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| 1 | Metal Fabrication by Additive Manufacturing Using Laser and Electron Beam Melting Technologies显示文摘Selective laser melting (SLM) and electron beam melting (EBM) are relatively new rapid, additive manufac- turing technologies which can allow for the fabrication of complex, multi-functional metal or alloy monoliths by CAD-directed, selective melting of precursor powder beds. By altering the beam parameters and scan strategies, new and unusual, even non-equilibrium microstructures can be produced; including controlled microstructural architectures which ideally extend the contemporary materials science and engineering paradigm relating structure-properties-processing-performance. In this study, comparative examples for SLM and EBM fabricated components from pre-alloyed, atomized precursor powders are presented. These include Cu, Ti–6Al–4V, alloy 625 (a Ni-base superalloy), a Co-base superalloy, and 17-4 PH stainless steel. These systems are characterized by optical metallography, scanning and transmission electron microscopy, and X-ray diffraction. | Lawrence E. Murr Sara M. Gaytan Diana A. Ramirez Edwin Martinez Jennifer Hernandez Krista N. Amato Patrick W. Shindo Francisco R. Medina Ryan B. Wicker | 2012 | Journal of Materials Science & Technology2012，28，1： | 98 |
| 2 | Inflammation, oxidative stress and renin angiotensin system in atherosclerosis显示文摘Atherosclerosis is a chronic inflammatory disease associated with cardiovascular dysfunction including myocardial infarction, unstable angina, sudden cardiac death, stroke and peripheral thromboses. It has been predicted that atherosclerosis will be the primary cause of death in the world by 2020. Atherogenesis is initiated by endothelial injury due to oxidative stress associated with cardiovascular risk factors including diabetes mellitus, hypertension, cigarette smoking, dyslipidemia, obesity, and metabolic syndrome. The impairment of the endothelium associated with cardiovascular risk factors creates an imbalance between vasodilating and vasoconstricting factors, in particular, an increase in angiotensin Ⅱ(Ang Ⅱ) and a decrease in nitric oxide. The renin-angiotensin system(RAS), and its primary mediator Ang Ⅱ, also have a direct influence on the progression of the atherosclerotic process via effects on endothelial function, inflammation, fibrinolytic balance, and plaque stability. Anti-inflammatory agents [statins, secretory phospholipase A2 inhibitor, lipoprotein-associated phospholipase A2 inhibitor, 5-lipoxygenase activating protein, chemokine motif ligand-2, C-C chemokine motif receptor 2 pathway inhibitors, methotrexate, IL-1 pathway inhibitor and RAS inhibitors(angiotensin-converting enzyme inhibitors)], Ang Ⅱ receptor blockers and ranin inhibitors may slow inflammatory processes and disease progression. Several studies in human using anti-inflammatory agents and RAS inhibitors revealed vascular benefits and reduced progression of coronary atherosclerosis in patients with stable angina pectoris; decreased vascular inflammatory markers, improved common carotid intima-media thickness and plaque volume in patients with diagnosed atherosclerosis. Recent preclinical studies have demonstrated therapeutic efficacy of vitamin D analogs paricalcitol in Apo E-deficient atherosclerotic mice. | Kazim Husain Wilfredo Hernandez Rais A Ansari Leon Ferder | 2015 | World Journal of Biological Chemistry2015，6，3： | 84 |
| 3 | Nutritional value of a partially defatted and a highly defatted black soldier fly larvae (Hermetia illucens L.) meal for broiler chickens: apparent nutrient digestibility,apparent metabolizable energy and apparent ileal amino acid digestibility显示文摘Background: The study aimed to determine the apparent total tract digestibility coefficients(ATTDC) of nutrients, the apparent metabolizable energy(AME and AMEn) and the amino acid(AA) apparent ileal digestibility coefficients(AIDC)of a partially defatted(BSFp) and a highly defatted(BSFh) black soldier fly larvae meal. The experimental diets were: a basal diet and two diets prepared by substituting 250 g/kg(w/w) of the basal diet with BSFp or BSFh, respectively.Results: