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| 1 | 有丝分裂激活蛋白激酶激活与前列腺癌的恶化进展显示文摘目的 :研究人前列腺癌组织中有丝分裂激活蛋白激酶 (MAPK)激活和前列腺癌发生、恶化进展的关系。方法 :采用免疫组织化学分析方法 ,用抗磷酸化MAPK蛋白的抗体检测 4 8例人前列腺癌组织标本中MAPK激活。结果 :所有前列腺癌组织中均有磷酸化MAPK蛋白表达 ,而非癌前列腺组织中未发现有磷酸化MAPK蛋白表达。磷酸化MAPK蛋白表达强阳性在Gleason分值≤ 7和 8~ 10组中分别为 2 0 %和 6 1.1% (P <0 .0 1) ;在局部浸润性肿瘤 (T3 期 )中强阳性率 5 7 1%明显高于局限性肿瘤 (T1~T2 期 ) 2 6 5 % (P <0 .0 1)。结论 :MAPK激活和人前列腺癌的发生及恶化进展密切相关 ,可以作为估价前列腺癌恶性程度和预后的指标。 | 叶定伟 李慧 Priscilla Chauvin 孙颖浩 钱松溪 郑家富 马永江 | 2002 | 肿瘤防治杂志2002，9，2： | 14 |
| 2 | Fully-coupled simulations of thermally-induced cracking in pegmatite due to microwave irradiation显示文摘Fully-coupled thermo-mechanical simulations are implemented in COMSOL Multiphysics to investigate micro-scale stress-strain variability in pegmatite specimens subjected to thermal loading using microwaves. Thermally-induced compressive and tensile stresses increase as the microwave irradiation duration increases. The dielectric constant, coefficient of expansion, and type and size of mineralogical boundary have significant impacts on the responses of the rock to microwave irradiation. The maximum principal stress of the chlorite is the smallest, indicating that the chlorite experiences the most damage under microwave irradiation, followed by the quartz. The maximum principal stress values of plagioclase and orthoclase are larger, indicating that they are likely to incur the least damage. Where quartz or chlorite is dominant, the resulting von Mises stresses are consistently higher after 120 s of microwave irradiation. The rate of generation of von Mises stresses increases most rapidly along the interface between quartz and plagioclase, and the interface between quartz and orthoclase, followed by the interface between quartz and chlorite, and finally the interface between plagioclase and orthoclase. The presented modeling approach provides a practical method to investigate stress-strain relationships within mineralogical boundaries inside a rock thin section. | Jielin Li Rennie B.Kaunda Shrey Arora Philipp Hartlieb Priscilla P.Nelson | 2019 | Journal of Rock Mechanics and Geotechnical Engineering2019，11，2： | 8 |
| 3 | 正常和退变腰椎间盘蛋白质的双向电泳和质谱鉴定显示文摘背景:近年来对于退变腰椎间盘组织蛋白质成分改变的研究取得了很大进展,但是对于正常和退变腰椎间盘整体蛋白质成分改变的分离和差异鉴定却鲜见报道。目的:建立正常和退变腰椎间盘蛋白质的双向电泳图谱,鉴定差异表达蛋白,探讨腰椎间盘退变的生物学机制。设计、时间及地点:对比观察,于2007-06/2008-12在南方医科大学病理生理实验室完成。材料:由自愿者提供的正常和退变腰椎间盘组织各6例,年龄21~45岁,其中男9例,女3例;取材范围L3~L5。方法:氯化铯梯度离心去除正常和退变腰椎间盘组织蛋白多糖,通过固相pH梯度(IPG)等电聚焦和梯度聚丙烯酰胺双向电泳分离蛋白质,分析电泳图像,使用基质辅助激光解吸附飞行时间质谱仪对差异蛋白质点进行分析鉴定。主要观察指标:正常腰椎间盘及退变腰椎间盘组织IPG等电聚焦双向凝胶电泳结果。结果:双向电泳显示正常和退变腰椎间盘蛋白质图谱差异显著,从中选取16个差异明显的位点进行质谱仪分析,确定了6种具有显著性意义的差异蛋白质。结论:双向电泳可有效地分离正常和退变腰椎间盘组织蛋白质,通过质谱仪鉴定可以确定其之间差异蛋白质的性质。 | 吕志德 周初松 靳安民 刘亚伟 赵亮 于博 Priscilla Heung | 2009 | 中国组织工程研究与临床康复2009，13，7： | 7 |
