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| 1 | 微型无人机低空变量喷药系统设计与雾滴沉积规律研究显示文摘针对我国施药机械和农药使用技术严重落后带来的农药用量大、资源有效利用率低、农作物产量和品质下降等问题,设计了微型无人机脉宽调制型变量喷药系统,并利用风洞的可控多风速环境,通过荧光粉测试方法对悬停无人机变量喷药的雾滴沉积规律进行了试验研究。变量喷药系统由地面测控单元和机载喷施系统两部分组成,基于Lab Windows/CVI的地面测控软件,采用频率为10 Hz、占空比可调的脉冲信号经无线数传模块远程控制机载喷施系统;机载喷施系统以ARM Cortex-M3系列的STM32F103VC微处理器为核心,接收地面控制信号实时调节电动隔膜泵电动机转速,以改变系统喷雾压力和喷药量,实现变量喷雾调节。悬停风洞试验中,选择了PWM占空比、喷孔直径、电动离心喷头转速等变量,对不同距离和风速条件下雾滴沉积效果进行了试验研究。试验结果表明,风速是影响雾滴沉积效果的最显著因素,雾滴沉积以抛物线形式分布在采集区域,沉积高峰区随风速增加不仅远离喷头,且飘移沉积量逐渐减少;雾滴粒径在风速小于3 m/s时对沉积效果影响不显著,当风速大于3 m/s时,不同粒径的雾滴均发生飘移,飘移沉积量明显减少且沉积范围向远离喷头运动;粒径101.74μm的雾滴更易发生飘移,沉积高峰区集中在距离喷头4 m以外,且飘移沉积量明显低于粒径164.00μm与228.16μm的雾滴。 | 王玲 兰玉彬 WClint Hoffmann Bradley KFritz 陈度 王书茂 | 2016 | 农业机械学报2016，47，1： | 74 |
| 2 | 应用组织追踪法评价左室功能的研究显示文摘目的 用超声心动图组织追踪法评价左室功能。方法 对 90例具有不同左室收缩功能患者的心尖四腔心、心尖长轴和心尖二腔心切面 ,用组织追踪法和M型超声心动图法记录收缩期二尖瓣瓣环向心尖方向的运动位移。所有患者均用Simpson方法确定左室射血分数 ,其中 2 7例患者又做了左室造影。 结果 在 5 0例患者中 (包括 2 5例正常左室功能患者和 2 5例左室整体功能减退患者 ) ,组织追踪法从二尖瓣环的 6个位置测得的收缩期平均二尖瓣瓣环距离与M型测得的值非常接近 (r =0 .99,P <0 .0 0 1) ,与左室射血分数的相关性很匹配 (r =0 .97,P <0 .0 0 1)。用组织追踪法测定的收缩期二尖瓣瓣环下移距离 4.8mm作为一个切断点的值(cut ofvalue) ,预测左室射血分数≤ 30 %的敏感性为 98%,特异性为 78%。但在陈旧性心肌梗死患者中 ,组织追踪法从二尖瓣瓣环的 6个位置测得的收缩期平均二尖瓣瓣环下移的距离与左室射血分数的相关性是较低的 (r= 0 .87,P <0 .0 0 1)。结论 组织追踪法测收缩期二尖瓣瓣环下移距离可为临床提供一种简单快速和无创伤性评价左室功能的方法。 | 潘翠珍 舒先红 陈灏珠 Rainer Hoffmann Peter Hanrath | 2001 | 中华超声影像学杂志2001，10，12： | 58 |
| 3 | 北京石景山工业区附近一个污染土壤剖面的磁学研究显示文摘对北京西郊石景山工业区附近的土壤剖面进行环境磁学研究,结合粒度、金属元素分析、磁学指标测试和多元统计分析,发现磁参数(χ,ARM,SIRM)与重金属元素(Mn,Cu,Fe,Pb,Zn,Al,Sr)含量呈同步垂向变化趋势.来源于工业区附近工业生产排放(钢铁厂、发电厂、水泥厂)的污染物是土壤剖面上部(0-3cm)磁性和金属含量增强的主要原因,由富集在细粉砂和中粉砂的多畴磁铁矿主导了样品的磁性特征.3—10cm重金属含量逐渐下降,土壤的磁性特征与上层相似,但磁性矿物含量降低,属于剖面中的迁移过渡阶段.10cm以下,土壤基本未受到污染,磁性矿物和重金属含量都低,磁性颗粒大小变化稳定,基本代表了该地区土壤的自然背景.指标聚类和相关分析表明,土壤磁参数与重金属元素含量显著相关.结合模糊聚类分析,磁参数可用于追踪、识别工业污染物质在土壤剖面中的富集、迁移状态,揭示不同深度土壤的污染程度. | 沈明洁 胡守云 U. Blaha 闫海涛 W. Rsler V. Hoffmann | 2006 | 地球物理学报2006，49，6： | 44 |
| 4 | Hepatic steatosis is associated with an increased risk of carotid atherosclerosis显示文摘AIM: Although an association between helatic steatosis and vascular risk factors has been described, direct relationships between fatty liver and atherosclerosis have not yet been investigated. The aim of the present study has been to investigate those relationships.METHODS: The Study of Health in Pomerania examined a random population sample aged between 20 and 79 years.A study population of 4 222 subjects without hepatitis B and C infections and without liver cirrhosis was available for the present analysis. Hepatic steatosis was defined sonographically and intima-media thickness (IMT) as well as plaque prevalence were estimated by carotid ultrasound.RESULTS: The prevalence rate of hepatic steatosis was 29.9%. Among subjects aged ≥45 years, an association between hepatic steatosis and IMT of the carotid arteries was found in bivariate analysis, but not after adjustment for atherosclerotic risk factors. Individuals with fatty liver had more often carotid plaques than persons without fatty liver (plaque prevalence rate 76.8% vs 66.6%; P<0.001).This association persisted after adjustment for confounding factors and was predominantly present in subjects with no to mild alcohol consumption.CONCLUSION: There is an independent association between hepatic steatosis and carotid atherosclerotic plaques. Metabolic changes due to nonalcoholic fatty liver disease may explain this relationship. | Henry V(o|¨)lzke Daniel M.Robinson Volker Kleine Roland Deutscher Wolfgang Hoffmann Jan Lüdemann Ulf Schminke Christof Kessler Ulrich John | 2005 | World Journal of Gastroenterology2005，11，12： | 29 |
