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| 1 | Prospects to the formation and control of potential dimer impurity E of pantoprazole sodium sesquihydrate显示文摘Pantoprazole sodium, a substituted benzimidazole derivative, is an irreversible proton pump inhibitor which is primarily used for the treatment of duodenal ulcers, gastric ulcers, and gastroesophageal reflux disease (GERD). The monographs of European Pharmacopoeia (Ph. Eur.) and United States Pharmacopoeia (USP) specify six impurities, viz.;impurities A, B, C, D, E and F, respectively for its active pharmaceutical ingredient (API). The identification and synthesis of all impurities except impurity E are well described in the literature;however, there is no report related to impurity E. The prospects to the formation and controlling of impurity E up to -0.03% in the synthesis of pantoprazole sodium sesquihydrate (PAN) were discussed in detail for the first time. The present work described the journey towards the successful development of an optimal preparation procedure of dimer impurity E. The most plausible mechanism involved in the formation of impurity E has been proposed. | Arun Kumar Awasthi Lalit Kumar Punit Tripathi Madhava Golla Cirandur Suresh Reddy Pramod Kumar | 2019 | Journal of Pharmaceutical Analysis2019，9，3： | 4 |
| 2 | Internal hydraulic analysis of impeller rounding in centrifugal pumps as turbines显示文摘 | Punit Singh Franz Nestmann | 2010 | Experimental Thermal and Fluid Science2010，，1： | 3 |
| 3 | An optimization routine on a prediction and selection model for the turbine operation of centrifugal pumps显示文摘 | Punit Singh Franz Nestmann | 2009 | Experimental Thermal and Fluid Science2009，，2： | 2 |
| 4 | Phenolic compounds isolated from Pilea microphylla prevent radiation-induced cellular DNA damage显示文摘Six phenolic compounds namely,quercetin-3-O-rutinoside(1),3-O-caffeoylquinic acid(2),luteolin-7-O-glucoside(3),apigenin-7-O-rutinoside(4),apigenin-7-O-b-D-glucopyranoside(5)and quercetin(6)were isolated from the whole plant of Pilea microphylla using conventional opensilica gel column chromatography and preparative HPLC.Further,these compounds were characterized by 1D,2D NMR techniques and high-resolution LC–MS.Compounds 1–3 and 6 exhibited significant antioxidant potential in scavenging free radicals such as DPPH,ABTS and SOD with IC_(50) of 3.3–20.4 mmol/L.The same compounds also prevented lipid peroxidation with IC_(50) of 10.4–32.2 mmol/L.The compounds also significantly prevented the Fenton reagent-induced calf thymus DNA damage.Pre-treatment with compounds 1–3 and 6 in V79 cells attenuated radiation-induced formation of reactive oxygen species,lipid peroxidation,cytotoxicity and DNA damage,correlating the antioxidant activity of polyphenols with their radioprotective effects.Compounds 1,3 and 6 significantly inhibited lipid peroxidation,presumably due to 30,40-catechol ortho-dihydroxy moiety in the B-ring,which has a strong affinity for phospholipid membranes.Oxidation of flavonoids,with catechol structure on B-ring,yields a fairly stable ortho-semiquinone radical by facilitating electron delocalization,which is involved in antioxidant mechanism.Hence,the flavonoid structure,number and location of hydroxyl groups together determine the antioxidant and radioprotection mechanism. | Punit Bansal Piya Paul Pawan GNayak Steve TPannakal Jian-hua Zou Hartmut Laatsch K.I.Priyadarsini M.K.Unnikrishnan | 2011 | Acta Pharmaceutica Sinica B2011，1，4： | 2 |
| 5 | Hybrid Machine Learning Model for Face Recognition Using SVM显示文摘Face recognition systems have enhanced human-computer interactions in the last ten years.However,the literature reveals that current techniques used for identifying or verifying faces are not immune to limitations.Principal Component Analysis-Support Vector Machine(PCA-SVM)and Principal Component Analysis-Artificial Neural Network(PCA-ANN)are among the relatively recent and powerful face analysis techniques.Compared to PCA-ANN,PCA-SVM has demonstrated generalization capabilities in many tasks,including the ability to recognize objects with small or large data samples.Apart from requiring a minimal number of parameters in face detection,PCA-SVM minimizes generalization errors and avoids overfitting problems better than PCA-ANN.PCA-SVM,however,is ineffective and inefficient in detecting human faces in cases in which there is poor lighting,long hair,or items covering the subject’s face.This study proposes a novel PCASVM-based model to overcome the recognition problem of PCA-ANN and enhance face detection.The experimental results indicate that the proposed model provides a better face recognition outcome than PCA-SVM. | Anil Kumar Yadav R.K.Pateriya Nirmal Kumar Gupta Punit Gupta Dinesh Kumar Saini Mohammad Alahmadi | 2022 | Computers, Materials & Continua2022，，8： | 2 |