Significant differences were found between BSFp and BSFh meals for ATTDC of the nutrients: BSFp resulted more digestible than BSFh, except for ATTDC of CP which did not differed between meals, while a statistical trend was observed for ATTDC of DM and EE. The AME and AMEn values were significantly(P < 0.05) different between the two BSF meals, with higher levels for BSFp(16.25 and 14.87 MJ/kg DM, respectively). The AIDC of the AA in BSFp ranged from 0.44 to 0.92, while in BSFh they ranged from 0.45 to 0.99. No significant differences were observed for the AA digestibility(0.77 and 0.80 for BSFp and BSFh, respectively), except for glutamic acid, proline and serine that were more digestible in the BSFh meal(P < 0.05).Conclusions: Defatted BSF meals can be considered as an excellent source of AME and digestible AA for broilers with a better efficient nutrient digestion. These considerations suggested the effective utilization of defatted BSF larvae meal in poultry feed formulation. | Achille Schiavone Michele De Marco Silvia Martínez Sihem Dabbou Manuela Renna Josefa Madrid Fuensanta Hernandez Luca Rotolo Pierluca Costa Francesco Gai Laura Gasco | 2017 | Journal of Animal Science and Biotechnology2017，8，4： | 27 |
| 4 | Pancreatic ductal adenocarcinoma: Risk factors, screening, and early detection显示文摘Pancreatic cancer is the fourth most common cause of cancer-related deaths in the United States, with over 38000 deaths in 2013. The opportunity to detect pancreatic cancer while it is still curable is dependent on our ability to identify and screen high-risk populations before their symptoms arise. Risk factors for developing pancreatic cancer include multiple genetic syndromes as well as modifiable risk factors. Genetic conditions include hereditary breast and ovarian cancer syndrome, Lynch Syndrome, familial adenomatous polyposis, Peutz-Jeghers Syndrome, familial atypical multiple mole melanoma syndrome, hereditary pancreatitis, cystic fibrosis, and ataxia-telangiectasia; having a genetic predisposition can raise the risk of developing pancreatic cancer up to 132-fold over the general population. Modifiable risk factors, which include tobacco exposure, alcohol use, chronic pancreatitis, diet, obesity, diabetes mellitus, as well as certain abdominal surgeries and infections, have also been shown to increase the risk of pancreatic cancer development. Several largevolume centers have initiated such screening protocols, and consensus-based guidelines for screening high-riskgroups have recently been published. The focus of this review will be both the genetic and modifiable risk factors implicated in pancreatic cancer, as well as a review of screening strategies and their diagnostic yields. | Andrew E Becker Yasmin G Hernandez Harold Frucht Aimee L Lucas | 2014 | World Journal of Gastroenterology2014，20，32： | 24 |
| 5 | 非维生素K拮抗与维生素K拮抗口服抗凝剂与脑出血患者住院死亡之间的关系显示文摘尽管非维生素K拮抗口服抗凝剂(non-vitamin K antagonist oral anticoagulants, NOACs)越来越多地应用于预防血栓栓塞性疾病,但关于NOACs相关性脑出血的数据仍然有限。 | 刘青 叶鹏 Inohara T Xian Y Liang L Matsouaka RA Saver JL Smith EE Schwamm LH Reeves MJ Hernandez AF Bhatt DL Peterson ED Fonarow GC | 2018 | 中华高血压杂志2018，26，2： | 16 |
| 6 | 7核苷酸切除修复交叉互补集团1蛋白表达预测晚期头颈癌患者对诱导化疗的客观应答及生存率显示文摘该文旨在评价核苷酸切除修复交叉互补集团1(ERCC1)的表达与基于铂类诱导化疗的晚期头颈癌患者癌症生存专率的关系。对1992—1996年间的107例行诱导化疗的晚期头颈鳞癌患者进行研究.其中96例存在活检样本。对组织切片行ERCC1蛋白免疫组化染色,双盲法评价蛋白的表达。结果,68例(71%)存在ERCC1蛋白强阳性表达,28例(29%)为低表达。Logistic回归分析显示.蛋白低表达者对化疗的敏感性较高表达者高4倍(P=0.01)。 | Handra-Luca A Hernandez J Mountzios G | 2007 | 中国口腔颌面外科杂志2007，5，5： | 13 |
| 7 | 移动机器人低能耗最优路径规划方法显示文摘在移动机器人路径规划中需要考虑距离约束和时间约束,同时,为了使机器人在能量补给不足的情况下更高效地执行更多的任务,降低运动过程中的能耗变得尤为重要。兼顾考虑机器人对降低能耗和路径规划效率两方面的需求,本文提出了一种基于改进AD*(Anytime dynamic A*)算法的移动机器人低能耗最优路径规划方法。首先,通过构建机器人动力学模型及其在运动过程中的能耗模型,实现对路径的能耗计算。结合机器人运动学模型,采用基于采样的模型预测算法(Sample based model predictive optimization,SBMPO)生成优化轨迹簇。然后,改进AD*算法,将距离成本和能耗成本融入搜索节点的评估函数,根据轨迹簇中的节点连接关系和环境地图进行在线规划,以获得能耗最优的路径。最后,通过设计仿真测试场景,将所提出的能耗最优路径规划方法与距离最优规划方法进行规划结果对比,验证了算法的有效性。 | 张浩杰 苏治宝 HERNANDEZ D E 苏波 | 2018 | 农业机械学报2018，49，9： | 12 |
