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| 1 | Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury:An update显示文摘Aldehyde dehydrogenase 2(ALDH2) is best known for its critical detoxifying role in liver alcohol metabolism. However, ALDH2 dysfunction is also involved in a wide range of human pathophysiological situations and is associated with complications such as cardiovascular diseases, diabetes mellitus, neurodegenerative diseases and aging. A growing body of research has shown that ALDH2 provides important protection against oxidative stress and the subsequent loading of toxic aldehydes such as 4-hydroxy-2-nonenal and adducts that occur in human diseases, including ischemia reperfusion injury(IRI). There is increasing evidence of its role in IRI pathophysiology in organs such as heart, brain, small intestine and kidney; however, surprisingly few studies have been carried out in the liver, where ALDH2 is found in abundance. This study reviews the role of ALDH2 in modulating the pathways involved in the pathophysiology of IRI associated with oxidative stress, autophagy and apoptosis. Special emphasis is placed on the role of ALDH2 in different organs, on therapeutic 'preconditioning' strategies, and on the use of ALDH2 agonists such as Alda-1, which may become a useful therapeutic tool for preventing the deleterious effects of IRI in organ transplantation. | Arnau Panisello-Roselló Alexandre Lopez Emma Folch-Puy Teresa Carbonell Anabela Rolo Carlos Palmeira René Adam Marc Net Joan Roselló-Catafau | 2018 | World Journal of Gastroenterology2018，24，27： | 6 |
| 2 | Sirtuin 1 in rat orthotopic liver transplantation:An I GL-1 preservation solution approach显示文摘AIM:To investigate the possible involvement of Sirtuin1(SIRT1)in rat orthotopic liver transplantation(OLT),when Institute Georges Lopez 1(IGL-1)preservation solution is enriched with trimetazidine(TMZ).METHODS:Male Sprague-Dawley rats were used as donors and recipients.Livers were stored in IGL-1 preservation solution for 8h at 4℃,and then underwent OLT according to Kamada’s cuff technique without arterialization.In another group,livers were stored in IGL-1 preservation solution supplemented with TMZ,at10-6 mol/L,for 8 h at 4℃and then underwent OLT.Rats were sacrificed 24 h after reperfusion,and liver and plasma samples were collected.Liver injury(transaminase levels),mitochondrial damage(glutamate dehydrogenase activity)oxidative stress(malondialdehyde levels),and nicotinamide adenine dinucleotide(NAD+),the cofactor necessary for SIRT1 activity,were determined by biochemical methods.SIRT1 and its substrates(acFox O1,ac-p53),the precursor of NAD+,nicotinamide phosphoribosyltransferase(NAMPT),as well as the phosphorylation of adenosine monophosphate activated protein kinase(AMPK),p-m TOR,p-p70S6K(direct substrate of m TOR),autophagy parameters(beclin-1,LC3B)and MAP kinases(p-p38 and p-ERK)were determined by Western blot.RESULTS:Liver grafts preserved in IGL-1 solution enriched with TMZ presented reduced liver injury and mitochondrial damage compared with those preservedin IGL-1 solution alone.In addition,livers preserved in IGL-1+TMZ presented reduced levels of oxidative stress.This was consistent with enhanced SIRT1 protein expression and elevated SIRT1 activity,as indicated by decreased acetylation of p53 and Fox O1.The elevated SIRT1 activity in presence of TMZ can be attributed to the enhanced NAMPT protein and NAD+/NADH levels.Up-regulation of SIRT1 was consistent with activation of AMPK and inhibition of phosphorylation of m TOR and its direct substrate(p-p70S6K).As a consequence,autophagy mediators(beclin-1 and LC3B)were overexpressed.Furthermore,MAP kinases were regulated in livers preserved with IGL-1+TMZ,as they were characterized by enhanced p-ERK and decreased p-p38protein expression.CONCLUSION:Our study shows that IGL-1 preservation solution enriched with TMZ protects liver grafts from the IRI associated with OLT,through SIRT1 up-regulation. | Eirini Pantazi Mohamed Amine Zaouali Mohamed Bejaoui Emma Folch-Puy Hassen Ben Abdennebi Ana Teresa Varela Anabela Pinto Rolo Carlos Marques Palmeira Joan Roselló-Catafau | 2015 | World Journal of Gastroenterology2015，21，6： | 5 |
