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| 1 | Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury:An update显示文摘Aldehyde dehydrogenase 2(ALDH2) is best known for its critical detoxifying role in liver alcohol metabolism. However, ALDH2 dysfunction is also involved in a wide range of human pathophysiological situations and is associated with complications such as cardiovascular diseases, diabetes mellitus, neurodegenerative diseases and aging. A growing body of research has shown that ALDH2 provides important protection against oxidative stress and the subsequent loading of toxic aldehydes such as 4-hydroxy-2-nonenal and adducts that occur in human diseases, including ischemia reperfusion injury(IRI). There is increasing evidence of its role in IRI pathophysiology in organs such as heart, brain, small intestine and kidney; however, surprisingly few studies have been carried out in the liver, where ALDH2 is found in abundance. This study reviews the role of ALDH2 in modulating the pathways involved in the pathophysiology of IRI associated with oxidative stress, autophagy and apoptosis. Special emphasis is placed on the role of ALDH2 in different organs, on therapeutic 'preconditioning' strategies, and on the use of ALDH2 agonists such as Alda-1, which may become a useful therapeutic tool for preventing the deleterious effects of IRI in organ transplantation. | Arnau Panisello-Roselló Alexandre Lopez Emma Folch-Puy Teresa Carbonell Anabela Rolo Carlos Palmeira René Adam Marc Net Joan Roselló-Catafau | 2018 | World Journal of Gastroenterology2018，24，27： | 6 |
| 2 | Sirtuin 1 in rat orthotopic liver transplantation:An I GL-1 preservation solution approach显示文摘AIM:To investigate the possible involvement of Sirtuin1(SIRT1)in rat orthotopic liver transplantation(OLT),when Institute Georges Lopez 1(IGL-1)preservation solution is enriched with trimetazidine(TMZ).METHODS:Male Sprague-Dawley rats were used as donors and recipients.Livers were stored in IGL-1 preservation solution for 8h at 4℃,and then underwent OLT according to Kamada’s cuff technique without arterialization.In another group,livers were stored in IGL-1 preservation solution supplemented with TMZ,at10-6 mol/L,for 8 h at 4℃and then underwent OLT.Rats were sacrificed 24 h after reperfusion,and liver and plasma samples were collected.Liver injury(transaminase levels),mitochondrial damage(glutamate dehydrogenase activity)oxidative stress(malondialdehyde levels),and nicotinamide adenine dinucleotide(NAD+),the cofactor necessary for SIRT1 activity,were determined by biochemical methods.SIRT1 and its substrates(acFox O1,ac-p53),the precursor of NAD+,nicotinamide phosphoribosyltransferase(NAMPT),as well as the phosphorylation of adenosine monophosphate activated protein kinase(AMPK),p-m TOR,p-p70S6K(direct substrate of m TOR),autophagy parameters(beclin-1,LC3B)and MAP kinases(p-p38 and p-ERK)were determined by Western blot.RESULTS:Liver grafts preserved in IGL-1 solution enriched with TMZ presented reduced liver injury and mitochondrial damage compared with those preservedin IGL-1 solution alone.In addition,livers preserved in IGL-1+TMZ presented reduced levels of oxidative stress.This was consistent with enhanced SIRT1 protein expression and elevated SIRT1 activity,as indicated by decreased acetylation of p53 and Fox O1.The elevated SIRT1 activity in presence of TMZ can be attributed to the enhanced NAMPT protein and NAD+/NADH levels.Up-regulation of SIRT1 was consistent with activation of AMPK and inhibition of phosphorylation of m TOR and its direct substrate(p-p70S6K).As a consequence,autophagy mediators(beclin-1 and LC3B)were overexpressed.Furthermore,MAP kinases were regulated in livers preserved with IGL-1+TMZ,as they were characterized by enhanced p-ERK and decreased p-p38protein expression.CONCLUSION:Our study shows that IGL-1 preservation solution enriched with TMZ protects liver grafts from the IRI associated with OLT,through SIRT1 up-regulation. | Eirini Pantazi Mohamed Amine Zaouali Mohamed Bejaoui Emma Folch-Puy Hassen Ben Abdennebi Ana Teresa Varela Anabela Pinto Rolo Carlos Marques Palmeira Joan Roselló-Catafau | 2015 | World Journal of Gastroenterology2015，21，6： | 5 |