| 5 | Development of a PWM Precision Spraying Controller for Unmanned Aerial Vehicles显示文摘This paper presents a new Pulse Width Modulation (PWM) controller for Unmanned Aerial Vehicle (UAV) precisionsprayer for agriculture using a TL494 fixed-frequency pulse width modulator together with a data acquisition board and developedsoftware. An UAV can be remotely controlled or flown autonomously by pre-programmed flight plans. The PWMcontroller was implemented through the guidance system on the UAV with control commands sent between the UAV helicopterand the ground control station via a wireless telemetry system. The PWM controller was tested and validated using LabVIEW8.2. Several analyses were performed in a laboratory to test different control signals. The results show that the PWM controllerhas promise as a higher precision technique for spray applications, which will improve efficiency of pesticide application,especially in crop production areas. | W.Clint Hoffmann Brad Fritz | 2010 | Journal of Bionic Engineering2010，7，3： | 27 |
| 6 | 组织追踪法快速而精确评价心梗患者左室功能显示文摘目的 :本研究旨在用一种新的超声心动图技术—组织追踪法评价心梗患者左室节段收缩功能。方法 :我们研究 4 0例陈旧性心梗患者和 2 5例左室收缩功能正常对照组 ,在心尖四腔心、三腔心和二腔心切面 ,用组织追踪法和 M型超声心动图法记录收缩期二尖瓣瓣环向心尖方向的运动位移。所有患者均用 Simpson s方法确定左室射血分数 ,其中 2 7例患者又做了对比造影。结果 :在陈旧性心梗患者中 ,组织追踪法从二尖瓣瓣环的 6个位置测得的收缩期平均二尖瓣瓣环下移的距离与 M- mode测得的距离相关性很匹配 (r=0 .98,P<0 .0 0 1) ,与左室射血分数的相关性很好 (r=0 .87,P<0 .0 0 1)。陈旧性心梗节段收缩减退患者与正常左室收缩功能患者的比较 ,收缩期二尖瓣瓣环下移距离在 6个位置都是有意义地减少 ,而且收缩期二尖瓣瓣环下移距离在 6个位置之间有较大的异质性。结论 :组织追踪法测收缩期二尖瓣瓣环下移距离为临床提供了一种简单的。 | 潘翠珍 Rainer Hoffmann Peter Hanrath 舒先红 陈灏珠 | 2002 | 中国超声医学杂志2002，18，2： | 22 |
| 7 | Development and prospect of unmanned aerial vehicle technologies for agricultural production management显示文摘Unmanned aerial vehicles have been developed and applied to support agricultural production management.Compared with piloted aircraft,an Unmanned Aerial Vehicle(UAV)can focus on small crop fields at lower flight altitudes than regular aircraft to perform site-specific farm management with higher precision.They can also“fill in the gap”in locations where fixed winged or rotary winged aircraft are not readily available.In agriculture,UAVs have primarily been developed and used for remote sensing and application of crop production and protection materials.Application of fertilizers and chemicals is frequently needed at specific times and locations for site-specific management.Routine monitoring of crop plant health is often required at very high resolution for accurate site-specific management as well.This paper presents an overview of research involving the development of UAV technology for agricultural production management.Technologies,systems and methods are examined and studied.The limitations of current UAVs for agricultural production management are discussed,as well as future needs and suggestions for development and application of the UAV technologies in agricultural production management. | Yanbo Huang Steven J.Thomson W.Clint Hoffmann Yubin Lan Bradley K.Fritz | 2013 | International Journal of Agricultural and Biological Engineering2013，6，3： | 22 |
