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| 1 | 基于眼动跟踪技术的界面可用性评估显示文摘为解决因界面而造成的整体系统效率低下的问题,以认知学为理论基础,提出将眼动跟踪技术运用于界面可用性检测.首先讨论了眼动跟踪设备的优势与技术原理,然后以德国汉堡城市轻轨U4线站台界面的交互设计为例,描述眼动跟踪实验的流程.最后从眼动路径、热度、信息量、任务用时和注视频率等方面对新旧界面进行实验,以定量实验方法评估新旧界面的优劣.实验结果分析比较表明:新界面的各项实验检测数据都明显优于旧界面,更符合用户的需求和认知习惯;同时,眼动跟踪实验的可靠性高,数据结果比较精确,适合进一步推广应用,并为后续航电系统界面设计研究工作提供了一种有效的评估方法. | 刘青 薛澄岐 Falk Hoehn | 2010 | 东南大学学报(自然科学版)2010，40，2： | 56 |
| 2 | 龋损管理:龋坏组织去除的专家共识显示文摘近30年来,尽管许多国家的龋病患病率逐年下降,但龋病仍然是世界上最流行的疾病,影响着数十亿人口[1],在全球产生巨额的医疗费用[2].因此,如何管理龋病以减少其对人类的影响,已经成为口腔医学领域的重要课题.为实现这一目标,制定龋病管理策略时需要有充分的临床证据做指导.目前,已有越来越多的临床研究证据支持在此基础上形成推荐规范[3]. | 陈智 卢展民 Falk Schwendicke Nicola P.T.Innes Jo E.Frencken | 2016 | 中华口腔医学杂志2016，51，12： | 22 |
| 3 | 反流性食管炎中埃索美拉唑比奥美拉唑更能促进病变愈合和症状缓解显示文摘 | Kahrilas PJ Falk GW Johnson DA Schmitt C Collins DW Whipple J D’Amino D Hamelin B Joelsson B 钟捷 | 2002 | 中华消化杂志2002，22，11： | 19 |
| 4 | Transforming growth factor-β1 induces intestinal myofibroblast differentiation and modulates their migration显示文摘AIM:To investigate the effects of transforming growth factorβ1(TGF-β1)on the differentiation of colonic lamina propria fibroblasts(CLPF)into myofibroblasts in vitro. METHODS:Primary CLPF cultures were incubated with TGF-β1 and analyzed for production ofα-smooth muscle actin(α-SMA),fibronectin(FN)and FN isoforms.Migration assays were performed in a modified 48-well Boyden chamber.Levels of total and phosphorylated focal adhesion kinase(FAK)in CLPF were analyzed after induction of migration.RESULTS:Incubation of CLPF with TGF-β1 for 2 d did not changeα-SMA levels,while TGF-β1 treatment for 6 d significantly increasedα-SMA production. Short term incubation(6 h)with TGF-β1 enhanced CLPF migration,while long term treatment(6 d)of CLPF with TGF-β1 reduced migration to 15%-37% compared to untreated cells.FN and FN isoform mRNA expression were increased after short term incubation with TGF-β1(2 d)in contrast to long term incubation with TGF-β1 for 6 d.After induction of migration, TGF-β1-preincubated CLPF showed higher amounts of FN and its isoforms and lower levels of total and phosphorylated FAK than untreated cells. CONCLUSION:Long term incubation of CLPF with TGF-β1 induced differentiation into myofibroblasts with enhancedα-SMA,reduced migratory potential and FAK phosphorylation,and increased FN production.In contrast,short term contact(6 h)of fibroblasts with TGF-β1 induced a dose-dependent increase of cell migration and FAK phosphorylation without induction ofα-SMA production. | Julia Brenmoehl Sandra Nicole Miller Claudia Hofmann Daniela Vogl Werner Falk Jrgen Schlmerich Gerhard Rogler | 2009 | World Journal of Gastroenterology2009，15，12： | 12 |
| 5 | Quantifying land degradation in the Zoige Basin,NE Tibetan Plateau using satellite remote sensing data显示文摘Considerable efforts have been dedicated to desertification research in the arid and semi-arid drylands of central Asia. However,there are few quantitative studies in conjunction with proper qualitative evaluation concerning land degradation and aeolian activity in the alpine realm. In this study,spectral information from two Landsat-5 TM scenes(04.08.1994 and 28.07.2009,respectively) was combined with reference information obtained in the field to run supervised classifications of eight landscape types for both time steps. Subsequently,the temporal and spatial patterns of the alpine wetlands/grasslands evolutions in the Zoige Basin were quantified and assessed based on these two classification maps. The most conspicuous change is the sharp increase of ~627 km^2 degraded meadow. Concerning other land-covers,shallow wetland increases ~107 km^2 and aeolian sediments(mobile dunes and sand sheets) have an increase of ~30 km^2. Considering the deterioration,an obvious decrease of ~440 km^2 degraded wetland can be observed. Likewise,decrease of deep wetland(~78 km^2),humid meadow(~80 km^2) and undisturbed meadow(~88 km^2) were determined. These entire evolution matrixes undoubtedly hint a deteriorating tendency of the Zoige Basin ecosystem,which is characterized by significantly declined proportion of intact wetlands,meadow,rangeland