| 4 | Classification of diabetic retinopathy and diabetic macular edema显示文摘The global incidence and prevalence of diabetes mellitus(DM)have reached epidemic proportions.Estimates indicate that more than 360 million people will be affected by DM by 2030.All of these individuals will be at risk of developing diabetic retinopathy(DR).It is extremely important to categorize,classify and stage the severity of DR in order to establish adequate therapy.With proper management more than 90%of cases of visual loss can be prevented.The purpose of the current paper is to review the classification of DR with a special emphasis on the International Clinical Disease Severity Scale for DR.This new classification is simple to use,easy to remember and based on scientific evidence.It does not require specialized examinations such as optical coherence tomography or fluorescein angiography.It is based on clinical examination and applying the Early Treatment of Diabetic Retinopathy Study 4:2:1 rule. | Lihteh Wu Priscilla Fernandez-Loaiza Johanna Sauma Erick Hernandez-Bogantes Marissé Masis | 2013 | World Journal of Diabetes2013，4，6： | 6 |
| 5 | 中国母婴健康促进策略的国际适用性分析——以马拉维为例显示文摘目的分析马拉维母婴保健的现状、需求和问题,探讨马拉维乃至其他非洲国家借鉴中国母婴保健干预实施策略的可能性。方法基于公开数据与文献资料梳理归纳马拉维的妇幼健康状况,通过开放式问卷和电话访谈方式总结马拉维母婴保健面临的主要挑战和急需的受援领域,并以SWOT分析法对马拉维利用中国经验与援助改善其母婴保健及妇幼卫生的策略进行分析。结果马拉维目前的母婴保健仍处于国际低端水平,实现可持续发展目标面临巨大挑战。主要问题集中在服务供给能力不足、医疗设备和药品/用品短缺、卫生人力资源缺乏、孕产保健服务的普遍覆盖程度较差、转诊系统能力不强等诸多方面。结论基于马拉维国内的母婴保健需求,结合中国本身的相对优势,中国可以在基础设施、人力资源、机构建设等方面对马拉维孕产保健进行重点援助,并结合中国相对成熟的经验,形成符合马拉维国情的援助实施方案,有效提升马拉维的孕产保健服务能力。 | Priscilla Funsani 杨肖光 钱序 | 2017 | 中国妇幼保健2017，32，14： | 6 |
| 6 | Photoluminescent Tb^(3+)-based metal-organic framework as a sensor for detection of methanol in ethanol fuel显示文摘The sensing capability of a Tb^(3+)-metal-organic framework, based on its photoluminescence, was used for detection of methanol in ethanol fuel. It was synthesized using terbium and trimesic acid as a metal ion center and ligand, respectively. Powder X-ray diffraction, infrared spectroscopy, thermogravimetric analysis and scanning electron microscopy were employed to characterize the synthesized MOF-76 structural features. According to the results, MOF-76 was successfully obtained with minor synthetic modification and its activated form(named TbTMA) was tested as a sensor for methanol. Tb^(3+) luminescence intensity increases as the methanol concentration in ethanol fuel also increases and the water content does not affect this response. Our findings indicate TbTMA as an appropriate sensor for evaluating ethanol fuel adulteration by methanol addition above the allowed limit. | Ramon R.F.Fonseca Rafael D.L.Gaspar Ivo M.Raimundo Jr. Priscilla P.Luz | 2019 | Journal of Rare Earths2019，37，3： | 6 |
| 7 | Serum vitamin D and colonic vitamin D receptor in inflammatory bowel disease显示文摘AIM: To determine serum vitamin D levels and colonic vitamin D receptor(VDR) expression in inflammatory bowel disease(IBD) and non-IBD patients and correlate these with histopathology.METHODS: Puerto Rican IBD(n = 10) and non-IBD(n = 10) patients ≥ 21 years old scheduled for colonoscopy were recruited. Each patient completed a questionnaire and provided a serum sample and a colonic biopsy of normal-appearing mucosa. For IBD patients, an