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| 1 | phytoestrogens/insoluble fibers and colonic estrogen receptor β: randomized, double-blind, placebo-controlled study显示文摘AIM:To assess the safety and effect of the supplementation of a patented blend of dietary phytoestrogens and insoluble fibers on estrogen receptor (ER)-β and biological parameters in sporadic colonic adenomas. METHODS:A randomized, double-blind placebo-controlled trial was performed. Patients scheduled to undergo surveillance colonoscopy for previous sporadic colonic adenomas were identified, and 60 eligible patients were randomized to placebo or active dietary intervention (ADI) twice a day, for 60 d before surveillance colonoscopy. ADI was a mixture of 175 mg milk thistle extract, 20 mg secoisolariciresinol and 750 mg oat fiber extract. ER-β and ER-α expression, apoptosis and proliferation (Ki-67 LI) were assessed in colon samples. RESULTS:No adverse event related to ADI was recorded. ADI administration showed a significant increases in ER-β protein (0.822 ± 0.08 vs 0.768 ± 0.10, P = 0.04) and a general trend to an increase in ER-β LI (39.222 ± 2.69vs 37.708 ± 5.31,P = 0.06), ER-β/ER-α LI ratio (6.564 ± 10.04 vs 2.437 ± 1.53, P = 0.06), terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (35.592 ± 14.97 vs 31.541 ± 11.54, P = 0.07) and Ki-67 (53.923 ± 20.91 vs 44.833 ± 10.38, P = 0.07) approximating statistical significance. A significant increase of ER-β protein (0.805 ± 0.13 vs 0.773 ± 0.13,P = 0.04), mRNA (2.278 ± 1.19vs 1.105 ± 1.07, P < 0.02) and LI (47.533 ± 15.47 vs 34.875 ± 16.67,P < 0.05) and a decrease of ER-α protein (0.423 ± 0.06vs 0.532 ± 0.11,P < 0.02) as well as a trend to increase of ER-β/ER-α protein in ADI vs placebo group were observed in patients without polyps (1.734 ± 0.20 vs 1.571 ± 0.42, P = 0.07). CONCLUSION:The role of ER-β on the control of apoptosis, and its amenability to dietary intervention, are supported in our study. | Mariabeatrice Principi Alfredo Di Leo Maria Pricci Maria Principia Scavo Raffaella Guido Sabina Tanzi Domenico Piscitelli Antonio Pisani Enzo Ierardi Maria Cristina Comelli Michele Barone | 2013 | World Journal of Gastroenterology2013，19，27： | 3 |
| 2 | Estrogen receptors expression in long-lasting ulcerative pancolitis with and without dysplasia: A preliminary report显示文摘 | Mariabeatrice Principi Nicola De Tullio Maria Principia Scavo Domenico Piscitelli Andrea Marzullo Silvana Russo Francesca Albano Katia Lofano Samanta Papagni Michele Barone Enzo Ierardi Alfredo Di Leo | 2012 | Scandinavian Journal of Gastroenterology2012，，10： | 2 |
| 3 | What is the role of circulation 1GF-1 显示文摘 | Le Roith D Scavo L Butle A | 2001 | Trend Endocfinol Metab2001，12，2： | 1 |
| 4 | Apoptosis in the development of rat and human fetal lungs显示文摘 | Scavo LM Ertsey R Chapin CJ Allen L Kitterman JA | 1998 | Am J Respir Cell Mol Biol1998，18，1： | 1 |
| 5 | Fibromatosis of the breast: a clinical radiological and pathological study of 6 cases显示文摘 | Magro G Gurrera A Scavo N | 2002 | Pathologica2002，94，： | 1 |