| 6 | Active Learning Query Strategies for Classification,Regression,and Clustering:A Survey显示文摘Generally,data is available abundantly in unlabeled form,and its annotation requires some cost.The labeling,as well as learning cost,can be minimized by learning with the minimum labeled data instances.Active learning(AL),learns from a few labeled data instances with the additional facility of querying the labels of instances from an expert annotator or oracle.The active learner uses an instance selection strategy for selecting those critical query instances,which reduce the generalization error as fast as possible.This process results in a refined training dataset,which helps in minimizing the overall cost.The key to the success of AL is query strategies that select the candidate query instances and help the learner in learning a valid hypothesis.This survey reviews AL query strategies for classification,regression,and clustering under the pool-based AL scenario.The query strategies under classification are further divided into:informative-based,representative-based,informative-and representative-based,and others.Also,more advanced query strategies based on reinforcement learning and deep learning,along with query strategies under the realistic environment setting,are presented.After a rigorous mathematical analysis of AL strategies,this work presents a comparative analysis of these strategies.Finally,implementation guide,applications,and challenges of AL are discussed. | Punit Kumar Atul Gupta | 2020 | Journal of Computer Science & Technology2020，35，4： | 2 |
| 7 | 一种大变形多空间域连续体结构拓扑优化方法显示文摘针对大变形非线性结构拓扑优化问题,提出了基于混合细胞自动机(HCA,Hybrid CellularAutomata)多空间域连续体结构拓扑优化方法;采用密度法,建立了单元相对密度表示的材料弹-塑性模型;以单元相对密度和应变能作为细胞自动机(CA,Cellular Automata)的状态信息,利用CA局部控制规则,修改相对密度,迭代实现各设计空间域应变能均匀分布;设计了多空间域拓扑优化HCA算法,采取多个对象同时耦合优化迭代,各自收敛策略,解决了多空间域优化迭代算法收敛稳定性问题;最后,以汽车保险杆结构横梁和支撑等两个设计空间为例,施加大变形动态载荷作用,对提出的多空间结构优化算法进行了验证,优化后结构有效地降低了碰撞作用力峰值达54%,提高了结构安全性. | 郭连水 Punit Bandi John E. Renaud | 2009 | 北京航空航天大学学报2009，35，2： | 2 |
| 8 | An optimization routine on a prediction and selection model for the turbine operation of centrifugal pumps显示文摘 | Punit Singh Franz Nestmann | 2009 | Experimental Thermal and Fluid Science2009，，2： | 2 |
| 9 | Primary gastric lymphoma: utility of 18F-fluorodeoxyglucose positron emission tomography-computed tomography for detecting relapse after treatment显示文摘 | Punit Sharma Sudhir KC Suman Harmandeep Singh Atul Sharma Chandrasekhar Bal Arun Malhotra Rakesh Kumar | 2013 | Leukemia & Lymphoma2013，，5： | 2 |
| 10 | Epidermal growth factor receptor inhibits colitis-associated cancer in mice显示文摘 | Dubé Philip E Yan Fang Punit Shivesh Girish Nandini McElroy Steven J Washington M Kay Polk D Brent | 2012 | EN2012，，8： | 2 |
| 11 | Combined laparoscopic and percutaneous management of calcified renal hydatid cyst-a novel nephroscope- and lithotripter-assisted technique 显示文摘 | SuryaPrakash V Punit M Ajit V | 2012 | Urology2012，79，6： | 1 |
| 12 | Can Hybrid SPECT-CT Overcome the Limitations Associated With Poor Imaging Properties of 131I-MIBG?: Comparison With Planar Scintigraphy and SPECT in Pheochromocytoma显示文摘 | Punit Sharma Varun Singh Dhull Sunil Jeph Rama Mohan Reddy Harmandeep Singh Niraj Naswa Chandrasekhar Bal Rakesh Kumar | 2013 | Clinical Nuclear Medicine2013，，： | 1 |
| 13 | Study of surface roughness effects in EHL lubrication of roiling line contacts using deterministic model 显示文摘 | Punit K Jains C Ray S | 2001 | Tribology International2001，34，： | 1 |
| 14 | Internal hydraulic analysis of impeller rounding in centrifugal pumps as turbines 显示文摘 | Punit S Franz N | 2011 | Experimental Thermal and Fluid Science2011，35，1： | 1 |
| 15 | Role of 18F-FDG PET/CT in Detecting Recurrent Gallbladder Carcinoma显示文摘 | Rakesh Kumar Punit Sharma Anita Kumari Dhanapathi Halanaik Arun Malhotra | 2012 | Clinical Nuclear Medicine2012，，5： | 1 |
| 16 | Anti-inflammatory activity of Terminalia paniculata bark extract against acute and chronic inflammation in rats显示文摘 | Sahil Talwar K. Nandakumar Pawan G. Nayak Punit Bansal Jayesh Mudgal Vijay Mor Chamallamudi Mallikarjuna Rao Richard Lobo | 2010 | Journal of Ethnopharmacology2010，，2： | 1 |
| 17 | Internal hydraulic analysis of impeller rounding in centrifugal pumps as turbines显示文摘 | Punit Singh Franz Nestmann | 2010 | Experimental Thermal and Fluid Science2010，，1： | 1 |
| 18 | Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system 显示文摘 | Garrett WS Lord GM Punit S | 2007 | Cell2007，131，1： | 1 |
| 19 | Collective migration of cancer-associated fibroblasts is enhanced by overexpression of tight junction-associated proteins claudin-11 and occludin显示文摘 | George S. Karagiannis David F. Schaeffer Chan-Kyung J. Cho Natasha Musrap Punit Saraon Ihor Batruch Andrea Grin Bojana Mitrovic Richard Kirsch Robert H. Riddell Eleftherios P. Diamandis | 2013 | Molecular Oncology2013，，： | 1 |
| 20 | Internal hydraulic analy- sis of impeller rounding in centrifugal pumps as turbines 显示文摘 | Punit Singh Franz Nestmann | 2011 | Experimental Thermal and Fluid Science2011，35，1： | 1 |
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