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| 1 | 2017欧洲心脏病学会/欧洲心胸外科协会心脏瓣膜病管理指南中经导管主动脉瓣置换术相关更新解读显示文摘自2012欧洲心脏协会/欧洲心胸外科协会关于心脏瓣膜病的管理指南发布以来,新的临床证据又大量积累。这些新证据使欧洲心脏协会/欧洲心胸外科协会需要更新瓣膜病的管理指南以达到心内科与心外科医师间的共识。该文将从经导管主动脉瓣置换术出发,解读2017年新指南所作出的更新。 | Tasalak Thonghong Manik Chopra Ole De Backer Lars Sndergaard 王玺 | 2018 | 华西医学2018，33，2： | 12 |
| 2 | 两个地面运动分量作用下建筑物的三维振型静力弹塑性分析及其对高层建筑的评估显示文摘目前局限于一个水平地面运动分量的振型静力弹塑性分析(MPA)程序,扩展到了建筑物在同时受两个水平地面运动分量作用下平面内对称或非对称结构的三维分析程序。也给出了该方法的变异形式,称为实用振型静力弹塑性分析(PMPA)程序,这种分析方法直接从地震响应(或设计)谱中估算地震需求。对它计算超高层建筑的地震需求的准确度进行了评估,说明该程序对非线性系统的分析和线性系统的响应谱分析几乎一样准确。因此,对于实际应用而言,实用振型静力弹塑性分析程序提供了一个诱人的可替代方法,使得地震需求可以直接从(弹性)设计响应谱估算出,从而避免了非线性响应谱时程分析中选择和标定地面运动的复杂性。 | J. C. Reyes A. K. Chopra 梁铁锚(译) 崔秋文(校) | 2011 | 世界地震译丛2011，42，4： | 11 |
| 3 | 化妆品与皮肤健康——皮肤微生态显示文摘随着化妆品科学的飞速发展,化妆品在维持、改善和促进皮肤健康以及提高人们生活质量方面的作用越来越受到人们的重视。例如,保湿剂不仅能够通过增强皮肤屏障功能发挥其维持和增进皮肤健康的作用,还能有效改善和缓解由皮肤屏障受损所导致的皮肤问题[1]。目前,含有神经酰胺1、3、6(与人体角质层必需成分相似的保湿因子)的产品系列在修复受损的皮肤屏障方面的功效不仅被国内外皮肤科专家认同,也备受消费者喜爱[2]。同样,防晒剂不仅可以预防由日光中紫外线(UV)导致的皮肤光老化、皮肤色素沉着、光免疫抑制以及降低UV 导致的皮肤癌的风险,还可以预防某些皮肤病的发生,如多形性日光疹等[3]。另外,针对头皮屑的洗护发产品也为受头皮屑困扰的消费者提供了日常头皮护理的有效方法。 | 甄雅贤 张晨慧 Chopra Tarun Verschoore Michèle 刘玮 | 2019 | 临床皮肤科杂志2019，48，10： | 10 |
| 4 | 曲率属性在3D地面地震资料中的应用显示文摘结合褶皱和弯曲在地震分辨率范围内或更小尺度内识别地下断层和预测裂缝是精细地震解释的主要目的之一。随着20世纪80年代后期3D地震的普遍使用,人们发现以一阶导数为基础的层位倾斜量和倾斜方位角可以指示用其他方法看不到的断层。最近,开始采用以二阶导数为基础的曲率图,现在可以在商业工作站环境下进行以地层为基础的曲率运算。这些方法已被还没有使用处理软件和没有时间编写程序的地球物理学家们接受。 | Satinder Chopra 赵剑敏 吴龙丽 | 2007 | 油气地球物理2007，5，4： | 8 |
| 5 | Recent advances in small bowel diseases:Part Ⅰ显示文摘As is the case in all parts of gastroenterology and hepatology,there have been many advances in our knowledge and understanding of small intestinal diseases.Over 1000 publications were reviewed for 2008 and 2009,and the important advances in basic science as well as clinical applications were considered.In Part Ⅰ of this Editorial Review,seven topics are considered:intestinal development;proliferation and repair;intestinal permeability;microbiotica,infectious diarrhea and probiotics;diarrhea;salt and water absorption;necrotizing enterocolitis;and immunology/allergy.These topics were chosen because of their importance to the practicing physician. | Alan BR Thomson Angeli Chopra Michael Tom Clandinin Hugh Freeman | 2012 | World Journal of Gastroenterology2012，18，26： | 5 |
| 6 | A Zebrafish Model of 5q-Syndrome Using CRISPR/Cas9 Targeting RPS14 Reveals a p53-Independent and p53-Dependent Mechanism of Erythroid Failure显示文摘5q-syndrome is a distinct form of myelodysplastic syndrome(MDS) where a deletion on chromosome 5 is the underlying cause.MDS is characterized by bone marrow failures,including macrocytic anemia.Genetic mapping and studies using various models support the notion that ribosomal protein S14(RPS14) is the candidate gene for the erythroid failure.Targeted disruption of RPS14 causes an increase in p53 activity and p53-mediated apoptosis,similar to what is observed with other ribosomal proteins.However,due to the higher risk for cancer development in patients with ribosome deficiency,targeting the p53 pathway is not a viable treatment option.To better understand the pathology of RPS14 