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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Human umbilical cord blood cells protect oligo dendrocytes from brain ischemia through Akt signal transduction 显示文摘 | Rowe DD Leonardo CC Recio JA | 2012 | J Biol Chem2012，287，6： | 1 |
| 3 | Imaging beta-amyloid burden in aging and dementia 显示文摘 | Rowe CC Ng S Ackermann U | 2007 | Neurology2007，68，： | 1 |
| 4 | Positron emission tomography and epilepsy显示文摘 | Casse R Rowe CC Newton M | 2002 | Mol Imaging Biol2002，4，： | 1 |
| 5 | Imaging- amyloid burden in aging and dementia显示文摘 | Rowe CC Ng S Ackermann U | 2007 | Neurology2007，68，： | 1 |
| 6 | Amyloid load in Parkinson's disease dementia and Lewy body de- mentia measured with PIB positron emission tomography 显示文摘 | Edison P Rowe CC Rinne JO | 2008 | J Neurol Neurosurg Psychiatry2008，79，12： | 1 |
| 7 | Amyloid imaging resultsfrom the Australian imaging,Biomarkers and Lifestyle(AIBL)studyof aging显示文摘 | Rowe CC Ellis KA Rimajova M | 2010 | Neurobiol Aging2010，31，8： | 1 |
| 8 | Imaging beta-amy- loid burden in aging and dementia显示文摘 | Rowe CC Ng S Ackermann U | 2007 | Neurology2007，68，20： | 1 |
| 9 | Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging 显示文摘 | Rowe CC Ellis KA Rimajova M | 2010 | Neurobiol Aging2010，31，8： | 1 |
| 10 | Mantle cell lymphoma of the hard palate: a case report and review of the differential diagnosis based on the histomorphology and immunophenotyping pattern 显示文摘 | Chang CC Rowe JJ Hawkins P | 2003 | Oral Surg Oral Meal Oral Pathol Oral Radiol Endod2003，96，3： | 1 |
| 11 | Imaging of amyloid in Alzheimer's disease with ^18F-BAY94-9172, a novel PET tracer: proof of mechanism显示文摘 | Rowe CC Ackerman U Browne W | 2008 | Lancet Neurol2008，7，： | 1 |
| 12 | Characterization of pib binding to white matter in Alzheimer Disease and other dementias显示文摘 | Fodero-Tavoletti MT Rowe CC McLean CA | 2009 | J Nucl Med2009，50，2： | 1 |
| 13 | Theta-frequen- cy synaptic potentiation in CA1 in vitro distinguishes cog- nitively impaired aged Fischer 344 rats显示文摘 | Tombaugh CC Rowe WB Chow AB | 2002 | J Neurosci2002，22，22： | 1 |
| 14 | Thromboelasmgraphic changes in patients experiencing an acute ischemic stroke and re- ceiving alteplase 显示文摘 | Rowe AS Greene CL Snider CC | 2014 | J Stroke Cerebrovasc Dis2014，23，6： | 1 |
| 15 | Amyloid load in Parkinson' s disease dementia and Lewybody dementia measured with PiB positron emission tomography 显示文摘 | Edison P Rowe CC Rinne JO | 2008 | Neurol Neurosurg Psychiatry2008，79，： | 1 |
| 16 | Imaging beta-amyloidburden in aging and dementia显示文摘 | Rowe CC Ng S Ackermann U | 2007 | Neurology2007，68，20： | 1 |
| 17 | Tuning the magnetic resonance imaging properties of positive contrast agent nanoparticles by surface modification with RAFT polymers 显示文摘 | ROWE MD CHANG CC THAMM DH | 2009 | Langmuir2009，25，16： | 1 |
| 18 | Downregulated expression of SHP-1 in Burkitt lymphomas and germinal center B lymphocytes显示文摘 | Floettmarn J Rowe M | 1997 | J Exp Med1997，186，9： | 1 |
| 19 | Thromboelasto- graphic changes in patients experiencing an acute ischemic stroke and receiving alteplase显示文摘 | ROWE AS GREENE CL SNIDER CC | 2014 | J Stroke Cerebrovasc Dis2014，23，6： | 1 |
| 20 | Localization of epileptic foci with postictal single photon emission computed tomography显示文摘 | Rowe CC Berkovic SF Sia STB | 1989 | Ann Neurol1989，26，： | 1 |
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