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| 1 | Ischemia/reperfusion injury and cardioprotective mechanisms:Role of mitochondria and reactive oxygen species显示文摘Reperfusion therapy must be applied as soon as possible to attenuate the ischemic insult of acute myocardial infarction(AMI).However reperfusion is responsible for additional myocardial damage,which likely involves opening of the mitochondrial permeability transition pore(mPTP).In reperfusion injury,mitochondrial damage is a determining factor in causing loss of cardiomyocyte function and viability.Major mechanisms of mitochondrial dysfunction include the long lasting opening of mPTPs and the oxidative stress resulting from formation of reactive oxygen species(ROS).Several signaling cardioprotective pathways are activated by stimuli such as preconditioning and postconditioning,obtained with brief intermittent ischemia or with pharmacological agents.These pathways converge on a common target,the mitochondria,to preserve their function after ischemia/reperfusion.The present review discusses the role of mitochondria in cardioprotection,especially the involvement of adenosine triphosphate-dependent potassium channels,ROS signaling,and the mPTP.Ischemic postconditioning has emerged as a new way to target the mitochondria,and to drastically reduce lethal reperfusion injury.Several clinical studies using ischemic postconditioning during angioplasty now support its protective effects,and an interesting alternative is pharmacological postconditioning.In fact ischemic postconditioning and the mPTP desensitizer,cyclosporine A,have been shown to induce comparable protection in AMI patients. | Maria-Giulia Perrelli Pasquale Pagliaro Claudia Penna | 2011 | World Journal of Cardiology2011，3，6： | 64 |
| 2 | Clinical Management of Hepatocellular Carcinoma. Conclusions of the Barcelona-2000 EASL Conference显示文摘 | Jordi Bruix Morris Sherman Josep M Llovet Michel Beaugrand Riccardo Lencioni Andrew K Burroughs Erik Christensen Luigi Pagliaro Massimo Colombo Juan Rodés | 2001 | Journal of Hepatology2001，，3： | 11 |
| 3 | Natural history and prognostic indicators of survival in cirrhosis: A systematic review of 118 studies显示文摘 | Gennaro D’Amico Guadalupe Garcia-Tsao Luigi Pagliaro | 2005 | Journal of Hepatology2005，，1： | 8 |
| 4 | Low hypoxia inducible factor-1α(HIF-1α)expression in testicular germ cell tumors--a major reason for enhanced chemosensitivity?显示文摘The molecular basis for enhanced chemosensitivity of testicular germ cell tumors(GCT)has been an area of great interest,as it could potentially give us therapeutic leads in other resistant malignancies.Thus far,however,the increased sensitivity of GCT has been variously attributed to multiple factors—an inability to detoxify cisplatin,a lack of export pumps,an inability to repair the DNA damage,an intact apoptotic cascade and lack of p53 mutation;but a unifying underlying etiology leading to the aforementioned processes and having a translational implication has so far been elusive.Herein,we offer evidence to support a potential significant role for the previously demonstrated low hypoxia inducible factor-1α(HIF-1α)expression in mediating the general exquisite chemosensitivity of testicular GCT,through the aforementioned processes.This molecular mechanism based hypothesis could have a significant translational implication in platinum refractory GCT as well as other platinum resistant malignancies. | niraj shenoy roxana dronca fernando quevedo stephen a boorjian john cheville brian costello manish kohli thomas witzig lance pagliaro | 2017 | Chinese Journal of Cancer Research2017，29，4： | 4 |