and a considerable increase ofdegraded meadow and larger areas of mobile dunes. In particular,not only temporal alteration of the landcover categories,the spatial and topographical characteristics of the land degradation also deserves more attention. In the alpine rangelands,the higher terraces of the river channels along with their slopes are more liable to the degradation and desertification. This tendency has significantly impeded the nomadic and agriculture activities. The set of anthropozoogenic factors encompassing enclosures,overgrazing and trampling,rodent damaging and exceedingly ditching in the wetlands are assumed to be the main controlling mechanisms for the landscape degradation. A suite of strict protection policies is urgent and indispensable for self-regulation and restoration of the alpine meadow ecosystem. Controlling the size of livestock,less ditching in the rangeland,and the launching of a more strict nature reserve management by adjacent Ruoergai,Maqu and Hongyuan Counties would be practical and efficacious in achieving these objectives. | YU Kai-feng Frank LEHMKUHL Dimitri FALK | 2017 | Journal of Mountain Science2017，14，1： | 12 |
| 6 | Epirubicin, oxaliplatin, and capecitabine with or without panitumumab for patients with previously untreated advanced oesophagogastric cancer (REAL3): a randomised, open-label phase 3 trial显示文摘 | Tom Waddell Ian Chau David Cunningham David Gonzalez Alicia Frances Clare Okines Andrew Wotherspoon Claire Saffery Gary Middleton Jonathan Wadsley David Ferry Wasat Mansoor Tom Crosby Fareeda Coxon David Smith Justin Waters Timothy Iveson Stephen Falk Sar | 2013 | Lancet Oncology2013，，6： | 10 |
| 7 | 基于物种分布模型的精确采样提高目标物种发现率——以黑颈鹤(Grus nigricollis),白头鹤(Grus monacha)为例显示文摘明确野生动植物的地理分布是基础生态学和应用生态学领域的一个基础但关键的步骤,为后续分析提供了重要的信息。而野生动植物分布调查是一项需要投入大量人力,精力和资金的工作,特别是稀有物种的调查。物种分布模型越来越受到广泛引用尤其是在生物保护方面。为了证明物种分布模型在野生生物调查中精确采样方法的可行性,以全球易危物种黑颈鹤和白头鹤的实际繁殖分布预测为例,使用随机森林(Random Forest)算法加以验证。比较发现物种分布模型预测实际调查分布点,随机样方法生成的随机点,系统样方法的规则点在空间相对出现概率具有显著差异(P<0.001),实际分布点具有较高的相对出现概率。该结果表明若在物种分布相对出现概率较高区域设置样方能够减少实际调查区域,有效提高发现目标物种的概率,从而减少调查投入。基于物种分布模型的精确采样方法将有效地提高我们对稀有物种分布的了解,有利于野生动植物的保护规划。 | 宓春荣 郭玉民 Huettmann Falk 韩雪松 | 2017 | 生态学报2017，37，13： | 10 |
| 8 | Role of nuclear factor kappa B in central nervous system regeneration显示文摘Activation of nuclear factor kappa B(NF-κB) is a hallmark of various central nervous system(CNS) pathologies. Neuron-specific inhibition of its transcriptional activator subunit RelA, also referred to as p65, promotes neuronal survival under a range of conditions, i.e., for ischemic or excitotoxic insults. In macro- and microglial cells, post-lesional activation of NF-κB triggers a growth-permissive program which contributes to neural tissue inflammation, scar formation, and the expression of axonal growth inhibitors. Intriguingly, inhibition of such inducible NF-κB in the neuro-glial compartment, i.e., by genetic ablation of RelA or overexpression of a transdominant negative mutant of its upstream regulator IκBα, significantly enhances functional recovery and promotes axonal regeneration in the mature CNS. By contrast, depletion of the NF-κB subunit p50, which lacks transcriptional activator function and acts as a transcriptional repressor on its own, causes precocious neuronal loss and exacerbates axonal degeneration in the lesioned brain. Collectively, the data imply that NF-κB orchestrates a multicellular program in which κB-dependent gene expression establishes a growth-repulsive terrain within the post-lesioned brain that limits structural regeneration of neuronal circuits. Considering these subunit-specific functions, interference with the NF-κB pathway might hold clinical potentials to improve functional restoration following traumatic CNS injury. | Christian Engelmann Falk Weih Ronny Haenold | 2014 | Neural Regeneration Research2014，9，7： | 8 |
| 9 | LIMS实施经验之谈显示文摘实验室必须花费必要的时间和资源去规划、选择并实施一个新的LIMS系统。 | George Avery Charles McGee Stan Falk 闫蕊 梁斌 | 2004 | 现代科学仪器2004，21，5： | 7 |