| 8 | Nutritional effects of the dietary inclusion of partially defatted Hermetia illucens larva meal in Muscovy duck显示文摘Background: The present work is aimed at evaluating the effect of different inclusion levels of a partially defatted black soldier fly(Hermetia illucens,L.;HI) larva meal for ducks.A total of 192 female 3-day-old Muscovy ducklings(Cairina moschata domestica,Canedins R71 L White,Grimaud Freres Selection,France) were divided into 4 groups,assigned 4 different dietary treatments(6 replicates/treatment and 8 birds/replicate) and reared from 3 to 50 days of age.HI larva meal was included at increasing levels(0,3%,6% and 9%,HI0,HI3,HI6 and HI9,respectively) in isonitrogenous and isoenergetic diets formulated for 3 feeding phases: starter(3–17 days of age),grower(18–38 days of age) and finisher(39–50 days of age).The growth performance and apparent total tract digestibility were evaluated during the trial using titanium dioxide as an inert marker(0.3% of inclusion).At 51 days of age,two birds per pen were slaughtered and histomorphological investigations were performed.Results: The live weight and average daily gain showed a quadratic response to increasing HI meal in the grower period(minimum corresponding to the HI6 group).No effects of dietary inclusion levels were observed for the daily feed intake or feed conversion ratio.The apparent dry matter and organic matter digestibility were not affected by the dietary treatment.A linear decrease was observed for the crude protein apparent digestibility in the starter period(minimum for the HI9 groups).The ether extract apparent digestibility increased linearly during the grower and finisher periods(minimum for the HI0 group).The morphometric indices were not influenced by the dietary treatments.Conclusions: The inclusion of up to 9% of HI partially defatted larva meal in the diet of ducks did not cause any effect on growth performance,as well as the apparent digestibility.Moreover,dietary HI inclusion preserved the physiological intestinal development. | Marta Gariglio Sihem Dabbou Ilaria Biasato Maria Teresa Capucchio Elena Colombino Fuensanta Hernandez Josefa Madrid Silvia Martinez Francesco Gai Christian Caimi Sara Bellezza Oddon Marco Meneguz Angela Trocino Riccardo Vincenzi Laura Gasco Achille Schiavone | 2019 | Journal of Animal Science and Biotechnology2019，10，3： | 12 |
| 9 | The impact of perceived social support, loneliness, and physical activity on quality of life in South Korean older adults显示文摘Purpose: The purpose of this study was to propose and test a conceptual model that explains the interrelationships among perceived social support, loneliness, physical activity(PA), and quality of life(QoL) among active older adults in South Korea.Methods: Data were collected from 332 individuals over the age of 65 using a systematic stratified convenience sampling method. Survey data were collected and analyzed using a structural equation model(SEM).Results: Perceived social support had a significantly positive effect on PA(b = 0.14, p < 0.01) and QoL(b = 0.28, p < 0.001) while decreasing loneliness(b = —0.55, p < 0.001). PA had a significant positive effect on QoL(b = 0.12, p < 0.01), and loneliness had a negative effect on QoL(b = —0.37, p < 0.001). Loneliness mediated the relationship between perceived social support and QoL.Conclusion: The SEM results of the current study support the proposed model that explained the interrelationships among perceived social support, loneliness, PA, and QoL among active older adults in South Korea. These findings suggest the importance of incorporating social support mechanisms for PA interventions in order to enhance QoL. The findings of this study can help create more effective health and physical education programs for the older generations in South Korea to enhance their QoL. | Hyun-Wook Kang Meungguk Park Juliane Poock Wallace (Hernandez) | 2018 | Journal of Sport and Health Science2018，7，2： | 9 |
| 10 | Optimized Nonbismuth Quadruple Therapies Cure Most Patients With Helicobacter pylori Infection in Populations With High Rates of Antibiotic Resistance显示文摘 | Javier Molina–Infante Marco Romano Miguel Fernandez–Bermejo Alessandro Federico Antonietta G. Gravina Liliana Pozzati Elena Garcia–Abadia Gema Vinagre–Rodriguez Carmen Martinez–Alcala Moises Hernandez–Alonso Agnese Miranda Maria Rosaria Iovene Carmen Pazo | 2013 | Gastroenterology2013，，1： | 8 |