deficiency in 5q-deletion,we generated a zebrafish model harboring a mutation in the RPS14 gene.This model mirrors the anemic phenotype seen in 5q-syndrome.Moreover,the anemia is due to a late-stage erythropoietic defect,where the erythropoietic defect is initially p53-independent and then becomes p53-dependent.Finally,we demonstrate the versatility of this model to test various pharmacological agents,such as RAP-011,L-leucine,and dexamethasone in order to identify molecules that can reverse the anemic phenotype. | Jason Ear Jessica Hsueh Melinda Nguyen QingHua Zhang Victoria Sung Rajesh Chopra Kathleen M.Sakamoto Shuo Lin | 2016 | Journal of Genetics and Genomics2016，43，5： | 5 |
| 7 | Anti-endothelial cell antibody rich sera from rheumatic heart disease patients induces proinflammatory phenotype and methylation alteration in endothelial cells显示文摘Rheumatic heart disease(RHD)is a major cause of cardiovascular morbidity and mortality in developing nations like India.RHD commonly affects the mitral valve which is lined by a single layer of endothelial cells(ECs).The role of ECs in mitral valve damage during RHD is not well elucidated.In here,anti-endothelial cell antibody from RHD patients has been used to stimulate the ECs(HUVECs and HMVECs).ECs proinflammatory phenotype with increased expression of TNFa,IL-6,IL-8,IFNg,IL-1b,ICAM1,VCAM1,E-selectin,laminin B,and vimentin was documented in both ECs.The promoter hypomethylation of various key inflammatory cytokines(TNFa,IL-6,and IL-8),integrin(ICAM1)associated with leukocyte transendothelial migration,and extracellular matrix genes(vimentin,and laminin)were also observed.Further,the in-vitro data was in accordance with ex-vivo observations which correlated significantly with the etiological factors such as smoking,socioeconomic status,and housing.Thus,the study sheds light on the role of ECs in RHD which is a step forward in the elucidation of disease pathogenesis. | Mukul Rastogi Subendu Sarkar Ankita Makol Rana Sandip Singh Uma Nahar Saikia Dibyajyoti Banerjee Seema Chopra Anuradha Chakraborti | 2018 | Genes & Diseases2018，5，3： | 5 |
| 8 | Changing organ allocation policy for kidney transplantation in the United States显示文摘The new kidney allocation scheme(KAS) in effect since December 4th 2014 was designed to overcome the shortcomings of previous system. A key feature of the new KAS is preferential allocation of best quality organs to wait-list candidates with the longest predictivesurvival in a concept called longevity matching. Highly sensitized recipients would get extra points and enjoy widespread sharing of organs in order to increase accessibility to transplant. Wait-list candidates with blood group B will be offered organs from donors with A2 and A2 B blood type in order to shorten their wait-list time. Time on the wait list will start from day of listing or date of initiation of dialysis whichever comes first which should benefit candidates with limited resources who might be late to get on the transplant list. Pay back system has been eliminated in the new KAS. These changes in organ allocation policy may lead to increase in median half-life of the allograft and increase the number of transplants; thus resulting in better utilization of a scarce resource. There could be unintended negative consequences which may become evident over time. | Bhavna Chopra Kalathil K Sureshkumar | 2015 | World Journal of Transplantation2015，5，2： | 4 |