| 8 | GIS互操作的实现途径评述显示文摘文中主要探讨了开放式GIS的规程和关键技术,促进数据、系统和机构的互操作,总结了世界上著名公司最近GIS产品实现互操作的技术途径,给出了国际上有关GIS互操作、开放式GIS研究的最新进展以及近期发展方向。 | 黄裕霞 FRANK HOFFMANN 陈常松 何建邦 | 1999 | 地理研究1999，18，1： | 20 |
| 9 | Detection of disseminated pancreatic cells by amplification of cytokeratin-19 with quantitative RT-PCR in blood,bone marrow and peritoneal lavage of pancreatic carcinoma patients显示文摘AIM: To evaluate the diagnostic potential of cytokeratin-19 (CK-19) mRNA for the detection of disseminated tumor cells in blood, bone marrow and peritoneal lavage in patients with ductal adenocarcinoma of the pancreas. METHODS: Sixty-eight patients with pancreatic cancer (n = 37), chronic pancreatitis (n = 16), and non-pan- creatic benign surgical diseases (n = 15, control group) were included in the study. Venous blood was taken preoperatively, intraoperatively and at postoperative d 1 and 10. Preoperative bone marrow aspirates and peritoneal lavage taken before mobilization of the tumor were analyzed. All samples were evaluated for disseminated tumor cells by CK-19-specific nested-PCR and quantitative fluorogenic RT-PCR. RESULTS: CK-19 mRNA expression was increased in 24 (64%) blood samples and 11 (30%) of the peritoneal lavage samples in the patients with pancreatic cancer. In 15 (40%) of the patients with pancreatic cancer, disseminated tumor cells were detected in venous blood and bone marrow and/or peritoneal lavage. In the peritoneal lavage, the detection rates were correlated with the tumor size and the tumor differentiation. CK-19 levels were increased in pT3/T4 and moderately/poorly differentiated tumors (G2/G3). Pancreatic cancer patients with at least one CK-19 mRNA-positive sample showed a trend towards shorter survival. Pancreatic cancerpatients showed significantly increased detection rates of disseminated tumor cells in blood and peritoneal lavage compared to the controls and the patients with chronic pancreatitis. CONCLUSION: Disseminated tumor cells can be detected in patients with pancreatic ductal adenocar- cinoma by CK-19 fluorogenic RT-PCR. In peritoneal lavage, detection rate is correlated with tumor stage and differentiation. In the clinical use, CK-19 is suitable for the distinction between malignant and benign pancreatic disease in combination with other tumor-specific markers. | Katrin Hoffmann Christiane Kerner Wolfgang Wilfert Marc Mueller Joachim Thiery Johann Hauss Helmut Witzigmann | 2007 | World Journal of Gastroenterology2007，13，2： | 20 |
| 10 | 北京首钢工业区大气重金属污染树叶的磁学响应显示文摘在北京西郊首钢工业区及附近混杂的居民区、公园绿地和农村耕作区采集了55个一年生的树叶样品,并对其进行岩石磁学和元素含量分析.结果表明:磁性矿物的含量和粒径由污染源区向周边递减.研究区域树叶的磁性由低矫顽力的磁铁矿主导.进一步研究表明样品的主要磁性参数(磁化率、非磁滞剩磁以及饱和等温剩磁)与元素Fe,Pb,Cr,V和Zn呈显著相关关系(0.73≤R≤0.88).因此树叶的磁参数可以作为大气重金属污染研究的理想替代指标. | 胡守云 段雪梅 沈明洁 Blaha U Rosler W 闫海涛 Appel E Hoffmann V | 2008 | 科学通报2008，53，4： | 19 |