| 6 | Estrogens, phytoestrogens and colorectal neoproliferative lesions显示文摘 | Michele Barone Sabina Tanzi Katia Lofano Maria Principia Scavo Raffaella Guido Lucia Demarinis Maria Beatrice Principi Antongiulio Bucci Alfredo Di Leo | 2008 | Genes & Nutrition2008，，1： | 1 |
| 7 | ERβ expression in normal, adenomatous and carcinomatous tissues of patients with familial adenomatous polyposis显示文摘 | Michele Barone Maria Principia Scavo Samanta Papagni Domenico Piscitelli Raffaella Guido Maria Di Lena Maria Cristina Comelli Alfredo Di Leo | 2010 | Scandinavian Journal of Gastroenterology2010，，11： | 1 |
| 8 | What is the role of circulating IGF-Ⅰ显示文摘 | Le Roith D Scavo L Butler A | 2001 | Trends Endocrinol Metab2001，12，2： | 1 |
| 9 | The sharp decline of beta estrogen receptors expression in long-lasting ulcerative-associated carcinoma显示文摘 | Mariabeatrice Principi Maria Principia Scavo Domenico Piscitelli Vincenzo Villanacci Rosa Lovero Giuseppe Losurdo Bruna Girardi Enzo Ierardi Alfredo Di Leo | 2014 | Scandinavian Journal of Gastroenterology2014，，8： | 1 |
| 10 | Isomorphic response in eruptive xanthomas显示文摘 | Scavo S Magro G Gurrera A et a! | 2004 | Dermatology2004，209，1： | 1 |
| 11 | Possible involve- nlent of androgen receptor alteratlons in hepatocarcinogenesls 显示文摘 | Barone M Margiotta M Scavo M P | 2009 | Dig Liver Dis2009，41，9： | 1 |
| 12 | High density lipoproteins downregulate basic fihroblast growth factor production and release in minimally oxidated-LDL treated smooth muscle cells 显示文摘 | Cucina A Scavo MP Muzzioli L | 2006 | Athorosclerosis2006，189，2： | 1 |
| 13 | growth factor-1 stimulates both cell growth and lipogenesis during differentiation of human mesenchymal stem cells into adipocytes显示文摘 | Scavo LM Karas M Murray M | 2004 | J Clin En docrinol Metab2004，89，： | 1 |
| 14 | Estrogens, phytoestrogens and colorectal neoproliferative lesions显示文摘 | Michele Barone Sabina Tanzi Katia Lofano Maria Principia Scavo Raffaella Guido Lucia Demarinis Maria Beatrice Principi Antongiulio Bucci Alfredo Di Leo | 2008 | Genes & Nutrition2008，，1： | 1 |
| 15 | The Use of Participative Mechanism by Large Us Cites显示文摘 | Scavo C | 1993 | Journal of Urban Affairs1993，15，1： | 1 |
| 16 | P013 The fall of estrogen receptors expression in long-lasting ulcerative-associated carcinoma显示文摘 | M. Principi M.P. Scavo D. Piscitelli V. Villanacci A. Contaldo V. Neve K. Lofano G. Piacentino N. De Tullio E. Ierardi A. Di Leo | 2013 | Journal of Crohn’s and Colitis2013，，： | 1 |
| 17 | Apoptosis in the development of rat and human fetal lungs 显示文摘 | Scavo LM Ertsey R Chapin C J | 1998 | Am J Respir Cell Mol Biol1998，18，1： | 1 |
| 18 | Effect of gonadectomy on HCC development in HBV transgenic mice 显示文摘 | Barone M Maiorano E Scavo MP | 2009 | Dig Liver Dis2009，41，2： | 1 |
| 19 | Fibromatosis of the breast:a clinical,radiological and pathological study of 6 cases显示文摘 | Magro G Gurrera A Scavo N | 2002 | Pathologica2002，94，5： | 1 |
| 20 | Angiotensin-converting enzyme activity in stools of healthy subjects and patients with celiac disease显示文摘 | C. Letizia A. Picarelli A. Ciocchis F. Giovambattista M. Greco S. Cerci A. Torsoli D. Scavo | 1996 | Digestive Diseases and Sciences1996，，11： | 1 |
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