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| 1 | phytoestrogens/insoluble fibers and colonic estrogen receptor β: randomized, double-blind, placebo-controlled study显示文摘AIM:To assess the safety and effect of the supplementation of a patented blend of dietary phytoestrogens and insoluble fibers on estrogen receptor (ER)-β and biological parameters in sporadic colonic adenomas. METHODS:A randomized, double-blind placebo-controlled trial was performed. Patients scheduled to undergo surveillance colonoscopy for previous sporadic colonic adenomas were identified, and 60 eligible patients were randomized to placebo or active dietary intervention (ADI) twice a day, for 60 d before surveillance colonoscopy. ADI was a mixture of 175 mg milk thistle extract, 20 mg secoisolariciresinol and 750 mg oat fiber extract. ER-β and ER-α expression, apoptosis and proliferation (Ki-67 LI) were assessed in colon samples. RESULTS:No adverse event related to ADI was recorded. ADI administration showed a significant increases in ER-β protein (0.822 ± 0.08 vs 0.768 ± 0.10, P = 0.04) and a general trend to an increase in ER-β LI (39.222 ± 2.69vs 37.708 ± 5.31,P = 0.06), ER-β/ER-α LI ratio (6.564 ± 10.04 vs 2.437 ± 1.53, P = 0.06), terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (35.592 ± 14.97 vs 31.541 ± 11.54, P = 0.07) and Ki-67 (53.923 ± 20.91 vs 44.833 ± 10.38, P = 0.07) approximating statistical significance. A significant increase of ER-β protein (0.805 ± 0.13 vs 0.773 ± 0.13,P = 0.04), mRNA (2.278 ± 1.19vs 1.105 ± 1.07, P < 0.02) and LI (47.533 ± 15.47 vs 34.875 ± 16.67,P < 0.05) and a decrease of ER-α protein (0.423 ± 0.06vs 0.532 ± 0.11,P < 0.02) as well as a trend to increase of ER-β/ER-α protein in ADI vs placebo group were observed in patients without polyps (1.734 ± 0.20 vs 1.571 ± 0.42, P = 0.07). CONCLUSION:The role of ER-β on the control of apoptosis, and its amenability to dietary intervention, are supported in our study. | Mariabeatrice Principi Alfredo Di Leo Maria Pricci Maria Principia Scavo Raffaella Guido Sabina Tanzi Domenico Piscitelli Antonio Pisani Enzo Ierardi Maria Cristina Comelli Michele Barone | 2013 | World Journal of Gastroenterology2013，19，27： | 3 |
| 2 | Estrogen receptors expression in long-lasting ulcerative pancolitis with and without dysplasia: A preliminary report显示文摘 | Mariabeatrice Principi Nicola De Tullio Maria Principia Scavo Domenico Piscitelli Andrea Marzullo Silvana Russo Francesca Albano Katia Lofano Samanta Papagni Michele Barone Enzo Ierardi Alfredo Di Leo | 2012 | Scandinavian Journal of Gastroenterology2012，，10： | 2 |
| 3 | Evolution of nonspecific duodenal lymphocytosis over 2 years of follow-up显示文摘AIM: To assess the evolution of duodenal lymphocytosis(DL), a condition characterized by increased intraepithelial lymphocytes(IELs), over 2 years of follow-up.METHODS: Consecutive patients undergoing upper endoscopy/histology for abdominal pain, diarrhea, weight loss, weakness or other extraintestinal features compatible with celiac disease(CD) were included. Evaluation of IELs infiltrate in duodenal biopsy sampleswas carried out by CD3-immunohistochemistry and expressed as number of positive cells/100 enterocytes. Diagnostic agreement on the IELs count was tested by calculating the weighted k coefficient. All patients underwent serological detection of autoantibodies associated with CD: Ig G and Ig A anti-tissue transglutaminase and endomysium. Each patient underwent further investigations to clarify the origin of DL at baseline and/or in the course of 2 years of follow-up every six months. Autoimmune thyroiditis, intestinal infections, parasitic diseases, bacterial