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| 1 | 卫生经济学评价报告标准共识2022(CHEERS 2022):卫生经济学评价报告指导意见更新版显示文摘卫生经济学评价是对备选行动方案的成本和结果的比较分析。2013年发表的《卫生经济学评价报告标准共识》(CHEERS)提出了卫生经济学评价的特点,确保结果正确阐释,以支持决策制订。2013版CHEERS旨在指导研究报告撰写者准确报告卫生干预和对照措施、背景、过程、结果等评价细节,使审稿人理解文章内容,帮助读者使用研究结果。本版共识将取代2013版共识,其更加适用于各类卫生经济学评价,结合学科发展和方法更新的需要,更注重患者、公众等相关利益方的参与。本共识适用多种个体或人群健康干预措施(简单或复杂)在不同政策场景的应用分析,包括医疗服务、公共卫生、教育、社会服务等。本文概要介绍了CHEERS 2022共识中包含的28个检查项及每一个检查项的相关建议。CHEERS 2022共识主要用于指导研究人员撰写拟投递同行评议学术期刊的卫生经济学评价文章,亦可用于期刊编辑和审稿专家对待发表文章的评价。熟悉了解本共识要求,还有助于研究人员规划评价研究。随着决策透明度要求提高,本共识可支持卫生技术评估机构建立评价报告标准。 | Don Husereau Michael Drummond Federico Augustovski Esther de Bekker-Grob Andrew H Briggs Chris Carswell Lisa Caulley Nathorn Chaiyakunapruk Dan Greenberg Elizabeth Loder Josephine Mauskopf C Daniel Mullins Stavros Petrou Raoh-Fang Pwu Sophie Staniszewska on behalf of CHEERSISPOR Good Research Practices Task Force 肖月(译) 邱英鹏(译) 史黎炜(译) 张治国(译) 张歆(译) 王海银(译) 翟铁民(译) | 2022 | 英国医学杂志中文版2022，25，8： | 31 |
| 2 | 血管内超声去肾交感神经术治疗高血压:一项多中心,国际,单盲,随机,假手术对照试验显示文摘早期研究表明,基于射频的去肾交感神经术可降低中度高血压患者的血压。研究者研究了在没有使用抗高血压药物的情况下,使用血管内超声去。肾交感神经术是否会降低高血压患者的动态血压。 | 刘青 叶鹏 Azizi M Schmieder RE Mahfoud F Weber MA Daemen J Davies J Basile J Kirtane AJ Wang Y Lobo MD Saxena M Feyz L Rader F Lurz P Sayer J Sapoval M Levy T Sanghvi K Abraham J Sharp ASP Fisher NDL Bloch MJ Reeve-Stoffer H Coleman L Mullin C Mauri L | 2018 | 中华高血压杂志2018，26，10： | 27 |
| 3 | Colorectal cancer vaccines: Tumor-associated antigens vs neoantigens显示文摘Therapeutic options for the treatment of colorectal cancer(CRC) are diverse but still not always satisfying. Recent success of immune checkpoint inhibition treatment for the subgroup of CRC patients suffering from hypermutated tumors suggests a permanent role of immune therapy in the clinical management of CRC. Substantial improvement in treatment outcome could be achieved by development of efficient patient-individual CRC vaccination strategies. This mini-review summarizes the current knowledge on the two general classes of targets: tumor-associated antigens(TAAs) and tumorspecific antigens. TAAs like carcinoembryonic antigen and melanoma associated antigen are present in and shared by a subgroup of patients and a variety of clinical studies examined the efficacy of different TAA-derived peptide vaccines. Combinations of several TAAs as the next step and the development of personalized TAA-based peptide vaccines are discussed. Improvements of peptidebased vaccines achievable by adjuvants and immunestimulatory chemotherapeutics are highlighted. Finally, we sum up clinical studies using tumor-specific antigens-in CRC almost exclusively neoantigens-which revealed promising results; particularly no severe adverse events were reported so far. Critical progress for clinical outcomes can be expected by individualizing neoantigen-based peptide vaccines and combining them with immunestimulatory chemotherapeutics and immune checkpoint inhibitors. In light of these data and latest developments, truly personalized neoantigen-based peptide vaccines can be expected to fulfill modern precision medicine's requirements and will manifest as treatment pillar for routine clinical management of CRC. | Sandra Wagner Christina S Mullins Michael Linnebacher | 2018 | World Journal of Gastroenterology2018，24，48： | 10 |
| 4 | Mouse models of colorectal cancer: Past, present and future perspectives显示文摘Colorectal cancer(CRC)is the third most common diagnosed malignancy among both sexes in the United States as well as in the European Union.While the incidence and mortality rates in western,high developed countries are declining,reflecting the success of screening programs and improved treatment regimen,a rise of the overall global CRC burden can be observed due to lifestyle changes paralleling an increasing human development index.Despite a growing insight into the biology of CRC and many therapeutic improvements in the recent decades,preclinical in vivo models are still indispensable for the development of new treatment approaches.Since the development of carcinogen-induced