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| 1 | Radiofrequency ablation vs surgical resection in elderly patients with hepatocellular carcinoma in Milan criteria显示文摘BACKGROUND Surgical resection and radiofrequency ablation(RFA)represent two possible strategy in treatment of hepatocellular carcinoma(HCC)in Milan criteria.AIM To evaluate short-and long-term outcome in elderly patients(>70 years)with HCC in Milan criteria,which underwent liver resection(LR)or RFA.METHODS The study included 594 patients with HCC in Milan criteria(429 in LR group and 165 in RFA group)managed in 10 European centers.Statistical analysis was performed using the Kaplan-Meier method before and after propensity score matching(PSM)and Cox regression.RESULTS After PSM,we compared 136 patients in the LR group with 136 patients in the RFA group.Overall survival at 1,3,and 5 years was 91%,80%,and 76%in the LR group and 97%,67%,and 41%in the RFA group respectively(P=0.001).Diseasefree survival at 1,3,and 5 years was 84%,60%and 44%for the LR group,and 63%,36%,and 25%for the RFA group(P=0.001).Postoperative Clavien-Dindo IIIIV complications were lower in the RFA group(1%vs 11%,P=0.001)in association with a shorter length of stay(2 d vs 7 d,P=0.001).In multivariate analysis,Model for End-stage Liver Disease(MELD)score(>10)[odds ratio(OR)=1.89],increased value of international normalized ratio(>1.3)(OR=1.60),treatment with radiofrequency(OR=1.46),and multiple nodules(OR=1.19)were independent predictors of a poor overall survival while a high MELD score(>10)(OR=1.51)and radiofrequency(OR=1.37)were independent factors associated with a higher recurrence rate.CONCLUSION Despite a longer length of stay and a higher rate of severe postoperative complications,surgery provided better results in long-term oncological outcomes as compared to ablation in elderly patients(>70 years)with HCC in Milan criteria. | Maria Conticchio Riccardo Inchingolo Antonella Delvecchio Letizia Laera Francesca Ratti Maximiliano Gelli Ferdinando Anelli Alexis Laurent Giulio Vitali Paolo Magistri Giacomo Assirati Emanuele Felli Taiga Wakabayashi Patrick Pessaux Tullio Piardi Fabrizio di Benedetto Nicola de'Angelis Javier Briceño AntonioRampoldi RenèAdam Daniel Cherqui Luca Antonio Aldrighetti Riccardo Memeo | 2021 | World Journal of Gastroenterology2021，27，18： | 4 |
| 2 | Estrogen receptors expression in long-lasting ulcerative pancolitis with and without dysplasia: A preliminary report显示文摘 | Mariabeatrice Principi Nicola De Tullio Maria Principia Scavo Domenico Piscitelli Andrea Marzullo Silvana Russo Francesca Albano Katia Lofano Samanta Papagni Michele Barone Enzo Ierardi Alfredo Di Leo | 2012 | Scandinavian Journal of Gastroenterology2012，，10： | 2 |
| 3 | Catestatin reduces myocardial ischaemia/reperfiasion injury: involvement of PI3K/Akt, PKCs, mitochondrial K ATP channels and ROS signalling显示文摘 | Maria-Giulia Perrelli Francesca Tullio Carmelina Angotti | 2013 | Pfl ti gets Archiv-European Journal of Physiology2013，25，7： | 1 |
| 4 | Comparison Between Coronary Angioplasty and Coronary Artery Bypass Surgery for the Treatment of Unprotected Left Main Coronary Artery Stenosis (the Bologna Registry)显示文摘 | Tullio Palmerini Antonio Marzocchi Cinzia Marrozzini Paolo Ortolani Francesco Saia Carlo Savini Letizia Bacchi-Reggiani Silvia Gianstefani Santo Virzì Francesca Manara Meron Kiros Weldeab Giuseppe Marinelli Roberto Di Bartolomeo Angelo Branzi | 2006 | The American Journal of Cardiology2006，，1： | 1 |
| 5 | Catestatin Improves Post-Ischemic Left Ventricular Function and Decreases Ischemia/Reperfusion Injury in Heart显示文摘 | Claudia Penna Giuseppe Alloatti Maria Pia Gallo Maria Carmela Cerra Renzo Levi Francesca Tullio Eleonora Bassino Serena Dolgetta Sushil K. Mahata Bruno Tota Pasquale Pagliaro | | 0，2010，： | 1 |
| 6 | Clinically-Staged T3N0 Rectal Cancer: Is Preoperative Chemoradiotherapy the Optimal Treatment?显示文摘 | Raffaele Lombardi Dajana Cuicchi Carmine Pinto Francesca Fabio Bruno Iacopino Stefano Neri Maria Lucia Tardio Claudio Ceccarelli Ferdinando Lecce Giampaolo Ugolini Sara Pini Piergiorgio Tullio Mario Taffurelli Francesco Minni Andrea Martoni Bruno Cola | 2010 | Annals of Surgical Oncology2010，，3： | 1 |
| 7 | Differential toxicity, conformation and morphology of typical initial aggregation states of Aβ1-42 and Aβ py 3-42 beta-amyloids显示文摘 | Denise Galante Alessandro Corsaro Tullio Florio Serena Vella Aldo Pagano Francesca Sbrana Massimo Vassalli Angelo Perico Cristina D’Arrigo | 2012 | International Journal of Biochemistry and Cell Biology2012，，11： | 1 |