additional biopsy was collected from visually diseased mucosa. Serum vitamin D levels were measured by ultra-performance liquid chromatography and mass spectrometry. Hematoxylin and eosin stained tissue sections from colonic biopsies were classified histologically as normal or colitis(active/inactive), and scored for the degree of inflammation present(0-3, inactive/absent to severe). Tissue sections from colonic biopsies were also stained by immunohistochemistry for VDR, for which representative diagnostic areas were photographed and scored for staining intensity using a 4-point scale.RESULTS: The IBD cohort was significantly younger(40.40 ± 5.27, P < 0.05) than the non-IBD cohort(56.70 ± 1.64) with a higher prevalence of vitamin D deficiency(40% vs 20%, respectively) and insufficiency(70% vs 50%, respectively). Histologic inflammation was significantly higher in visually diseased mucosa from IBD patients(1.95 ± 0.25) than in normalappearing mucosa from control patients(0.25 ± 0.08, P < 0.01) and from IBD patients(0.65 ± 0.36, P < 0.05) and correlated inversely with VDR expression in visually diseased colonic tissue from IBD patients(r =-0.44, P < 0.05) and from IBD patients with Crohn's disease(r =-0.69, P < 0.05), but not in normal-appearing colonic tissue from control patients or IBD patients. Control and IBD patient serum vitamin D levels correlated positively with VDR expression in normal colon from control and IBD patients(r = 0.38, P < 0.05) and with patient age(r = 0.54, P < 0.01). CONCLUSION: Levels of serum vitamin D correlate positively with colonic VDR expression in visually normal mucosa whereas inflammation correlates negatively with colonic VDR expression in visually diseased mucosa in Puerto Rican patients. | Yamilka Abreu-Delgado Raymond A Isidro Esther A Torres Alexandra González Myrella L Cruz Angel A Isidro Carmen I González-Keelan Priscilla Medero Caroline B Appleyard | 2016 | World Journal of Gastroenterology2016，22，13： | 5 |
| 8 | 有丝分裂激活蛋白激酶在人前列腺癌细胞中的激活显示文摘目的 探讨前列腺癌 (PCa)细胞中有丝分裂激活蛋白激酶 (MAPK)的激活。 方法 采用免疫沉淀和Westernblot方法 ,检测人PCa细胞株LNCaP及DU 145中磷酸化MAPK的表达及雄激素或表皮生长因子 (EGF)对其表达的影响。 结果 在DU 145中 ,磷酸化MAPK表达本底水平比LNCaP高 10倍。雄激素和EGF处理后 8hLNCaP中MAPK激活水平升高 ,2 4h达最高 ,分别比本底高约 10倍和 5倍 ,在DU 145中仅EGF可促使MAPK激活水平升高 ,8h开始升高 ,2 4h达最高 ,比本底高约 10倍。 结论 在雄激素非依赖性人PCa细胞增生中 ,MAPK激活比在雄激素依赖性人PCa细胞中作用大 ,MAPK激活也参与了雄激素和EGF的增生刺激作用。 | 叶定伟 李慧 Jane Tseng Priscilla Chauvin 钱松溪 孙颖浩 郑家富 马永江 | 2001 | 中华泌尿外科杂志2001，22，5： | 4 |
| 9 | 去除雄激素对前列腺癌细胞周期调节蛋白表达的影响显示文摘目的 研究去除雄激素对前列腺癌细胞周期调节蛋白表达的影响。方法 在人前列腺癌细胞株LNCaP和PC 3中 ,先加 1× 10 -9mol/L双氢睾酮 (DHT)维持培养 2 4h后分别于去除DTH 0、8和 2 4h行免疫沉淀和WesternBlot分析检测细胞周期素依赖激酶CDK 2、CDK4、CDK6和p2 7kip1的表达。结果 在LNCaP中去除雄激素 8h后CDK2、CDK4、CDK6的表达开始降低 ;而p2 7kip1的表达开始升高 ,到 2 4h时CDK 2、CDK 4、CDK6的表达达到最低 ,而p2 7kip1的表达达到最高。在PC 3细胞中未见CDK2、CDK 4、CDK 6和 p2 7kip1的表达改变。结论 CDK2、CDK4和CDK6的表达降低及 p2 | 叶定伟 李慧 Jane Tseng Priscilla Chauvin 钱松溪 孙颖浩 郑家富 马永江 | 2001 | 中华实验外科杂志2001，18，3： | 4 |