| 11 | 锰尘对工人血脂质过氧化、抗氧化酶及金属元素的影响显示文摘目的 :探讨长期暴露于锰尘对工人血脂质过氧化、抗氧化酶及金属元素的影响。方法 :测定了 6 0名接触锰尘 (接锰 )工人和 2 5名对照工人血浆总超氧化物歧化酶 (SOD)、Cu Zn- SOD、谷胱甘肽过氧化物酶 (GSH- Px)、过氧化氢酶 (CAT)活力、丙二醛 (MDA)以及全血 Zn、Cu、Fe、Ca、Mn和 Mg含量。结果 :作业环境空气锰尘中 Mn O2 平均浓度为 0 .38mg/ m3(0 .0 2~ 1 .5 1mg/ m3) ,样品超标率为 5 0 %。接锰工人血浆总 SOD活力明显高于对照工人 ,GSH- Px活力和全血 Mg含量明显低于对照工人。结论 :过量锰能使机体脂质过氧化增加 。 | 张振明 高玉秋 姜岳明 陆继培 廖风玲 曾海玑 Herrero Hernandez Elena Kim Yangho PiraEnrico | 2003 | 广西医科大学学报2003，20，6： | 7 |
| 12 | Multidisciplinary management of nonfunctional neuroendocrine tumor of the pancreas显示文摘Pancreatic neuroendocrine tumors(PNETs) are a rare and diverse group of tumors; nonfunctional(NF) PNETs account for the majority of cases. Most patients with NF-PNETs have metastatic disease at the time of presentation. A variety of treatment modalities exist, including medical, liver directed, and surgical treatments. Aggressive surgical management is associated with prolonged survival, however available data are limited by selection bias and the frequent combination of PNETs with carcinoid tumors. Although few patients with metastatic disease will be cured, application of currently available therapies in a multidisciplinary setting can lead to excellent outcomes with prolonged patient survival. | Ian W Folkert Paul Hernandez Robert E Roses | 2016 | World Journal of Gastroenterology2016，22，11： | 6 |
| 13 | Role of the Microenvironment in the Pathogenesis and Treatment of Hepatocellular Carcinoma显示文摘 | Virginia Hernandez–Gea Sara Toffanin Scott L. Friedman Josep M. Llovet | 2013 | Gastroenterology2013，，3： | 6 |
| 14 | MicroRNA in pancreatic ductal adenocarcinoma and its precursor lesions显示文摘Pancreatic ductal adenocarcinoma(PDAC) is the 4^(th) deadliest cancer in the United States, due to its aggressive nature, late detection, and resistance to chemotherapy. The majority of PDAC develops from 3 precursor lesions, pancreatic intraepithelial lesions(PanIN), intraductual papillary mucinous neoplasm(IPMN), and mucinous cystic neoplasm. Early detection and surgical resection can increase PDAC 5-year survival rate from 6% for Stage Ⅳ to 50% for Stage Ⅰ. To date, there are no reliable biomarkers that can detect PDAC. MicroRNAs(miRNA) are small noncoding RNAs(18-25 nucleotides) that regulate gene expression by affecting translation of messenger RNA(mRNA). A large body of evidence suggests that miRNAs are dysregulated in various types of cancers. MiRNA has been profiled as a potential biomarker in pancreatic tumor tissue, blood, cyst fluid, stool, and saliva. Four mi RNA biomarkers(miR-21, miR-155, miR-196, and miR-210) have been consistently dysregulated in PDAC. MiR-21, miR-155, and miR-196 have also been dysregulated in IPMN and PanIN lesions suggesting their use as early biomarkers of this disease. In this review, we explore current knowledge of miRNA sampling, miR NA dysregulation in PDAC and its precursor lesions, and advances that have been made in using miRNA as a biomarker for PDAC and its precursor lesions. | yasmin g hernandez aimee l lucas | 2016 | World Journal of Gastrointestinal Oncology2016，8，1： | 6 |
| 15 | Chemical oxygen demand reduction in coffee wastewater through chemical flocculation and advanced oxidation processes显示文摘在通过化学凝结絮凝和先进氧化过程( AOP )的咖啡 processingwastewater 在场的自然有机物的移动用商业凝聚剂 andUV/H2O2 , UV/O3 和 UV/H2O2/O3 有自然有机物的移动的 beenstudied.The 有效性过程在 theseprocesses 的酸的 conditions.For 各个下面被决定,不同运作的条件被探索优化 thecoffee wastewater.Coffee 废水的处理效率是 | ZAYAS Pérez Teresa GEISSLER Gunther HERNANDEZ Fernando | 2007 | Journal of Environmental Sciences2007，19，3： | 6 |
| 16 | Micro- and nanoporous materials capable of absorbing solvents and oils reversibly: the state of the art显示文摘Treatment of petroleum spills and organic solvent pollution in general is an important issue; several techniques are under development to remove oil from water. The use of absorbents is one of the most common techniques to tackle this problem. These absorbents can be classified based on their characteristics of recyclability into irreversible and reversible ones. In this review, we discuss the application of several materials as oil absorbents,according to their classification and characteristics such as hydrophobicity, surface area and oil absorption capacity.Also, the fabrication methods for some materials are presented and analyzed. | Javier S. Acevedo Cortez Boris I. Kharisov Thelma E. Serrano Quezada Tomas C. Hernandez Garcia | 2017 | Petroleum Science2017，14，1： | 5 |
