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| 1 | 美国临床肿瘤学会IV期非小细胞肺癌化疗的临床实践指南更新显示文摘本文旨在为IV期非小细胞肺癌患者的治疗提供更新版推荐。本文资料检索源自2002年以来公布的相关随机试验文献。此指南范围限于化疗与生物治疗。更新委员会对这些文献进行了总结并提供了推荐更新。162篇文献符合标准被纳入参考。本推荐基于可改善总生存期的治疗方法。仅改善无进展生存期的治疗方法推动了对毒性及生存质量的监测。对于体力状态评分为0分或1分患者的一线治疗,可推荐以铂类为基础的细胞毒性药物的两药联用。对铂类治疗有禁忌的患者,可采用非铂类细胞毒性两药联合。对于体力状态评分为2分的患者,单一细胞毒性药物即可。对于疾病进展或经过4个周期的治疗仍对治疗无反应的患者,应停止一线细胞毒性化疗。即使在6个周期后患者对治疗仍有反应,亦应停止两药细胞毒性化疗。对于伴有明确的表皮生长因子受体(epidermal growth factor receptor,EGFR)突变的患者,可推荐一线采用吉非替尼治疗;对于EGFR突变为阴性或不明确的患者,细胞毒性化疗更佳。除具有特定临床特征的患者外,可推荐贝伐单抗与卡铂-紫杉醇联用。对于通过免疫组化证实EGFR阳性的肿瘤患者,可推荐西妥昔单抗与顺铂-长春瑞滨联用。多西紫杉醇、厄洛替尼、吉非替尼或培美曲塞被推荐作为二线治疗。对于未曾接受过厄洛替尼或吉非替尼治疗的患者,可推荐厄洛替尼作为三线治疗。现有数据不足以推荐常规三线采用细胞毒性药物。已有的证据也不足以推荐常规应用分子标记物选择化疗。 | Christopher G. AZZOLI Sherman Baker JR Sarah TEMIN William PAO Timothy ALIFF Julie BRAHMER David H. JOHNSON Janessa L. LASKIN Gregory MASTERS Daniel MILTON Luke NORDQUIST David G. PFISTER Steven PIANTADOSI Joan H. SCHILLER Reily SMITH Thomas J. SMITH John R. STRAWN David TRENT Giuseppe GIACCONE 丁燕(翻译) 南娟(翻译) 刘谦(翻译) 周清华(校对) 陈军(校对) | 2010 | 中国肺癌杂志2010，13，3： | 43 |
| 2 | SWEET as Sugar: New Sucrose Effluxers in Plants显示文摘 | R. Frank Baker Kristen A. Leach David M. Braun | 2012 | Molecular Plant2012，5，4： | 29 |
| 3 | Camouflage Patterning in Maize Leaves Results from a Defect in Porphobilinogen Deaminase显示文摘玉米叶子从导致沿着叶的长轴穿的同种细胞的房间系的极化的房间部门被生产。我们利用了这个 stereotypical 部门模式识别形成违背同种细胞的房间系的叶绿体色素沉着部门的许多异种。这里,我们描述 camouflage1 (cf1 ) 异种,开发 nonclonal,在它的叶子的 yellowgreen 部门。我们由标注的 transposon 克隆 cf1 基因并且决定它编码 porphobilinogen 脱氨基酶(PBGD ) ,在叶绿素和 heme 早工作的酶生合成。当 PBGD 生物化学地被描绘了时,在这基因的可行变化都没在植物被报导。调查在里面 PBGD 的 vivo 功能,我们描绘了 cf1 异种。组织学的分析表明 cf1 黄扇区显示捆鞘的新奇显型房间特定的死亡。轻移动的实验决定经常的光压制了 cf1 部门形成,黑暗 / 轻的转变被要求仅仅在叶开发的一有限时间期间导致黄部门,和那种部门形式。生物化学的实验决定 cf1 异种叶子减少了 PBGD 活动和在绿、黄的区域的酶底层的增加的层次。而且, cf1 黄区域在过氧化氢酶活动显示了减小。一个阀值模型被假设向 cf1 解释上色并且合并光合的细胞区别,清除的反应的氧种,和 PBGD 功能。 | Mingshu Huanga Thomas L. Slewinski R. Frank Baker , Diane Janick-Buckner Brent Buckner Gurmukh S. Johal David M. Braun | 2009 | Molecular Plant2009，2，4： | 6 |
| 4 | Durable, superhydrophobic, antireflection, and low haze glass surfaces using scalable metal dewetting nanostructuring显示文摘在这份报纸,我们在第一次,联合的玻璃上报导多功能的 nanostructured 表面大量光,弄湿并且耐久性性质,包括的低全向的反射率,低薄雾,高传播, superhydrophobicity, oleophobicity,和高度机械抵抗。Nanostructures 被反应离子通过 nanomask 蚀刻在玻璃表面上制作了,它被 dewetting ultrathin 金属电影形成(< 10 nm 厚度) 使遭到了到快速的热退火(RTA ) 。nanostructures 强烈减少起始的表面反射率(4%) ,当在低价值保留薄雾时,在 390800 nm 波长变化到不到 0.4%(<0.9%) 。相应的水接触角度(c ) 是 24.5 敶愠朠晩吗?? | Daniel Infante Karl W. Koch Prantik Mazumder Lili Tian Albert Carrilero Domenico Tullit David Baker Valerio Pruneri | 2013 | Nano Research2013，6，6： | 6 |
