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| 1 | DEM speedup: Stiffness effects on behavior of bulk material显示文摘A number of techniques exist for minimizing the computational cost of discrete element simulations(DEMs). One such method is a reduction of particle stiffness, which allows for bigger time steps and therefore fewer iterations in a simulation. However, the limits and drawbacks of this approach are still unclear, and may lead to invalid results. This paper investigates the effect of a stiffness reduction on bulk behavior by examining three case studies. Two cases demonstrate that particle stiffness can be reduced without affecting the bulk material behavior, whereas the third test shows that a stiffness reduction influences the bulk behavior. | Stef Lommen Dingena Schott Gabriel Lodewijks | 2014 | Particuology2014，12，1： | 11 |
| 2 | Juvenile polyposis syndrome显示文摘Juvenile polyposis syndrome is a rare autosomal dominant syndrome characterized by multiple distinct juvenile polyps in the gastrointestinal tract and an increased risk of colorectal cancer.The cumulative life-time risk of colorectal cancer is 39% and the relative risk is 34.Juvenile polyps have a distinctive histology characterized by an abundance of edematous lamina propria with inflammatory cells and cystically dilated glands lined by cuboidal to columnar epithelium with reactive changes.Clinically,juvenile polyposis syndrome is defined by the presence of 5 or more juvenile polyps in the colorectum,juvenile polyps throughout the gastrointestinal tract or any number of juvenile polyps and a positive family history of juvenile polyposis.In about 50%-60% of patients diagnosed with juvenile polyposis syndrome a germline mutation in the SMAD4 or BMPR1A gene is found.Both genes play a role in the BMP/TGF-beta signalling pathway.It has been suggested that cancer in juvenile polyposis may develop through the socalled 'landscaper mechanism' where an abnormal stromal environment leads to neoplastic transformation of the adjacent epithelium and in the end invasive carcinoma.Recognition of this rare disorder is important for patients and their families with regard to treatment,follow-up and screening of at risk individuals.Each clinician confronted with the diagnosis of a juvenile polyp should therefore consider the possibility of juvenile polyposis syndrome.In addition,juvenile polyposis syndrome provides a unique model to study colorectal cancer pathogenesis in general and gives insight in the molecular genetic basis of cancer.This review discusses clinical manifestations,genetics,pathogenesis and management of juvenile polyposis syndrome. | Lodewijk AA Brosens Danielle Langeveld W Arnout van Hattem Francis M Giardiello G Johan A Offerhaus | 2011 | World Journal of Gastroenterology2011，17，44： | 7 |
| 3 | Botulinum toxin injections after surgery for Hirschsprung disease:Systematic review and meta-analysis显示文摘BACKGROUND A large proportion of patients with Hirschsprung disease experience persistent obstructive symptoms after corrective surgery.Persistent obstructive symptoms may result in faecal stasis that can develop into Hirschsprung-associated enterocolitis,a potential life-threatening condition.Important treatment to improve faecal passage is internal anal sphincter relaxation using botulinum toxin injections.AIM To give an overview of all empirical evidence on the effectiveness of botulinum toxin injections in patients with Hirschsprung disease.METHODS A systematic review and meta-analysis was done by searching PubMed,EMBASE and the Cochrane Library,using entry terms related to:(1)Hirschsprung disease;and(2)Botulinum toxin injections.14 studies representing 278 patients met eligibility criteria.Data that were extracted were proportion of patients with improvement of obstructive symptoms or less enterocolitis after injection,proportion of patients with adverse effects and data on type botulinum toxin,mean dose,average age at first injection and patients with associated syndromes.Random-effects meta-analysis was used to aggregate effects and random-effects meta-regression was used to test for possible confounding factors.RESULTS Botulinum toxin injections are effective in treating obstructive symptoms in on average 66%of patients[event rate(ER)=0.66,P=0.004,I2=49.5,n=278 patients].Type of botulinum toxin,average dose,average age at first injections and proportion of patients with associated syndromes were not predictive for this effect.Mean 7 duration of improvement after one botulinum toxin injections was 6.4 mo and patients needed on average 2.6 procedures.There was a significant higher response rate within one month after botulinum toxin injections compared to more than one month after Botulinum toxin injections(ER=0.79,vs ER=0.46,Q=19.37,P<0.001).Botulinum toxin injections were not effective in treating enterocolitis(ER 0.58,P=0.65,I2=71.0,n=52 patients).There were adverse effects in on average 17%of patients(ER=0.17,P<0.001,I2=52.1,n=187 patients),varying from temporary incontinence to mild anal pain.CONCLUSION Findings from this systematic review and meta-analysis indicate that botulinum toxin injections are effective in treating obstructive symptoms and that adverse effects were present,but mild and temporary. | Danielle Roorda Zarah AM Abeln Jaap Oosterlaan Lodewijk WE van Heurn Joep PM Derikx | 2019 | World Journal of Gastroenterology2019，25，25： | 4 |