| 10 | From Vulnerable Plaque to Vulnerable Patient: A Call for New Definitions and Risk Assessment Strategies: Part I显示文摘 | Morteza Naghavi Peter Libby Erling Falk S. Ward Casscells Silvio Litovsky John Rumberger Juan Jose Badimon Christodoulos Stefanadis Pedro Moreno Gerard Pasterkamp Zahi Fayad Peter H. Stone Sergio Waxman Paolo Raggi Mohammad Madjid Alireza Zarrabi Allen Bu | 2003 | Circulation: Journal of the American Heart Association2003，，14： | 6 |
| 11 | Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial显示文摘 | Matthew T Seymour Sarah R Brown Gary Middleton Timothy Maughan Susan Richman Stephen Gwyther Catherine Lowe Jennifer F Seligmann Jonathan Wadsley Nick Maisey Ian Chau Mark Hill Lesley Dawson Stephen Falk Ann O’Callaghan Kim Benstead Philip Chambers Alfred | 2013 | Lancet Oncology2013，，8： | 6 |
| 12 | Removal of perfluorinated surfactants from wastewater by adsorption and ion exchange--Influence of material properties,sorption mechanism and modeling显示文摘Perfluorooctane sulfonate(PFOS) has attracted increasing concern in recent years due to its world-wide distribution, persistence, bioaccumulation and potential toxicity. The influence of sorbent properties on the adsorptive elimination of PFOS from wastewater by activated carbons, polymer adsorbents and anion exchange resins was investigated with regard to their isotherms and kinetics. The batch and column tests were combined with physicochemical characterization methods, e.g., N_2 physisorption, mercury porosimetry, infrared spectroscopy, differential scanning calorimetry, titrations, as well as modeling. Sorption kinetics was successfully modelled applying the linear driving force(LDF) approach for surface diffusion after introducing a load dependency of the mass transfer coefficient βs.The big difference in the initial mass transfer coefficient βs,0, when non-functionalized adsorbents and ion-exchange resins are compared, suggests that the presence of functional groups impedes the intraparticle mass transport. The more functional groups a resin possesses and the longer the alkyl moieties are the bigger is the decrease in sorption rate.But the selectivity for PFOS sorption is increasing when the character of the functional groups becomes more hydrophobic. Accordingly, ion exchange and hydrophobic interaction were found to be involved in the sorption processes on resins, while PFOS is only physisorptively bound to activated carbons and polymer adsorbents. In agreement with the different adsorption mechanisms, resins possess higher total sorption capacities than adsorbents. Hence, the latter ones are rendered more effective in PFOS elimination at concentrations in the low μg/L range, due to a less pronounced convex curvature of the sorption isotherm in this concentration range. | Falk Schuricht Ekaterina S.Borovinskaya Wladimir Reschetilowski | 2017 | Journal of Environmental Sciences2017，29，4： | 5 |
| 13 | Muscle RING-finger protein-1 (MuRFl) functions and cellular localization are regulated by SUMOl post-translational modification显示文摘The muscle RING-finger protein-1 (MuRFl) is an E3 ubiquitin ligase expressed in skeletal and cardiac muscle tissues and it plays important roles in muscle remodeling. Upregulation of MuRFl gene transcription participates in skeletal muscle atrophy, on contrary downregulation of protein expression leads to cardiac hypertrophy. MuRFl gene point mutations have been found to generate protein aggregate myopathies defined as muscle disorder characterized by protein accumulation in muscle fibers. We have discovered that MuRFl turned out to be also a target for a new post-translational modification arbitrated by conjugation of SUM01 and it is mediated by the SUMO ligases E2 UBC9 and the E3 PIASy/4. SUMOylation takes place at lysine 238 localized at the second coiled-coil protein domain that is required for efficient substrate interaction for polyubiquitination. We provided evidence that SUMOylation is essential for MuRFl nuclear translocation and its mitochondria accumulation is enhanced in hyper? glycemic conditions delivering a stabilization of the overall SUMOylated proteins in cultured myocytes. Thus, our findings add this SUM01 post-translational modification as a new concept to understand muscle disorders related to the defect in MuRFl activity. | Gabriel Heras Arvind Venkat Namuduri Leonardo Traini Ganna Shevchenko Alexander Falk Sara Bergstrom Lind Mi Jia Geng Tian Stefano Gastaldello | 2019 | Journal of Molecular Cell Biology2019，11，5： | 4 |
