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| 1 | 塞来昔布治疗骨关节炎的随机对照试验显示文摘目的 :比较塞来昔布、萘普生以及安慰剂在治疗膝关节骨关节炎时的疗效、安全性。方法 :10 0 3名有症状的膝关节骨关节炎患者随机接受塞来昔布 5 0 ,10 0 ,2 0 0mg ,bid ;萘普生 5 0 0mg ,bid或安慰剂 12周。患者在停用既往NSAID药或止痛治疗后 2~ 7d以及服用受试药物治疗后 2 ,6 ,12周 ,根据标准疗效判定方法进行评估。结果 :塞来昔布在改善骨关节炎的症状和体征上有显著效果。在治疗后的 2d内疼痛明显缓解 ,最大抗炎和镇痛作用出现在 2周内并持续至 12周。各剂量的塞来昔布与安慰剂比较均有效 ,但 5 0mg ,bid的剂量效果较差 ;较大剂量的塞来昔布 (10 0和 2 0 0mg ,bid)疗效相似 ,所观察到的改善程度与萘普生 5 0 0mg ,bid相当。各剂量的塞来昔布和萘普生均有良好的耐受性。结论 :COX 2抑制剂塞来昔布是治疗骨关节炎的有效药物 ,对骨关节炎临床症状和体征的改善与萘普生相当。 | Bensen WG Fiechtner JJ Mcmillen JI Zhao WW Yu SS Woods EM Hubbard RC Isakson PC Verburg KM Geis GS | 2000 | 中国新药杂志2000，9，8： | 17 |
| 2 | Declining NAD + Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging显示文摘 | Ana P. Gomes Nathan L. Price Alvin J.Y. Ling Javid J. Moslehi Magdalene K. Montgomery Luis Rajman James P. White Jo?o S. Teodoro Christiane D. Wrann Basil P. Hubbard Evi M. Mercken Carlos M. Palmeira Rafael de Cabo Anabela P. Rolo Nigel Turner Eric L. Bel | 2013 | Cell2013，，7： | 2 |
| 3 | Experimental and theoretical investigation of time setting polymer gels in porous media显示文摘 | Hubbard S Robert L J Sorbie K S | 1988 | Soc Petrol Engrs Reservoir Eval Engng1988，，： | 2 |
| 4 | Postoperative Complications and Mortality Following Colectomy for Ulcerative Colitis显示文摘 | Shanika de Silva Christopher Ma Marie–Claude Proulx Marcelo Crespin Belle S. Kaplan James Hubbard Martin Prusinkiewicz Andrew Fong Remo Panaccione Subrata Ghosh Paul L. Beck Anthony MacLean Donald Buie Gilaad G. Kaplan | 2011 | Clinical Gastroenterology and Hepatology2011，，11： | 2 |
| 5 | Urban Design and Local Economic Development 显示文摘 | Phil Hubbard | 1999 | Cities1999，，12： | 2 |
| 6 | Prognostically relevant gene signatures of high-grade serous ovarian carcinoma显示文摘 | Verhaak Roel G W Tamayo Pablo Yang Ji-Yeon Hubbard Diana Zhang Hailei Creighton Chad J Fereday Sian Lawrence Michael Carter Scott L Mermel Craig H Kostic Aleksandar D Etemadmoghadam Dariush Saksena Gordon Cibulskis Kristian Duraisamy Sekhar | 2013 | Journal of Clinical Investigation2013，，1： | 2 |
| 7 | The utilization of recycled concrete aggregate to produce controlled low-strength materials without using Portland cement显示文摘 | Sasha Achtemichuk Justin Hubbard Richard Sluce Medhat H. Shehata | 2009 | Cement and Concrete Composites2009，，8： | 2 |
| 8 | 3D打印对环境空气质量的影响显示文摘3D打印作为近年来涌现出的一种新兴技术,似乎每周都有相关的故事出现在身边。根据WOhlers Associates发布的年度报告,3D打印发展迅速,在2008-2011年间,个人3D打印机的增长速度达到了350%。而实际上,学术上称为增材制造的这项重要技术,已经存在了数十年。受益于近年来CAD/CAM软件的快速发展,以及一些3D打印相关重要专利的到期失效,这项技术受到了公众广泛的关注,实现了爆炸性增长。 | Tim Ryan Daniel Hubbard 黄瑶 | 2017 | 新材料产业2017，，1： | 2 |
| 9 | Neutron reflectivity investigation of the effects of harsh environments on TaN thin films显示文摘 | Thomas Risker Paul Hubbard Jaroslaw Majewski | 1999 | Thin Solid Films1999，346，： | 2 |
| 10 | Soil moisture content estimation using ground-penetrating radar reflection data显示文摘 | I.A. Lunt S.S. Hubbard Y. Rubin | 2004 | Journal of Hydrology2004，，1： | 2 |
| 11 | Oxidative Stress and Matrix Metalloproteinase-9 in Acute Ischemic Stroke: The Biomarker Evaluation for Antioxidant Therapies in Stroke (BEAT-Stroke) Study显示文摘 | Peter J. Kelly Jason D. Morrow MingMing Ning Walter Koroshetz Eng H. Lo Erin Terry Ginger L. Milne Jane Hubbard Hang Lee Elizabeth Stevenson Megan Lederer Karen L Furie | 2008 | Stroke2008，，1： | 2 |
| 12 | The role of metabolites in bioequivalence显示文摘 | MIDHA KK RAWSON M J HUBBARD JW | 2004 | Pharmacol Res2004，21，8： | 1 |
| 13 | Sucrose-phosphate synthase and other sucrose metabolizing enzymes in fruit of various species 显示文摘 | Hubbard N L Pharr D M Huber S C | 1991 | Physiol Plant1991，82，： | 1 |
| 14 | Role of sucrose phosphate synthase in sucrose biosynthesis in ripening bananas and its relationship to the respiratory climacteric 显示文摘 | HUBBARD N L PARR D M HUBER S C | 1990 | Plant Physiol1990，94，1： | 1 |
| 15 | An encephalomyocardit is virus epizootic in a baboon colony 显示文摘 | Hubbard G B Soike K F Butler T M | 1992 | Lab Anim Sci1992，42，3： | 1 |
| 16 | Financing constraints and corporate investment显示文摘 | Fazzari S M R G Hubbard B C Petersen | 1988 | Brookings Papers on Economic Activity1988，19，： | 1 |
| 17 | Adenoviral vector-mediated gene transfer: timing of wild-type p53 gene expression in vivo and effect of tumor transduction on survival in a rat glioma brachytherapy model显示文摘 | Bampoe J Glen J Hubbard SL | 2000 | J Neurooncol2000，49，： | 1 |
| 18 | The pathologic and clinical heterogeneity of lymphocyte-depleted Hodgkin's disease显示文摘 | Kant J A Hubbard S M Longo D L | 1986 | J Clin Oncol1986，4，3： | 1 |
| 19 | Role of sucrose phosphate synthase in sucrose biosynthesis in ripening bananas and its relationship to the respiratory climacteric显示文摘 | HUBBARD N L PHARR D M HUBER S C | 1990 | Plant Physiol1990，94，： | 1 |
| 20 | Congenital chest lesions: diagnosis and characterization with prenatal MR imaging显示文摘 | Hubbard AM Adzick NS Crombleholme TM | 1999 | Radiology1999，212，： | 1 |
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