| 4 | Coronary-cameral fistulas in adults: Acquired types(second of two parts)显示文摘Acquired coronary artery fistulas(CCFs)are infrequently detected during conventional coronary angiography.To delineate the characteristics of congenital(first part)and acquired(second part)CCFs in adults,a PubMed search was conducted for papers dealing with congenital or acquired CCFs.None of the publications describing patients with coronary-vascular fistulas were included.Papers dealing with pediatric subjects were excluded.From the world literature,a total of 243adult patients were selected who had congenital(n=159/243,65%)and acquired(n=84/243,35%)CCFs.Among the acquired types(n=72,85.7%)were traumatic(iatrogenic(n=65/72,90%),accidental(n=7/72,10%)and(n=12,14.3%)spontaneously developing in relation to severe coronary atherosclerosis or myocardial infarction.A high incidence of spontaneousresolution of iatrogenic CCFs resulting from endomyocardial biopsy or following post-septal myectomy was reported.Spontaneous CCFs associated with myocardial ischemia or infarction resolved completely in 8%of the subjects.Early surgical intervention was the treatment of choice in acquired traumatic accidental CCFs.The congenital types are addressed in a previous issue of this journal(first part).In this review(second of two parts,partⅡ),we describe the acquired coronarycameral fistulas. | Salah AM Said Rikke HM Schiphorst Richard Derksen Lodewijk J Wagenaar | 2013 | World Journal of Cardiology2013，5，12： | 2 |
| 5 | MC-LMAC : A multi-channel MAC prttoeol for wireless sensor networks 显示文摘 | Ozlem Durmaz Lodewijk Pierre Paul | 2010 | Ad hoe networks2010，9，5： | 1 |
| 6 | Non-Linear Dynamics of Belt Conveyor Sys- tems 显示文摘 | Lodewijks G | 1997 | Bulk Solids Handling1997，17，1： | 1 |
| 7 | Monoclonal origin of primary unilateral multifocal pleomorphic adenoma of the parotid gland显示文摘 | Sylvia L. van Egmond Wendy W.J. de Leng Folkert H.M. Morsink G.Johan A. Offerhaus Lodewijk A.A. Brosens | 2012 | Human Pathology2012，，： | 1 |
| 8 | Simulation ofa muhiterminal system for container handling 显示文摘 | J A Ottjes H P M Veeke M B Duinkerken J C Rijsenbrij G Lodewijks | 2006 | OR Spectrum2006，28，4： | 1 |
| 9 | Two Decades Dynamics of Belt Conveyor Systems 显示文摘 | Lodewijks G | 2002 | Bulk Solids Handling2002，22，2： | 1 |
| 10 | Modeling particle sedimentation in viscous fluids with a coupled immersed boundary method and discrete element method显示文摘 | Sayed M. Derakhshani Dingena L. Schott Gabriel Lodewijks | 2017 | Particuology2017，15，2： | 1 |
| 11 | Tuning the Fano resonance between localized and propagating surface plasmon resonances for refractive index sensing applications显示文摘 | LODEWIJKS K RYKEN J ROY W V | 2013 | Plasmonics2013，8，： | 1 |
| 12 | 基于数据驱动方法的腐蚀管道线在内压下爆破极限强度预测显示文摘A corrosion defect is recognized as one of the most severe phenomena for high-pressure pipelines,especially those served for a long time.Finite-element method and empirical formulas are thereby used for the strength prediction of such pipes with corrosion.However,it is time-consuming for finite-element method and there is a limited application range by using empirical formulas.In order to improve the prediction of strength,this paper investigates the burst pressure of line pipelines with a single corrosion defect subjected to internal pressure based on data-driven methods.Three supervised ML(machine learning)algorithms,including the ANN(artificial neural network),the SVM(support vector machine)and the LR(linear regression),are deployed to train models based on experimental data.Data analysis is first conducted to determine proper pipe features for training.Hyperparameter tuning to control the learning process is then performed to fit the best strength models for corroded pipelines.Among all the proposed data-driven models,the ANN model with three neural layers has the highest training accuracy,but also presents the largest variance.The SVM model provides both high training accuracy and high validation accuracy.The LR model has the best performance in terms of generalization ability.These models can be served as surrogate models by transfer learning with new coming data in future research,facilitating a sustainable and intelligent decision-making of corroded pipelines. | Jie Cai Xiaoli Jiang Yazhou Yang Gabriel Lodewijks Minchang Wang | 2022 | Journal of Marine Science and Application2022，21，2： | 1 |
| 13 | A Cardiac Sodium Channel Mutation Cosegregates With a Rare Connexin40 Genotype in Familial Atrial Standstill显示文摘 | W. Antoinette Groenewegen Mehran Firouzi Connie R. Bezzina Saskia Vliex Irene M. van Langen Lodewijk Sandkuijl Jeroen P.P. Smits Miriam Hulsbeek Martin B. Rook Habo J. Jongsma Arthur A.M. Wilde | 2003 | Circulation Research: Journal of the American Heart Association2003，，1： | 1 |
| 14 | Non-linear Dynamics of Belt Conveyor Systems显示文摘 | Lodewijks G | 1997 | Bulk Solids Handling1997，17，1： | 1 |
| 15 | Consistency and Variability of Learning Strategies in Different University Courses 显示文摘 | Vermetten Y J Lodewijks H G Vermunt J D | 1999 | Higher Education1999，37，1： | 1 |
| 16 | Two decades dynamics of belt conveyor systems 显示文摘 | Lodewijks G | 2002 | Bulk Solids Handing2002，22，2： | 1 |
| 17 | Modern Dry Bulk Terminal Design显示文摘 | Lodewijks G Schott D.L Ottjes | | 0，，06： | 1 |
| 18 | Reliability of Large Scale Bulk Material Handling Systems显示文摘 | Lodewijks G Ottjes | | 0，，01： | 1 |
| 19 | Slow recovery of follicular B cells and marginal zone B cells after chemotherapy : implications for humoral immunity 显示文摘 | Zandvoort A Lodewijk ME Klok PA | 2001 | Clin Exp Immunol2001，124，2： | 1 |
| 20 | Two Decades Dynamics of Belt Conveyor Systems 显示文摘 | Lodewijks G | 2002 | Bulk Solids Handling2002，22，2： | 1 |
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