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| 1 | Aquaporins:Their role in cholestatic liver disease显示文摘This review focuses on current knowledge on hepato-cyte aquaporins(AQPs)and their significance in bile formation and cholestasis.Canalicular bile secretion results from a combined interaction of several solute transporters and AQP water channels that facilitate water flow in response to the osmotic gradients created. During choleresis,hepatocytes rapidly increase their canalicular membrane water permeability by modulating the abundance of AQP8.The question was raised as to whether the opposite process,i.e.a decreased canalicular AQP8 expression would contribute to the development of cholestasis.Studies in several experimental models of cholestasis,such as extrahepatic obstructive cholestasis,estrogen-induced cholestasis, and sepsis-induced cholestasis demonstrated that the protein expression of hepatocyte AQP8 was impaired. In addition,biophysical studies in canalicular plasma membranes revealed decreased water permeability associated with AQP8 protein downregulation.The combined alteration in hepatocyte solute transporters and AQP8 would hamper the efficient coupling of osmotic gradients and canalicular water flow.Thus cholestasis may result from a mutual occurrence of impaired solute transport and decreased water permeability. | Guillermo L Lehmann Maria C Larocca Leandro R Soria Raúl A Marinelli | 2008 | World Journal of Gastroenterology2008，14，46： | 8 |
| 2 | Intestinal obstruction caused by torsed gangrenous Meckel's diverticulum encircling terminal ileum显示文摘Meckel's diverticulum(MD)is considered the most prevalent congenital anomaly of the gastrointestinal tract. It may result in a number of complications including hemorrhage,obstruction,and inflammation.Obstruction of various types is the most common presenting symptom in the adult population.Loop formations with the end of an MD and adjacent mesentery constricting the distal ileum is an uncommon cause of obstruction. Axial torsion and gangrene of MD is the rarest of the complications.The correct diagnosis of complicated MD before surgery is often difficult because this condition may mimic other acute abdominal pathologies.Delay in the diagnosis of a complicated MD can lead to signifi- cant morbidity and mortality.Here we describe the case of a patient with a very rare form of acute small bowel obstruction secondary to giant torsed gangrenous MD encircling the terminal ileum.To our knowledge, this co-occurrence of axial torsion and a loop-forming mechanism of obstruction has been reported only once in English medical literature. | Carmine Cartanese Tommaso Petitti Ernesto Marinelli Antonio Pignatelli Davide Martignetti Matteo Zuccarino Lucio Ferrozzi | 2011 | World Journal of Gastrointestinal Surgery2011，3，7： | 7 |
| 3 | Colonic stenting versus emergency surgery for acute left-sided malignant colonic obstruction: a multicentre randomised trial显示文摘 | Jeanin E van Hooft Willem A Bemelman Bas Oldenburg Andreas W Marinelli Martijn F Lutke Holzik Marina J Grubben Mirjam A Sprangers Marcel G Dijkgraaf Paul Fockens | 2011 | Lancet Oncology2011，，4： | 3 |
| 4 | Rare genera of actinomycetes as potential producers of new antibiotics显示文摘 | Ameriga Lazzarini Linda Cavaletti Giorgio Toppo Flavia Marinelli | 2000 | Antonie van Leeuwenhoek (-)2000，，3： | 3 |
| 5 | Adherence to AASLD guidelines for the treatment of hepatocellular carcinoma in clinical practice: Experience of the Bologna Liver Oncology Group显示文摘 | Simona Leoni Fabio Piscaglia Ilaria Serio Eleonora Terzi Irene Pettinari Luca Croci Sara Marinelli Francesca Benevento Rita Golfieri Luigi Bolondi | 2014 | Digestive and Liver Disease2014，，： | 2 |