| 14 | Gemcitabine-based or capecitabine-based chemoradiotherapy for locally advanced pancreatic cancer (SCALOP): a multicentre, randomised, phase 2 trial显示文摘 | Somnath Mukherjee Christopher N Hurt John Bridgewater Stephen Falk Sebastian Cummins Harpreet Wasan Tom Crosby Catherine Jephcott Rajarshi Roy Ganesh Radhakrishna Alec McDonald Ruby Ray George Joseph John Staffurth Ross A Abrams Gareth Griffiths Tim Maugh | 2013 | Lancet Oncology2013，，4： | 4 |
| 15 | Burn injury prevention in low-and middleincome countries:scoping systematic review显示文摘Background:Burn injuries are a leading cause of morbidity and disability,with the burden of disease being disproportionately higher in low-and middle-income countries(LMIC).Burn prevention programmes have led to significant reductions in the incidence of burns in high-income countries.However,a previous systematic review published in 2015 highlighted that implementation and evaluation of similar programmes has been limited in LMIC.The objective of this scoping review and narrative synthesis was to summarise and understand the initiatives that have been carried out to reduce burn injuries in LMIC and their effectiveness.Methods:We aimed to identify publications that described studies of effectiveness of burn prevention interventions applied to any population within a LMIC and measured burn incidence or burns-related outcomes.Suitable publications were identified from three sources.Firstly,data was extracted from manuscripts identified in the systematic review published by Rybarczyk et al.We then performed a search for manuscripts on burn prevention interventions published between January 2015 and September 2020.Finally,we extracted data from two systematic reviews where burn evidence was not the primary outcome,which were identified by senior authors.A quality assessment and narrative synthesis of included manuscripts were performed.Results:In total,24 manuscripts were identified and categorized according to intervention type.The majority of manuscripts(n=16)described education-based interventions.Four manuscripts focused on environmental modification interventions and four adopted a mixedmethods approach.All of the education-based initiatives demonstrated improvements in knowledge relating to burn safety or first aid,however few measured the impact of their intervention on burn incidence.Four manuscripts described population-based educational interventions and noted reductions in burn incidence.Only one of the four manuscripts describing environmental modification interventions reported burns as a primary outcome measure,noting a reduction in burn incidence.All mixed-method interventions demonstrated some positive improvements in either burn incidence or burns-related safety practices.Conclusion:There is a lack of published literature describing large-scale burn prevention programmes in LMIC that can demonstrate sustained reductions in burn incidence.Populationlevel,collaborative projects are necessary to drive forward burn prevention through specific environmental or legislative changes and supplementary educational programmes. | Kate Price Kwang Chear Lee Katherine E.Woolley Henry Falk Michael Peck Richard Lilford Naiem Moiemen | 2021 | Burns & Trauma2021，9，1： | 4 |
| 16 | Intestinal mucosal MMP-1 – a prognostic factor in colon cancer显示文摘 | Marcus Langenski?ld Marie-Lois Ivarsson Lena Holmdahl Peter Falk Christina K?bj?rn-Gustafsson Eva Angenete | 2013 | Scandinavian Journal of Gastroenterology2013，，5： | 3 |