| 10 | 前列腺癌细胞中表皮生长因子受体的表达和激活显示文摘目的 探讨前列腺癌 (PCa)细胞中表皮生长因子受体 (EGFR)表达和激活及其与雄激素之间的相互作用。 方法 采用免疫沉淀和Westernblot方法 ,检测雄激素依赖人PCa细胞株LNCaP及雄激素非依赖人PCa细胞株DU 145、PC 3中EGFR的表达和磷酸化激活 ,测定雄激素对LNCaPEGFR表达和激活的影响。 结果 在DU 145和PC 3中 ,EGFR表达和激活的基础与表皮生长因子 (EGF)处理后水平均比LNCaP高。雄激素可促使LNCaP中EGFR的表达和激活。 结论在雄激素非依赖人PCa细胞增生中EGFR的表达和激活比在雄激素依赖人PCa细胞中作用大 ,EGFR的表达和激活参与了雄激素的增生刺激作用。 | 李慧 Jane Tseng Priscilla Chauvin 孙颖浩 钱松溪 郑家富 马永江 | 2000 | 中华泌尿外科杂志2000，21，11： | 3 |
| 11 | 儿童青少年运动员的营养需要显示文摘1.儿童青少年运动员应该食用多样化的食物,其中,蛋白质应占膳食总能量的12%~15%,碳水化合物至少占55%,而脂肪至多占30%。日常生活中如何吃才能满足这些要求呢?膳食指南宝塔提供了一条可行之道。2.有些营养素对热爱运动的儿童青少年运动员非常重要,要保证摄入充足,这些营养素是碳水化合物(包括纤维素)、维生素B_6、维生素D、铁、钙、镁、锌、铬。科学合理、包罗各类食物的平衡膳食,对青少年运动员最大程度地全面摄取各种营养素,满足生长发育和运动训练的需要,是非常必要的。3.鼓励儿童青少年运动员在运动训练前、中、后进行补液,以避免脱水的发生。4.如果膳食合理平衡,就没必要额外补充营养品。 | Oded Bar-Or Susan Barr Michael Bergeron Ruth Carey Priscilla Clarkson Linda Houtkooper Anita Rivera-Brown Tom Rowland Suzanne Steen 艾华 | 2001 | 体育科学2001，21，5： | 3 |
| 12 | Management of opioid side effects in cancer-related and chronic noncancer pain: a systematic review显示文摘 | Ewan McNicol Nathalie Horowicz-Mehler Ruth A Fisk Kyle Bennett Maria Gialeli-Goudas Priscilla W Chew Joseph Lau Daniel Carr | 2003 | Journal of Pain2003，，5： | 3 |
| 13 | Relationships among student and graduate caring ability and professional school climate显示文摘 | Priscilla R. Simmons Sally H. Cavanaugh | 2000 | Journal of Professional Nursing2000，，2： | 3 |
| 14 | Low-level laser therapy enhances the number of osteocytes in calvaria bone defects of ovariectomized rats显示文摘Background : Osteoporosis can make bone repair difficult. Low-level laser therapy( LLLT) has been shown to be a promising tool for bone neoformation. This study aimed to analyze the effect of LLLT on calvaria bone defects of ovariectomized rats using stereology. Methods : Fifty-four Wistar rats were subjected to bilateral ovariectomy, and bone defects were created in calvaria after 150 days. The animals were divided into nine groups(n = ?6 per group), and 24 hours after the bone defects were created they received three, six or 12 sessions of LLLT at 0, 20 or 30 J/cm 2, using a 780-nm low-intensity GaAlAs laser. One-way ANOVA followed by Tukey ' s post hoc test was used for data processing. A difference of P < 0.05 was considered statistically significant. The parameters evaluated were osteocyte density( Nv_(ost)), total osteocyte number( Nto ost), trabecular surface density( Sv_t), and trabecular surface area( Sa_t). Results : Data obtained showed that Nto ost, Sv t, and Sa t in group G2 rats were significantly different from G1(0 J/cm^2)( P < 0.05). Compared to group G4, G5 presented higher values for the parameters Sv t and Sa t, and G6 presented significantly higher values for almost all the analyzed parameters( Nv _(ost), Nto_(ost), Sv_t, and Sa t)( P < 0.05). Compared to group G7, G8 showed a higher value only for the parameter Sa t, and G9 showed significantly higher values for parameters Nv ost, Nto ost, Sv_t, and Sa_t. Conclusion : We conclude that LLLT stimulated bone neoformation and contributed to an increase in the total number of osteocytes, especially with a laser energy density of 30 J/cm^2 given for six and 12 sessions. | Priscilla Hakime Scalize Luiz Gustavo de Sousa Lígia Maria Napolitano Goncalves Dimitrius Leonardo Pitol Marcelo Palinkas Antonio Augusto Coppi Mariah Acioli Righeti Vitória Ricardo Karina Fittipaldi Bombonato-Prado Simone Cecílio Hallak Regalo Selma Siessere | 2019 | Animal Models and Experimental Medicine2019，2，1： | 2 |
