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| 1 | Gender gap in acute coronary heart disease:Myth or reality?显示文摘AIM: To investigate potential gender differences in the prevalence of cardiovascular risk factors, cardiovascular disease (CVD) management, and prognosis in acute coronary syndrome (ACS). METHODS: A systematic literature search was performed through Medline using pre-specified key words . An additional search was performed, focusing specifically on randomized controlled clinical trials in relation to therapeutic intervention and prognosis. In total, 92 relevant articles were found. RESULTS: Women with CVD tended to have more hypertension and diabetes at the time of presentation, whereas men were more likely to smoke. Coronary angiography and revascularization by percutaneous coronary intervention were performed more often in men. Women were at a greater risk of short-term mortality and complications after revascularization. Interestingly, women under 40 years presenting with ACS were athighest risk of cardiovascular death compared with men of the same age, irrespective of risk factors. This disadvantage disappeared in older age. The long-term mortality risk of ACS was similar in men and women, and even in favor of women. CONCLUSION: Mortality rates are higher among young women with ACS, but this difference tends to disappear with age, and long-term prognosis is even better among older women. | Mette Claassen Kirsten C Sybrandy Yolande E Appelman Folkert W Asselbergs | 2012 | World Journal of Cardiology2012，4，2： | 9 |
| 2 | Pharmacomicrobiomics: a novel route towards personalized medicine?显示文摘在药反应的内部个人的异质是影响病人幸福并且在社会水平上提出庞大的临床、金融的负担的一个严重问题。Pharmacogenomics 在关于药反应可变性或药毒性的对单个基因背景的影响的研究的最前线,并且最近,内脏 microbiome,也被称为第二个染色体,在这个方面作为一个重要播放器被认出了。而且, microbiome 是为由于机会改进药功效和安全操作它的作文的一个很吸引人的目标。Pharmacomicrobiomics 是调查 microbiome 变化和药反应和布置(吸收,分发,新陈代谢和排泄) 的相互影响的一个新兴的领域。在这评论,我们提供历史的概述并且在在内脏 microbiome,主人和药之间的复杂相互作用上检验当前的最先进的知识。我们主张那联合 pharmacogenomics 和 pharmacomicrobiomics 将为在个性化的药做主要进展提供一个重要基础。 | Marwah Doestzada Arnau Vich Vila Alexandra Zhernakova Debby P.Y. Koonen Rinse K. Weersma Daan J. TOUW Folkert Kuipers Cisca Wijmenga Jingyuan Fu | 2018 | Protein & Cell2018，9，5： | 7 |
| 3 | Multidisciplinary management of nonfunctional neuroendocrine tumor of the pancreas显示文摘Pancreatic neuroendocrine tumors(PNETs) are a rare and diverse group of tumors; nonfunctional(NF) PNETs account for the majority of cases. Most patients with NF-PNETs have metastatic disease at the time of presentation. A variety of treatment modalities exist, including medical, liver directed, and surgical treatments. Aggressive surgical management is associated with prolonged survival, however available data are limited by selection bias and the frequent combination of PNETs with carcinoid tumors. Although few patients with metastatic disease will be cured, application of currently available therapies in a multidisciplinary setting can lead to excellent outcomes with prolonged patient survival. | Ian W Folkert Paul Hernandez Robert E Roses | 2016 | World Journal of Gastroenterology2016，22，11： | 6 |
| 4 | Emerging roles of the intestine in control of cholesterol metabolism显示文摘The liver is considered the major “control center” for maintenance of whole body cholesterol homeostasis. This organ is the main site for de novo cholesterol synthesis, clears cholesterol-containing chylomicron remnants and low density lipoprotein particles from plasma and is the major contributor to high density lipoprotein (HDL; good cholesterol) formation. The liver has a central position in the classical definition of the reverse cholesterol transport pathway by taking up periphery-derived cholesterol from lipoprotein particles followed by conversion into bile acids or its direct secretion into bile for eventual removal via the feces. During the past couple of years, however, an additional important role of the intestine in maintenance of cholesterol homeostasis and regulation of plasma cholesterol levels has become apparent. Firstly, molecular mechanisms of cholesterol absorption have been elucidated and novel pharmacological compounds have been identified that interfere with the process and positively impact plasma cholesterol levels. Secondly, it is now evident that the intestine itself contributes to fecal neutral sterol loss as a cholesterol-secreting organ. Finally, very recent work has unequivocally demonstrated that the intestine contributes significantly to plasma HDL cholesterol levels. Thus, the intestine is a potential target for novel anti-atherosclerotic treatment strategies that, in addition to interference with cholesterol absorption, modulate direct cholesterol excretion and plasma HDL cholesterol levels. | Janine K Kruit Albert K Groen Theo J van Berkel Folkert Kuipers | 2006 | World Journal of Gastroenterology2006，12，40： | 4 |
