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| 1 | phytoestrogens/insoluble fibers and colonic estrogen receptor β: randomized, double-blind, placebo-controlled study显示文摘AIM:To assess the safety and effect of the supplementation of a patented blend of dietary phytoestrogens and insoluble fibers on estrogen receptor (ER)-β and biological parameters in sporadic colonic adenomas. METHODS:A randomized, double-blind placebo-controlled trial was performed. Patients scheduled to undergo surveillance colonoscopy for previous sporadic colonic adenomas were identified, and 60 eligible patients were randomized to placebo or active dietary intervention (ADI) twice a day, for 60 d before surveillance colonoscopy. ADI was a mixture of 175 mg milk thistle extract, 20 mg secoisolariciresinol and 750 mg oat fiber extract. ER-β and ER-α expression, apoptosis and proliferation (Ki-67 LI) were assessed in colon samples. RESULTS:No adverse event related to ADI was recorded. ADI administration showed a significant increases in ER-β protein (0.822 ± 0.08 vs 0.768 ± 0.10, P = 0.04) and a general trend to an increase in ER-β LI (39.222 ± 2.69vs 37.708 ± 5.31,P = 0.06), ER-β/ER-α LI ratio (6.564 ± 10.04 vs 2.437 ± 1.53, P = 0.06), terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (35.592 ± 14.97 vs 31.541 ± 11.54, P = 0.07) and Ki-67 (53.923 ± 20.91 vs 44.833 ± 10.38, P = 0.07) approximating statistical significance. A significant increase of ER-β protein (0.805 ± 0.13 vs 0.773 ± 0.13,P = 0.04), mRNA (2.278 ± 1.19vs 1.105 ± 1.07, P < 0.02) and LI (47.533 ± 15.47 vs 34.875 ± 16.67,P < 0.05) and a decrease of ER-α protein (0.423 ± 0.06vs 0.532 ± 0.11,P < 0.02) as well as a trend to increase of ER-β/ER-α protein in ADI vs placebo group were observed in patients without polyps (1.734 ± 0.20 vs 1.571 ± 0.42, P = 0.07). CONCLUSION:The role of ER-β on the control of apoptosis, and its amenability to dietary intervention, are supported in our study. | Mariabeatrice Principi Alfredo Di Leo Maria Pricci Maria Principia Scavo Raffaella Guido Sabina Tanzi Domenico Piscitelli Antonio Pisani Enzo Ierardi Maria Cristina Comelli Michele Barone | 2013 | World Journal of Gastroenterology2013，19，27： | 3 |
| 2 | Estrogen receptors expression in long-lasting ulcerative pancolitis with and without dysplasia: A preliminary report显示文摘 | Mariabeatrice Principi Nicola De Tullio Maria Principia Scavo Domenico Piscitelli Andrea Marzullo Silvana Russo Francesca Albano Katia Lofano Samanta Papagni Michele Barone Enzo Ierardi Alfredo Di Leo | 2012 | Scandinavian Journal of Gastroenterology2012，，10： | 2 |
| 3 | Estrogens, phytoestrogens and colorectal neoproliferative lesions显示文摘 | Michele Barone Sabina Tanzi Katia Lofano Maria Principia Scavo Raffaella Guido Lucia Demarinis Maria Beatrice Principi Antongiulio Bucci Alfredo Di Leo | 2008 | Genes & Nutrition2008，，1： | 1 |
| 4 | ERβ expression in normal, adenomatous and carcinomatous tissues of patients with familial adenomatous polyposis显示文摘 | Michele Barone Maria Principia Scavo Samanta Papagni Domenico Piscitelli Raffaella Guido Maria Di Lena Maria Cristina Comelli Alfredo Di Leo | 2010 | Scandinavian Journal of Gastroenterology2010，，11： | 1 |
| 5 | The sharp decline of beta estrogen receptors expression in long-lasting ulcerative-associated carcinoma显示文摘 | Mariabeatrice Principi Maria Principia Scavo Domenico Piscitelli Vincenzo Villanacci Rosa Lovero Giuseppe Losurdo Bruna Girardi Enzo Ierardi Alfredo Di Leo | 2014 | Scandinavian Journal of Gastroenterology2014，，8： | 1 |
| 6 | Estrogens, phytoestrogens and colorectal neoproliferative lesions显示文摘 | Michele Barone Sabina Tanzi Katia Lofano Maria Principia Scavo Raffaella Guido Lucia Demarinis Maria Beatrice Principi Antongiulio Bucci Alfredo Di Leo | 2008 | Genes & Nutrition2008，，1： | 1 |
| 7 | Ellipsometric determination of permittivity in a negative index photonic crystal metamaterial显示文摘In this work,we present the first experimental evidence of negative dielectric susceptibility in a two-dimensional silicon photonic crystal(PhC)with negative refractive index behavior.In the frequency range in which the effective refractive index neff is equal to 21,the incident light couples efficiently to the guided modes in the top surface layer of the PhC metamaterial.These modes resemble surface plasmon polariton resonances.This finding was confirmed by ellipsometric measurements,demonstrating the isotropy of the PhC resonances.Such negative index PhC materials may be of use in biosensing applications. | Principia Dardano Massimo Gagliardi Ivo Rendina Stefano Cabrini Vito Mocella | 2012 | Light(Science & Applications)2012，1，1： | 1 |
| 8 | Versatile synthesis of Zn O nanowires for quantitative optical sensing of molecular biorecognition显示文摘 | Jane P Ilaria R Principia D | 2015 | Sensors and Actuators B:Chemical2015，220，： | 1 |
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