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| 1 | Interleukin-28B Polymorphism Improves Viral Kinetics and Is the Strongest Pretreatment Predictor of Sustained Virologic Response in Genotype 1 Hepatitis C Virus显示文摘 | Alexander J. Thompson Andrew J. Muir Mark S. Sulkowski Dongliang Ge Jacques Fellay Kevin V. Shianna Thomas Urban Nezam H. Afdhal Ira M. Jacobson Rafael Esteban Fred Poordad Eric J. Lawitz Jonathan McCone Mitchell L. Shiffman Greg W. Galler William M. Lee | 2010 | Gastroenterology2010，，1： | 7 |
| 2 | Cholestatic liver diseases:An era of emerging therapies显示文摘Recently the field of cholestasis has expanded enormously reflecting an improved understanding of the molecular mechanisms underlying bile secretion and its perturbation in chronic cholestatic disease. Novel anti-cholestatic therapeutic options have been developed for patients not favorably responding to ursodeoxycholic acid (UDCA), the current standard treatment for cholestatic liver disease. Important novel treatment targets now also include nuclear receptors involved in bile acid (BA) homoeostasis like farnesoid X receptor and G proteincoupled receptors e.g., the G-protein-coupled BA receptor “transmembrane G coupled receptor 5”. Fibroblast growth factor-19 and enterohepatic BA transporters also deserve attention as additional drug targets as does the potential treatment agent norUDCA. In this review, we discuss recent and future promising therapeutic agents and their potential molecular mechanisms in cholestatic liver disorders. | Hrishikesh Samant Wuttiporn Manatsathit David Dies Hosein Shokouh-Amiri Gazi Zibari Moheb Boktor Jonathan Steve Alexander | 2019 | World Journal of Clinical Cases2019，7，13： | 6 |
| 3 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 4 | Evaluation of a point of care ultrasound curriculum for Indonesian physicians taught by fi rst-year medical students显示文摘BACKGROUND: The purpose of this study was to assess the short-term efficacy of a 4-week ultrasound curriculum taught by American first-year medical students to general practitioners working in public health care clinics, or puskesmas, in Bandung, Indonesia.METHODS: We performed a prospective, observational study of Indonesian health care practitioners from public clinics in Bandung, Indonesia. These practitioners were enrolled in a 4-week ultrasound training course taught by first-year American medical students. A total of six sessions were held comprising of 38 ultrasound milestones. A pre-course and post-course written exam and practical exam was taken by each participant.RESULTS: We enrolled 41 clinicians in the course. The average pre-course exam score was 35.2% with a 2.4% pass rate, whereas the average post-course exam score was 82.0% with a 92.7% pass rate. The average practical score at the completion of the course was 83.2%(SD=0.145) with 82.9% of the class passing(score above 75.0%).CONCLUSION: Our data suggests that first-year medical students can effectively teach ultrasound to physicians in Indonesia using a 4-week intensive ultrasound training course. Future studies are needed to determine the amount of training required for proficiency and to evaluate the physicians' perceptions of the student-instructors' depth of knowledge and skill in point of care ultrasound. | Jonathan B.Lee Christina Tse Thomas Keown Michael Louthan Christopher Gabriel Alexander Anshus Bima Hasjim Katrina Lee Esther Kim Luke Yu Allen Yu Shadi Lahham Steven Bunch Maili Alvarado Abdulatif Gari John C.Fox | 2017 | World Journal of Emergency Medicine2017，8，4： | 4 |
| 5 | Pregnancy and inflammatory bowel diseases: Current perspectives, risks and patient management显示文摘Inflammatory bowel diseases(IBD) are chronic idiopathic inflammatory conditions characterized by relapsing and remitting episodes of inflammation which can affect several different regions of the gastrointestinal tract, but also shows extra-intestinal manifestations. IBD is most frequently diagnosed during peak female reproductive years, with 25% of women with IBD conceiving after their diagnosis. While IBD therapy has improved dramatically with enhanced surveillance and more abundant and powerful treatment options, IBD disease can have important effects on pregnancy and presents several challenges for maintaining optimal outcomes for mothers with IBD and the developing fetus/neonate. Women with IBD, the medical team