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| 1 | Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer显示文摘Inflammatory bowel diseases are characterised by inflammation that compromises the integrity of the epithelial barrier. The intestinal epithelium is not only a static barrier but has evolved complex mechanisms to control and regulate bacterial interactions with the mucosal surface. Apical tight junction proteins are critical in the maintenance of epithelial barrier function and control of paracellular permeability. The characterisation of alterations in tight junction proteins as key players in epithelial barrier function in inflammatory bowel diseases is rapidly enhancing our understanding of critical mechanisms in disease pathogenesis as well as novel therapeutic opportunities. Here we give an overview of recent literature focusing on the role of tight junction proteins, in particular claudins, in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer. | Jonathan Landy Emma Ronde Nick English Sue K Clark Ailsa L Hart Stella C Knight Paul J Ciclitira Hafid Omar Al-Hassi | 2016 | World Journal of Gastroenterology2016，22，11： | 39 |
| 2 | The Molecular Pathogenesis of Osteosarcoma: A Review显示文摘 | Matthew L. Broadhead Jonathan C. M. Clark Damian E. Myers Crispin R. Dass Peter F. M. Choong H. Kovar | 2011 | Sarcoma2011，，： | 4 |
| 3 | Pushing the boundaries of diode-pumped solid-state lasers for high-energy applications显示文摘We report on the successful demonstration of a 150 J nanosecond pulsed cryogenic gas cooled,diode-pumped multi-slab Yb:YAG laser operating at 1 Hz.To the best of our knowledge,this is the highest energy ever recorded for a diodepumped laser system. | Saumyabrata Banerjee Paul Mason Jonathan Phillips Jodie Smith Thomas Butcher Jacob Spear Mariastefania De Vido Gary Quinn Danielle Clarke Klaus Ertel Cristina Hernez-Gomez Chris Edwards John Collier | 2020 | High Power Laser Science and Engineering2020，8，2： | 4 |
| 4 | 扁桃体鳞癌中HPV感染与EGFR、VEGF表达的相关性研究显示文摘目的:研究扁桃体鳞癌(squamous cell carcinomas of the tonsil tonsillar,SCCs)中人乳头瘤病毒(human papillomavirus,HPV)感染与血管内皮生长因子(vascular endothelial growth factor,VEGF)和表皮生长因子受体(epidermal growth factor,EGFR)表达的关系,探讨HPV与EGFR和VEGF在扁桃体鳞癌发生中的交互效应。方法:采用多重实时荧光定量聚合酶链反应(multiplex real-time polymerase chain reaction,MT-PCR)检测85例扁桃体鳞癌HPV DNA及型别,通过HPV DNA分析进行HPV感染状况的测定;同时采用半定量免疫组化检测HPV(+)组和HPV(-)组中VEGF、EGFR蛋白表达情况。结果:扁桃体鳞癌中HPV感染率为49.4%(42/85),HPV-16型占所有感染者的比例为90.5%(38/42),明显高于其他型别;HPV(+)组EGFR蛋白表达明显低于HPV(-)组(P值均<0.01);HPV(+)组与HPV(-)组VEGF蛋白表达无明显差异;此外,VEGF表达与EGFR、患者的年龄、性别、TNM分期、组织学分级均无明显相关性。结论:HPV感染与扁桃体鳞癌的发生存在相关性,HPV相关的扁桃体鳞癌中,HPV基因可能通过改变EGFR表达致癌,为HPV致癌机理进一步研究提供一个新的视角,具有重要的理论意义。 | 费继敏 Timothy A Dobbins Deanna Jones C Soon Lee Christine Loo Jonathan Clark Barbara Rose | 2015 | 现代肿瘤医学2015，23，4： | 3 |
| 5 | A next-generation marker genotyping platform(AmpSeq)in heterozygous crops:a case study for marker-assisted selection in grapevine显示文摘Marker-assisted selection(MAS)is often employed in crop breeding programs to accelerate and enhance cultivar development,via selection during the juvenile phase and parental selection prior to crossing.Next-generation sequencing and its derivative technologies have been used for genome-wide molecular marker discovery.To bridge the gap between marker development and MAS implementation,this study developed a novel practical strategy with a semi-automated pipeline that incorporates trait-associated single nucleotide polymorphism marker discovery,low-cost genotyping through amplicon sequencing(AmpSeq)and decision making.The results document the development of a MAS package derived from genotyping-by-sequencing using three traits(flower sex,disease resistance and acylated anthocyanins)in grapevine breeding.The vast majority of sequence reads(⩾99%)were from the targeted regions.Across 380 individuals and up to 31 amplicons sequenced in each lane of MiSeq data,most amplicons(83 to 87%)had<10%missing data,and read depth had a median of 220–244×.Several strengths of the AmpSeq platform that make this approach of broad interest in diverse crop species include accuracy,flexibility,speed,high-throughput,low-cost and easily automated analysis. | Shanshan Yang Jonathan Fresnedo-Ramíre Minghui Wang Linda Cote Peter Schweitzer Paola Barba Elizabeth M Takacs Matthew Clark James Luby David C Manns Gavin Sacks Anna Katharine Mansfield Jason Londo Anne Fennell David Gadoury Bruce Reisch Lance Cadle-Davidson Qi Sun | 2016 | Horticulture Research2016，3，1： | 2 |
