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| 1 | Chronic hepatitis C virus infection and atherosclerosis: Clinical impact and mechanisms显示文摘Hepatitis C virus(HCV)infection represents a major health issue worldwide due to its burden of chronic liver disease and extrahepatic manifestations including cardiovascular diseases,which are associated with excess mortality.Analysis of published studies supports the view that HCV infection should be considered a risk factor for the development of carotid atherosclerosis,heart failure and stroke.In contrast,findings from studies addressing coronary artery disease and HCV have yielded conflicting results.Therefore,meta-analytic reviews and prospective studies are warranted.The pathogenic mechanisms connecting HCV infection,chronic liver disease,and atherogenesis are not completely understood.However,it has been hypothesized that HCV may promote atherogenesis and its complications through several direct and indirect biological mechanisms involving HCV colonization and replication within arterial walls,liver steatosis and fibrosis,enhanced and imbalanced secretion of inflammatory cytokines,oxidative stress,endotoxemia,mixed cryoglobulinemia,perturbed cellular and humoral immunity,hyperhomocysteinemia,hypo-adiponectinaemia,insulin resistance,type 2 diabetes and other components of the metabolic syndrome.Understanding these complex mechanisms is of fundamental importance for the development of novel therapeutic approaches to prevent and to treat vascular complications in patients with chronic HCV infection.Currently,it seems that HCV clearance by interferon and ribavirin treatment significantly reduces non-liver-related mortality;moreover,interferon-based treatment appears to decrease the risk of ischemic stroke. | Luigi E Adinolfi Rosa Zampino Luciano Restivo Amedeo Lonardo Barbara Guerrera Aldo Marrone Fabio Nascimbeni Anna Florio Paola Loria | 2014 | World Journal of Gastroenterology2014，20，13： | 6 |
| 2 | Chronic HCV infection is a risk of atherosclerosis. Role of HCV and HCV-related steatosis显示文摘 | Luigi E. Adinolfi Luciano Restivo Rosa Zampino Barbara Guerrera Amedeo Lonardo Laura Ruggiero Francesco Riello Paola Loria Anna Florio | 2012 | Atherosclerosis2012，，2： | 3 |
| 3 | Dyspepsia and celiac disease: Prevalence, diagnostic tools and therapy显示文摘The prevalence of dyspepsia is up to 40% in population-based study. Functional dyspepsia is an exclusion diagnosis and it is classified as a chronic abdominal pain-related functional disorder, characterized by the presence of persistent or recurrent pain or discomfort centered in the upper abdomen, neither relief by defecation, nor association with the onset of a change in stool frequency or form. Celiac disease(CD) is a common autoimmune enteropathy, with a prevalence around 1% in the general population. Its diagnosis includes a serological screening and an upper gastrointestinal endoscopy with multiple biopsies. Gluten-free diet is the only effective treatment. CD diagnosis is often delayed in asymptomatic patients or in individuals with less clinical gastrointestinal symptoms. Several studies performed coeliac disease screening in patients with symptoms suggestive of dyspepsia, showing a biopsy-proved prevalence that ranged from 0.5% to 2%. The typical endoscopic markers of villous atrophy are not sufficiently sensitive, so some endoscopic techniques, such as 'water immersion' and confocal endomicroscopy were proposed to improve the diagnosticsensitivity and target biopsies. A recent meta-analysis estimated that the prevalence of CD was higher in patients with dyspepsia, but not in a statistically significant way. However this assumption should be confirmed further larger studies. | Laura Petrarca Raffaella Nenna Gerarda Mastrogiorgio Matteo Florio Manuela Brighi Stefano Pontone | 2014 | World Journal of Methodology2014，4，3： | 3 |
| 4 | Chronic HCV infection is a risk of atherosclerosis. Role of HCV and HCV-related steatosis显示文摘 | Luigi E. Adinolfi Luciano Restivo Rosa Zampino Barbara Guerrera Amedeo Lonardo Laura Ruggiero Francesco Riello Paola Loria Anna Florio | 2012 | Atherosclerosis2012，，2： | 2 |
| 5 | Changes in inhibins and activin secretion in healthy and pathological pregnancies显示文摘 | Florio P Cobellis L Luisi S | 2001 | Mol Cell Endocrinol2001，180，12： | 1 |
| 6 | Biochemical markers of perinatal brain damage显示文摘 | Florio P Abella R Marinoni E | 2010 | Front Biosci (Schol Ed)2010，2，： | 1 |
| 7 | Levels of maternal plasma corticotropin-releasing factor and urocortin during labor显示文摘 | Florio P Cobellis L Woodman J | 2002 | J Soc Gynecol Investig2002，9，4： | 1 |
| 8 | High maternal and fetal plasma urocortin levels in pregnancies complicated by hypertension显示文摘 | Florio P Torricolli M De Falco G | 2006 | J Hypertens2006，9，： | 1 |
| 9 | Transformer: an adaptation framework with contextual adaptation behavior composition support显示文摘 | Gui N Florio V D | 2013 | Software Practice & Experience2013，43，6： | 1 |
| 10 | Inhibins in female and male reproductive physiology:role in gametogenesis,conception,implantation and early pregnancy显示文摘 | Luisi S Florio P Reis FM | | 0，，02： | 1 |
| 11 | Surgical hysteroscopic treatmentof cesarean -induced isthmocele in restoring fertility : prospectivestudy显示文摘 | Gubbini G Centini G Florio P | 2011 | J Minim Invasive Gynecol2011，18，2： | 1 |
| 12 | Mycobacterium tuberculosis FurA autoregulates its own expression 显示文摘 | Sala C Forti F Di Florio E | 2003 | J Bacteriol2003，185，18： | 1 |
| 13 | Detection of potential fields source boundaries by enhanced horizontal derivative method 显示文摘 | Fedi M Florio G | 2001 | Geophysical pros-pecting2001，49，： | 1 |
| 14 | Amniotic fluid S100B protein in mid-gestation and intrauterine fetal death显示文摘 | Michetti F Bruschettini M | 2004 | Lancet2004，364，9430： | 1 |
| 15 | Asymmetric Monetary Policy: Empirical Evidence for Italy 显示文摘 | Florio A | 2005 | Applied Economics2005，，37： | 1 |
| 16 | In vitro susceptibility of Candida species to fiveantifungal agents in a German universityhospital assessed by the reference brothmicrodilution method and Etest显示文摘 | DE Carolis E Sanguinetti M Florio A R | 2010 | JChemother2010，22，1： | 1 |
| 17 | Immunological modulation of human cardiac mast cells显示文摘 | Marone G de Crescenzo G Florio G Granata F Dente V Genovese A | 1999 | Neurochem Res1999，24，9： | 1 |
| 18 | Activin a plasma levels at birth:an index of fetal hypoxia in preterm newborn显示文摘 | Florio P Perrone S Luisi S | 2003 | Pediatric Research2003，54，5： | 1 |
| 19 | Anabolic effects of basiciibroblast growth factor in the tibial diaphysis of ovariectomized rats 显示文摘 | Pun S Florio L Wronski T J | 2000 | Bone2000，27，2： | 1 |
| 20 | Changes in inhibins and activin secretion in healthy and pathological pregnancies 显示文摘 | Florio P Cobellis L Luisi S | 2001 | Mol Cell Endocrinol2001，180，12： | 1 |
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