| 6 | Coronal plane deformity around the knee in the skeletally immature population:A review of principles of evaluation and treatment显示文摘Coronal plane deformity around the knee,also known as genu varum or genu valgum,is a common finding in clinical practice for pediatricians and orthopedists.These deformities can be physiological or pathological.If untreated,pathological deformities can lead to abnormal joint loading and a consequent risk of premature osteoarthritis.The aim of this review is to provide a framework for the diagnosis and management of genu varum and genu valgum in skeletally immature patients. | Valentino Coppa Mario Marinelli Roberto Procaccini Danya Falcioni Luca Farinelli Antonio Gigante | 2022 | World Journal of Orthopedics2022，13，5： | 2 |
| 7 | A Lagrangian heuristic for satellite range scheduling with resource constraints显示文摘 | Fabrizio Marinelli Salvatore Nocella Fabrizio Rossi Stefano Smriglio | 2011 | Computers and Operations Research2011，，11： | 2 |
| 8 | Early closure of a multicenter randomized clinical trial of endoscopic stenting versus surgery for stage IV left-sided colorectal cancer显示文摘 | J. van Hooft P. Fockens A. Marinelli R. Timmer A. van Berkel P. Bossuyt W. Bemelman | 2008 | Endoscopy2008，，03： | 2 |
| 9 | 神经生长因子增强小胶质细胞的神经保护作用显示文摘小胶质细胞是脑组织内的防御细胞,但在病理和生理条件下,调控小胶质细胞活化的因子并不十分清楚。本研究发现,神经生长因子(NGF)可以增强小胶质细胞的神经保护和抗炎功能。在体内和体外研究中都发现,小胶质细胞表达NGF受体。原代培养小胶质细胞,给予NGF处理,转录本分析结果显示,NGF对小胶质细胞的运动、吞噬和降解吞噬物的能力均产生影响。对功能的研究显示,NGF可增加小胶质细胞的膜运动能力和胞饮作用;在体研究显示,NGF可激活小胶质细胞释放向外整流电流,调节周围谷氨酸能神经元的神经传递。既往研究提示,小胶质细胞有清除脑内Aβ肽的功能,本研究观察了NGF对小胶质细胞吞噬能力的影响。结果显示,NGF可促进小胶质细胞通过Trk A途径清除Aβ,并加速其降解。此外,NGF还可减轻由Aβ导致的炎症激活。特异性激活小胶质细胞还可以减轻由Aβ导致的神经元树突损伤和长时程增强抑制。在对离体脑片的研究中,我们也发现NGF可以促进小胶质细胞吞噬Aβ。综上所述,本研究证实NGF可以促进小胶质细胞活化,活化的小胶质细胞通过抗炎作用减轻Aβ聚集,发挥神经保护作用。 | 唐颖馨 Rizzi C Tiberi A Giustizieri M Marrone MC Gobbo F Carucci NM Meli G Arisi I D'Onofrio M Marinelli S Capsoni S Cattaneo A | 2018 | 神经损伤与功能重建2018，13，2： | 2 |
| 10 | Patients'Knowledge, Attitudes, and Behavior Toward Hospital-associated Infections in Italy显示文摘 | Abbate R Di Giuseppe G Marinelli E | 2008 | Am J Infect Control2008，36，1： | 1 |
| 11 | Binuclear Diorganotin ( IV ) Complexes with Bis ( O, O'-4-acyl-5-pyrazolonato ) bis (bidentate) Ligands 显示文摘 | Effendy Marchetti F Marinelli A | 2011 | Inorg Chem Acta2011，366，： | 1 |
| 12 | Biotrans- formations of cinnamic and ferulic acid with Actinomycetes显示文摘 | Brunati M Marinelli F Bertolini C | 2004 | Enzyme and Microbial Technology2004，34，1： | 1 |
| 13 | Secretin induces the apical insertion of aquaporin-1 water channels in rat cholangiocytes显示文摘 | Marinelli RA Tietz PS Pham LD | 1999 | Am J Physiol1999，276，： | 1 |
| 14 | Clinical outcome of closed isolated subtalar dislocations显示文摘 | de Palma L Santucci A Marinelli M | 2008 | Arch Orthop Trauma Surg2008，128，6： | 1 |
| 15 | Antimycins, inhibitors ofATP-citrate lyase, from a Streptomyces sp显示文摘 | Barrow C J Oleynek J J Marinelli V | 1997 | J Antibiot1997，50，9： | 1 |
| 16 | Pursuing aldose reductase inhibitors through in situ cross-docking and similarity-based virtual screening 显示文摘 | Cosconati S Marinelli L La Motta C | 2009 | J Med Chem2009，52，18： | 1 |
| 17 | On the nature of mycobacteriophage diversity and host preference显示文摘 | Jacobs-seca D Marinelli L J Bowman C | 2012 | Virology2012，434，2： | 1 |
| 18 | Organic thin filmtransistors as plastic chiral sensors 显示文摘 | TORSI L FARrNOLA G MARINELLI F | 2008 | Sensors IEEE2008，，： | 1 |
| 19 | Water transport by epithelia of the digestive tract显示文摘 | Masyuk AI Marinelli RA LaRusso NF | 2002 | Gastroenterology2002，122，2： | 1 |
| 20 | T2 relaxation times correlated with stage of lumbar intervertebral disk degeneration and patient age 显示文摘 | Marinelli N L Haughton V M Anderson P A | 2010 | AJNR Am J Neuroradiol2010，31，7： | 1 |
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