intestinal overgrowth, hypolactasia and wheat allergy were detected. Colonoscopy and enteric magnetic resonance i m a g i n g w e r e p e r f o r m e d w h e n n e c e s s a r y. R i s k factors affecting the final diagnosis were detected by multinomial logistic regression and expressed as OR.RESULTS: Eighty-five patients(16 males, 69 females, aged 34.1 ± 12.5 years) were followed up for a mean period of 21.7 ± 11.7 mo. At baseline, endoscopy/duodenal biopsy, CD3 immunohistochemistry revealed: > 25 IELs/100 enterocytes in 22 subjects, 15-25 IELs in 37 and < 15 IELs in 26. They all had negative serum anti-transglutaminase and anti-endomysium, whilst 5 showed Ig G anti-gliadin positivity. In the course of follow-up, 23 developed CD seropositivity and gluten sensitivity(GS) was identified in 19. Other diagnoses were: 5 Helicobacter pylori infections, 4 jejunal Crohn's disease, 1 lymphocytic colitis and 1 systemic sclerosis. The disease in the remaining 32 patients was classified as irritable bowel syndrome because of the lack of diagnostic evidence. At multivariate analysis, the evolution towards CD was associated with an IELs infiltrate > 25(OR = 1640.4) or 15-25(OR = 16.95), human leukocyte antigen(HLA) DQ2/8(OR = 140.85) or DQA1*0501(OR = 15.36), diarrhea(OR = 5.56) and weakness(OR = 11.57). GS was associated with IELs 15-25(OR = 28.59), autoimmune thyroiditis(OR = 87.63), folate deficiency(OR = 48.53) and diarrhea(OR = 54.87).CONCLUSION: DL may have a multifactorial origin but the IELs infiltrate and HLA are strong predictive factors for CD development and a clinical diagnosis of GS. | Giuseppe Losurdo Domenico Piscitelli Antonio Giangaspero Mariabeatrice Principi Francesca Buffelli Floriana Giorgio Lucia Montenegro Claudia Sorrentino Annacinzia Amoruso Enzo Ierardi Alfredo Di Leo | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 4 | Ten years of hip fractures in Italy: For the first time a decreasing trend in elderly women显示文摘AIM:To evaluate the hospitalization rate of femoralneck fractures in the elderly Italian population over ten years.METHODS:We analyzed national hospitalizations records collected at central level by the Ministry of Health from 2000 to 2009.Age-and sex-specific rates of fractures occurred at femoral neck in people≥65 years old.We performed a sub-analysis over a three-year period(2007-2009),presenting data per five-year age groups,in order to evaluate the incidence of the hip fracture in the oldest population.RESULTS:We estimated a total of 839008 hospitalizations due to femoral neck fractures between 2000 and2009 in people≥65,with an overall increase of 29.8%over 10 years.The incidence per 10000 inhabitants remarkably increased in people≥75,passing from158.5 to 166.8(+5.2%)and from 72.6 to 77.5(+6.8%)over the ten-year period in women and men,respectively.The oldest age group(people>85 years old)accounted for more than 42%of total hospital admissions in 2009(n=39000),despite representing only 2.5%of the Italian population.Particularly,women aged>85accounted for 30.8%of total fractures,although they represented just 1.8%of the general population.The results of this analysis indicate that the incidence of hip fractures progressively increased from 2000 to 2009,but a reduction can be observed for the first time in women≤75(-7.9%between 2004 and 2009).CONCLUSION:Incidence of hip fractures in Italy are continuously increasing,although women aged 65-74years old started showing a decreasing trend. | Prisco Piscitelli Maurizio Feola Cecilia Rao Monica Celi Elena Gasbarra Cosimo Neglia Giuseppe Quarta Federico Maria Liuni Simone Parri Giovanni Iolascon Maria Luisa Brandi Alessandro Distante Umberto Tarantino | 2014 | World Journal of Orthopedics2014，5，3： | 2 |