treating them(both gastroenterologists and obstetricians/gynecologists) must often make highly complicated choices regarding conception, pregnancy, and post-natal care(particularly breastfeeding) related to their choice of treatment options at different phases of pregnancy as well as post-partum. This current review discusses current concerns and recommendations for pregnancy duringIBD and is intended for gastroenterologists, general practitioners and IBD patients intending to become,(or already) pregnant, and their families. We have addressed patterns of IBD inheritance, effects of IBD on fertility and conception(in both men and women), the effects of IBD disease activity on maintenance of pregnancy and outcomes, risks of diagnostic procedures during pregnancy and potential risks and complications associated with different classes of IBD therapeutics. We also have evaluated the clinical experience using 'top-down' care with biologics, which is currently the standard care at our institution. Post-partum care and breastfeeding recommendations are also addressed. | Pegah Hosseini-Carroll Monica Mutyala Abhishek Seth Shaheen Nageeb Demiana Soliman Moheb Boktor Ankur Sheth Jonathon Chapman James Morris Paul Jordan Kenneth Manas Felix Becker Jonathan Steven Alexander | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 4 |
| 6 | Order from Chaos: Self-Assembly of Nanoprism from a Mixture of Tetratopic Terpyridine-Porphyrin Conformers显示文摘Background and Originality Content Porphyrins are a vibrant class of organic dyes found widely in nature,ranging from the well-studied chlorophyll and heme found in the cells of plants and red blooded animals to the less known chlorocruoroporphyrin found in annelids. | Alexander Filosa Heng Wang Wei-Jian Li Wenjing Zhang Ellie Ngo Jonathan EPiccolo Hai-Bo Yang Xiaopeng Li | 2019 | Chinese Journal of Chemistry2019，37，11： | 3 |
| 7 | Partial Shape Matching Without Point-Wise Correspondence显示文摘Partial similarity of shapes is a challenging problem arising in many important applications in computer vision,shape analysis,and graphics,e.g.when one has to deal with partial information and acquisition artifacts.The problem is especially hard when the underlying shapes are non-rigid and are given up to a deformation.Partial matching is usually approached by computing local descriptors on a pair of shapes and then establishing a point-wise non-bijective correspondence between the two,taking into account possibly different parts.In this paper,we introduce an alternative correspondence-less approach to matching fragments to an entire shape undergoing a non-rigid deformation.We use region-wise local descriptors and optimize over the integration domains on which the integral descriptors of the two parts match.The problem is regularized using the Mumford-Shah functional.We show an efficient discretization based on the Ambrosio-Tortorelli approximation generalized to triangular point clouds and meshes,and present experiments demonstrating the success of the proposed method. | Jonathan Pokrass Alexander M.Bronstein Michael M.Bronstein | 2013 | Numerical Mathematics(Theory,Methods and Applications)2013，6，1： | 3 |
| 8 | Pneumatosis Intestinalis in Adults: Management, Surgical Indications, and Risk Factors for Mortality显示文摘 | Alexander J. Greenstein Scott Q. Nguyen Ana Berlin Jacqueline Corona Jonathan Lee Everlyn Wong Stephanie H. Factor Celia M. Divino | 2007 | Journal of Gastrointestinal Surgery2007，，10： | 3 |
| 9 | A striking local esophageal cytokine expression profile in eosinophilic esophagitis显示文摘 | Carine Blanchard Emily M. Stucke Beatriz Rodriguez-Jimenez Karen Burwinkel Margaret H. Collins Annette Ahrens Eileen S. Alexander Bridget K. Buckmeier Butz Sean C. Jameson Ajay Kaul James P. Franciosi Jonathan P. Kushner Philip E. Putnam J. Pablo Abonia M | 2010 | The Journal of Allergy and Clinical Immunology2010，，1： | 3 |
| 10 | Sofosbuvir and Ribavirin Prevent Recurrence of HCV Infection after Liver Transplantation: An Open-Label Study显示文摘 | Michael P. Curry Xavier Forns Raymond T. Chung Norah A. Terrault Robert Brown Jonathan M. Fenkel Fredric Gordon Jacqueline O’Leary Alexander Kuo Thomas Schiano Gregory Everson Eugene Schiff Alex Befeler Edward Gane Sammy Saab John G. McHutchison G. Mani S | 2014 | Gastroenterology2014，，： | 3 |
