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| 1 | Electro-acupuncture to prevent prolonged postoperative ileus:A randomized clinical trial显示文摘AIM:To examine whether acupuncture can prevent prolonged postoperative ileus(PPOI)after intraperitoneal surgery for colon cancer. METHODS:Ninety patients were recruited from the Fudan University Cancer Hospital,Shanghai,China. After surgery,patients were randomized to receive acupuncture(once daily,starting on postoperative day 1, for up to six consecutive days)or usual care.PPOI was defined as an inability to pass flatus or have a bowel movement by 96 h after surgery.The main outcomes were time to first flatus,time to first bowel movement, and electrogastroenterography.Secondary outcomes were quality of life(QOL)measures,including pain, nausea,insomnia,abdominal distension/fullness,and sense of well-being. RESULTS:No significant differences in PPOI on day 4 (P=0.71)or QOL measures were found between the groups.There were also no group differences when the data were analyzed by examining those whose PPOI had resolved by day 5(P=0.69)or day 6(P= 0.88).No adverse events related to acupuncture were reported. CONCLUSION:Acupuncture did not prevent PPOI andwas not useful for treating PPOI once it had developed in this population. | M Kay Garcia Joseph S Chiang Bob Thornton J Lynn Palmer Jennifer McQuade Lorenzo Cohen | 2010 | World Journal of Gastroenterology2010，16，1： | 27 |
| 2 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 3 | Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study显示文摘 | Patrick Marcellin Edward Gane Maria Buti Nezam Afdhal William Sievert Ira M Jacobson Mary Kay Washington George Germanidis John F Flaherty Raul Aguilar Schall Jeffrey D Bornstein Kathryn M Kitrinos G Mani Subramanian John G McHutchison E Jenny Heathcote | 2012 | The Lancet2012，，： | 14 |
| 4 | 高纤维膳食和补充乙酸盐改变肠道菌群,预防醋酸脱氧皮质酮-盐型高血压小鼠高血压和心力衰竭的发展显示文摘水果和蔬菜的膳食摄入与高血压的发生率较低有关,但所涉及的机制尚未阐明。该研究评估了高纤维膳食和短链脂肪酸(short-chain fatty acid,SCFA)(乙酸盐)对肠道微生物群和预防心血管病的影响。方法:用盐皮质激素诱发小鼠高血压模型,观测正常喂食组、高纤维喂食组和补充乙酸盐组的肠道微生物、心脏结构/功能和血压水平。 | 刘莉 叶鹏 Marques FZ Nelson EM Chu PY Horlock D Fiedler A Ziemann M Tan JK Kuruppu S Rajapakse NW El-Osta A Mackay CR Kaye DM | 2016 | 中华高血压杂志2016，24，12： | 8 |
| 5 | Identification of pathologic features associated with “ulcerative colitis-like” Crohn's disease显示文摘AIM: To identify pathologic features associated with this 'ulcerative colitis(UC)-like' subgroup of Crohn's disease(CD).METHODS: Seventeen subjects diagnosed as having UC who underwent proctocolectomy(RPC) from 2003-2007 and subsequently developed CD of the ileal pouch were identified. UC was diagnosed based on preoperative clinical, endoscopic, and pathologic studies. Eighteen patients who underwent RPC for UC within the same time period without subsequently developing CD were randomly selected and used as controls. Pathology reports and histological slides were reviewed for a wide range of gross and microscopic pathological features, as well as extent of disease. The demographics, gross description and histopathology of the resection specimens were reviewed and compared between the two groups. RESULTS: Patients with 'UC-like' CD were on average 13 years younger than those with 'true' UC(P < 0.01). More severe disease in the proximal involved region and active ileitis with/without architectural distortion were observed in 6 of 17(35%) and 7 of 17(41%) 'UC-like' CD cases, respectively, but in none of the 'true' UC cases(P < 0.05). Active appendicitis occurred in 8 of 16(50%) 'UC-like' CD cases but in only two(11%) 'true' UC cases(P < 0.05). Conspicuous lamina propria neutrophils were more specific for 'UClike' CD(76% vs 22%, P < 0.05). In addition, prominent lymphoid aggregates tended to be more common in 'UC-like' CD(P = 0.07). The 'true' UC group contained a greater number of cases with severe activity(78% vs 47%). Therefore, the features more commonly seen in 'UC-like' CD were not due to a more severe disease process. Crohn's granulomas and transmural inflammation in non-ulcerated areas were absent in both groups.CONCLUSION: More severe disease in the proximal involved region, terminal ileum involvement, active appendicitis, and prominent lamina propria neutrophils may be morphological factors associated with 'UC-like' CD. | Samuel D James Paul E Wise Tania Zuluaga-Toro David A Schwartz M Kay Washington Chanjuan Shi | 2014 | World Journal of Gastroenterology2014，20，36： | 4 |