| 8 | Liver resection vs radiofrequency ablation in single hepatocellular carcinoma of posterosuperior segments in elderly patients显示文摘BACKGROUND Liver resection and radiofrequency ablation are considered curative options for hepatocellular carcinoma.The choice between these techniques is still controversial especially in cases of hepatocellular carcinoma affecting posterosuperior segments in elderly patients.AIM To compare post-operative outcomes between liver resection and radiofrequency ablation in elderly with single hepatocellular carcinoma located in posterosuperior segments.METHODS A retrospective multicentric study was performed enrolling 77 patients age≥70-years-old with single hepatocellular carcinoma(≤30 mm),located in posterosuperior segments(4a,7,8).Patients were divided into liver resection and radiofrequency ablation groups and preoperative,peri-operative and long-term outcomes were retrospectively analyzed and compared using a 1:1 propensity score matching.RESULTS After propensity score matching,twenty-six patients were included in each group.Operative time and overall postoperative complications were higher in the resection group compared to the ablation group(165 min vs 20 min,P<0.01;54%vs 19%P=0.02 respectively).A median hospital stay was significantly longer in the resection group than in the ablation group(7.5 d vs 3 d,P<0.01).Ninety-day mortality was comparable between the two groups.There were no significant differences between resection and ablation group in terms of overall survival and disease free survival at 1,3,and 5 years.CONCLUSION Radiofrequency ablation in posterosuperior segments in elderly is safe and feasible and ensures a short hospital stay,better quality of life and does not modify the overall and disease-free survival. | Antonella Delvecchio Riccardo Inchingolo Rita Laforgia Francesca Ratti Maximiliano Gelli Massimiliano Ferdinando Anelli Alexis Laurent Giulio Vitali Paolo Magistri Giacomo Assirati Emanuele Felli Taiga Wakabayashi Patrick Pessaux Tullio Piardi Fabrizio di Benedetto Nicola de'Angelis Javier Briceño Antonio Rampoldi RenèAdam Daniel Cherqui Luca Antonio Aldrighetti Riccardo Memeo | 2021 | World Journal of Gastrointestinal Surgery2021，13，12： | 1 |
| 9 | Abdominal hernias:Radiological features显示文摘Abdominal wall hernias are common diseases of the abdomen with a global incidence approximately 4%-5%. They are distinguished in external,diaphragmatic and internal hernias on the basis of their localisation.Groin hernias are the most common with a prevalence of 75%, followed by femoral(15%)and umbilical(8%).There is a higher prevalence in males(M:F,8:1).Diagnosis is usually made on physical examination.However,clinical diagnosis may be difficult,especially in patients with obesity,pain or abdominal wall scarring.In these cases, abdominal imaging may be the first clue to the correct diagnosis and to confirm suspected complications. Different imaging modalities are used:conventional radiographs or barium studies,ultrasonography and Computed Tomography.Imaging modalities can aid in the differential diagnosis of palpable abdominal wall masses and can help to define hernial contents suchas fatty tissue,bowel,other organs or fluid.This work focuses on the main radiological findings of abdominal herniations. | Francesco Lassandro Francesca Iasiello Nunzia Luisa Pizza Tullio Valente Maria Luisa Mangoni di Santo Stefano Roberto Grassi Roberto Muto | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，6： | 1 |
| 10 | Peri-operative score for elderly patients with resectable hepatocellular carcinoma显示文摘BACKGROUND Liver resection is the mainstay for a curative treatment for patients with resectable hepatocellular carcinoma(HCC),also in elderly population.Despite this,the evaluation of patient condition,liver function and extent of disease remains a demanding process with the aim to reduce postoperative morbidity and mortality.AIM To identify new perioperative risk factors that could be associated with higher 90-and 180-d mortality in elderly patients eligible for liver resection for HCC considering traditional perioperative risk scores and to develop a risk score.METHODS A multicentric,retrospective study was performed by reviewing the medical records of patients aged 70 years or older who electively underwent liver resection for HCC;several independent variables correlated with death from all causes at 90 and 180 d were studied.The coefficients of Cox regression proportional-hazards model for sixmonth mortality were rounded to the nearest integer to assign risk factors'weights and derive the scoring algorithm.RESULTS Multivariate analysis found variables(American Society of Anesthesiology