| 5 | Intraepithelial lymphocytes: bystanders or causative factors in functional gastrointestinal disorders?显示文摘Intraepithelial lymphocytes(IELs)are immune cells located in the epithelium of the mucosal layer of the gastrointestinal tract that typically show a CD3-positive phenotype.They are T lymphocytes that are involved in the primary immune response to several luminal antigens,such as food proteins and infectious agents.For this reason,their increase may be pathogenetic in several diseases,the most important being celiac disease.However,an increase above 25 IELs/100 enterocytes in the duodenum,which is considered the cutoff value for celiac disease,may occur in several conditions,such as nonceliac gluten sensitivity,food allergy,Helicobacter pylori(H.pylori)infection,gastroenteritis,and even irritable bowel syndrome(IBS).Therefore,the generic term“microscopic enteritis”or“duodenal lymphocytosis”has been proposed for this condition. | Giuseppe Losurdo Domenico Piscitelli Enzo Ierardi Alfredo Di Leo | 2021 | Cellular & Molecular Immunology2021，18，7： | 2 |
| 6 | A data analytics-based tool for the detection and diagnosis of anomalous daily energy patterns in buildings显示文摘In this paper,a tool for the detection and diagnosis of anomalous electrical daily energy patterns relative to a transformer substation of a university campus was developed and tested.Through an innovative pattern recognition analysis consisting in a multi-step clustering process,six clusters of anomalous daily load profiles were identified and isolated in two-year historical data of total electrical energy consumption.The infrequent electrical load profiles were found to be strongly affected,in terms of both shape and magnitude,by the energy consumption behaviour related to the heating/cooling mechanical room.Then,a fault-free predictive model,which uses artificial neural network(ANN)in combination with a Regression Tree,was developed to detect anomalous trends of the electrical energy consumption.The model was able to detect the 93.7%of the anomalous profiles and only the 5%of fault-free days were wrongly predicted as anomalous.Eventually,a diagnosis phase was conceived and validated with a testing data set.A number of daily abnormal load profiles were detected and compared with the centroids of the anomalous clusters identified in the pattern-recognition stage.The work led to the development of a flexible intelligent tool useful for operating a continuous commissioning of the campus facilities. | Marco Savino Piscitelli Silvio Brandi Alfonso Capozzoli Fu Xiao | 2021 | Building Simulation2021，14，1： | 2 |
| 7 | Altered molecular pattern of mucosal healing in Crohn's disease fibrotic stenosis显示文摘AIM: To investigate tumor necrosis factor-α (TNF-α), syndecan 1 and basic fibroblast growth factor (bFGF) balance in Crohn's disease (CD) strictures. METHODS: Our study was performed on 24 surgical specimens of CD fibrotic stenosis. Ten histological normal surgical samples were retrieved for both the large and small bowel from patients with benign conditions and healthy tissue represented control collection. Sex and age in controls did not differ from CD group. Three endoscopic biopsy specimens taken after informed consent in subjects with normal colon were also used as negative controls. TNF-α, syndecan 1 and bFGF were detected by both reverse transcriptase reverse transcriptase polymerase chain reaction after mRNA extraction (results expressed as fold-change) and immunohistochemistry.RESULTS: TNF-α did not show any significant difference between CD