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| 1 | Expenditure and financial burden for the diagnosis and treatment of colorectal cancer in China:a hospital.based,multicenter,cross-sectional survey显示文摘Background: The increasing prevalence of colorectal cancer(CRC) in China and the paucity of information about relevant expenditure highlight the necessity of better understanding the financial burden and effect of CRC diagnosis and treatment. We performed a survey to quantify the direct medical and non-medical expenditure as well as the resulting financial burden of CRC patients in China.Methods: We conducted a multicenter, cross-sectional survey in 37 tertiary hospitals in 13 provinces across China between 2012 and 2014. Each enrolled patient was interviewed using a structured questionnaire. All expenditure data were inflated to the 2014 Chinese Yuan(CNY; 1 CNY = 0.163 USD). We quantified the overall expenditure and financial burden and by subgroup(hospital type, age at diagnosis, sex, education, occupation, insurance type, household income, clinical stage, pathologic type, and therapeutic regimen). We then performed generalized linear modeling to determine the factors associated with overall expenditure.Results: A total of 2356 patients with a mean age of 57.4 years were included, 57.1 % of whom were men; 13.9% of patients had stage I cancer; and the average previous-year household income was 54,525 CNY.The overall average direct expenditure per patient was estimated to be 67,408 CNY, and the expenditures for stage Ⅰ, Ⅱ, Ⅲ, and Ⅳ disease were 56,099 CNY, 59,952 CNY, 67,292 CNY, and 82,729 CNY, respectively. Non-medical expenditure accounted for 8.3%of the overall expenditure. The 1-year out-of-pocket expenditure of a newly diagnosed patient was 32,649 CNY, which accounted for 59.9% of their previous-year household income and caused 75.0% of families to suffer an unmanageable financial burden. Univariate analysis showed that financial burden and overall expenditure differed in almost all subgroups(P < 0.05), except for sex. Multivariate analysis showed that patients who were treated in specialized hospitals and those who were diagnosed with adenocarcinoma or diagnosed at a later stage were likely to spend more,whereas those with a lower household income and those who underwent surgery spent less(all P < 0.05).Conclusions: For patients in China, direct expenditure for the diagnosis and treatment of CRC seemed catastrophic,and non-medical expenditure was non-ignorable. The financial burden varied among subgroups, especially among patients with different clinical stages of disease, which suggests that, in China, CRC screening might be cost-effective. | Hui-Yao Huang Ju-Fang Shi Lan-Wei Guo Ya-Na Bai Xian-Zhen Liao Guo-iangLiu A-Yan Mao Jian-Song Ren Xiao-Jie Sun Xin-Yu Zhu Le Wang Bing-Bing Song Ling-Bin Du Lin Zhu Ji-Yong Gong Qi Zhou Yu-Qin Liu Rong Cao Ling Mai Li Lan Xiao-Hua Sun Ying Ren Jin-Yi Zhou Yuan-Zheng Wang Xiao Qi Pei-An Lou Dian Shi Ni Li Kai Zhang Jie He Min Dai | 2017 | Chinese Journal of Cancer2017，36，8： | 25 |
| 2 | PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins显示文摘Mutations in RNA-binding proteins (RBPs) localized in ribonucleoprotein (RNP) granules, such as hnRNP A1 and TDP-43, promote aberrant protein aggregation, which is a pathological hallmark of various neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Protein posttranslational modifications (PTMs) are known to 佗gulate RNP granules. In this study, we investigate the function of poly(ADP-ribosyl)ation (PARylation), an important PTM involved in DNA damage repair and cell death, in RNP granule-related neurodegeneration. We reveal that PARylation levels are a major regulator of the assembly-disassembly dynamics of RNP granules containing disease-related RBPs, hnRNP A1 and TDP-43. We find that hnRNP A1 can both be PARylated and bind to PARylated proteins or poly(ADP-ribose)(PAR). We further uncover that PARylation of hnRNP A1 at K298 controls its nucleocytoplasmic transport, whereas PAR-binding via the PAR-binding motif (PBM) of hnRNP Al regulates its association with stress granules. Moreover, we reveal that PAR not only dramatically enhances the liquid-liquid