| 17 | Cancer stem cell impact on clinical oncology显示文摘Cancer is a widespread worldwide chronic disease. In most cases, the high mortality rate from cancer correlates with a lack of clear symptoms, which results in late diagnosis for patients, and consequently, advanced tumor disease with poor probabilities for cure, since many patients will show chemo-and radio-resistance. Several mechanisms have been studied to explain chemo-and radio-resistance to anti-tumor therapies, including cell signaling pathways, anti-apoptotic mechanisms, stemness, metabolism, and cellular phenotypes. Interestingly, the presence of cancer stem cells(CSCs), which are a subset of cells within the tumors, has been related to therapy resistance. In this review, we focus on evaluating the presence of CSCs in different tumors such as breast cancer, gastric cancer, lung cancer, and hematological neoplasias, highlighting studies where CSCs were identified in patient samples. It is evident that there has been a great drive to identify the cell surface phenotypes of CSCs so that they can be used as a tool for anti-tumor therapy treatment design. We also review the potential effect of nanoparticles, drugs, natural compounds, aldehyde dehydrogenase inhibitors, cell signaling inhibitors, and antibodies to treat CSCs from specific tumors. Taken together, we present an overview of the role of CSCs in tumorigenesis and how research is advancing to target these highly tumorigenic cells to improve oncology patient outcomes. | Mariel E Toledo-Guzmán Gabriele D Bigoni-Ordonez Miguel Ibanez Hernandez Elizabeth Ortiz-Sánchez | 2018 | World Journal of Stem Cells2018，10，12： | 4 |
| 18 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 19 | Biliary cystadenoma显示文摘The diagnosis of cystadenoma is rare, even more so when located in the extrahepatic bile duct.Unspeciflc clinical signs may lead this pathology to be misdiagnosed.The need for pathological anatomy in order to distinguish cystadenomas from simple biliary cysts is crucial.The most usual treatment nowadays is resection of the bile duct, together with cholecystectomy and Roux-en-Y reconstruction. | Miguel A Hernandez Bartolome Sagrario Fuerte Ruiz Israel Manzanedo Romero Beatriz Ramos Lojo Ignacio Rodriguez Prieto Luis Gimenez Alvira Rosario Granados Carreo Manuel Limones Esteban | 2009 | World Journal of Gastroenterology2009，15，28： | 4 |
| 20 | Season of the year influences infection rates following total hip arthroplasty显示文摘AIM To research the influence of season of the year on periprosthetic joint infections.METHODS We conducted a retrospective review of the entire Medicare files from 2005 to 2014. Seasons were classified as spring, summer, fall or winter. Regional variations were accounted for by dividing patients into four geographic regions as per the United States Census Bureau(Northeast, Midwest, West and South). Acute postoperative infection and deep periprosthetic infections within 90 d after surgery were tracked. RESULTS In all regions, winter had the highest incidence of periprosthetic infections(mean 0.98%, SD 0.1%) and was significantly higher than other seasons in the Midwest, South and West(P < 0.05 for all) but not the Northeast(P = 0.358). Acute postoperative infection rates were more frequent in the summer and were significantly affected by season of the year in the West.CONCLUSION Season of the year is a risk factor for periprosthetic joint infection following total hip arthroplasty(THA). Understanding the influence of season on outcomes following THA is essential when risk-stratifying patients to optimize outcomes and reduce episode of care costs. | Samuel Rosas Alvin C Ong Leonard T Buller Karim G Sabeh Tsun yee Law Martin W Roche Victor H Hernandez | 2017 | World Journal of Orthopedics2017，8，12： | 4 |
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