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| 1 | Psychological controversies in gastroparesis: A systematic review显示文摘AIM To systematically review literature addressing three key psychologically-oriented controversies associated with gastroparesis. METHODS A comprehensive search of Pub Med, CINAHL, and PsycI NFO databases was performed to identify literature addressing the relationship between gastroparesis and psychological factors. Two researchers independently screened all references. Inclusion criteria were: an adult sample of gastroparesis patients, a quantitative methodology, and at least one of the following:(1) evaluation of the prevalence of psychopathology;(2) an outcome measure of anxiety, depression, or quality of life; and(3) evidence of a psychological intervention. Case studies, review articles, and publications in languages other than English were excluded from the current review. RESULTS Prevalence of psychopathology was evaluated by three studies(n = 378), which found that combined anxiety/depression was present in 24% of the gastroparesis cohort, severe anxiety in 12.4%, depression in 21.8%-23%, and somatization in 50%. Level of anxiety and depression was included as an outcome measure in six studies(n = 1408), and while limited research made it difficult to determine the level of anxiety and depression in the cohort, a clear positive relationship with gastroparesis symptom severity was evident.Quality of life was included as an outcome measure in 11 studies(n = 2076), with gastroparesis patients reporting lower quality of life than population norms, and a negative relationship between quality of life and symptom severity. One study assessed the use of a psychological intervention for gastroparesis patients(n = 120) and found that depression and gastric function were improved in patients who received psychological intervention, however the study had considerable methodological limitations. CONCLUSION Gastroparesis is associated with significant psychological distress and poor quality of life. Recommendations for future studies and the development of psychological interventions are provided. | Sally Woodhouse Geoff Hebbard Simon R Knowles | 2017 | World Journal of Gastroenterology2017，23，7： | 12 |
| 2 | The Clock Protein CCA1 and the bZIP Transcription Factor HY5 Physically Interact to Regulate Gene Expression in Arabidopsis显示文摘生理节奏的钟调整象编码轻收获的叶绿素 A/B (Lhcb ) 的那些那样的一连串的 Arabidopsis 基因的表示蛋白质。我们以前学习了二这些 Arabidopsis genesLhcb1 *1 的倡导者, Lhcb1 *3and 识别了绑钟蛋白质的一个序列联系的生理节奏的钟 1 (CCA1 ) 。这个序列,指明的 CCA1 有约束力的地点(CBS ) ,为 phytochrome 和这些基因的生理节奏的应答是必要的。在到这个序列的靠近的最近,在那里存在被显示了在另外的调整光的植物倡导者绑 bZIP 抄写因素 HY5 的一个 G 盒子核心元素。在现在的学习,我们检验了抄写因素绑定的相互作用的重要性在 Lhcb 基因的正常生理节奏的有韵律的表示的控制的 CBS 和 G 盒子核心元素。我们的结果证明 HY5 能明确地在 Lhcb 倡导者绑 G 盒子元素并且 CCA1 能改变 HY5 的有约束力的活动。我们进一步证明 CCA1 和 HY5 罐头身体上交往并且他们能在酵母记者基因试金对抄写 synergistically 起作用。HY5 的缺席导致 Lhcb1 *1 的一个更短的时期生理节奏的表示但是不影响 CATALASE3 (CAT3 ) 的生理节奏的表示,其倡导者缺乏一个 G 盒子元素。我们的结果建议 Lhcb 倡导者上的 HY5 和 CCA1 蛋白质的那个相互作用为 Lhcb 基因的正常生理节奏的表示是必要的。 | Christos Andronis Simon Barak Stephen M. Knowles Shoji Sugano Elaine M. Tobin | 2008 | Molecular Plant2008，1，1： | 9 |
| 3 | 安全农药剂型和农药助剂的发展趋势显示文摘目前世界各国政府登记管理机构和农化公司愈发关注更安全、更环境友好的农药制剂以及更便捷包装的开发。制剂技术在提高农药使用价值和吸引对农药关注方面是非常有效的,同时也能提高使用时的安全性,减少使用量和浪费,由此减少对环境的影响和增进食品安全。 | Alan Knowles 商建(编译) 刘峰(校) | 2011 | 世界农药2011，33，4： | 7 |
| 4 | The effect of platform switching on the levels of metal ion release from different implant–abutment couples显示文摘The improved peri-implant bone response demonstrated by platform switching may be the result of reduced amounts of metal ions released to the surrounding tissues. The aim of this study was to compare the levels of metal ions released from platform-matched and platform-switched implant–abutment couples as a result of accelerated corrosion. Thirty-six titanium alloy(Ti-6Al-4V) and cobalt–chrome alloy abutments were coupled with titanium cylinders forming either platform-switched or platform-matched groups(n = 6). In addition, 18 unconnected samples served as controls. The specimens were subjected to accelerated corrosion by static immersion in 1% lactic acid for 1 week. The amount of metal ions ion of each test tube was measured using inductively coupled plasma mass spectrometry. Scanning electron microscope(SEM) images and energy dispersive spectroscopy X-ray