phase separation of hnRNP A1, but also promotes the co-phase separation of hnRNP A1 and TDP-43 in vitro and their interaction in vivo. Finally, both genetic and pharmacological inhibition of PARP mitigates hnRNP Al- and TDP-43-mediated neurotoxicity in cell and Drosophila models of ALS. Together, our findings suggest a novel and crucial role for PARylation in regulating the dynamics of RNP granules, and that dysregulation in PARylation and PAR levels may con tribute to ALS disease pathoge nesis by promoting protei n aggregation. | Yongjia Duan Aiying Du Jinge Gu Gang Duan Chen Wang Xinrui Gui Zhiwei Ma Beituo Qian Xue Deng Kai Zhang Le Sun Kuili Tian Yaoyang Zhang Hong Jiang Cong Liu Yanshan Fang | 2019 | Cell Research2019，29，3： | 13 |
| 3 | Psychological impact of the COVID-19 pandemic on healthcare workers:a cross-sectional study in China显示文摘Background Healthcare workers fighting against the coronavirus disease 2019(COVID-19)pandemic are under tremendous pressure,which puts them at an increased risk of developing psychological problems.Aims This study aimed to investigate the prevalence of psychological problems in different healthcare workers(ie,physicians,medical residents,nurses,technicians and public health professionals)during the COVID-19 pandemic in China and explore factors that are associated with the onset of psychological problems in this population during this public health crisis.Methods A cross-sectional,web-based survey was conducted in February 2020 among healthcare workers during the COVID-19 pandemic.Psychological problems were assessed using the Generalized Anxiety Disorder Scale,Patient Health Questionnaire and Insomnia Severity Index.Logistic regression analyses were used to explore the factors that were associated with psychological problems.Results The prevalence of symptoms of anxiety,depression,insomnia and the overall psychological problems in healthcare workers during the COVID-19 pandemic in China was 46.04%,44.37%,28.75%and 56.59%,respectively.The prevalence of the overall psychological problems in physicians,medical residents,nurses,technicians and public health professionals was 60.35%,50.82%,62.02%,57.54%and 62.40%,respectively.Compared with healthcare workers who did not participate in front-line work,front-line healthcare workers had a higher risk of anxiety,insomnia and overall psychological problems.In addition,attention to negative or neutral information about the pandemic,receiving negative feedback from families and friends who joined front-line work,and unwillingness to join front-line work if given a free choice were three major factors for these psychological problems.Conclusions Psychological problems are pervasive among healthcare workers during the COVID-19 pandemic.Receiving negative information and participating in front-line work appear to be.important risk factors for psychological problems.The psychological health of different healthcare workers should be protected during the COVID-19 pandemic with timely interventions and proper information feedback. | Jianyu Que Le Shi Jiahui Deng Jiajia Liu Li Zhang Suying Wu Yimiao Gong Weizhen Huang Kai Yuan Wei Yan Yankun Sun Maosheng Ran Yanping Bao Lin Lu | 2020 | General Psychiatry2020，33，3： | 8 |
| 4 | Dual-comb spectroscopy resolved three-degreeof-freedom sensing显示文摘Precise and fast determination of position and orientation, which is normally achieved by distance and angle measurements, has broad applications in academia and industry. We propose a dynamic three-degree-of-freedom measurement technique based on dual-comb interferometry and a self-designed grating-corner-cube(GCC) combined sensor. Benefiting from its unique combination of diffraction and reflection characteristics, the absolute distance, pitch, and yaw of the GCC sensor can be determined simultaneously by resolving the phase spectra of the corresponding diffracted beams. We experimentally demonstrate that the method exhibits a ranging precision(Allan deviation) of 13.7 nm and an angular precision of 0.088 arcsec, alongside a 1 ms reaction time. The proposed technique is capable of precise and fast measurement of distances and two-dimensional angles over long stand-off distances. A system with such an overall performance may be potentially applied to space missions,including in tight formation-flying satellites, for spacecraft rendezvous and docking, and for antenna measurement as well as the precise manufacture of components including lithography machines and aircraftmanufacturing devices. | SIYU ZHOU VUNAM LE SHILIN XIONG YUETANG YANG KAI NI QIAN ZHOU GUANHAO WU | 2021 | Photonics Research2021，9，2： | 8 |
