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| 1 | Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk显示文摘AIM: To investigate the role that single nucleotide polymorphisms (SNPs) in the promoter of the tumour necrosis factor-alpha (TNF-α) gene play in the risk of inflammatory bowel diseases (IBDs) in a New Zealand population, in the context of international studies. METHODS: DNA samples from 388 patients with Crohn's disease (CD), 405 ulcerative colitis (UC), 27 indeterminate colitis (IC) and 201 randomly selected controls, from Canterbury, New Zealand were screened for 3 common polymorphisms in the TNF-α receptor: -238 G→A, -308 G→A and -857C→T, using a TaqmanR assay. A meta-analysis was performed on the data obtained on these polymorphisms combined with that from other published studies. RESULTS: Individuals carrying the -308 G/A allele had a significantly (OR = 1.91, χ2 = 17.36, P < 0.0001) increased risk of pancolitis, and a 1.57-fold increased risk (OR = 1.57, χ2 = 4.34, P = 0.037) of requiring a bowel resection in UC. Carrying the -857 C/T variant decreased the risk of ileocolonic CD (OR = 0.56, χ2 =4.32, P = 0.037), and the need for a bowel resection (OR = 0.59, χ2 = 4.85, P = 0.028). The risk of UC was reduced in individuals who were smokers at diagnosis, (OR = 0.48, χ2 = 4.86, P = 0.028). CONCLUSION: TNF-α is a key cytokine known to play a role in inflammatory response, and the locus for the gene is found in the IBD3 region on chromosome 6p21, known to be associated with an increased risk for IBD. The -308 G/A SNP in the TNF-α promoter is functional, and may account in part for the increased UC risk associated with the IBD3 genomic region. The -857 C/T SNP may decrease IBD risk in certain groups. Pharmaco- or nutrigenomic approaches may be desir- able for individuals with such affected genotypes. | Lynnette R Ferguson Claudia Huebner Ivonne Petermann Richard B Gearry Murray L Barclay Pieter Demmers Alan McCulloch Dug Yeo Han | 2008 | World Journal of Gastroenterology2008，14，29： | 7 |
| 2 | The FHIT Gene, Spanning the Chromosome 3p14.2 Fragile Site and Renal Carcinoma–Associated t(3;8) Breakpoint, Is Abnormal in Digestive Tract Cancers显示文摘 | Masataka Ohta Hiroshi Inoue Maria Grazia Cotticelli Kumar Kastury Raffaele Baffa Juan Palazzo Zurab Siprashvili Masaki Mori Peter McCue Teresa Druck Carlo M Croce Kay Huebner | 1996 | Cell1996，，4： | 2 |
| 3 | An analysis of hope as a psychological strength显示文摘 | Michael F. Valle E. Scott Huebner Shannon M. Suldo | 2006 | Journal of School Psychology2006，，5： | 2 |
| 4 | Is There a Role for Endoscopic Therapy as a Definitive Treatment for Post-Laparoscopic Bile Duct Injuries?显示文摘 | Javairiah Fatima Joshua G. Barton Travis E. Grotz Zhimin Geng William S. Harmsen Marianne Huebner Todd H. Baron Michael L. Kendrick John H. Donohue Florencia G. Que David M. Nagorney Michael B. Farnell | 2010 | Journal of the American College of Surgeons2010，，4： | 2 |
| 5 | On some aspects of the chemical evolution of cave waters 显示文摘 | Holland M Kirsipu T Huebner J | 1964 | Journal of geology1964，72，： | 2 |
| 6 | Adolescents' perceived quality of life: an exploratory investigation显示文摘 | Dew T Huebner E S | 1994 | Journal of School Psychology1994，32，2： | 1 |
| 7 | Interaction of silver/palladium electrodeswith lead-and bismuth-based electroceramics显示文摘 | WANG S F HUEBNER W | 1993 | J Am Ceram Soc1993，76，47： | 1 |
| 8 | FHIT in human cancer显示文摘 | Sozzi G Huebner K Croce CM | 1998 | Adv Cancer Res1998，141，： | 1 |
| 9 | Preliminary development and validation of a multidimensional life satisfaction scale for children 显示文摘 | Huebner E S | 1994 | Psychological Assessment1994，2，： | 1 |
| 10 | Initial development of the student' s life satisfaction scale显示文摘 | Huebner ES | | 0，，03： | 1 |
| 11 | Reentry and the Ties that Bind: An Examination of Social Ties, Employment, and Recidivism显示文摘 | MarkT. Berg BethM. Huebner | 2011 | Justice Quarterly2011，，： | 1 |
| 12 | Microcontacts with Sub-30 tan Pitch for 3D Chip-on-chip Integration显示文摘 | Huebner H Penka S Barchmann B | 2006 | Microelectronic Engineering2006，83，1112： | 1 |
| 13 | Cancer and the FRA3B/FHIT fragile locus:it's a HIT显示文摘 | Croce CM | 2003 | Br J Cancer2003，88，10： | 1 |
| 14 | The FHIT gene, a multiple tumor suppressor gene encompassing the carcinogen sensitive chromosome fragile site, FRA3B 显示文摘 | Huebner K Hadaczek P Siprashvili Z | 1997 | Biochem Biophys Acta1997，1332，1： | 1 |
| 15 | Levels and demographic correlates of adolescent life satisfaction reports显示文摘 | Huebner E S Drane W Valois R F | 2000 | School Psychology International2000，21，3： | 1 |
| 16 | Preparation of cellodextrins: an engineering approach 显示文摘 | HUEBNER A LADISCH M R TSAO G T | 1978 | Biotechnology and Bioengineering1978，20，12： | 1 |
| 17 | Heterogeneity in anatomic outcome of sacrospinous ligament fixation for prolapse:a systematic review 显示文摘 | Morgan DM Rogers MA Huebner M | 2007 | Obstet Gynecol2007，109，6： | 1 |
| 18 | Demonstration of high opioid-like activity in isolated peptides from wheat gluten hydrolysates显示文摘 | Huebner F R Lieberman K W Rubino R P | 1984 | Peptides1984，5，6： | 1 |
| 19 | Stability and predictive validity of the brief multidimensional Students'Life Satisfaction Scale显示文摘 | Huebner ES Antaramian SP Hills KJ | | 0，，01： | 1 |
| 20 | Isolation of a cyto- pathogenic agent from human adenoids undergoing spontaneous de- generation in tissue culture显示文摘 | Rowe WP Huebner R J Gilmore LK | 1953 | Proc Soc Exp Biol Med1953，84，3： | 1 |
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