and control specimens (1.54 ± 1.19; P > 0.05). Very high levels of bFGF were observed in CD (11.76 ± 4.65; P < 0.001) unlike syndecan 1 which showed a moderate increase (5.53 ± 2.18; P < 0.005). analysis of variance (ANOVA) plus Student-NeumannKeuls showed: bFGF > syndecan 1 > TNF-α = control. Immunoreactivity for bFGF was observed in epithelial, stromal, endothelial cells and even in the muscular layer, whilst in normal tissue it was almost unexpressed. Syndecan 1 and TNF-α staining was confined to mucosal epithelial and stromal cells, while in controls syndecan 1 was found in its normal site, i.e. , basolateral area of the crypts and TNF-α very poorly expressed. CONCLUSION: Fibrotic stenosis of CD may be the final result of an irreversible transformation of different cells into fibrogenic phenotype no longer inhibited by posttranscriptional regulation. | Enzo Ierardi Floriana Giorgio Domenico Piscitelli Mariabeatrice Principi Santina Cantatore Maria Grazia Fiore Roberta Rossi Michele Barone Alfredo Di Leo Carmine Panella | 2013 | World Journal of Gastrointestinal Pathophysiology2013，4，3： | 2 |
| 8 | Drug inter-actions in patients infected with human immunodeficien-cy virus 显示文摘 | Piscitelli S C Flexner C Minor J R | 1996 | Clin Infect Dis1996，23，4： | 1 |
| 9 | Synthetic strategies of nonpeptidic β-secretase(BACE1)inhibitors显示文摘 | Regina GL Piscitelli F Silvestri R | 2009 | J Heterocyclic Chem2009，40，29： | 1 |
| 10 | Indinavir concentrations and St John' s wort 显示文摘 | Piscitelli SC Burstein AH Chaitt D | 2000 | Lancet2000，355，： | 1 |
| 11 | Clinical pharmacology of systemic antifungal agents:a comprehensive review of agents in clinical use,current investigational compounds,and putative targets for antifungal drug development显示文摘 | Groll AH Piscitelli SC Walsh TJ | 1998 | Adv Pharmacol1998，44，7： | 1 |
| 12 | Clinical pharmacology of systemic antifungal agents:A comprehensive review of agents in clinical use,current investigational compounds,and putative targets for antifungal drug development显示文摘 | Groll AH Piscitelli SC Walsh TJ | 1998 | Adv Pharmacol1998，44，： | 1 |
| 13 | Clarithromycin and azithromycin: new macrolide antibiotics 显示文摘 | Piscitelli SC Danziger LH Rodvold KA | 1992 | Clinical Phar- macy1992，11，2： | 1 |
| 14 | Clinical pharmacology of systemic antifungal agents: a comprehensive review of agents in clinical use, current investigational compounds, and putative targets for antifungal drug development 显示文摘 | Groll AH Piscitelli SC Walsh TJ | 1998 | Adv Pharmacol1998，44，1： | 1 |
| 15 | Chromogranin A: is it a useful marker of ncuroendoerine tumors? 显示文摘 | Campana D Nori F Piscitelli L | 2007 | J Clin Oneol2007，25，15： | 1 |
| 16 | Effect of milk thistle on the pharmacokinetics of indinavir in healthy volunteers显示文摘 | Piscitelli SC Formentini E Burstein AH | 2002 | Pharmacotherapy2002，22，： | 1 |
| 17 | Clarithromycin lower plasma zidovudine levels in persons with human immunodeficiency virus infection显示文摘 | Piscitelli S C Vogel S | 1997 | Antimicrob Agents Chemother1997，41，8： | 1 |
| 18 | Socioeconomic burden of total joint arthroplasty for symptomatic hip and knee osteoarthritis in the Italian population:A 5-year analysis based on hospitalization records显示文摘 | Piscitelli P Iolascon G Di Tanna G | | 0，，： | 1 |
| 19 | Which cystography in the diagnosis and grading of vesicoureteral reflux? 显示文摘 | Piscitelli A Galiano R Serrao F | 2008 | Pediatr Nephro12008，23，1： | 1 |
| 20 | Effect of milk thistle on the pharmacokinetics of indinavir in healthy volunteers显示文摘 | Piscitelli SC Formentini E Burstein AH | 2002 | Pharm acotherapy2002，22，5： | 1 |
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