| 11 | Evaluating effective swath width and droplet distribution of aerial spraying systems on M-18B and Thrush 510G airplanes显示文摘Aerial spraying plays an important role in promoting agricultural production and protecting the biological environment due to its flexibility,high effectiveness,and large operational area per unit of time.In order to evaluate the performance parameters of the spraying systems on two fixed wing airplanes M-18B and Thrush 510G,the effective swath width and uniformity of droplet deposition under headwind flight were tested while the planes operated at the altitudes of 5 m and 4 m.The results showed that although wind velocities varied from 0.9 m/s to 4.6 m/s,and the directions of the atomizer switched upward and downward in eight flights,the effective swath widths were kept approximately at 27 m and 15 m for the M-18B and Thrush 510G,respectively,and the latter was more stable.In addition,through analyzing the coefficients of variation(CVs)of droplet distribution,it was found that the CVs of the M-18B were 39.57%,33.54%,47.95%,and 59.04% at wind velocities of 0.9,1.1,1.4 and 4.6 m/s,respectively,gradually enhancing with the increasing of wind speed;the CVs of Thrush 510G were 79.12%,46.19%,14.90%,and 48.69% at wind velocities of 1.3,2.3,3.0 and 3.4 m/s,respectively,which displayed the irregularity maybe due to change of instantaneous wind direction.Moreover,in terms of the CVs and features of droplet distribution uniformity for both airplanes in the spray swath,choosing smaller CV(20%-45%)as the standard of estimation,it was found that the Thrush 510G had a better uniform droplet distribution than the M-18B.The results provide a research foundation for promoting the development of aerial spraying in China. | Zhang Dongyan Chen Liping Zhang Ruirui Xu Gang Lan Yubin Wesley Clint Hoffmann Wang Xiu Xu Min | 2015 | International Journal of Agricultural and Biological Engineering2015，8，2： | 18 |
| 12 | Attractive but Toxic: Emerging Roles of Glycosidically Bound Volatiles and Glycosyltransferases Involved in Their Formation显示文摘 | Chuankui Song Katja Hartl Kate McGraphery Thomas Hoffmann Wilfried Schwab | 2018 | Molecular Plant2018，11，10： | 16 |
| 13 | Using a Surface Plasmon Resonance Biosensor for Rapid Detection of Salmonella Typhimurium in Chicken Carcass显示文摘Chicken is one of the most popular meat products in the world. Salmonella Typhimurium is a common foodborne pathogens associated with the processing of poultry. An optical Surface Plasmon Resonance (SPR) biosensor was sensitive to the presence of Salmonella Typhimurium in chicken carcass. The Spreeta biosensor kits were used to detect Salmonella Typhimurium on chicken carcass successfully. A taste sensor like electronic tongue or biosensors was used to basically 'taste' the object and differentiated one object from the other with different taste sensor signatures. The surface plasmon resonance biosensor has potential for use in rapid, real-time detection and identification of bacteria, and to study the interaction of organisms with different antisera or other molecular species. The selectivity of the SPR biosensor was assayed using a series of antibody concentrations and dilution series of the organism. The SPR biosensor showed promising to detect the existence of Salmonella Typhimurium at 1 × 106 CFU/ml. Initial results show that the SPR biosensor has the potential for its application in pathogenic bacteria monitoring. However, more tests need to be done to confirm the detection limitation. | Yu-bin Lan Shi-zhou Wang Yong-guang Yin W. Clint Hoffmann Xian-zhe Zheng | 2008 | Journal of Bionic Engineering2008，5，3： | 14 |