rodent models for CRC more than 80 years ago,a plethora of animal models has been established to study colon cancer biology.Despite tenuous invasiveness and metastatic behavior,these models are useful for chemoprevention studies and to evaluate colitis-related carcinogenesis.Genetically engineered mouse models(GEMM)mirror the pathogenesis of sporadic as well as inherited CRC depending on the specific molecular pathways activated or inhibited.Although the vast majority of CRC GEMM lack invasiveness,metastasis and tumor heterogeneity,they still have proven useful for examination of the tumor microenvironment as well as systemic immune responses;thus,supporting development of new therapeutic avenues.Induction of metastatic disease by orthotopic injection of CRC cell lines is possible,but the so generated models lack genetic diversity and the number of suited cell lines is very limited.Patient-derived xenografts,in contrast,maintain the pathological and molecular characteristics of the individual patient's CRC after subcutaneous implantation into immunodeficient mice and are therefore most reliable for preclinical drug development–even in comparison to GEMM or cell line-based analyses.However,subcutaneous patient-derived xenograft models are less suitable for studying most aspects of the tumor microenvironment and anti-tumoral immune responses.The authors review the distinct mouse models of CRC with an emphasis on their clinical relevance and shed light on the latest developments in the field of preclinical CRC models. | Florian Bürtin Christina S Mullins Michael Linnebacher | 2020 | World Journal of Gastroenterology2020，26，13： | 9 |
| 5 | Sieving characteristics of cytokine-and peroxide-induced epithelial barrier leak:Inhibition by berberine显示文摘AIM:To study whether the inflammatory bowel disease(IBD)colon which exhibits varying severity and cytokine levels across its mucosa create varying types of transepithelial leak.METHODS:We examined the effects of tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ),interleukin-1-β(IL1β)and hydrogen peroxide(H_2O_2)-singly and in combinations-on barrier function of CACO-2 cell layers.Our focus was on the type(not simply the magnitude)of transepithelial leak generated by these agents as measured by transepithelial electrical resistance(TER)and transepithelial flux of ^(14)C-D-mannitol,3H-Lactulose and ^(14)C-Polyethylene glycol as radiolabeled probe molecules.The isoquinoline alkaloid,berberine,was then examined for its ability to reduce specific types of transepithelial leak.RESULTS:Exposure to TNF-α alone(200 ng/mL;48 h)induced a 50% decrease in TER,i.e.,increased leak of Na^+ and Cl--with only a marginal but statistically significant increase in transepithelial leak of ^(14)C-mannitol(Jm).Exposure to TNF-α + IFN-γ(200 ng/mL;48 h)+ IL1β(50 ng/mL;48 h)did not increase the TER change(from TNF-α alone),but there was now a 100% increase in J_m.There however was no increase in transepithelial leak of two larger probe molecules,~3H-lactulose and ^(14)C-polyethylene glycol(PEG).However,exposure to TNF-α + IFN-γ + IL1β followed by a 5 h exposure to2 mmol/L H_2O_2 resulted in a 500% increase in ^(14)C-PEG leak as well as leak to the luminal mitogen,epidermal growth factor.CONCLUSION:This model of graded transepithelial leak is useful in evaluating therapeutic agents reducing IBD morbidity by reducing barrier leak to various luminal substances. | Katherine M DiGuilio Christina M Mercogliano Jillian Born Brendan Ferraro Julie To Brittany Mixson Allison Smith Mary Carmen Valenzano James M Mullin | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，2： | 6 |
