evaluation of RF sputtered silicon dioxide film for MEMs显示文摘 | Vivekanaand Bhatt Sudhir Chandra Sushil Kumar | 2007 | Indian Journal of pure &applied physics2007，45，： | 1 |
| 18 | Application of hurdle technology for the development of Caprine keema and its stability at ambient temperature显示文摘 | J. Karthikeyan Sushil Kumar A.S.R. Anjaneyulu K.H. Rao | 1999 | Meat Science1999，，1： | 1 |
| 19 | Studies on seasonal eyelieity of Bactrocera correctus Bezzi in mango and sapota orchards using methyl eugenol trap 显示文摘 | Sushil Kumar Bhatt RI Patel CB | 1997 | Gujarat Agricultural University Research Journal1997，22，2： | 1 |
| 20 | Information and communication technologies(ICTs)and farmers* decision-making across the agricultural supply chain 显示文摘 | Jabir Ali Sushil Kumar | 2011 | Inter-national Journal of Information Management2011，，31： | 1 |
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