| 5 | NUMERICAL SIMULATION OF HIGHLY UNDEREXPANDED AXISYMMETRIC JET WITH RUNGE-KUTTA DISCONTINUOUS GALERKIN FINITE ELEMENT METHOD显示文摘Highly underexpanded axisymmetric jet was simulated using the Runge-Kutta Discontinuous Galerkin (RKDG) finite element method, which, based on two-dimensional conservation laws, was used to solve the axisymmetric Euler equations. The computed results show that the complicated flow field structures of interest, including shock waves, slipstreams and the triple point observed in experiments could be well captured using the RKDG finite element method. Moreover, comparisons of the Mach disk location exhibit excellent agreements between the computed results and experimental measurements, indicating that this method has high capability of capturing shocks without numerical oscillation and artificial viscosity occurring near the discontinuous point. | CHEN Er-yun MA Da-wei LE Gui-gao WANG kai ZHAO Gai-ping | 2008 | Journal of Hydrodynamics2008，20，5： | 7 |
| 6 | Highly ordered graphene architectures by duplicating melamine sponges as a three-dimensional deformation- tolerant electrode显示文摘在这研究,宏观的包 graphene 的三聚氰胺泡沫(MF-G ) 被模板 MF 的 layer-by-layer (LBL ) 制作把 graphene 氧化物用作积木的汇编,由处理答案的减小列在后面。由简明地从 MF 复制像海绵的、高度订的三维的体系结构,有互连的基于 graphene 的脚手架和悦耳的 nanostructure 的产生 MF-G 为有效精力存储作为可压缩的、柔韧的电极被探索。pseudocapacitive polypyrrole (PPy ) 的薄层然后被依附,导致 MF-G-PPy 第三的合成海绵的一种明确的 core-double-shell 配置并且在 MF-G 上一致地涂。同样装配的设备展出了 supercapacitor 性能的改进,与解决这四的系列的 427 Ff 的一个高特定的电容哼很好。为 Chr,咩, BaP,和 BbF 的察觉(LOD ) 的限制是 13.0, 8.64, 0.16,和 7.68 ? g ? kg 1, 分别地。在为 Chr,咩, BaP,和 BbF 的各种各样的油样品的恢复作为第二重要灰尘 emitter 是 86.2d 吗?? | Le Li Kai Wang Zhaoqi Huang Chao Zhang Tianxi Liu | 2016 | Nano Research2016，9，10： | 7 |
| 7 | Recent developments in microfluidic device-based preparation, functionalization, and manipulation of nano- and micro-materials显示文摘Microfluidic systems provide a powerful platform for preparing,functionalizing,and manipulating nano-/micro-materials.In this review,we summarize the characteristics of state-of-the-art microfluidic techniques and their application to processing novel nano-/micro-materials with tunable size,shape,morphology,composition,and properties.A variety of synthesis strategies based on novel microfiuidic devices are presented and compared,including their integration with real-time monitoring,external fields,and automatic feedback control.Novel functional nano-/micro-materials with complex structures have been controllably prepared and post-processed to obtain high-quality products.Strategies for controlling and tuning physical and chemical properties are also examined in terms of the design and function of microfluidic platforms.We provide an outlook on future developments in the processing of nano-/micro-materials by microfluidic technologies. | Guangsheng Luo Le Du Yujun Wang Kai Wang | 2019 | Particuology2019，17，4： | 5 |
| 8 | Integrated energy storage system based on triboelectric nanogenerator in electronic devices显示文摘The emergence of electronic devices has brought earth-shaking changes to people's life.However,an extemal power source may become indispensable to the electronie devices due to the limited capacity of batteries.As one of the possible solutions for the extermal power sources,the triboelectric nanogenerator(TENG)provides a novel idea to the increasing mumber of personal electronic devices.TENG is a new type of energy ollector,which has become a hot spot in the field of nanotechnology.It is widely used at the acquisition and conversion of mechan-ical enegy to electrice energy through the principle of electrostatic induction.On this basis,the TENG could be integrated with the energy stonage system into a self-powered system,W hich can supply power to the electronic devices and make them work continuously.In this review,TENG's basic structure as well as its working process and working mode are firstly discussed.The integration method of TENGs with enegy storage systems and the related research status are then introduced in detail.At the end of this paper,we put forward some problems and discuss the prospect in the future. | Xiao Feng Yang Zhang Le Kang Licheng Wang Chongxiong Duan Kai Yin Jinbo Pang Kai Wang | 2021 | Frontiers of Chemical Science and Engineering2021，15，2： | 5 |