| 6 | Plant species identification using digital morphometrics: A review显示文摘 | James S. Cope David Corney Jonathan Y. Clark Paolo Remagnino Paul Wilkin | 2012 | Expert Systems With Applications2012，，8： | 2 |
| 7 | Data Preprocessing tbr A- nomaly based Network Intrusion Detection: A Review 显示文摘 | Jonathan J Davis Andrew J Clark | 2011 | Computers & Securities2011，，30： | 1 |
| 8 | Reservoir quality variation on an Eocene carbonate ramp, EI Garia Formation, offshore Tunisia: Structural eontrol of burial corrosion and dolomitisation显示文摘 | Nadin P Clarke E Jonathan M | 2008 | Sedimentary Geology2008，209，： | 1 |
| 9 | Photocatalytic activities of N-doped nano-titanias and titanium nitride显示文摘 | Zhice Zhang Josephine B.M. Goodall David J. Morgan Sonal Brown Robin J.H. Clark Jonathan C. Knowles Nicola J. Mordan Julian R.G. Evans Albert F. Carley Michael Bowker Jawwad A. Darr | 2009 | Journal of the European Ceramic Society2009，，11： | 1 |
| 10 | Occurrence and determinants of increases in blood lead levels in children shortly after lead hazard control activities显示文摘 | Scott Clark JoAnn Grote Jonathan Wilson Paul Succop Mei Chen Warren Galke Pat McLaine | 2003 | Environmental Research2003，，2： | 1 |
| 11 | Reservoir quality variation on an Eocene carbonate ramp, EI Garia Formation, offshore Tunisia: Structural controlof burial corrosion and dolomitisation显示文摘 | Nadin P Clarke E Jonathan M | 2008 | Sedimenta- ry Geology2008，209，： | 1 |
| 12 | Usefulness of Baseline Plasma Myeloperoxidase Levels as an Independent Predictor of Myocardial Infarction at Two Years in Patients Presenting With Acute Coronary Syndrome显示文摘 | Erdal Cavusoglu Cyril Ruwende Calvin Eng Vineet Chopra Sunitha Yanamadala Luther T. Clark David J. Pinsky Jonathan D. Marmur | 2007 | The American Journal of Cardiology2007，，10： | 1 |
| 13 | A review of clinical and molecular prognostic factors in osteosarcoma显示文摘 | Jonathan C. M. Clark Crispin R. Dass Peter F. M. Choong | 2008 | Journal of Cancer Research and Clinical Oncology2008，，3： | 1 |
| 14 | How good is capsule endoscopy for detection of periampullary lesions? Results of a tertiary-referral center显示文摘 | John O. Clarke Samuel A. Giday Priscilla Magno Eun Ji Shin Jonathan M. Buscaglia Sanjay B. Jagannath Gerard E. Mullin | 2008 | Gastrointestinal Endoscopy2008，，2： | 1 |
| 15 | The effect of vitamin E on blood pressure in individuals with type 2 diabetes: a randomized, double-blind, placebo-controlled trial显示文摘 | Natalie C Ward Jason HY Wu Michael W Clarke Ian B Puddey Valerie Burke Kevin D Croft Jonathan M Hodgson | 2007 | Journal of Hypertension2007，，1： | 1 |
| 16 | The Molecular Pathogenesis of Osteosarcoma: A Review显示文摘 | Matthew L. Broadhead Jonathan C. M. Clark Damian E. Myers Crispin R. Dass Peter F. M. Choong H. Kovar | 2011 | Sarcoma2011，，： | 1 |
| 17 | High-throughput cellular microarray platforms: applications in drug discovery, toxicology and stem cell research显示文摘 | Tiago G. Fernandes Maria Margarida Diogo Douglas S. Clark Jonathan S. Dordick Joaquim M.S. Cabral | 2009 | Trends in Biotechnology2009，，6： | 1 |
| 18 | Surgical Shunting versus Transjugular Intrahepatic Portasystemic Shunting for Bleeding Varices Resulting from Portal Hypertension and Cirrhosis: A Meta-Analysis显示文摘 | Clark Whalen Hernandez Jonathan McKeon Brianne Villadolid Desiree Al-Saadi Sam Mullinax John Ross Sharona B Rosemurgy Alexander S | 2010 | The American Surgeon2010，，8： | 1 |
| 19 | A phylogeny of the families of Scarabaeoidea (Coleopteran)显示文摘 | Jonathan B Clarke H S | 1999 | Systematic Entomo-logy1999，24，： | 1 |
| 20 | Entropy and information causality in general probabilistie theories 显示文摘 | Howard Barnum Jonathan Barrett Lisa Orloff Clark | 2010 | New Journal of Physics2010，3，： | 1 |
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