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| 1 | Glycated hemoglobin and antidiabetic strategies as risk factors for hepatocellular carcinoma显示文摘AIM: To evaluate the relationship between glycemic control [assessed by glycated hemoglobin (HbA1c)], antidiabetic therapies and the risk of hepatocellular carcinoma (HCC).METHODS: We recruited 465 patients with HCC, 618 cases with liver cirrhosis and 490 controls with no liver disease. Among subjects with type 2 diabetes mellitus (DM2), the associations between the antidiabetic strategies and HbA1c level with HCC were determined through 2 series of multivariate logistic regression models using cirrhotic patients and controls as comparison groups. RESULTS: DM2 prevalence was 31.2% in patients with HCC, 23.2% in cirrhotic patients and 12.6% in controls (P < 0.0001). In 86% of study subjects, DM2 had been diagnosed for more than 1 year before the HCC diagnosis. HCC patients with DM2 had a 1.52.5fold increased risk of liver cancer. The HbA1c mean levels were signif icantly higher in DM2 patients with HCC than in cirrhoticand control DM2 patients. Antidiabetic treatment with metformin was more common among cirrhotic and control DM2 subjects than among cases with HCC. In both series of multivariate analyses, treatment with metformin signif icantly reduced the risk of HCC by more than 80% compared with sulphonylureas and insulin therapy. No signif icant differences were seen between sulphonylureas and insulin treatment. Elevated HbA1c levels were positively related to the risk for HCC in diabetic patients, with a 26%50% increase in risk for each 1% increase in HbA1c values.CONCLUSION: In patients with preexisting DM2, the risk of HCC is positively associated with poor chronic glycemic control and significantly decreased by metformin therapy. | Valter Donadon Massimiliano Balbi Francesca Valent Angelo Avogaro | 2010 | World Journal of Gastroenterology2010，16，24： | 15 |
| 2 | Simultaneous intraductal papillary neoplasms of the bile duct and pancreas treated with chemoradiotherapy显示文摘Some authors have suggested that intraductal papillary mucinous neoplasms of the bile duct(IPMN-B) could be the the biliary counterpart of IPMN of the pancreas(IPMN-P) since they share several clinical-pathological features.These include prominent intraductal papil-lary proliferation pattern,a gastrointestinal phenotype,frequent mucin hyper-secretion and progression to mu-cinous carcinoma.To date there are just four reported cases of patients with synchronous IPMN-B and IPMN-P all of which were treated surgically.We hereby report the case of a 76-year-old woman who was incidentally diagnosed with both an asymptomatic 3 cm bulky uid lesion obstructing the bile duct lumen,diagnosed as a malignant IPMN-B,and synchronous multiple pancreatic cystic lesions(10-13 mm) communicating with an irreg-ular Wirsung,diagnosed as branch duct IPMN-P.Since surgery was ruled-out because of the patient's age and preferences,she underwent a conservative manage-ment regimen comprising both chemotherapy and radio-therapy.This was effective in decreasing the mass size and in resolving subsequent jaundice.This is also the f irst reported case of IPMN-B successfully treated with chemoradiotherapy.Clinicians should consider medical treatment as an option in this clinical scenario,in pa-tients who may be unf it for surgery. | Roberto Valente Gabriele Capurso Paola Pierantognetti Elsa Iannicelli Matteo Piciucchi Adriana Romiti Paolo Mercantini Alberto Larghi Giulia Francesca Federici Viola Barucca Maria Falchetto Osti Emilio Di Giulio Vincenzo Ziparo Gianfranco Delle Fave | 2012 | World Journal of Gastrointestinal Oncology2012，4，2： | 13 |
| 3 | Rosuvastatin elicits KDR-dependent vasculogenic response of human placental stem cells through PI3K/AKT pathway显示文摘 | Silvia Cantoni Claudia Cavallini Francesca Bianchi Francesca Bonavita Valentina Vaccari Elena Olivi Irene Frascari Riccardo Tassinari Sabrina Valente Vincenzo Lionetti Carlo Ventura | 2011 | Pharmacological Research2011，，3： | 1 |
| 4 | SJWD14080700000148显示文摘 | Emilio Bajetta Laura Catena Nicola Fazio Sara Pusceddu Pamela Biondani Giusi Blanco Sergio Ricci Michele Aieta Francesca Pucci Monica Valente Nadia Bianco Chiara Maria Mauri Francesca Spada | 2014 | Cancer2014，，16： | 1 |
| 5 | Risk factors for fatal road traffic accidents in Udine, Italy显示文摘 | FRANCESCA Valent FLAVIO Schiava CECILIA Savonitto | 2002 | Accident Analysis & Prevention2002，34，1： | 1 |
| 6 | Prognostic Stratification of Stage IIIA pN2 Non-small Cell Lung Cancer by Hierarchical Clustering Analysis of Tissue Microarray Immunostaining Data: An Alpe Adria Thoracic Oncology Multidisciplinary Group Study (ATOM 014)显示文摘 | Francesco Grossi Riccardo Spizzo Domenico Bordo Veronica Cacitti Francesca Valent Ciro Rossetto Alessandro Follador Silvia Di Terlizzi Marianna Aita Angelo Morelli Gianpiero Fasola Clara Consiglieri Tino Ceschia Carlo A. Beltrami Ornella Belvedere | 2010 | Journal of Thoracic Oncology2010，，9： | 1 |
| 7 | Differentiation of bacterial and viral communi- ty-acquired pneumonia in children显示文摘 | Massimiliano Don Francesca Valent Matti Korpp | 2009 | Pediatrics In- ternational2009，51，1： | 1 |