| 9 | 地震属性的历史回顾(上)显示文摘地震属性是对目的层地震特性的量化测量。自地球物理工作者开始将旅行时拾取到野外地震记录上的20世纪30年代起,属性分析在反射波地震解释方面已经变得相当重要。现在已经从地震资料中计算出50多个明确的地震属性,并将其应用到了地质构造、地层和岩石/孔隙流体特性的解释中。地震属性技术的发展与计算机技术的发展紧密相连。今天,能够将不同资料综合成大数据体并计算大量地震属性的大型计算机工作站已经成为地震解释人员从地震资料中寻找地质和油藏工程信息的日常工具。在庆祝SEG75界年会的回顾文章中,我们列出了现代地震属性分析技术发展中的重大历史事件。 | Satinder Chopra Kurt J Marfurt 赵剑敏 | 2006 | 油气地球物理2006，4，3： | 4 |
| 10 | Recent advances in celiac disease显示文摘Celiac disease now affects about one person in a hundred in Europe and North America. In this review, we consider a number of important and exciting recent developments, such as clinical associations, HLA-DQ2 and HLA-DQ8 predispositions, the concept of potential celiac disease, the use of new imaging/endoscopy techniques, and the development of refractory disease. This review will be of use to all internists, pediatricians and gastroenterologists. | Hugh James Freeman Angeli Chopra Michael Tom Clandinin Alan BR Thomson | 2011 | World Journal of Gastroenterology2011，17，18： | 3 |
| 11 | 地震属性的历史回顾(下)显示文摘 | Satinder Chopra Kurt J Marfurt 赵剑敏 | 2006 | 油气地球物理2006，4，4： | 3 |
| 12 | Transparent conductors - a status review 显示文摘 | Chopra K L Major S Pandya D K | 1983 | Thin Solid Films1983，102，： | 3 |
| 13 | 白细胞内IRE1αlpha-XBP1信号通路控制前列腺素的生物合成进而参与对痛觉的调控显示文摘IRE1alpha-XBP1信号通路在调控免疫代谢过程中参与维持内质网的稳态(Homeostasis),但该信号通路在白细胞内的生理功能尚无研究报道。本研究发现IRE1αlpha缺陷的髓系白细胞在发生内质网应激(ER stress)或通过模式识别受体(PRR)被刺激以后,前列腺素内过氧化物合成酶2(Ptgs2/Cox-2)及前列腺素E合酶(Ptges/mPGES-1)的水平下调。在IRE1α或XBP1缺陷的髓系白细胞中,可诱导的前列腺素包括致痛介质—前列腺素E2(PGE2)的生物合成减少;但在其他内质网应激感受器缺陷时,未发现PGE2的合成减少。功能性XBP1反式激活人源PTGS2及PTGES基因以保证适量的PGE2生成。白细胞内IRE1alpha-XBP1功能缺陷或给予IRE1alpha抑制剂的小鼠,在PGE2依赖的疼痛模型中表现出痛行为的减轻。因此,IRE1alpha-XBP1是控制前列腺素生物合成的通路,也是治疗疼痛的潜在靶点。 | Chopra S 张静冰(译) 刘兴君(校) | 2019 | 中国疼痛医学杂志2019，25，12： | 3 |
| 14 | Resolution of chronic hepatitis C following parasitosis显示文摘An inefficient cellular immune response likely leads to chronic hepatitis C virus (HCV) infection. Resolution of chronic HCV infection in the absence of treatment is a rare occurrence. We report the case of a 39-year old white male with a 17-year history of chronic HCV infection, who eradicated HCV following a serious illness due to co-infection with Babesia (babesiosis), Borriela Borgdorferi (Lyme disease) and Ehrlichia (human granulocytic ehrlichiosis). We hypothesize that the cellular immune response mounted by this patient in response to his infection with all three agents but in particular Babesia was suffi cient to eradicate HCV. | Valerie Byrnes Sanjiv Chopra Margaret J Koziel | 2007 | World Journal of Gastroenterology2007，13，31： | 2 |
| 15 | Boron nitride nanotubes显示文摘 | Chopra G C Luyken R J Cherrey k | 1995 | Science1995，296，18： | 2 |
