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| 1 | The IL-1R/TLR signaling pathway is essential for efficient CD8+ T-cell responses against hepatitis B virus in the hydrodynamic injection mouse model显示文摘The outcome of hepatitis B viral(HBV)infection is determined by the complex interactions between replicating HBV and the immune system.While the role of the adaptive immune system in the resolution of HBV infection has been studied extensively,the contribution of innate immune mechanisms remains to be defined.Here we examined the role of the interleukin-1 receptor/Toll-like receptor(IL-1R/TLR)signaling pathway in adaptive immune responses and viral clearance by exploring the HBV mouse model.Hydrodynamic injection with a replication-competent HBV genome was performed in wild-type mice(WT)and a panel of mouse strains lacking specific innate immunity component expression.We found higher levels of HBV protein production and replication in Tlr2^(−/−),Tlr23479^(−/−),3d/Tlr24^(−/−),Myd88/Trif^(−/−)and Irak4^(−/−)mice,which was associated with reduced HBV-specific CD8+T-cell responses in these mice.Importantly,HBV clearance was delayed for more than 2 weeks in 3d/Tlr24^(−/−),Myd88/Trif^(−/−)and Irak4^(−/−)mice compared to WT mice.HBV-specific CD8+T-cell responses were functionally impaired for producing the cytokines IFN-γ,TNF-αand IL-2 in TLR signaling-deficient mice compared to WT mice.In conclusion,the IL-1R/TLR signaling pathway might contribute to controlling HBV infection by augmenting HBV-specific CD8+T-cell responses. | Zhiyong Ma Jia Liu Weimin Wu Ejuan Zhang Xiaoyong Zhang Qian Li Gennadiy Zelinskyy Jan Buer Ulf Dittmer Carsten J Kirschning Mengji Lu | 2017 | Cellular & Molecular Immunology2017，14，12： | 6 |
| 2 | Not interferon, but interleukin‐6 controls early gene expression in hepatitis B virus infection显示文摘 | Marianna H?sel Maria Quasdorff Katja Wiegmann Dennis Webb Uta Zedler Mathias Broxtermann Raindy Tedjokusumo Knud Esser Silke Arzberger Carsten J. Kirschning Anja Langenkamp Christine Falk Hildegard Büning Stefan Rose‐John Ulrike Protzer | 2009 | Hepatology2009，，6： | 3 |
| 3 | Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8显示文摘 | Heil F Hemmi H Hochrein H Ampenberger F Kirschning C Akira S | 2004 | Science2004，303，： | 1 |
| 4 | Accurate wide-range design equations for thefrequency-dependent characteristic of parallel coupled microstrip lines显示文摘 | KIRSCHNING M JANSEN R H | 1984 | IEEETrans MTT1984，32，1： | 1 |
| 5 | Accurate wide-range design equations for thefrequency-dependent characteristic of parallel coupled microstrip lines (corre-ctions)显示文摘 | KIRSCHNING M JANSEN R H | 1985 | IEEE Trans MTT1985，33，3： | 1 |
| 6 | Toll -Like receptors as key mediators in innate antifungal immunity显示文摘 | Roeder A Kirschning C J Rupec R A | 2004 | Medical Mycology2004，42，： | 1 |
| 7 | A dominant role ofToll-like receptor 4in the signaling of apoptosis in bacte-ria-faced macrophages显示文摘 | Haase R Kirschning CJ Sing A | 2003 | J Immunol2003，171，8： | 1 |
| 8 | Toll-like receptors: cellular signal transducers for exogenous molecular patterns causing immune responses显示文摘 | Kirschning CJ Bauer S | 2001 | Int J Med Microbiol2001，291，4： | 1 |
| 9 | Endosomal translocation of vertebrate DNA activates dendritic cells via TLR9- dependent and -independent pathways 显示文摘 | Yasuda K Yu P Kirschning CJ | 2005 | J Immunol2005，174，： | 1 |
| 10 | Chemical and biochemical aspects of deoxysugars and deoxysugar oligosaceharides 显示文摘 | Kirschning A Bechthold A F-W Rohr J | 1997 | TopCurrChem1997，18，： | 1 |
| 11 | Containment of aerogenic Mycobacterium tuberculosis infection in mice does not require MyD88 adaptor function for TLR2, -4 and-9显示文摘 | oscher C Reiling N Schaible UE HOlscher A Bathmann C Korbel D Lenz I Sonntag T KrOger S Akira S Mossmann H Kirschning CJ Wagner H Freudenberg M Ehlers S | 2008 | EurJ Immunol2008，38，3： | 1 |
| 12 | Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition显示文摘 | Bauer S Kirschning CJ Hacker H | 2001 | Proc Natl Acad Sci USA2001，98，16： | 1 |
| 13 | Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide显示文摘 | Kirschning CJ Weshe H Ayres TM | 1998 | J Exp Med1998，188，11： | 1 |
| 14 | Human toll-like receptor-2 confers responsiveness to bacterial lipopolysaccharide显示文摘 | Kirschning CJ Wesche H Merrill AT | 1998 | J Exp Med1998，188，： | 1 |
| 15 | Role of Chlamydial Heat Shock Protein 60 in the Stimulation of Innate Immune Cells by Chlamydia Pneumoniae 显示文摘 | Costa CP Kirschning CJ Busch D | 2002 | Eur J lmmunol2002，32，9： | 1 |
| 16 | Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition显示文摘 | Stefan B Carsten J Kirschning M | 2001 | PNAS2001，98，16： | 1 |
| 17 | Cutting edge:Cell that carry null allele for Toll-like receptor-2 are capable of responding to endotoxin显示文摘 | Lien E Kirschning CJ Heine H | 1999 | J Immunol1999，162，： | 1 |
| 18 | Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition显示文摘 | Bauer S Kirschning CJ H(o)cker H | | 0，，： | 1 |
| 19 | Human TLR9 confers responsiveness to bacterial DNA via species - specific CpG motif recognition显示文摘 | Bauer S Kirschning C J Hacker H | 2001 | Proc Nail Acad Sci USA2001，98，16： | 1 |
| 20 | Role of chlamydial heat shock protein 60 in the stimulation of innate immune cells by Chlamydia pneumoniae 显示文摘 | cla Costa CP Kirschning CJ Busch D | 2002 | Eur J Immunol2002，32，： | 1 |
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