| 3 | Declining NAD + Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging显示文摘 | Ana P. Gomes Nathan L. Price Alvin J.Y. Ling Javid J. Moslehi Magdalene K. Montgomery Luis Rajman James P. White Jo?o S. Teodoro Christiane D. Wrann Basil P. Hubbard Evi M. Mercken Carlos M. Palmeira Rafael de Cabo Anabela P. Rolo Nigel Turner Eric L. Bel | 2013 | Cell2013，，7： | 2 |
| 4 | Development of fetal brain sulci and gyri:assessment through two and three-dimensional ultrasound and magnetic resonance imaging显示文摘 | Rolo LC Araujo Júnior E Nardozza LM | | 0，，02： | 1 |
| 5 | Diabetes and mitochondrial function:role of hyperglycemia and oxidative stress显示文摘 | Rolo AP Palmeira CM | | 0，，02： | 1 |
| 6 | Mitochondrially mediated synergistic cell killing by bile acids显示文摘 | Anabela P Rolo Carlos M Palmeira Kendall B Wallace | 2002 | BBA - Molecular Basis of Disease2002，，1： | 1 |
| 7 | Development of fetal brain sulei and gyri: assessment through two and three- dimensional ultrasound and magnetic resonance imaging显示文摘 | Rolo L C Araujo J E Nardozza L M | 2011 | Arch Gynecol Obstet2011，283，2： | 1 |
| 8 | Hepatic FXR: key regulator of whole-body energy metabolism 显示文摘 | Teodoro JS Rolo AP Pahneira CM | 2011 | Trends Endocrinol Metab2011，22，11： | 1 |
| 9 | Advantages inthe use of carvedilol versus propranolol for the protectionof cardiac mitochondrial function显示文摘 | Oliveira PJ Rolo AP SardoVA | 2004 | Rev Port Cardiol2004，23，10： | 1 |
| 10 | Diabetes and mitochondrial function : role of hyperglyce- mia and oxidative stress显示文摘 | Rolo AP Palmeira CM | 2006 | Toxicol Appl Pharmaco12006，212，2： | 1 |
| 11 | Se-roepidemiology of porcine enteric sapovirus in pig farms inVenezuela显示文摘 | ALCALA C RODRGUEZ-DAZ J DE ROLO M | 2010 | Vet Immunol Immunopathol2010，137，34： | 1 |
| 12 | Reference ranges of atrioventricular valve areas by means of four-dimensonal ultrasonography using spatiotemporal image correlation in the rendering mode显示文摘 | Rolo LC Nardozza LM Araujo Junior E | 2013 | Prenat Diagn2013，33，1： | 1 |
| 13 | Influence of chronic exercise on the amphetamine-induced dopamine release and neurodegeneration in the striatum of the rat显示文摘 | Marques E Vasconcelos F Rolo MR | 2008 | Ann N Y Acad Sci2008，1139，： | 1 |
| 14 | Hyperglycemia decreases mitochondrial function: the regulatory role of mitochondrial biogenesis 显示文摘 | Palmeira CM Rolo AP Berthiaume J | 2007 | Toxicol Appl Pharmacol2007，225，2： | 1 |
| 15 | Mitochondrially-mediated toxicity of bile acids显示文摘 | Carlos M. Palmeira Anabela P. Rolo | 2004 | Toxicology2004，，1： | 1 |
| 16 | Role of oxidative stress in the pathogenesis of nonalcoholic stcatohepatitis 显示文摘 | Rolo AP Teodoro JS Palmeira CM | 2012 | Free Radic Biol Med2012，52，1： | 1 |
| 17 | Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis显示文摘 | Anabela P. Rolo Jo?o S. Teodoro Carlos M. Palmeira | 2011 | Free Radical Biology and Medicine2011，，1： | 1 |
| 18 | Carvedilol inhibits the mitochondrial permeability transition by an antioxidant mechanism显示文摘 | Oliveira PJ Esteves T Rolo AP | 2004 | Cardiovasc Toxicol2004，4，1： | 1 |
| 19 | Diabetes and mitochondrial func- tion: role of hyperglycemia and oxidative stress显示文摘 | Rolo A P Palmeira C M | 2006 | Toxicol Appl Pharmacol2006，212，2： | 1 |
| 20 | Disruption of mitochonchial calcium homeostasis after chronic alphanaphthylisothiocyanate administration:Relevance for cholestasis显示文摘 | Rolo AP Oliveira PJ Seica R | 2002 | J Invest Med2002，50，3： | 1 |
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