| 3 | Declining NAD + Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging显示文摘 | Ana P. Gomes Nathan L. Price Alvin J.Y. Ling Javid J. Moslehi Magdalene K. Montgomery Luis Rajman James P. White Jo?o S. Teodoro Christiane D. Wrann Basil P. Hubbard Evi M. Mercken Carlos M. Palmeira Rafael de Cabo Anabela P. Rolo Nigel Turner Eric L. Bel | 2013 | Cell2013，，7： | 2 |
| 4 | Tumor Regression Grades: Can They Influence Rectal Cancer Therapy Decision Tree?显示文摘 | Marisa D. Santos Cristina Silva Anabela Rocha Eduarda Matos Carlos Nogueira Carlos Lopes Frank A. Frizelle | 2013 | International Journal of Surgical Oncology2013，，： | 2 |
| 5 | Mitochondrially mediated synergistic cell killing by bile acids显示文摘 | Anabela P Rolo Carlos M Palmeira Kendall B Wallace | 2002 | BBA - Molecular Basis of Disease2002，，1： | 1 |
| 6 | Phenolic profile of seventeen Portuguese wild mushrooms显示文摘 | Josiana A. Vaz Lillian Barros Anabela Martins Jorge Sá Morais M. Helena Vasconcelos Isabel C.F.R. Ferreira | 2010 | LWT - Food Science and Technology2010，，1： | 1 |
| 7 | Method to evaluate foaming performance显示文摘 | Anabela R Jose E Isabel S | 1998 | Journal of Food Engineering1998，36，： | 1 |
| 8 | Adsorption of Phenylalanine onto Polymeric Resins: Equilibrium, Kinetics and Operation of a Parametric Pumping Unit 显示文摘 | Sergi D Anabela L Licinio F etal | 1998 | Separation and Purification Technology1998，13，： | 1 |
| 9 | Towards chemical and nutritional inventory of Portuguese wild edible mushrooms in different habitats显示文摘 | Eliana Pereira Lillian Barros Anabela Martins Isabel C.F.R. Ferreira | 2011 | Food Chemistry2011，，2： | 1 |
| 10 | Dehydration of xylose into furfural over micro-mesoporous sulfonic acid catalysts显示文摘 | Ana S Dias Martyn Pillinger Anabela A Valente | 2005 | Journal of Catalysis2005，229，2： | 1 |
| 11 | Chemical composition and nutritional value of the most widely appreciated cultivated mushrooms: An inter-species comparative study显示文摘 | Filipa S. Reis Lillian Barros Anabela Martins Isabel C.F.R. Ferreira | 2011 | Food and Chemical Toxicology2011，，2： | 1 |
| 12 | Optimisation of a microbial bioassay for contaminated soil monitoring : bacterial inoculum standardization and comparison with Microtox assay显示文摘 | Federica Abbondanzi Anabela Cachada Tiziana Campisi | 2003 | Chemosphere2003，53，： | 1 |
| 13 | Mitochondrially-mediated toxicity of bile acids显示文摘 | Carlos M. Palmeira Anabela P. Rolo | 2004 | Toxicology2004，，1： | 1 |
| 14 | Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis显示文摘 | Anabela P. Rolo Jo?o S. Teodoro Carlos M. Palmeira | 2011 | Free Radical Biology and Medicine2011，，1： | 1 |
| 15 | Liquid phase dehydration of D-xylose in the presence of keggin-type heteropolyacids显示文摘 | ANA S D MARTYN P ANABELA | 2005 | Applied Catalysis A:General2005，285，： | 1 |
| 16 | Diversity and fruiting pattern of macrofungi associated with chestnut ( Castanea sativa ) in the Trás-os-Montes region (Northeast Portugal)显示文摘 | Paula Baptista Anabela Martins Rui Manuel Tavares Teresa Lino-Neto | 2009 | Fungal Ecology2009，，1： | 1 |
| 17 | Fenton oxidation of cork cooking wastewateroverall kinetic analysis显示文摘 | Anabela M F Guedes M Luis M P | 2003 | Water Research2003，37，： | 1 |
| 18 | Exfoliated titanate, niobate and titanoniobate nanosheets as solid acid catalysts for the liquid-phase dehydration of d -xylose into furfural显示文摘 | Ana S. Dias Sérgio Lima Daniel Carriazo Vicente Rives Martyn Pillinger Anabela A. Valente | 2006 | Journal of Catalysis2006，，2： | 1 |
| 19 | Fenton oxidation of cork cooking wastewater-overall kinetic analysis 显示文摘 | Anabela M F M Guedes Luis M P Madeira Rui A R Boaventura | 2003 | Water Research2003，37，13： | 1 |
| 20 | Dehydration of xylose into furfural over micro-mesoporous sulfonic acid catalysts显示文摘 | Dias Ana S Pillinger Martyn Valente Anabela A | 2005 | Journal of Catalysis2005，229，： | 1 |
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