| 16 | Gliosarcoma:A rare variant of glioblastoma multiforme in paediatric patient:Case report and review of literature显示文摘Gliosarcoma is rare central nervous system tumour and a variant of glioblastoma multiforme with bimorphic histological pattern of glial and sarcomatous differentiation. It occurs in elderly between 5^(th) and 6^(th) decades of life and extremely rare in children. It is highly aggressive tumour and managed like glioblastoma multiforme. A 12-year-old female child presented with complaints of headache and vomiting from 15d and blurring of vision from 3d. Magnetic resonance imaging of brain shows heterogeneous mass in right parieto-occipital cortex. A right parieto-occipito-temporal craniotomy with complete excision of mass revealed a primary glioblastoma on histopathological investigation. Treatment consists of maximum surgical excision followed by adjuvant radiotherapy. The etiopathogenesis, treatment modalities and prognosis is discussed. The available literature is also reviewed. | Ugan Singh Meena Sumit Sharma Sanjeev Chopra Shashi Kant Jain | 2016 | World Journal of Clinical Cases2016，4，9： | 2 |
| 17 | Comparison of surgically induced astigmatism in various incisions in manual small incision cataract surgery显示文摘AIM: To determine the surgically induced astigmatism(SIA) in Straight, Frown and Inverted V shape(Chevron)incisions in manual small incision cataract surgery(SICS).METHODS: A prospective cross sectional study was done on a total of 75 patients aged 40 y and above with senile cataract. The patients were randomly divided into three groups(25 each). Each group received a particular type of incision(Straight, Frown or Inverted V shape incisions). Manual SICS with intraocular lens(IOL)implantation was performed. The patients were compared4 wk post operatively for uncorrected visual acuity(UCVA), best corrected visual acuity(BCVA) and SIA. All calculations were performed using the SIA calculator version 2.1, a free software program. The study was analyzed using SPSS version 15.0 statistical analysis software.RESULTS: The study found that 89.5% of patients in Straight incision group, 94.2% in Frown incision group and 95.7% in Inverted V group attained BCVA post-operatively in the range of 6/6 to 6/18. Mean SIA was minimum(-0.88 ±0.61 D ×90 degrees) with Inverted V incision which was statistically significant.CONCLUSION: Inverted V(Chevron) incision gives minimal SIA. | Nidhi Jauhari Deepak Chopra Rajan Kumar Chaurasia Ashutosh Agarwal | 2014 | International Journal of Ophthalmology(English edition)2014，7，6： | 2 |
| 18 | 岩石物理和AVO在天然气水合物勘探中的应用显示文摘与其他的孔隙流体相比,天然气水合物展示出独特的弹性。本文通过AVO研究孔隙流体,对天然气水合物填充岩石的AVO特性进行研究,并且探索了AVO在天然气水合物勘探中应用的潜力。 | Yong Xu S. Chopra 赵京凤(译) 冯义钧(译) 葛洪魁(校) | 2006 | 世界地震译丛2006，，6： | 2 |
| 19 | Effects of some metalions on protomental growth and bud formation in the moss Timmiella anomala grown in aseptic cultures 显示文摘 | KAPUR A CHOPRA R M | 1989 | J Hattori Botlab1989，66，： | 2 |
| 20 | Assessment of plant nitrogen stress in wheat (Triticum aestivum L.) through hyperspectral indices显示文摘 | Rajeev Ranjan Usha Kiran Chopra RabiN. Sahoo Anil Kumar Singh Sanatan Pradhan | 2012 | International Journal of Remote Sensing2012，，20： | 2 |
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