| 5 | Complexity, Accuracy, and Fluency in Second Language Acquisition显示文摘 | Alex Housen Folkert Kuiken | 2009 | Applied Linguistics2009，，4： | 2 |
| 6 | THE PREDICTIVE VALUE OF DONOR LIVER BIOPSIES FOR THE DEVELOPMENT OF PRIMARY NONFUNCTION AFTER ORTHOTOPIC LIVER TRANSPLANTATION显示文摘 | ANTHONY M. D?ALESSANDRO MUNCI KALAYOGLU HANS W. SOLLINGER ROBERT M. HOFFMANN ALAN REED STUART J. KNECHTLE JOHN D. PIRSCH GHOLAM R. HAFEZ DAVID LORENTZEN FOLKERT O. BELZER | 1991 | Transplantation1991，，1： | 2 |
| 7 | Delayed Left Ventricular Untwisting in Hypertrophic Cardiomyopathy显示文摘 | Bas M. van Dalen Floris Kauer Michelle Michels Osama I.I. Soliman Wim B. Vletter Heleen B. van der Zwaan Folkert J. ten Cate Marcel L. Geleijnse | 2009 | Journal of the American Society of Echocardiography2009，，12： | 2 |
| 8 | Left ventricular twist and untwist in aortic stenosis显示文摘 | Bas M. van Dalen Apostolos Tzikas Osama I.I. Soliman Floris Kauer Helena J. Heuvelman Wim B. Vletter Folkert J. ten Cate Marcel L. Geleijnse | 2009 | International Journal of Cardiology2009，，3： | 2 |
| 9 | Two types of luminescence from Pb^2+ in alkaline-earth carbonates with the aragonite structure显示文摘 | FOLKERTS H F BLASSE G | 1995 | Journal of Physics Chemical Solids1995，57，3： | 1 |
| 10 | Different types of s^2 ion luminescence in compounds with eulytite structure显示文摘 | FOLKERTS H F ZUIDEMA J BLASSE G | 1996 | Chemical Physics Letters1996，249，： | 1 |
| 11 | Altered bile composition after liver transplantation is associated with the development of nonanastomotic biliary strictures显示文摘 | Carlijn I. Buis Erwin Geuken Dorien S. Visser Folkert Kuipers Elizabeth B. Haagsma Henkjan J. Verkade Robert J. Porte | 2008 | Journal of Hepatology2008，，1： | 1 |
| 12 | Apocynin inhibits peroxynitrite formation by murine macrophages 显示文摘 | Muijsers R B R van Den Worm E Folkerts G | 2000 | British journal of pharmacology2000，130，4： | 1 |
| 13 | Monoclonal origin of primary unilateral multifocal pleomorphic adenoma of the parotid gland显示文摘 | Sylvia L. van Egmond Wendy W.J. de Leng Folkert H.M. Morsink G.Johan A. Offerhaus Lodewijk A.A. Brosens | 2012 | Human Pathology2012，，： | 1 |
| 14 | Airway hyperresponsiveness: first eosinophils and then neuropeptides显示文摘 | Kraneveld AD Folkerts G Van Oosterhout AJ | 1997 | Int J Immunopharmacol1997，19，910： | 1 |
| 15 | Mycobacteria, genes and the ‘ hygiene hypothesis' 显示文摘 | Smit JJ Folkerts G Nijkamp FP | 2004 | Curr Opin Allergy Clin Immunol2004，4，1： | 1 |
| 16 | The luminescence of Pb^2+ in alkaline earth sulfates显示文摘 | FOLKERTS H F HAMSTRA M A BLASSE G | 1995 | Chemical Physics Letters1995，246，： | 1 |
| 17 | Peroxynitrite:A Tow-Faced Metabolite of Nitric Oxide显示文摘 | Muijsers R B R Folkerts G Henricks P A J | 1997 | Life Sciences1997，60，： | 1 |
| 18 | Transcriptional Activation of Apolipoprotein CIII Expression by Glucose May Contribute to Diabetic Dyslipidemia显示文摘 | Sandrine Caron An Verrijken Ilse Mertens Carolina Huaman Samanez Gisèle Mautino Joel T. Haas Daniel Duran-Sandoval Janne Prawitt Sven Francque Emmanuelle Vallez Anne Muhr-Tailleux Isabelle Berard Folkert Kuipers Jan A. Kuivenhoven Sudha B. Biddinger Marja | 2011 | Arteriosclerosis Thrombosis and Vascular Biology2011，，3： | 1 |
| 19 | Assessment of subclinical atherosclerosis using contrast-enhanced ultrasound显示文摘 | Stijn C.H. van den Oord Gerrit L. ten Kate Zeynettin Akkus Guillaume Renaud Eric J.G. Sijbrands Folkert J. ten Cate Aad van der Lugt Johan G. Bosch Nico de Jong Antonius F.W. van der Steen Arend F.L. Schinkel | 2013 | European Heart Journal – Cardiovascular Imaging2013，，1： | 1 |
| 20 | Structure and function of higher plant mito- chondrial genome显示文摘 | Hanson M R Folkerts O | 1992 | International review of cytology1992，141，： | 1 |
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