| 6 | Reproducibility of the diagnosis of dysplasia in Barrett esophagus: A reaffirmation显示文摘 | Elizabeth Montgomery Mary P Bronner John R Goldblum Joel K Greenson Marian M Haber John Hart Laura W Lamps Gregory Y Lauwers Audrey J Lazenby David N Lewin Marie E Robert Alicia Y Toledano Yu Shyr Kay Washington | 2001 | Human Pathology2001，，4： | 3 |
| 7 | The FHIT Gene, Spanning the Chromosome 3p14.2 Fragile Site and Renal Carcinoma–Associated t(3;8) Breakpoint, Is Abnormal in Digestive Tract Cancers显示文摘 | Masataka Ohta Hiroshi Inoue Maria Grazia Cotticelli Kumar Kastury Raffaele Baffa Juan Palazzo Zurab Siprashvili Masaki Mori Peter McCue Teresa Druck Carlo M Croce Kay Huebner | 1996 | Cell1996，，4： | 2 |
| 8 | The β-lactam antibiotic, ceftriaxone, dramatically improves survival, increases glutamate uptake and induces neurotrophins in stroke显示文摘 | Christa Th?ne-Reineke Christian Neumann Pawel Namsolleck Kristin Schmerbach Maxim Krikov Jan H Schefe Kristin Lucht Heide H?rtnagl Michael Godes Susanne Müller Kay Rumschüssel Heiko Funke-Kaiser Arno Villringer U Muscha Steckelings Thomas Unger | 2008 | Journal of Hypertension2008，，12： | 2 |
| 9 | Population-based epidemiology,risk factors and screening of intraductal papillary mucinous neoplasm patients显示文摘Intraductal papillary mucinous neoplasm(IPMN) was first recognized in the 1980s with increasing publications over the last decade as the incidence increased sharply,especially at tertiary-care referral centers.Populationbased studies have estimated the age and sex-adjusted cumulative incidence of IPMN to be 2.04 per 100 000 person-years(95% conf idence interval:1.28-2.80).It is now understood that IPMN can be classified anywhere along the spectrum of the adenoma to carcinoma sequence and often harbors mutations in genes such as KRAS early in the disease process.Many patients are diagnosed incidentally after imaging of the abdomen for other diagnostic purposes.Patients that present with a history of symptoms such as pancreatitis and abdominal pain are at high risk of harboring a malignancy.Clini-copathologic features such as involvement of the main pancreatic duct,presence of mural nodules,and side branch disease > 3.0 cm in size may indicate that there is an underlying invasive component to the IPMN.In addition,the incidence of extra-pancreatic neoplasms is higher in patients with IPMN,with reported rates of 25% to 50%.There are no current screening recommendations to detect and diagnose IPMN but once the diagnosis is made,screening for extrapancreatic neoplasms such as colon polyps and colorectal cancer should be considered.Surgical resection is the recommend treatment for patients with high-risk features while close observation can be offered to patients without worrisome signs and symptoms of carcinoma. | Saboor Khan Guido Sclabas Kaye M Reid-Lombardo | 2010 | World Journal of Gastrointestinal Surgery2010，2，10： | 2 |
| 10 | Epidermal growth factor receptor inhibits colitis-associated cancer in mice显示文摘 | Dubé Philip E Yan Fang Punit Shivesh Girish Nandini McElroy Steven J Washington M Kay Polk D Brent | 2012 | EN2012，，8： | 2 |
| 11 | Physical properties of dewatered wastewater sludge for landfilling 显示文摘 | Koening A Kay J N Wan I M | 1996 | War Sci Tech1996，34，34： | 2 |
| 12 | Epothilones in the treatment of cancer 显示文摘 | Larkin J M Kaye S B | 2006 | Expert Opin Investig Drugs2006，15，6： | 1 |
| 13 | Brain magnetic resonance imaging with contrast dependent on blc, od oxygenation显示文摘 | Ogawa S Lee T M Kay A R | 1990 | Proceedings of the National Academy of Sciences USA1990，87，98： | 1 |
| 14 | Pulmonary aspergilloma:analysis of prognosis in relation to haemoptysis and survey of treatment显示文摘 | JEWKES J KAY P H PANETH M | 1983 | Thorax1983，38，8： | 1 |
| 15 | DNA replication licensing factors and aneuploidy are linked to tumor cell cycle state and clinical outcome in penile carcinoma显示文摘 | Kayes O J Loddo M Patel N | 2009 | Clin Cancer Res2009，15，23： | 1 |
| 16 | Transgenic mice expressing human Immuno-Deficiency Virus Type 1 in immune cells develop a severe AIDS-like disease显示文摘 | Hanna Z Kay D G Cool M | 1998 | J Virol1998，72，1： | 1 |
| 17 | Adrenec nervous systemin heat failure 显示文摘 | Esler M Kaye D Lambert G | 1997 | Am J Cardid1997，80，： | 1 |
| 18 | Resuscitation Training: A Time for Reassessment显示文摘 | Mancini M E Kaye W | 1996 | J Card Nurs1996，10，4： | 1 |
| 19 | Application of Taguchi's robust parameter design methodology for process improve- ment显示文摘 | Antony J Mazharsolook E Kaye M | 1996 | Quality World1996，，： | 1 |
| 20 | Novel proteasome inhibitors to overcome bortezomib resistance显示文摘 | Ruschak AM Slassi M Kay LE | 2011 | J Natl Cancer Inst2011，103，13： | 1 |
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