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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Cholinergic sprouting in the hippocampus: A proposed role for IL-1 显示文摘 | Gage FH | 1990 | Exp Neurol1990，110，： | 1 |
| 3 | Multimodal techniques for diagnosis and prognosis of Alzheimers disease显示文摘 | Perrin RJ Fagan AM Holtzman DM | 2009 | Nature2009，461，7266： | 1 |
| 4 | Cholinergic sprouting in the hippocampus:A proposed role for IL-1 显示文摘 | Gage FH | 1990 | Exp Neurol1990，110，： | 1 |
| 5 | Human and murine APOE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimerg disease显示文摘 | Fagan AM Watson M parsadanian M | 2002 | Neurobiol Dis2002，9，3： | 1 |
| 6 | Multimodal techniques for diagnosis and prognosis of Alzheimer's disease显示文摘 | Perrin RJ Fagan AM Holtzman DM | 2009 | Nature2009，461，7266： | 1 |
| 7 | Reducing cigarette smoking among working adolescents: results from the SMART study 显示文摘 | Stoddard AM Fagan P Sorensen G | 2005 | Cancer Causes Control2005，16，10： | 1 |
| 8 | Inhibition of stress-induced hepatic tryptophan 2,3-dioxygenase exhibits antidepressant activity in an animal model of depressive behaviour显示文摘 | Gibney SM Fagan EM Waldron AM | 2014 | Int J Neuropsychopharmacol2014，，： | 1 |
| 9 | Finite element analysis in spine research显示文摘 | Fagan MJ Julian S Mohsen AM | | 0，，： | 1 |
| 10 | A Role for TrkA during Maturation of Striatal and Basal Forebrain Cholinergic Neurons in Vivo显示文摘 | Fagan AM Garber M Barbacid M | 1997 | J Neurosci1997，17，： | 1 |
| 11 | Progress update : fluid and imaging biomarkers in Alzheimer' s disease 显示文摘 | Sutphen CL Fagan AM Holtzman DM | 2014 | Biol Psychiatry2014，75，7： | 1 |
| 12 | Astrocyte lipoproteins, effects of apoE on neuronal function, and role of apoE in amyloid-beta depo sition in vivo显示文摘 | Holtzman DM | 2000 | Microsc Res Tech2000，50，： | 1 |
| 13 | Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease显示文摘 | Hu WT Holtzman DM Fagan AM | 2012 | Neurology2012，79，9： | 1 |
| 14 | Alzheimer disease cerebrospinal fluid biomarkers moderate baseline differences and predict longitudinal change in attentional control and episodic memory composites in the adult children study显示文摘 | ASCHENBRENNER AJ BALOTA DA FAGAN AM | 2015 | J Int Neuropsychol Soc2015，21，8： | 1 |
| 15 | Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease显示文摘 | Watson M Parsadanian M | 2002 | Neurobiol Dis2002，9，： | 1 |
| 16 | Cerebrospinal fluid tau/beta- amyloid(42) ratio as a prediction of cognitive decline in nonde- mented older adults显示文摘 | Fagan AM Roe CM Xiong C | 2007 | Arch Neurol2007，64，3： | 1 |
| 17 | P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model显示文摘 | Cirrito JR Dearie R Fagan AM | 2005 | Clin Invest2005，115，： | 1 |
| 18 | Evidence for normal aging of the septo -hippocampal cholinergic system in apoE ( -/-)mice but impaired clearance of axonal degeneration products following injury显示文摘 | Murphy BA Patel SN | 1998 | Exp Neurol1998，151，2： | 1 |
| 19 | Human and murine APOE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer' s disease显示文摘 | Fagan AM Watson M parsadanian M | 2002 | Neurobiol Dis2002，9，3： | 1 |
| 20 | Finite element analysis in spine research显示文摘 | Fagan MJ Julian S Mohsen AM | | 0，，： | 1 |
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