score,high rate of comorbidities,Mayo end stage liver disease score and size of biggest lesion)that had independent correlations with increased 90-and 180-d mortality.A clinical risk score was developed with survival profiles.CONCLUSION This score can aid in stratifying this population in order to assess who can benefit from surgical treatment in terms of postoperative mortality. | Maria Conticchio Riccardo Inchingolo Antonella Delvecchio Francesca Ratti Maximiliano Gelli Massimiliano Ferdinando Anelli Alexis Laurent Giulio Cesare Vitali Paolo Magistri Giacomo Assirati Emanuele Felli Taiga Wakabayashi Patrick Pessaux Tullio Piardi Fabrizio di Benedetto Nicola de'Angelis Javier Briceño Antonio Rampoldi RenèAdam Daniel Cherqui Luca Antonio Aldrighetti Riccardo Memeo | 2023 | World Journal of Hepatology2023，15，12： | 0 |
| 11 | Impact of body mass index in elderly patients treated with laparoscopic liver resection for hepatocellular carcinoma显示文摘BACKGROUND The impact of obesity on surgical outcomes in elderly patients candidate for liver surgery is still debated.AIM To evaluate the impact of high body mass index(BMI)on perioperative and oncological outcome in elderly patients(>70 years old)treated with laparoscopic liver resection for hepatocellular carcinoma(HCC).METHODS Retrospective multicenter study including 224 elderly patients(>70 years old)operated by laparoscopy for HCC(196 with a BMI<30 and 28 with BMI≥30),observed from January 2009 to January 2019.RESULTS After propensity score matching,patients in two groups presented comparable results,in terms of operative time(median range:200 min vs 205 min,P=0.7 respectively in non-obese and obese patients),complications rate(22%vs 26%,P=1.0),length of hospital stay(median range:4.5 d vs 6.0 d,P=0.1).There are no significant differences in terms of short-and long-term postoperative results.CONCLUSION The present study showed that BMI did not impact perioperative and oncologic outcomes in elderly patients treated by laparoscopic resection for HCC. | Maria Conticchio Riccardo Inchingolo Antonella Delvecchio Francesca Ratti Maximiliano Gelli Massimiliano Ferdinando Anelli Alexis Laurent Giulio Cesare Vitali Paolo Magistri Giacomo Assirati Emanuele Felli Taiga Wakabayashi Patrick Pessaux Tullio Piardi Fabrizio di Benedetto Nicola de’Angelis Javier Briceño Antonio Rampoldi RenèAdam Daniel Cherqui Luca Antonio Aldrighetti Riccardo Memeo | 2023 | World Journal of Gastrointestinal Surgery2023，15，1： | 0 |
| 12 | Glycaemic control, antidiabetic medications and influenza vaccination coverage among patients with diabetes in Udine, Italy显示文摘Objective The objectives of this study were to estimate influenza vaccination coverage among patients with diabetes mellitus in an Italian 250000-inhabitant area in the 2017-2018 season and to assess whether glycaemic control and pharmacological treatment were associated with the likelihood of being vaccinated.Design In this cross-sectional study,we analysed anonymous health administrative databases,linked with each other at the individual patient level through a stochastic key:diabetes mellitus registry,vaccinations,drug prescriptions and laboratory database.setting The study was conducted in the catchment area of the University Hospital of Udine(‘the Udine area’),a 250000-inhabitant area in the northeast of Italy.Participants The study included all subjects included in the regional registry of patients with diabetes mellitus,living in the Udine area as of 1 October 2017.Main outcome measures Vaccination coverage in the 2017-2018 influenza season was calculated.The association between patients’characteristics and the likelihood of being vaccinated was assessed through multivariate log binomial regression.result 53.0%of 15900 patients with diabetes living in the area were vaccinated.Coverage increased with age,approaching 75%at≥85 years.Patients lacking recent glycated haemoglobin testing were less likely to be vaccinated(43.4%vaccination coverage),as were those not treated pharmacologically(44.4%vaccination coverage).Patients treated with both insulin,metformin and other antidiabetic medications were more likely to be vaccinated than those treated with metformin alone(58.1%vaccination coverage;adjusted relative risk=1.07,95%CI 1.01 to 1.14).Conclusion Influenza vaccination coverage was suboptimal in this Italian population of patients with diabetes.Strategies to improve diabetes management could in turn positively affect influenza coverage. | Francesca Valent Annarita Tullio | 2019 | Family Medicine and Community Health2019，7，3： | 0 |
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