| 17 | California Simulation of Evapotranspiration of Applied Water and Agricultural Energy Use in California显示文摘The California Simulation of Evapotranspiration of Applied Water (Cal-SIMETAW) model is a new tool developed by the California Department of Water Resources and the University of California, Davis to perform daily soil water balance and determine crop evapotranspiration (ET c ), evapotranspiration of applied water (ET aw ), and applied water (AW) for use in California water resources planning. ET aw is a seasonal estimate of the water needed to irrigate a crop assuming 100% irrigation efficiency. The model accounts for soils, crop coefficients, rooting depths, seepage, etc. that influence crop water balance. It provides spatial soil and climate information and it uses historical crop and land-use category information to provide seasonal water balance estimates by combinations of detailed analysis unit and county (DAU/County) over California. The result is a large data base of ET c and ET aw that will be used to update information in the new California Water Plan (CWP). The application uses the daily climate data, i.e., maximum (T x ) and minimum (T n ) temperature and precipitation (P cp ), which were derived from monthly USDA-NRCS PRISM data (PRISM Group 2011) and daily US National Climate Data Center (NCDC) climate station data to cover California on a 4 km×4 km change grid spacing. The application uses daily weather data to determine reference evapotranspiration (ET o ), using the Hargreaves-Samani (HS) equation (Hargreaves and Samani 1982, 1985). Because the HS equation is based on temperature only, ET o from the HS equation were compared with CIMIS ET o at the same locations using available CIMIS data to determine correction factors to estimate CIMIS ET o from the HS ET o to account for spatial climate differences. Cal-SIMETAW also employs near real-time reference evapotranspiration (ET o ) information from Spatial CIMIS, which is a model that combines weather station data and remote sensing to provide a grid of ET o information. A second database containing the available soil water holding capacity and soil depth information for all of California was also developed from the USDA-NRCS SSURGO database. The Cal-SIMETAW program also has the ability to generate daily weather data from monthly mean values for use in studying climate change scenarios and their possible impacts on water demand in the state. The key objective of this project is to improve the accuracy of water use estimates for the California Water Plan (CWP), which provides a comprehensive report on water supply, demand, and management in California. In this paper, we will discuss the model and how it determines ET aw for use in water resources planning. | Morteza N Orang Richard L Snyder Shu Geng Quinn J Hart Sara Sarreshteh Matthias Falk Dylan Beaudette Scott Hayes Simon Eching | 2013 | Journal of Integrative Agriculture2013，12，8： | 3 |
| 18 | Role of NK, NKT cells and macrophages in liver transplantation显示文摘Liver transplantation has become the treatment of choice for acute or chronic liver disease. Because the liver acts as an innate immunity-dominant organ, there are immunological differences between the liver and other organs. The specific features of hepatic natural killer(NK), NKT and Kupffer cells and their role in the mechanism of liver transplant rejection, tolerance and hepatic ischemia-reperfusion injury are discussed in this review. | René Fahrner Felix Dondorf Michael Ardelt Utz Settmacher Falk Rauchfuss | 2016 | World Journal of Gastroenterology2016，22，27： | 3 |
| 19 | Eosinophilic esophagitis: Updated consensus recommendations for children and adults显示文摘 | Chris A. Liacouras Glenn T. Furuta Ikuo Hirano Dan Atkins Stephen E. Attwood Peter A. Bonis A. Wesley Burks Mirna Chehade Margaret H. Collins Evan S. Dellon Ranjan Dohil Gary W. Falk Nirmala Gonsalves Sandeep K. Gupta David A. Katzka Alfredo J. Lucendo Jo | 2011 | The Journal of Allergy and Clinical Immunology2011，，1： | 3 |
| 20 | Not interferon, but interleukin‐6 controls early gene expression in hepatitis B virus infection显示文摘 | Marianna H?sel Maria Quasdorff Katja Wiegmann Dennis Webb Uta Zedler Mathias Broxtermann Raindy Tedjokusumo Knud Esser Silke Arzberger Carsten J. Kirschning Anja Langenkamp Christine Falk Hildegard Büning Stefan Rose‐John Ulrike Protzer | 2009 | Hepatology2009，，6： | 3 |
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