| 11 | Comparison of ultrasound-measured properties of the common carotid artery to tobacco smoke exposure in a cohort of Indonesian patients显示文摘BACKGROUND: The purpose of this study was to use point-of-care ultrasound(POCUS) to investigate the relationship between tobacco smoke exposure and the characteristics of the common carotid artery(CCA). The effect of both primary and secondary smoking on CCA properties was evaluated.METHODS: We performed a prospective cross-sectional study across 20 primary care clinics in Bandung, West Java, Indonesia in July 2016. Point of care ultrasound was performed on a convenience sample of Indonesian patients presenting to clinic. The CCA wall stiffness and carotid intima-media thickness(CIMT) were measured during diastole and systole. These measurements were correlated with smoke exposure and cardiovascular disease.RESULTS: We enrolled 663 patients in the study, with 426 patients enrolled in the smoking category and 237 patients enrolled in the second-hand smoke category. There was an overall positive correlation with the measured lifestyle factors and the ultrasound-measured variables in the group of individuals who smoked. For all variables, age seemed to contribute the most out of all of the lifestyle factors for the positive changes in CIMT and CCA wall stiffness.CONCLUSION: Our data yielded correlations between CCA properties and cardiovascular risk, as well as between CIMT and arterial stiffness. We were also able to demonstrate an increase in thickness of the CIMT in patients who have been exposed by tobacco through the use of ultrasound. Further large scale studies comparing patients with multiple cardiac risk factors need to be performed to confi rm the utility of ultrasound fi ndings of cardiovascular disease and stroke. | Allen R.Yu Bima Hasjim Luke E.Yu Christopher Gabriel Alexander Anshus Jonathan B.Lee Michael J. Louthan Esther C.Kim Katrina Lee Christina Tse Thomas Keown Shadi Lahham Maili Alvarado Steven Bunch Abdulatif Gari J.Christian Fox | 2017 | World Journal of Emergency Medicine2017，8，3： | 2 |
| 12 | Prevalence of intra-abdominal hypertension in critically ill patients: a multicentre epidemiological study显示文摘 | Manu L. N. G. Malbrain Davide Chiumello Paolo Pelosi Alexander Wilmer Nicola Brienza Vincenzo Malcangi David Bihari Richard Innes Jonathan Cohen Pierre Singer Andre Japiassu Elizabeth Kurtop Bart L. De Keulenaer Ronny Daelemans Monica Del Turco P. Cosimin | 2004 | Intensive Care Medicine2004，，5： | 2 |
| 13 | Immune Response to Influenza Vaccine in Pediatric Patients With Inflammatory Bowel Disease显示文摘 | Petar Mamula Jonathan E. Markowitz David A. Piccoli Alexander Klimov Louis Cohen Robert N. Baldassano | 2007 | Clinical Gastroenterology and Hepatology2007，，7： | 2 |
| 14 | Wavelet analysis of wall-pressure fluctuations in a supersonic blunt- fin flow显示文摘 | JONATHAN P ALEXANDER J SMITS | 1997 | AIAA Journal1997，35，10： | 1 |
| 15 | Speed and area trade-offs in Cluster-based FPGA architectures显示文摘 | Marquardt Alexander Betz Vaughn Rose Jonathan | 2000 | IEEE Transactions on VLSI Systems2000，8，2： | 1 |
| 16 | A Spectrum of PCSK9 Alleles Contributes to Plasma Levels of Low-Density Lipoprotein Cholesterol显示文摘 | Ingrid K. Kotowski Alexander Pertsemlidis Amy Luke Richard S. Cooper Gloria L. Vega Jonathan C. Cohen Helen H. Hobbs | 2006 | The American Journal of Human Genetics2006，，： | 1 |
| 17 | Emerging Roles of Competing Endogenous RNAs in Cancer: Insights from the Regulation of PTEN显示文摘 | Alexander de Giorgio Jonathan Krell Victoria Harding Justin Stebbing Leandro Castellano | 2013 | Molecular and Cellular Biology2013，，20： | 1 |
| 18 | The Incidental Finding of a Persistent Left Superior Vena Cava: Implications for Primary Care Providers—Case and Review显示文摘 | Loren Garrison Morgan Jonathan Gardner Joe Calkins Alexander Bauer | 2015 | Case Reports in Medicine2015，，： | 1 |
| 19 | An Isoform-Selective, Small-Molecule Inhibitor Targets the Autoregulatory Mechanism of p21-Activated Kinase显示文摘 | Sean W. Deacon Alexander Beeser Jami A. Fukui Ulrike E.E. Rennefahrt Cynthia Myers Jonathan Chernoff Jeffrey R. Peterson | 2008 | Chemistry & Biology2008，，4： | 1 |
| 20 | Timing of Complications After Spinal Fusion Surgery显示文摘 | Daniel D. Bohl Matthew L. Webb Adam M. Lukasiewicz Andre M. Samuel Bryce A. Basques Junyoung Ahn Kern Singh Alexander R. Vaccaro Jonathan N. Grauer | 2015 | Spine2015，，19： | 1 |
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