| 9 | Bispecific antibody simultaneously targeting PD1 and HER2 inhibits tumor growth via direct tumor cell killing in combination with PD1/PDL1 blockade and HER2 inhibition显示文摘Immune checkpoint blockade has shown significant clinical benefit in multiple cancer indications,but many patients are either refractory or become resistant to the treatment over time.HER2/neu oncogene overexpressed in invasive breast cancer patients associates with more aggressive diseases and poor prognosis.Anti-HER2 mAbs,such as trastuzumab,are currently the standard of care for HER2-overexpressing cancers,but the response rates are below 30%and patients generally suffer relapse within a year.In this study we developed a bispecific antibody(BsAb)simultaneously targeting both PD1 and HER2 in an attempt to combine HER2-targeted therapy with immune checkpoint blockade for treating HER2-positive solid tumors.The BsAb was constructed by fusing scFvs(anti-PD1)with the effector-functional Fc of an IgG(trastuzumab)via a flexible peptide linker.We showed that the BsAb bound to human HER2 and PD1 with high affinities(EC50 values were 0.2 and 0.14 nM,respectively),and exhibited potent antitumor activities in vitro and in vivo.Furthermore,we demonstrated that the BsAb exhibited both HER2 and PD1 blockade activities and was effective in killing HER2-positive tumor cells via antibody-dependent cellular cytotoxicity.In addition,the BsAb could crosslink HER2-positive tumor cells with T cells to form PD1 immunological synapses that directed tumor cell killing without the need of antigen presentation.Thus,the BsAb is a new promising approach for treating late-stage metastatic HER2-positive cancers. | Chang-ling Gu Hai-xia Zhu Lan Deng Xiao-qing Meng Kai Li Wei Xu Le Zhao Yue-qin Liu Zhen-ping Zhu Hao-min Huang | 2022 | Acta Pharmacologica Sinica2022，43，3： | 3 |
| 10 | Efficacy and safety of berberine in the prophylactic treatment of acute radiation proctitis in postoperative patients with cervical cancer:a randomized controlled study显示文摘Objective The aiom of this study was to study the efficacy and safety of berberine as a prophylactic treatment of acute radiation proctitis in postoperative patients with cervical cancer.Methods A total of 120 postoperative patients with cervical cancer were enrolled between July 2016 and October 2019,and randomly divided into a treatment group(berberine 300 mg three times a day,n=60)and a control group(receiving vitamin C tablets,100 mg three times a day;n=60)using the random number table method.All patients received pelvic intensity-modulated radiation therapy(IMRT)and concurrent sensitizing chemotherapy weekly.The difference in the percentage of irradiation volume to the rectum and small intestine as well as the incidence,onset time,severity,and duration of acute radiation proctitis and cystitis during radiotherapy were compared between the two groups.The completion rate,completion time,number of chemotherapy sessions,and quality of life during radiotherapy were also compared.Results There were no statistical differences in age,FIGO stage,pathological type,complications,highrisk factors,and rectum and small intestine irradiation dose distribution(V20,V30,V40,and V50)between the two groups(P>0.05).No acute radiation proctitis of grade 3 or above occurred in the two groups.There was no significant difference in the incidence of acute radiation cystitis,grade 2 acute radiation proctitis,completion rate of IMRT,and frequency of sensitization chemotherapy between the two groups.After prophylactic treatment with berberine,the incidence of grade 1 acute radiation proctitis,occurrence of grade 1 radiation proctitis,and completion time of radiotherapy in the treatment group were significantly