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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | ESPEN Guidelines for Nutrition Screening 2002显示文摘 | J Kondrup S.P Allison M Elia B Vellas M Plauth | 2003 | Clinical Nutrition2003，，4： | 11 |
| 3 | Impact of the COVID-19 pandemic on liver donation and transplantation:A review of the literature显示文摘The coronavirus disease 2019(COVID-19)pandemic has upended healthcare systems worldwide and led to an inevitable decrease in liver transplantation(LT)activity.During the first pandemic wave,administrators and clinicians were obliged to make the difficult decision of whether to suspend or continue a lifesaving procedure based on the scarce available evidence regarding the risk of transmission and mortality in immunosuppressed patients.Those centers where the activity continued or was heavily restricted were obliged to screen donors and recipients,design COVID-safe clinical pathways,and promote telehealth to prevent nosocomial transmission.Despite the ever-growing literature on COVID-19,the amount of high-quality literature on LT remains limited.This review will provide an updated view of the impact of the pandemic on LT programs worldwide.Donor and recipient screening,strategies for waitlist prioritization,and posttransplant risk of infection and mortality are discussed.Moreover,a particular focus is given to the possibility of donor-to-recipient transmission and immunosuppression management in COVID-positive recipients. | Riccardo De Carlis Ivan Vella NiccolòIncarbone Leonardo Centonze Vincenzo Buscemi Andrea Lauterio Luciano De Carlis | 2021 | World Journal of Gastroenterology2021，27，10： | 4 |
| 4 | PrP^C-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site显示文摘铜绑定,抛锚膜的、细胞的 prion 蛋白质(PrPC ) 有二个组成的劈开地点生产不同 N 终端和 C 终端碎片(N1/C1 和 N2/C2 ) 。用表示也人的 PrPC,鼠标 PrPC 或鼠标 PrPC 的 RK13 房间带 3F4 epitope,这研究在 endoproteolytic 劈开和一个通常认为的 PrPC 函数上探索了 PrPC 主要顺序的影响,地图 kinase 信号 transduction,响应外长的铜与或没有使不安的膜环境。PrPC 主要顺序,特别在 N1/C1 劈开地点附近,看起来在这个地点和细胞外的调整信号的 kinase 1/2 (ERK1/2 ) phosphorylation 影响解朊作用的基础层次,与处理激活增加与基础 ERK1/2 表明一种反的关系。人的 PrPC 独自响应铜显示出增加的 N1/C1 劈开,由特定的 p38 和 JNK/SAPK phosphorylation 伴随了。到加扣押胆固醇的抗菌素 filipin 的铜的联合暴露导致了一只老鼠信号蛋白质 phosphorylation 的 PrPC 特定的实质的增加,由 N1/C1 劈开的增加伴随了。怀有人的 N1/C1 劈开地点的老鼠 PrPC 基础地并且响应铜假定更似人类的侧面并且改变了膜环境。我们的结果证明在 N1/C1 劈开地点附近的 PrPC 主要顺序影响在这个地点处理的 endoproteolytic,它显得连接了基础地并且响应铜印射 kinase 信号 transduction。进一步,主要顺序看起来响应外长的刺激在 PrPC 相关的信号 transduction 的忠实上授与 N1/C1 劈开和膜完整的相互的依赖。 | Cathryn L Haigh | 2009 | Cell Research2009，19，9： | 4 |
| 5 | Identifying the elderly at risk for malnutrition显示文摘 | Yves Guigoz Sylvie Lauque Bruno J Vellas | 2002 | Clinics in Geriatric Medicine2002，，4： | 3 |
| 6 | ESPEN Guidelines for Nutrition Screening 2002显示文摘 | J Kondrup S.P Allison M Elia B Vellas M Plauth | 2003 | Clinical Nutrition2003，，4： | 2 |
| 7 | The mini nutritional assessment (MNA) and its use in grading the nutritional state of elderly patients显示文摘 | Bruno Vellas Yves Guigoz Philip J Garry Fati Nourhashemi David Bennahum Sylvie Lauque Jean-Louis Albarede | 1999 | Nutrition1999，，： | 2 |
| 8 | Sarcopenia: An Undiagnosed Condition in Older Adults. Current Consensus Definition: Prevalence, Etiology, and Consequences. International Working Group on Sarcopenia显示文摘 | Roger A. Fielding Bruno Vellas William J. Evans Shalender Bhasin John E. Morley Anne B. Newman Gabor Abellan van Kan Sandrine Andrieu Juergen Bauer Denis Breuille Tommy Cederholm Julie Chandler Capucine De Meynard Lorenzo Donini Tamara Harris Aimo Kannt F | 2011 | Journal of the American Medical Directors Association2011，，4： | 2 |
| 9 | Cyclin B1 and other cyclins as tumor antigens in immunosurveillance and immunotherapy of cancer显示文摘 | Egloff AM Vella LA Finn OJ | 2006 | Cancer Res2006，66，： | 1 |
| 10 | Architecture of a validated microRNA: target interaction显示文摘 | Vella MC Reinert K Slack FJ | 2004 | Chem Biol2004，11，12： | 1 |
| 11 | Gender Roles and Human Capital Investment:The Relationship between Traditional Attitudes and Female Labour Market Performance 显示文摘 | Francis Vella | 1994 | Economica1994，61，242： | 1 |
| 12 | Assessing the nutritional status of the elderly The mini nutritional assessment as part of the geriatric evaluation显示文摘 | Guigoz Y Vellas B Garry P J | 1996 | Nutr Rev1996，54，12： | 1 |
| 13 | Urinary incontinence in the female patient显示文摘 | Vella M Cardozo L | 2005 | Practitioner2005，249，： | 1 |
| 14 | Bladder pheochromocytoma:a 3-year follow-up after transurethral resection(TURB)显示文摘 | Baima C Casetta G Vella R | | 0，，： | 1 |
| 15 | Interleukin4 stimulates papillary thy- roid cancer cell survival : implications in patients with thyroid cancer and concomitant Graves' disease 显示文摘 | Vella V Mineo R Frasca F | 2004 | J Clin Endocrinal Metal~2004，89，6： | 1 |
| 16 | MALDI-TOF mass spectrometry in the clinical mycology laboratory: identification of fungi and beyond 显示文摘 | Posteraro B1 De Carolis E Vella A et ol | 2013 | Expert Rev Proteomics2013，10，2： | 1 |
| 17 | Bladder pheochromocytoma: a 3-year follow-up after transurethral resection (TURB)显示文摘 | Baima C Casetta G Vella R | 2000 | Urol Int2000，65，3： | 1 |
| 18 | Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men显示文摘 | John E. Morley Fran E. Kaiser Horace M. Perry Ping Patrick Patricia M.K. Morley Patricia M. Stauber Bruno Vellas Richard N. Baumgartner Phillip J. Garry | 1997 | Metabolism1997，，： | 1 |
| 19 | Strontium ranelate reduces the risk of vertebral and nonvertebral fractures in women eighty years of age and older显示文摘 | Seeman E Vellas B Benhamou C | 2006 | J Bone Miner Res2006，21，7： | 1 |
| 20 | Nonparametric estimation of triangular simultaneous equations models 显示文摘 | Whitney K Newey James L Powell Francis Vella | 1999 | Econometrica1999，67，3： | 1 |
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