| 5 | Non-seminomatous germ cell tumor with bone metastasis only at diagnosis:A rare clinical presentation显示文摘Bone metastasis of non-seminomatous germ cell tumors(NSGCT)of the testes is a rare event and even more uncommon at initial presentation.Generally,bone lesions are discovered in the presence of concurrent retroperitoneal lymph node or visceral disease.However,in this case,a 37 years old male complaining of a growing testicular mass was found to have isolated bone metastasis with associated caudaequina syndrome without apparent abnormal findings on initial computed tomography(CT)scans.Continued neurologic symptoms prompted further evaluation with magnetic resonance imaging(MRI),which demonstrated multiple sites of bone metastasis without evidence of retroperitoneal lymph node or visceral organ involvement.This case represents a rare clinical presentation and disease manifestation of NSGCT. | K.C.Biebighauser Jianjun Gao Priya Rao Gene Landon Lance Pagliaro Colin PNDinney Jose Karam Neema Navai | 2017 | Asian Journal of Urology2017，4，2： | 3 |
| 6 | Treatment of hepatocellular carcinoma: A systematic review of randomized controlled trials显示文摘 | R. G. Simonetti A. Liberati C. Angiolini L. Pagliaro | 1997 | Annals of Oncology1997，，2： | 3 |
| 7 | Pharmacological Treatment of Portal Hypertension: An Evidence-Based Approach显示文摘 | Gennaro D’Amico Luigi Pagliaro Jaime Bosch | 1999 | Semin Liver Dis1999，，04： | 2 |
| 8 | Repeated Intravesical Inxtilladons of an Adenoviral Vector in Pationts With Locally Advanced Bladder Cancer: A Phase I Study of p53Gene Therapy 显示文摘 | Pagliaro LC Keyhani A Wilfiams D | 2003 | J Clin Oncol2003，21，12： | 1 |
| 9 | Protection against ischemia/reperfusion injuries by vasostatin-1 in the isolated rat heart显示文摘 | Cappello S Rastaldo R | 2007 | Comp Biochem Physiol A Mol Integr Physiol2007，147，1： | 1 |
| 10 | Myocardial general and vascular aspects of ischemic preconditioning显示文摘 | Losano G Gattullo D Pagliaro P | 1996 | Life Sci1996，59，： | 1 |
| 11 | Natural history and prognostic in- dicators of survival in cirrhosis:a systematic review of 118 studies显示文摘 | DAmico G Garcia-Tsao G Pagliaro L | 2006 | J Hepato12006，44，： | 1 |
| 12 | Nitric oxide and cardiac function显示文摘 | Rastaldo R Pagliaro P Cappello S | 2007 | Life Sci2007，81，10： | 1 |
| 13 | Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies显示文摘 | D' Amico G Garcia-Tsao G Pagliaro L | 2006 | J Hepatol2006，44，1： | 1 |
| 14 | A Phase II Trial of Gemcitabine Plus Capecitabine for Metastatic Renal Cell Cancer Previously Treated With Immunotherapy and Targeted Agents显示文摘 | Nizar M. Tannir Peter F. Thall Chaan S. Ng Xuemei Wang Leiko Wooten Arlene Siefker-Radtke Paul Mathew Lance Pagliaro Christopher Wood Eric Jonasch | 2007 | The Journal of Urology2007，，： | 1 |
| 15 | From glycerol to value-added products 显示文摘 | Pagliaro M Ciriminna R Kimura H | 2007 | Angew Chem Int Ed2007，46，24： | 1 |
| 16 | Mortality and Causes of Death in Celiac Disease in a Mediterranean Area显示文摘 | Mario Cottone Anna Termini Lorenzo Oliva Antonino Magliocco Ciro Marrone Ambrogio Orlando Filippo Pinzone Roberto Di Mitri Matteo Rosselli Aroldo Rizzo Luigi Pagliaro | 1999 | Digestive Diseases and Sciences1999，，12： | 1 |
| 17 | Repeated intravesical instillations of an adenoviral vector in patients with locally advanced bladder cancer: a phase Ⅰ study of p53 gene therapy显示文摘 | Pagliaro LC Keyhani A Williams D | 2003 | J Clin Oncol2003，21，12： | 1 |
| 18 | Pharmacological treatment of portal hypertension : an evidence - based approach 显示文摘 | D'Amico G Pagliaro L Bosch J | 1999 | Semin Liver Dis1999，19，4： | 1 |
| 19 | Consensus recommendations for managing asymptomatic persistent non-virus non-alcohol related elevation of aminotransferase levels:suggestions for diagnostic procedures and monitoring显示文摘 | Morisco F Pagliaro L Caporaso N | 2008 | Dig Liver Dis2008，40，： | 1 |
| 20 | From glycerol to valueadded products 显示文摘 | Pagliaro M Ciriminna R Kimura H | 2007 | Angewandte Chemie : International Edition2007，46，： | 1 |
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