lower than those in the control group(P<0.05).The SF-36 score of the treatment group after radiotherapy was 67.53±4.21,which was significantly better than that of the control group(64.90±6.32;P<0.05).The incidence of grade 3-4 neutropenia in the treatment group was 10%and lower than that in the control group(31.7%,P=0.003).No adverse reactions related to berberine were observed.Conclusion Prophylactic prescription with oral berberine can reduce the incidence,onset time,and duration of grade 1 acute radiation proctitis,and improve the quality of life of postoperative patients with cervical cancer receiving concurrent chemoradiotherapy. | Kai Qin Yi Cheng Xianglin Yuan Jing Zhang Le Huang | 2021 | Oncology and Translational Medicine2021，7，1： | 2 |
| 11 | Surgery Upregulates High Mobility Group Box‐1 and Disrupts the Blood–Brain Barrier causing Cognitive Dysfunction in Aged Rats显示文摘 | Hui‐Juan He Yi Wang Yuan Le Kai‐Ming Duan Xue‐Bin Yan Qin Liao Yan Liao Jian‐Bin Tong Niccolò Terrando Wen Ouyang | 2012 | CNS Neurosci Ther2012，，： | 2 |
| 12 | Texture evolution and slip mode of a Ti-5.5Mo-7.2Al-4.5Zr-2.6Sn-2.1Cr dual-phase alloy during cold rolling based on multiscale crystal plasticity finite element model显示文摘The complex micromechanical response among grains remains a persistent challenge to understand the deformation mechanism of titanium alloys during cold rolling.Therefore,in this work,a multiscale crystal plasticity finite element method of dual-phase alloy was proposed and secondarily developed based on LS-DYNA software.Afterward,the texture evolution and slip mode of a Ti-5.5Mo-7.2Al-4.5Zr-2.6Sn-2.1Cr alloy,based on the realistic 3D microstructure,during cold rolling(20%thickness reduction)were systematically investigated.The relative activity of the■slip system in theαphase gradually increased,and then served as the main slip mode at lower Schmid factor(<0.2).In contrast,the contribution of the■slip system to the overall plastic deformation was relatively limited.For theβphase,the relative activity of the<111>{110}slip system showed an upward tendency,indicating the important role of the critical resolved shear stress relationship in the relative activity evolutions.Furthermore,the abnormally high strain of very fewβgrains was found,which was attributed to their severe rotations compelled by the neighboring pre-deformedαgrains.The calculated pole figures,rotation axes,and compelled rotation behavior exhibited good agreement to the experimental results. | Duoduo Wang Qunbo Fan Xingwang Cheng Yu Zhou Ran Shi Yan Qian Le Wang Xinjie Zhu Haichao Gong Kai Chen Jingjiu Yuan Liu Yang | 2022 | Journal of Materials Science & Technology2022，，16： | 2 |
| 13 | Recent advances in the synthesis of nanoscale hierarchically porous metal–organic frameworks显示文摘Nanoscale hierarchically porous metal–organic frameworks(NHP-MOFs)have received unprecedented attention in many fields owing to their integration of the strengths of nanoscale size(<1μm)and hierarchical porous structure(micro-,meso-and/or macro-pores)of MOFs.This review focuses on recent advances in the main synthetic strategies for NHP-MOFs based on different metal ions(e.g.,Cu,Fe,Co,Zn,Al,Zr,and Cr),including the template method,composite technology,post-synthetic modification,in situ growth and the grind method.In addition,the mechanisms of synthesis,regulation techniques and the advantages and disadvantages of various methods are discussed.Finally,the challenges and prospects of the commercialisation of promising NHP-MOFs are also presented.The purpose of this review is to provide a road map for future design and development of NHP-MOFs for practical application. | Chongxiong Duan Kuan Liang Zena Zhang Jingjing Li Ting Chen Daofei Lv Libo Li Le Kang Kai Wang Han Hu Hongxia Xi | 2022 | Nano Materials Science2022，4，4： | 2 |
| 14 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 15 | Selection of DNA aptamers with affinity for pro-gastrin-releasing peptide(pro GRP),a tumor marker for small cell lung cancer显示文摘 | Mie M Kai T Le T | 2013 | Appl Biochem Biotechnol2013，169，1： | 1 |