| 6 | Influence of vitamin D on liver fibrosis in chronic hepatitis C: A systematic review and meta-analysis of the pooled clinical trials data显示文摘AIM To investigate the relationship between vitamin D and liver fibrosis in hepatitis C-monoinfected or hepatitis C virus(HCV)-human immunodeficiency virus(HIV) coinfected patients. METHODS Pertinent studies were located by a library literature search in PubM ed/Embase/Cochrane/Scopus/LILACS by two individual reviewers. Inclusion criteria:(1) studies with patients with HCV or co-infected HCV/HIV;(2) studies with patients ≥ 18 years old;(3) studies that evaluated liver fibrosis stage, only based on liver biopsy; and(4) studies that reported serum or plasma 25(OH)D levels. Studies that included pediatric patients, other etiologies of liver disease, or did not use liver biopsy for fibrosis evaluation, or studies with inadequate data were excluded. Estimated measures of association reported in the literature, as well as corresponding measures of uncertainty, were recorded and corresponding odds ratios with 95%CI were included in a meta-analysis. RESULTS The pooled data of this systematic review showed that 9 of the 12 studies correlated advanced liver disease defined as a Metavir value of F3/4 with 25(OH) D level insufficiency. The meta-analysis indicated a significant association across studies.CONCLUSION Low vitamin D status is common in chronic Hepatitis C patients and is associated with advanced liver fibrosis. | Alia S Dadabhai Behnam Saberi Katie Lobner Russell T Shinohara Gerard E Mullin | 2017 | World Journal of Hepatology2017，9，5： | 6 |
| 7 | Human endogenous retroviruses and cancer:Causality and therapeutic possibilities显示文摘A substantial part of the human genome is derived from transposable elements;remnants of ancient retroviral infections.Conservative estimates set the percentage of human endogenous retroviruses(HERVs) in the genome at 8%.For the most part,the interplay between mutations,epigenetic mechanisms and posttranscriptional regulations silence HERVs in somatic cells.We first highlight mechanisms by which activation of members of several HERV families may be associated with tumor development before discussing the arising chances for both diagnosis and therapy.It has been shown that at least in some cases,tumor cells expressing HERV open reading frames(ORFs) thus gain tumor-promoting functions.However,since these proteins are not expressed in healthy tissues,they become prime target structures.Of potential pharmacological interest are the prevention of HERV transposition,the inhibition of HERV-encoded protein expression and the interference with these proteins' activities.Evidence from recent studies unequivocally proves that HERV ORFs represent a very interesting source of novel tumor-specific antigens with even the potential to surpass entity boundaries.The development of new tumor(immune-) therapies is a very active field and true tumor-specific targets are of outstanding interest since they minimize the risk of autoimmunity and could reduce side effects.Finally,we postulate on main future research streams in order to stimulate discussion on this hot topic. | Christina S Mullins Michael Linnebacher | 2012 | World Journal of Gastroenterology2012，18，42： | 4 |
| 8 | Vitamin D levels do not predict the stage of hepatic fibrosis in patients with non-alcoholic fatty liver disease: A PRISMA compliant systematic review and meta-analysis of pooled data显示文摘AIM To investigate the relationship between 25-hydroxyvitamin D [25(OH)D] levels and fibrosis stage in patients with non-alcoholic fatty liver disease(NAFLD).METHODS Two individual reviewers identified relevant studies using the Pub Med, EMBASE, Cochrane, and Scopus databases. Inclusion criteria were as follows:(1) Studies that evaluated adults with NAFLD and serum or plasma 25(OH)D levels; and(2) assessed fibrosis stage using liver biopsy. A rigorous analysis yielded six articles as having sufficient data to employ in evaluating the association of serum vitamin D levels in patients with NAFLD based on their liver fibrosis stage by histopathological analysis. The lead investigators of each of the six studies were contacted and the data were collected. To meta-analyze vitamin D levels in F0-F2 vs F3-F4 fibrosis, a random-effects meta-analysis fit using restricted maximum likelihood was applied. To examine trends across each stage of fibrosis with respect to vitamin D