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| 1 | HBV Integration Induces Complex Interactions between Host and Viral Genomic Functions at the Insertion Site显示文摘Hepatitis B virus(HBV),one of the well-known DNA oncogenic viruses,is the leading cause of hepatocellular carcinoma(HCC).In infected hepatocytes,HBV DNA can be integrated into the host genome through an insertional mutagenesis process inducing tumorigenesis.Dissection of the genomic features surrounding integration sites will deepen our understanding of mechanisms underlying integration.Moreover,the quantity and biological activity of integration sites may reflect the DNA damage within affected cells or the potential survival benefits they may confer.The wellknown human genomic features include repeat elements,particular regions(such as telomeres),and frequently interrupted genes(e.g.,telomerase reverse transcriptase[i.e.TERT],lysine methyltransferase 2B[i.e.KMT2B],cyclin E1[CCNE1],and cyclin A2[CCNA2]).Consequently,distinct genomic features within diverse integrations differentiate their biological functions.Meanwhile,accumulating evidence has shown that viral proteins produced by integrants may cause cell damage even after the suppression of HBV replication.The integration-derived gene products can also serve as tumor markers,promoting the development of novel therapeutic strategies for HCC.Viral integrants can be single copy or multiple copies of different fragments with complicated rearrangement,which warrants elucidation of the whole viral integrant arrangement in future studies.All of these considerations underlie an urgent need to develop novel methodology and technology for sequence characterization and function evaluation of integration events in chronic hepatitis B-associated disease progression by monitoring both host genomic features and viral integrants.This endeavor may also serve as a promising solution for evaluating the risk of tumorigenesis and as a companion diagnostic for designing therapeutic strategies targeting integration-related disease complications. | Dake Zhang Ke Zhang Urlike Protzer Changqing Zeng | 2021 | Journal of Clinical and Translational Hepatology2021，9，3： | 4 |
| 2 | Not interferon, but interleukin‐6 controls early gene expression in hepatitis B virus infection显示文摘 | Marianna H?sel Maria Quasdorff Katja Wiegmann Dennis Webb Uta Zedler Mathias Broxtermann Raindy Tedjokusumo Knud Esser Silke Arzberger Carsten J. Kirschning Anja Langenkamp Christine Falk Hildegard Büning Stefan Rose‐John Ulrike Protzer | 2009 | Hepatology2009，，6： | 3 |
| 3 | A novel therapeutic hepatitis B vaccine induces cellular and humoral immune responses and breaks tolerance in hepatitis B virus (HBV) transgenic mice显示文摘 | Pascale Buchmann Claudia Dembek Larissa Kuklick Clemens J?ger Raindy Tedjokusumo Miriam John von Freyend Uta Drebber Zbigniew Janowicz Karl Melber Ulrike Protzer | 2013 | Vaccine2013，，8： | 3 |
| 4 | Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection显示文摘 | Julie Lucifora Silke Arzberger David Durantel Laura Belloni Michel Strubin Massimo Levrero Fabien Zoulim Olivier Hantz Ulrike Protzer | 2011 | Journal of Hepatology2011，，5： | 2 |
| 5 | Interferon gene transfer by a hepatitis B vires vector efficiently suppresses wild-type virus infection 显示文摘 | Protzer U Nassal M Chiang P W | 1999 | Proc Natl Acad Sci1999，96，10： | 1 |
| 6 | Antiviral activity and hepatoprotection by heme oxygenase-1 in hepatitis B virus infection显示文摘 | Protzer U Seyfried S Quasdorff M Sass G Svorcova M Webb D | | Gastroenterology0，，： | 1 |
| 7 | The direct and indirect roles of HBV in liver cancer: prospective markers for HCC screening and potential therapeutic targets显示文摘 | Marc Ringelhan Tracy O’Connor Ulrike Protzer Mathias Heikenwalder | 2015 | J. Pathol2015，，2： | 1 |
| 8 | 5′ Triphosphorylated Small Interfering RNAs Control Replication of Hepatitis B Virus and Induce an Interferon Response in Human Liver Cells and Mice显示文摘 | Gregor Ebert Hendrik Poeck Julie Lucifora Nikola Baschuk Knud Esser Irene Esposito Gunther Hartmann Ulrike Protzer | 2011 | Gastroenterology2011，，2： | 1 |
| 9 | Inhibition of cellular proteasome activities enhances hepadnavirus replication in an HBX-dependent manner显示文摘 | Zhang Z Protzer U Hu Z | 2004 | J Virol2004，78，9： | 1 |
| 10 | Living in the liver:hepatic infections显示文摘 | Protzer U Maini M K Knolle P A | 2012 | Nat Rev Immunol2012，12，3： | 1 |
| 11 | Interleukin-10 expression is autoregullated at the transcriptional level in human and murine kupffer cells显示文摘 | Knolle PA Uhring A Protzer U | 1998 | Hepatology1998，27，： | 1 |
| 12 | Interferon gene transfer by a hepatitis B virus vector efficiently suppresses wild-type virus infection显示文摘 | PROTZER U NASSAL M CHIANG P W | 1999 | Proc Natl Acad Sci USA1999，，10： | 1 |
| 13 | The direct and indirect roles of HBV in liver cancer: prospective markers for HCC screening and potential therapeutic targets 显示文摘 | Ringelhan M O' Connor T Protzer U | 2015 | J Pathol2015，235，2： | 1 |
| 14 | Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection显示文摘 | Julie Lucifora Silke Arzberger David Durantel Laura Belloni Michel Strubin Massimo Levrero Fabien Zoulim Olivier Hantz Ulrike Protzer | 2011 | Journal of Hepatology2011，，5： | 1 |
| 15 | Interferon gene transfer by a hepatitis B virus vector efficiently suppresses wild-type virus infection显示文摘 | Protzer U Nassal M Chiang PW | 1999 | Proe Natl Acad Sei USA1999，96，10： | 1 |
| 16 | The German guide- line for the management of hepatitis B virus infection: short version 显示文摘 | Comberg M Protzer U Dollinger MM | 2008 | J Viral Hepat2008，15，1： | 1 |
| 17 | Ezetimibe blocks hepatitis B virus infection after virus uptake into hepatocytes显示文摘 | Lucifora J Esser K Protzer U | 2013 | Antiviral research2013，97，2： | 1 |
| 18 | Primary human hepatocytes-a valuable tool for investi- gation of apoptosis and hepatitis B virus infection 显示文摘 | Schulze-Bergkamen H Untergasser A Dax A Vogel H Biichler P Klar E Lehnert T Friess H Btichler MW Kir- schfink M Stremmel W Krammer PH Miiller M Protzer U | 2003 | J Hepatol2003，38，6： | 1 |
| 19 | Endotoxin Stimulates Liver Macrophages To Release Mediators That Inhibit an Early Step in Hepadnavirus Replication显示文摘 | Uta Klocker Ursula Schultz Heinz Schaller Ulrike Protzer | | 0，，： | 1 |
| 20 | Regulation of endotoxininduced IL-6 production in liver sinusoidal endothelial cells and Kupffer cells by IL-10显示文摘 | Knolle PA Lser E Protzer U | 1997 | Clin Exp Immunol1997，107，3： | 1 |
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