analyses were performed pre- and post-immersion to assess corrosion at the interface. The platform-matched groups demonstrated higher ion release for vanadium, aluminium, cobalt, chrome, and molybdenum compared with the platform-switched groups(Po0.05). Titanium was the highest element to be released regardless of abutment size or connection(Po0.05). SEM images showed pitting corrosion prominent on the outer borders of the implant and abutment platform surfaces. In conclusion, implant–abutment couples underwent an active corrosion process resulting in metal ions release into the surrounding environment. The highest amount of metal ions released was recorded for the platform-matched groups, suggesting that platform-switching concept has a positive effect in reducing the levels of metal ion release from the implant–abutment couples. | Ghada O Alrabeah Jonathan C Knowles Haralampos Petridis | 2016 | International Journal of Oral Science2016，8，2： | 5 |
| 5 | A history of high-power laser research and development in the United Kingdom显示文摘The first demonstration of laser action in ruby was made in 1960 by T.H.Maiman of Hughes Research Laboratories,USA.Many laboratories worldwide began the search for lasers using different materials,operating at different wavelengths.In the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications.This historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years. | Colin N.Danson Malcolm White John R.M.Barr Thomas Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer Anthony Dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin Denis R.Hall David C.Hanna Wayne Harris David I.Hillier Christopher J.Hooker Simon M.Hooker Nicholas Hopps Janet Hull David Hunt Dino A.Jaroszynski Mark Kempenaars Helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE Stuart P.D.Mangles William Martin Paul McKenna Richard O.Moore Clive Morrison Zulfikar Najmudin David Neely Geoff H.C.New Michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel Seddon MBE Zheng-Ming Sheng David Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin S.Wark Colin Webb S.Mark Wiggins Dave Willford Trevor Winstone | 2021 | High Power Laser Science and Engineering2021，9，2： | 5 |
| 6 | Pulmonary complications of transcatheter arterial chemoembolization for hepatocellular carcinoma显示文摘Transcatheter arterial chemoembolization(TACE) is an effective palliative intervention that is widely accepted for the management of hepatocellular carcinoma(HCC). Post-TACE pulmonary complications resulting in acute lung injury(ALI) or acute respiratory distress syndrome(ARDS) are rare events. Pulmonary complications after TACE are thought to be related to chemical injury subsequent to the migration of the infused ethiodized oil or chemotherapeutic agent to the lung vasculature, facilitated by arteriovenous(AV) shunts within the hyper-vascular HCC. We review herein the literature on pulmonary complications related to TACE for HCC. Post-TACE pulmonary complications have included pulmonary oil embolism, interstitial pneumonitis, chemical pneumonitis, ALI, ARDS, lipoid pneumonia, acute eosinophilic and neutrophilic pneumonia, bilious pleuritis, pulmonary abscess, pulmonary tumor embolism, and possibly pulmonary metastasis with HCC. The risk factors associated with post-TACE pulmonary complications identified in the literature include large hyper-vascular HCC with AV shunts, large-volume Lipiodol infusion, and embolization via the right inferior phrenic artery. However, the absence of known risk factors is not a guarantee against serious complications. An astute awareness of the potential post-TACE pulmonary complications should expedite appropriate therapeutic interventions and increase potential for early recovery. | Quan M Nhu Harry Knowles Paul J Pockros Catherine T Frenette | 2016 | World Journal of Respirology2016，6，3： | 4 |
| 7 | The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression显示文摘 | Thomas Derrien Rory Johnson Giovanni Bussotti Andrea Tanzer Sarah Djebali Hagen Tilgner Gregory Guernec David Martin Angelika Merkel David G. Knowles Julien Lagarde Lavanya Veeravalli Xiaoan Ruan Yijun Ruan Timo Lassmann Piero Carninci James B. Brown Leon | 2012 | Genome Research2012，，9： | 3 |