levels, a meta-regression was performed. P < 0.05 was considered statistically significant. RESULTS A total of 937 subjects from six studies were included in the final analysis to evaluate the association of serum vitamin D levels in patients with NAFLD based on their liver fibrosis stage by histopathological analysis. The lead investigators of each of the six studies were contacted and the data were collected. First, the investigators performed a meta-analysis to compare serum vitamin D levels in patients with NAFLD with stage F0-F2 compared to F3-F4, which did not show significance [meta-estimate of the pooled mean difference =-0.86, P = 0.08(-4.17, 2.46)]. A metaregression evaluation of serum vitamin 25(OH)D levels across the individual stages(F0-F4) of fibrosis did not show an association for the six included studies.CONCLUSION Low vitamin D status is not associated with higher stages of liver fibrosis in patients with NAFLD. | Behnam Saberi Alia S Dadabhai Julie Nanavati Lin Wang Russell T Shinohara Gerard E Mullin | 2018 | World Journal of Hepatology2018，10，1： | 3 |
| 9 | 环境水样品中药物残留的潜在代谢物的鉴定显示文摘使用超高效液相色谱-串联四极杆飞行时间质谱(QTOF),对环境水样品中的药物和个人护理品(PPCPs)、滥用药物和农兽药等1000多种化合物进行高分辨质谱筛查,并对潜在代谢物进行结构鉴定.水样经过浓缩,使用ACQUITY UPLC HSS C18色谱柱分离后,进行UPLC-QTof分析.筛查出的潜在代谢物经UNIFI科学软件进行结构鉴定. | Gareth Cleland Mark Wrona Lauren Mullin Jennifer Burgess | 2015 | 环境化学2015，34，12： | 2 |
| 10 | TEEATMENT OF CARCINOMA OF THE AMPULLA OF VATER显示文摘 | ALLEN O. WHIPPLE WILLIAM BARCLAY PARSONS CLINTON R. MULLINS | 1935 | Annals of Surgery1935，，4： | 2 |
| 11 | 展望柴油机活塞组件的未来显示文摘讨论了几种活塞的结构设计及其在满足新一代活塞特殊要求方面的作用。 | Mullins P 陆明 | 1997 | 国外内燃机1997，29，1： | 2 |
| 12 | Off-clamp Robot-assisted Partial Nephrectomy Preserves Renal Function: A Multi-institutional Propensity Score Analysis显示文摘 | Bartosz F. Kaczmarek Youssef S. Tanagho Shahab P. Hillyer Jeffrey K. Mullins Mireya Diaz Quoc-Dien Trinh Sam B. Bhayani Mohamad E. Allaf Michael D. Stifelman Jihad H. Kaouk Craig G. Rogers | 2012 | European Urology2012，，： | 2 |
| 13 | 扫描电化学显微镜在光电能源研究领域的应用显示文摘作为一种扫描探针技术,扫描电化学显微镜(SECM)在金属防腐、材料表征、生物医学和新能源技术等领域的研究中扮演着重要角色。本文简要介绍了SECM的基本工作原理和常用的两种工作模式:反馈模式和收集/产生模式;综述了SECM在太阳能电池和太阳光解水制氢两个光电能源研究领域的应用进展,同时结合课题组的工作基础,特别是近期利用SECM筛选合适金属离子掺杂改性WO3光阳极的工作,对SECM在筛选半导体电极材料方面的应用特点进行了实例展示介绍,最后简要总结了SECM在光电能源研究领域的发展及方向。 | 何辉超 Sean P.Berglund C.Buddie Mullins 周勇 柯改利 董发勤 | 2016 | 化学进展2016，28，6： | 2 |
| 14 | How much liver resection is too much?显示文摘 | Emma J. Mullin Matthew S. Metcalfe Guy J. Maddern | 2005 | The American Journal of Surgery2005，，1： | 2 |
| 15 | Diagnosis and management of blunt pancreatic ductal injury in the era of high-resolution computed axial tomography显示文摘 | Swee H. Teh Brett C. Sheppard Richard J. Mullins Martin A. Schreiber John C. Mayberry | 2007 | The American Journal of Surgery2007，，5： | 2 |
| 16 | Multiphasic Enhancement Patterns of Small Renal Masses (≤4 cm) on Preoperative Computed Tomography: Utility for Distinguishing Subtypes of Renal Cell Carcinoma, Angiomyolipoma, and Oncocytoma显示文摘 | Phillip M. Pierorazio Elias S. Hyams Salina Tsai Zhaoyong Feng Bruce J. Trock Jeffrey K. Mullins Pamela T. Johnson Elliot K. Fishman Mohamad E. Allaf | 2013 | Urology2013，，6： | 2 |
| 17 | 超高效液相色谱/三重四极杆质谱联用(ACQUITY UPLC/Xevo TQ-S)检测蜂花粉中吡虫啉残留量显示文摘在分析复杂环境样品中的痕量污染物时,通常会受到基质的严重干扰,使得在进行亚ng·g-1浓度水平检测时,所用仪器面临着必须满足灵敏度要求的挑战.杀虫剂暴露会对蜂群产生致死和亚致死效应,若要监控这些效应带来的影响则需要对蜜蜂和蜂产品中的杀虫剂水平进行可靠定量.某地区使用吡虫啉杀虫剂来应对昆虫的侵害, | Lauren Mullin Michael Young Jennifer Burgess | 2014 | 环境化学2014，33，6： | 2 |
| 18 | Rib Fracture Pain and Disability: Can We Do Better?显示文摘 | Mahlon A. Kerr-Valentic Melanie Arthur Richard J. Mullins Tuesday E. Pearson John C. Mayberry | 2003 | The Journal of Trauma: Injury, Infection, and Critical Care2003，，6： | 2 |
| 19 | Conditional transgenic technologies 显示文摘 | Ryding ADS Sharp MGF Mullins JJ | 2001 | Journal of Endocrinology2001，171，： | 2 |
| 20 | Management of the Major Coagulopathy with Onset during Laparotomy显示文摘 | H. HARLAN STONE PRISCILLA R. STROM RICHARD J. MULLINS | 1983 | Annals of Surgery1983，，5： | 2 |
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