| 14 | 藏毛窦发病率和远期复发率现况及其影响因素分析显示文摘目的调查德国部队中藏毛窦的发病率和术后远期复发率的现状及其发展变化趋势,分析不同手术治疗方法、体格状况和吸烟量等因素对藏毛窦的发病率和术后远期复发率的影响。方法对德国三家部队医院1980至1996年收治的所有藏毛窦患者的资料进行统计,随机抽取其中500例患者进行随访。结果德国部队中藏毛窦的发病率由1985年的0.3/1000上升到2007年的2.4/1000。随机抽取的500例患者中2例死亡,498例接受了随访。其术后复发率从1981年的33%,到1986年的23%,再到1996年的12%,呈明显下降趋势(P=0.01)。藏毛窦切除后行开放愈合的复发率为16.8%,显著低于行一期缝合的复发率31.0%(P〈0.01)。部队中人均体质量每十年增加1kg,德国国民人均体质量每十年增加1.9kg,但是体质量的增加与藏毛窦复发率之间无显著相关性(P=0.72)。每天吸烟20支以上者藏毛窦的复发率比吸烟≤20支者显著升高(P=0.015)。结论在藏毛窦的术后复发率下降,特别是切除后开放愈合的术后复发率下降的同时,藏毛窦的发病率上升了近十倍。 | Theo Evers Dietrich Doll Edouard Matevossian Sebastian Noe Konrad Neumann 李挥力 Norbert Huser Rainer Ludde Sebastian Hoffmann Bjorn Dirk Krapohl | 2011 | 中华外科杂志2011，49，9： | 14 |
| 15 | 金刚烷胺模拟废水Fenton氧化及其中间产物分析显示文摘采用Fenton试剂氧化法处理模拟金刚烷胺废水,研究不同反应条件下Fenton试剂对金刚烷胺的去除效果,确定反应的最佳条件。结果表明:当反应温度为常温(23~25℃),pH为4,H2O2投加量为3000mg/L,H2O2与Fe2+的质量比为1.28时,处理含金刚烷胺浓度为500mg/L废水,CODCr去除率为30%~80%,处理效果良好。因此,Fenton试剂可以有效降解金刚烷胺。通过Fenton反应,金刚烷胺废水的可生化性得到提高,B/C由0提高到0.1~0.4。对Fenton氧化金刚烷胺的中间产物的分析发现,Fenton氧化反应5min后,系统中没有检出金刚烷胺。反应30min后,中间产物已基本完全降解。 | 曾萍 宋永会 DRESELY Johanna HOFFMANN Erhard | 2011 | 环境工程技术学报2011，1，6： | 13 |
| 16 | Multisensor Data Fusion for High Quality Data Analysis and Processing in Measurement and Instrumentation显示文摘Multisensor data fusion (MDF) is an emerging technology to fuse data from multiple sensors in order to make a more accurate estimation of the environment through measurement and detection. Applications of MDF cross a wide spectrum in military and civilian areas. With the rapid evolution of computers and the proliferation of micro-mechanical/electrical systems sensors,the utilization of MDF is being popularized in research and applications. This paper focuses on application of MDF for high quality data analysis and processing in measurement and instrumentation. A practical,general data fusion scheme was established on the basis of feature extraction and merge of data from multiple sensors. This scheme integrates artificial neural networks for high performance pattern recognition. A number of successful applications in areas of NDI (Non-Destructive Inspection) corrosion detection,food quality and safety characterization,and precision agriculture are described and discussed in order to motivate new applications in these or other areas. This paper gives an overall picture of using the MDF method to increase the accuracy of data analysis and processing in measurement and instrumentation in different areas of applications. | Yan-bo Huang Yu-bin Lan W. C. Hoffmann R. E. Lacey | 2007 | Journal of Bionic Engineering2007，4，1： | 13 |