| 8 | Comparison of cytokine and phosphoprotein profiles in idiopathic and Crohn’s disease-related perianal fistula显示文摘BACKGROUND Perianal fistulae are either primary(idiopathic)or secondary[commonly associated with Crohn’s disease,(CD)].It is assumed,although not proven,that the pathophysiology differs.AIM To systematically compare the clinical phenotypes,cytokine and phosphoprotein profiles of idiopathic and CD-related perianal fistulae.METHODS Sixty-one patients undergoing surgery for perianal fistula were prospectively recruited(48 idiopathic,13 CD)into a cohort study.Clinical data,including the Perineal Disease Activity Index(PDAI)and EQ-5D-5L were collected.Biopsies of the fistula tract,granulation tissue,internal opening mucosa and rectal mucosa were obtained at surgery.Concentrations of 30 cytokines and 39 phosphoproteins were measured in each biopsy using a magnetic bead multiplexing instrument and a chemiluminescent antibody array respectively.Over 12000 clinical and 23500 laboratory measurements were made.RESULTS The PDAI was significantly higher(indicating more active disease)in the CD group with a mean difference of 2.40(95%CI:0.52-4.28,P=0.01).Complex pathoanatomy was more prevalent in the CD group,namely more multiple fistulae,supralevator extensions,collections and rectal thickening.The IL-12p70 concentration at the internal opening specimen site was significantly higher(median difference 19.7 pg/mL,99%CI:0.2-40.4,P=0.008)and the IL-1RA/IL-1βratio was significantly lower in the CD group at the internal opening specimen site(median difference 15.0,99%CI=0.4-50.5,P=0.008).However in the remaining 27 cytokines and all 39 of the phosphoproteins across the four biopsy sites,no significant differences were found between the groups.CONCLUSION CD-related perianal fistulae are more clinically severe and anatomically complex than idiopathic perianal fistulae.However,overall there are no major differences in cytokine and phosphoprotein profiles. | James B Haddow Omar Musbahi Thomas T MacDonald Charles H Knowles | 2019 | World Journal of Gastrointestinal Pathophysiology2019，10，4： | 2 |
| 9 | The I nhibitor of wax 1 locus ( I w1 ) prevents formation of β‐ and OH ‐β‐diketones in wheat cuticular waxes and maps to a sub‐c M interval on chromosome arm 2 BS显示文摘 | Nikolai M. Adamski Maxwell S. Bush James Simmonds Adrian S. Turner Sarah G. Mugford Alan Jones Kim Findlay Nikolai Pedentchouk Penny Wettstein‐Knowles Cristobal Uauy | 2013 | Plant J2013，，6： | 2 |
| 10 | Evacuation proctography: a reappraisal of normal variability显示文摘 | S. Palit C. Bhan P. J. Lunniss D. J. Boyle M. A. Gladman C. H. Knowles S. M. Scott | 2014 | Colorectal Dis2014，，7： | 2 |
| 11 | The crystallography of the martensitic transformation in equiatomic nickel-titanium显示文摘 | Knowles K M Smith D A | 1981 | ActaMetall1981，29，： | 2 |
| 12 | Nitric oxide synthases: structure, function and inhibition显示文摘 | Alderton W K Cooper C E Knowles R G | 2001 | Biochem J2001，357，3： | 2 |
| 13 | Biochar for the mitigation of nitrate leaching from soil amended with biosolids显示文摘 | O.A. Knowles B.H. Robinson A. Contangelo L. Clucas | 2011 | Science of the Total Environment2011，，17： | 2 |
| 14 | Performance of Neural Network: Mapping Forests Using GIS and Remotely Sensed Data 显示文摘 | Skidmore A Turner B Brinkhof W Knowles E | 1997 | ISPRS Journal of Photogrammetric Engineering & Remote Sensing1997，63，： | 2 |
| 15 | Emergence in Asia of foot-and-mouth disease viruses with altered host range:characterization of alteration in the 3A protein显示文摘 | Knowles N J Davies P R Henry T | 2001 | J Virol2001，75，3： | 2 |
| 16 | Endothelin - 1 and angiogenesis in cancer显示文摘 | Knowles J Loizidou M Taylor I | 2005 | Curr Vasc Pharmacol2005，3，4： | 1 |
| 17 | Macrophage infiltration and angiogenesis in human malignancy显示文摘 | Knowles H Leek R Harris AL | 2004 | Novartis Found Syrup2004，256，： | 1 |
| 18 | Mechanism of action of Bocillus thuringiensis in- secticidalδ-endotoxins 显示文摘 | Knowles B H | 1994 | Advances in Insect Physiology1994，24，： | 1 |
| 19 | An evolutionary approach to multiobjective clustering显示文摘 | Handl J Knowles J | 2006 | IEEE Trans on EC2006，11，1： | 1 |
| 20 | The murine double- stranded RNA-dependent protein kinase PKR is required for resistance to vesicular stomatitis virus 显示文摘 | Stojdl DF Abraham N Knowles S | 2000 | J Virol2000，74，20： | 1 |
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