| 15 | Type 2 diabetes in a Senegalese rural area显示文摘AIM To estimate the prevalence of diabetes in the rural population of Tessekere(Senegal) and investigate associated risk factors. METHODS Data from a 2015 survey of 500 individuals age 20 and over representative of the population of the municipality of Tessekere were used. Sociodemographic characteristics, health related variables, capillary whole blood glucose, and weight and height measurements of individuals were collected during face-to-face interviews. Statistical analyses used were bivariate tests and binary logistic regressions.RESULTS The percentage of individuals having impaired fasting glucose(IFG) is 6.6%. Those with fasting blood glucose(FBG) levels ≥ 126 mg/dL and/or currently being treated for diabetes is 4.2%. Only mean body mass index(BMI) is significantly higher among diabetic individuals and among those having FBG levels ≥ 110 mg/dL. After adjustment for sex, age, educational level, BMI and hypertension, only BMIis associated with diabetes. CONCLUSION Prevalence of diabetes and IFG in our study correspond to the high range of rural sub-Saharan Africa prevalence. Diabetes is thus becoming a pressing public health concern, even in rural areas. But the risk factors identified in Tessekere suggest that the diabetes epidemic is still in the early stages, such that concerted action would make it possible to contain the devastating impact of this chronic condition. | Priscilla Duboz Gilles Boetsch Lamine Gueye Enguerran Macia | 2017 | World Journal of Diabetes2017，8，7： | 2 |
| 16 | Muscle adaptation prior to recovery following eccentric exercise显示文摘 | Cara B. Ebbeling Priscilla M. Clarkson | 1990 | European Journal of Applied Physiology and Occupational Physiology1990，，： | 2 |
| 17 | Bcl-2 Gene Family and Related Proteins in Mammary Gland Involution and Breast Cancer显示文摘 | Kristel Schorr Minglin Li Stanislaw Krajewski John C. Reed Priscilla A. Furth | 1999 | Journal of Mammary Gland Biology and Neoplasia1999，，2： | 2 |
| 18 | Management of the Major Coagulopathy with Onset during Laparotomy显示文摘 | H. HARLAN STONE PRISCILLA R. STROM RICHARD J. MULLINS | 1983 | Annals of Surgery1983，，5： | 2 |
| 19 | Ionic liquids in dispersive liquid-liquid microextraction显示文摘 | María J. Trujillo-Rodríguez Priscilla Rocío-Bautista Verónica Pino Ana M. Afonso | 2013 | Trends in Analytical Chemistry2013，，： | 1 |
| 20 | Evaluation of groundwater quality of Mubi town in Adamawa State, Nigeria 显示文摘 | Priscilla Alexander | 2005 | African Journal of Biotechnology2005，11，7： | 1 |
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