| 17 | Effect of humic substances on the precipitation of calcium phosphate显示文摘For phosphorus (P) recovery from wastewater, the effect of humic substances (HS) on the precipitation of calcium phosphate was studied. Batch experiments of calcium phosphate precipitation were undertaken with synthetic water that contained 20 mg/L phosphate (as P) and 20 mg/L HS (as dissolved organic carbon, DOC) at a constant pH value in the range of 8.0—10.0. The concentration variations of phosphate, calcium (Ca) and HS were measured in the precipitation process; the crystalline state and compositions of the precipitates were analysed by powder X-ray diffraction (XRD) and chemical methods, respectively. It showed that at solution pH 8.0, the precipitation rate and removal efficiency of phosphate were greatly reduced by HS, but at solution pH ≥9.0, the effect of HS was very small. The Ca consumption for the precipitation of phosphate increased when HS was added; HS was also removed from solution with the precipitation of calcium phosphate. At solution pH 8.0 and HS concentrations ≤ 3.5 mg/L, and at pH ≥ 9.0 and HS concentrations ≤ 10 mg/L, the final precipitates were proved to be hydroxyapatite (HAP) by XRD. The increases of solution pH value and initial Ca/P ratio helped reduce the influence of HS on the precipitation of phosphate. | SONG Yong-hui Hermann H. HAHN Erhard HOFFMANN Peter G. WEIDLER | 2006 | Journal of Environmental Sciences2006，18，5： | 11 |
| 18 | Magnetic response to atmospheric heavy metal pollution recorded by dust-loaded leaves in Shougang industrial area, western Beijing显示文摘Fifty-five evergreen tree's leaves growing less than one year were collected from Shougang industrial area in western suburb of Beijing, including steel plants and its ambient residential areas, recreational parks and farmlands. Rock magnetic properties and heavy metal contents were studied. The results show that the magnetic properties of leaf samples are predominated by low-coercivity magnetite, and both the concentration and grain size of magnetite particles gradually decreased with the distance from the main pollution source increases. Moreover, there is a significant linear relationship between magnetic parameters (the low-field magnetic susceptibility, saturation isothermal remanent magnetization and anhysteretic remanent magnetization) and heavy metals contents (Fe, Pb, V, Cr and Zn) (0.73≤R≤ 0.88). Hence, the magnetic parameters of leaves can serve as a proxy for quick detecting of the recent atmospheric metallic pollution. | HU ShouYun DUAN XueMei SHEN MingJie U BLAHA W ROESLER YAN HaiTao E APPEL V HOFFMANN | 2008 | Chinese Science Bulletin2008，53，10： | 10 |
| 19 | Incidence trends and survival prediction of hepatoblastoma in children:a population-based study显示文摘Background:Hepatoblastoma is a rare disease that nevertheless accounts for the majority of liver malignancies in children.Due to limited epidemiological data,therapy for hepatoblastoma tends to be individualized.This study aimed to evaluate incidence trends of hepatoblastoma and to develop a nomogram to predict the survival of children with newly diagnosed hepatoblastoma on a population-based level.Methods:Individuals up to 18 years of age with hepatoblastoma recorded in 18 registries of the Surveillance,Epi-demiology,and End Results(SEER)database between 2004 and 2015 were examined.Joinpoint regression analyses were applied to assess incidence