| 16 | Preparation of Al-based amorphous coatings and their properties显示文摘Al_(86)Ni_(8)Co_(1)La_(1)Y_(2)Gd_(2) amorphous coatings were prepared using cold gas kinetic spray technology.The results show that Al_(86)Ni_(8)Co_(1)La_(1)Y_(2)Gd_(2) amorphous coatings are achieved with the porosity about 3.2%,thickness about 893 μm,the amount of amorphous phase about 82.5%,the hardness about 300 HV0.2.The corrosion potential and anti-corrosion life of 7075 T6 alloy aluminum are about-0.78 V and 72 h,respectively.The electrochemical analysis and neutral salt spray are about-0.69 V corrosion potential and 274 h anti-corrosion life for amorphous Al-based coatings,respectively.Therefore,the life of the Albased amorphous coatings is about 3.8 times that of 7075 T6 aluminum alloy.Besides,the failure mechanism was analyzed using TEM in this investigation.In a word,Al_(86)Ni_(8)Co_(1)La_(1)Y_(2)Gd_(2) coatings keep dense structure,high amorphous content,favorable amorphous phase stabilizing ability and longer anticorrosion life.That is,Al_(86)Ni_(8)Co_(1)La_(1)Y_(2)Gd_(2) coatings have better comprehensive properties.Therefore,these findings indicate that the present Al_(86)Ni_(8)Co_(1)La_(1)Y_(2)Gd_(2) amorphous coatings prepared using cold gas kinetic spray technique can protect aluminum alloy very well and they can be considered to be used in aviation field. | Lei Jin Le Zhang Kaige Liu Zhigang Che Kai Li Ming Zhang Bo Zhang | 2021 | Journal of Rare Earths2021，39，3： | 1 |
| 17 | Global Burden of Cardiovascular Disease Attributable to High Temperature in 204 Countries and Territories from 1990 to 2019显示文摘Objective This study aimed to estimate spatiotemporal variations of global heat-related cardiovascular disease(CVD)burden from 1990 to 2019.Methods Data on the burden of heat-related CVD were derived from the Global Burden of Disease Study 2019.Deaths and disability-adjusted life years(DALYs)were used to quantify heat-induced CVD burden.We calculated the age-standardized mortality rate(ASMR)and DALY rate(ASDR)per 100,000population to compare this burden across regions.Generalized linear models were applied to evaluate estimated annual percentage changes(EAPC)for temporal trends from 1990 to 2019.The correlation between the socio-demographic index(SDI)and age-standardized rate was measured using the Spearman rank test.Results Heat-induced CVD caused approximately 90 thousand deaths worldwide in 2019.Global ASMR and ASDR of heat-related CVD in 2019 were 1.17[95%confidence interval(CI):0.13-1.98]and 25.59(95%CI:2.07-44.17)per 100,000 population,respectively.The burden was significantly increased in middle and low-SDI regions and slightly decreased in high-SDI regions from 1990 to 2019.ASMR showed an upward trend,with the most considerable increase in low-latitude countries.We observed a negative correlation between SDI and EAPC in ASMR(rs=-0.57,P<0.01)and ASDR(rs=-0.59,P<0.01)among204 countries.Conclusion Heat-attributable CVD burden substantially increased in most developing countries and tropical regions. | HONG Le YAN Miao Miao ZHANG Yun Quan WANG Kai WANG Ya Qi LUO Si Qi WANG Fang | 2023 | Biomedical and Environmental Sciences2023，36，3： | 1 |
| 18 | Selection of DNA aptamers with affinity for pro-gastrin-releasing peptide (proGRP), a tumor marker for small cell lung cancer显示文摘 | Mie M Kai T Le T | 2013 | Appl Biochem Biotechnol2013，169，1： | 1 |
| 19 | A novel CO 2 cryogenic liquefaction and separation system显示文摘 | Gang Xu Le Li Yongping Yang Longhu Tian Tong Liu Kai Zhang | 2012 | Energy2012，，1： | 1 |
| 20 | Fecal Nucleic Acid Test as a Complementary Standard for Cured COVID-19 Patients显示文摘To date,no vaccine or specific antiviral treatment is yet available for COVID-19.The most effective control measures for the disease mainly depend on early diagnosis,strict patient quarantine,and close contact monitoring[1].Thus,reliable and accurate diagnostic methods play a critical role in global disease control and prevention.Reverse transcription-polymerase chain reaction(RT-PCR)assays are widely used for the laboratory diagnosis of virus-borne diseases. | HAN Mei ZOU Jing Bo LI Huan WEI Xiao Yu YANG Song ZHANG Hui Zheng WANG Peng Sen QIU Qian WANG Le Le CHEN Yao Kai PAN Pin Liang | 2020 | Biomedical and Environmental Sciences2020，33，12： | 1 |
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