| 8 | Abdominal hernias:Radiological features显示文摘Abdominal wall hernias are common diseases of the abdomen with a global incidence approximately 4%-5%. They are distinguished in external,diaphragmatic and internal hernias on the basis of their localisation.Groin hernias are the most common with a prevalence of 75%, followed by femoral(15%)and umbilical(8%).There is a higher prevalence in males(M:F,8:1).Diagnosis is usually made on physical examination.However,clinical diagnosis may be difficult,especially in patients with obesity,pain or abdominal wall scarring.In these cases, abdominal imaging may be the first clue to the correct diagnosis and to confirm suspected complications. Different imaging modalities are used:conventional radiographs or barium studies,ultrasonography and Computed Tomography.Imaging modalities can aid in the differential diagnosis of palpable abdominal wall masses and can help to define hernial contents suchas fatty tissue,bowel,other organs or fluid.This work focuses on the main radiological findings of abdominal herniations. | Francesco Lassandro Francesca Iasiello Nunzia Luisa Pizza Tullio Valente Maria Luisa Mangoni di Santo Stefano Roberto Grassi Roberto Muto | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，6： | 1 |
| 9 | Relevance of Spike/Estrogen Receptor-αinteraction for endothelial-based coagulopathy induced by SARS-CoV-2显示文摘Dear Editor,The severe coagulation syndrome in numerous organs is the major life-threatening conditions characterizing the acute infection by SARS-CoV-2.Endothelial inflammation/dysfunction,platelet hyper-reactivity,generation of neutrophil extracellular traps,promote the activation of the coagulation cascade in an infection-dependent manner.^(1) | Silvia Stella Barbieri Franca Cattani Leonardo Sandrini Magda Maria Grillo Alessandra Amendola Carmen Valente Carmine Talarico Daniela Iaconis Gabriele Turacchio Miriam Lucariello Lucia Lione Erika Salvatori Patrizia Amadio Gloria Garoffolo Mariano Maffei Francesca Galli Andrea Rosario Beccari Giuseppe Sberna Emanuele Marra Marica Zoppi Michael Michaelides Giuseppe Roscilli Luigi Aurisicchio Riccardo Bertini Marcello Allegretti Maurizio Pesce | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
| 10 | Review of recent advances in medical treatment for neuroendocrine neoplasms:somatostatin analogs and chemotherapy显示文摘Neuroendocrine neoplasms(NENs)are a heterogeneous group of rare tumours often producing high levels of hormones and causing symptoms.There are a number of different types of NENs.They usually arise as advanced and low/intermediate grade only in a minority of cases,as high grade.Treatment depends on which type and may include surgery,interventional radiology,and systemic treatment,including chemotherapy,somatostatin analogs,interferonα2b,peptide receptor radionuclide therapy,and only for pancreatic neuroendocrine tumors,molecular targeted agents,including everolimus and sunitinib.The aim of the article is to review the medical approaches with somatostatin analogs and chemotherapy.The treatment of NENs is mainly based on their biological characteristics of aggressiveness and functional features,such as symptoms and endocrine markers. | Francesca Spada Monica Valente | 2016 | Journal of Cancer Metastasis and Treatment2016，2，1： | 0 |
| 11 | Glycaemic control, antidiabetic medications and influenza vaccination coverage among patients with diabetes in Udine, Italy显示文摘Objective The objectives of this study were to estimate influenza vaccination coverage among patients with diabetes mellitus in an Italian 250000-inhabitant area in the 2017-2018 season and to assess whether glycaemic control and pharmacological treatment were associated with the likelihood of being vaccinated.Design In this cross-sectional study,we analysed anonymous health administrative databases,linked with each other at the individual patient level through a stochastic key:diabetes mellitus registry,vaccinations,drug prescriptions and laboratory database.setting The study was conducted in the catchment area of the University Hospital of Udine(‘the Udine area’),a 250000-inhabitant area in the northeast of Italy.Participants The study included all subjects included in the regional registry of patients with diabetes mellitus,living in the Udine area as of 1 October 2017.Main outcome measures Vaccination coverage in the 2017-2018 influenza season was calculated.The association between patients’characteristics and the likelihood of being vaccinated was assessed through multivariate log binomial regression.result 53.0%of 15900 patients with diabetes living in the area were vaccinated.Coverage increased with age,approaching 75%at≥85 years.Patients lacking recent glycated haemoglobin testing were less likely to be vaccinated(43.4%vaccination coverage),as were those not treated pharmacologically(44.4%vaccination coverage).Patients treated with both insulin,metformin and other antidiabetic medications were more likely to be vaccinated than those treated with metformin alone(58.1%vaccination coverage;adjusted relative risk=1.07,95%CI 1.01 to 1.14).Conclusion Influenza vaccination coverage was suboptimal in this Italian population of patients with diabetes.Strategies to improve diabetes management could in turn positively affect influenza coverage. | Francesca Valent Annarita Tullio | 2019 | Family Medicine and Community Health2019，7，3： | 0 |
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