trends in annual percentage change(APC).Multivariable Cox regression was used to identify factors associated with overall survival(OS).A nomogram was constructed to predict OS in individual cases based on independent predictors.Concordance index(C-index)and calibration curves were used to evaluate predic-tive performance.Results:Between 2004 and 2015,hepatoblastoma incidence increased significantly(APC,2.2%;95%confidence interval[CI]0.5%to 3.8%,P<0.05).In particular,this increase was observed among 2-to 4-year-old patients,males,and African-Americans.The 5-and 10-year OS rates were 81.5%and 81.0%,respectively.Age of 2 to 4 years,Afri-can-American ethnicity,and no surgery were independent predictors for short OS.Distant disease at presentation was found not to be an independent factor of survival.The nomogram had a C-index of 0.79(95%CI 0.74-0.84)with appropriate calibration curve fitting.Conclusions:We constructed a nomogram that integrates common factors associated with survival for hepatoblas-toma patients.It provides accurate prognostic prediction for children with hepatoblastoma. | Jincheng Feng Georgios Polychronidis Ulrike Heger Giovanni Frongia Arianeb Mehrabi Katrin Hoffmann | 2019 | Cancer Communications2019，39，1： | 10 |
| 20 | Prevalence and risk factors of nonalcoholic fatty liver disease in patients with inflammatory bowel diseases:A cross-sectional and longitudinal analysis显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is common in the German population,with an even higher prevalence in inflammatory bowel disease patients.AIM To investigate the risk factors for NAFLD in inflammatory bowel disease patients.METHODS This monocentric retrospective study with a cross-sectional and a longitudinal part included 694 patients.Inclusion criteria were diagnosed inflammatory bowel disease,age≥18 years,availability of at least one abdominal ultrasound.Patients with infectious or suspected alcoholic fatty liver disease were excluded.NAFLD was defined by increased echogenicity at liver ultrasound.Demographic characteristics,disease activity and medications were analyzed as potential risk factors.Parameters influencing the course of NAFLD were identified by a generalized linear mixed model.RESULTS Forty-eight percent of Crohn’s disease(CD)patients and 44%of ulcerative colitis patients suffered from NAFLD.Its occurrence was associated with greater age,hypertension and body mass index(BMI)in both groups,and with higher disease activity and dyslipidemia in CD.2467 ultrasound results were included in the longitudinal analysis.Risk factors for NAFLD were age,BMI,higher disease activity,bowel resection(s),endoscopic activity and azathioprine use in CD;and BMI and endoscopic activity in ulcerative colitis.CONCLUSION NAFLD was highly prevalent in this cohort of German inflammatory bowel disease patients.Its risk increased mainly with rising age and BMI.This analysis provides a rationale for non-invasive liver screening in inflammatory bowel disease patients. | Peter Hoffmann Victoria Jung Rouven Behnisch Annika Gauss | 2020 | World Journal of Gastroenterology2020，26，46： | 8 |
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