| 5 | Prognostic impact of the Bismuth-Corlette classification:Higher rates of local unresectability in stageⅢb hilar cholangiocarcinoma显示文摘Background:The Bismuth-Corlette(BC)classification is used to categorize hilar cholangiocarcinoma by proximal extension along the biliary tree.As the right hepatic artery crosses just behind the left bile duct,we hypothesized that BCⅢb tumors would have a higher likelihood of local unresectability due to involvement of the contralateral artery.Methods:A retrospective review of a prospectively maintained database identified patients with hilar cholangiocarcinoma taken to the operating room for intended curative resection between April 2008 and September 2016.Cases were assigned BC stages based on preoperative imaging.Results:Sixty-eight patients were included in the study.All underwent staging laparoscopy after which 16 cases were aborted for metastatic disease.Of the remaining 52 cases,14 cases were explored and aborted for locally advanced disease.Thirty-eight underwent attempt at curative resection.After exclud-ing cases aborted for metastatic disease,the chance of proceeding with resection was 55.6%for BCⅢb staged lesions compared to 80.0%of BCⅢa lesions and to 82.4%for BCⅠ-Ⅲa staged lesions(P<0.05).About 44.4%of BCⅢb lesions were aborted for locally advanced disease versus 17.6%of remaining BC stages.Conclusions:When hilar cholangiocarcinoma is preoperatively staged as BCⅢb,surgeons should antici-pate higher rates of locally unresectable disease,likely involving the right hepatic artery. | Michael J Passeri Maria R Baimas-George Jesse K Sulzer David A Iannitti John B Martinie Erin H Baker Lee M Ocuin Dionisios Vrochides | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，2： | 3 |
| 6 | The meaning and the measure of health literacy显示文摘 | David W. Baker MD MPH | 2006 | Journal of General Internal Medicine2006，，8： | 2 |
| 7 | Increased Quality of Life Among Hepatocellular Carcinoma Patients Treated with Radioembolization, Compared with Chemoembolization显示文摘 | Riad Salem Margaret Gilbertsen Zeeshan Butt Khairuddin Memon Michael Vouche Ryan Hickey Talia Baker Michael M. Abecassis Rohi Atassi Ahsun Riaz David Cella James L. Burns Daniel Ganger Al B. Benson Mary F. Mulcahy Laura Kulik Robert Lewandowski | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 2 |
| 8 | The test of functional health literacy in adults显示文摘 | Dr. Ruth M. Parker MD David W. Baker MD MPH Mark V. Williams MD Joanne R. Nurss PhD | 1995 | Journal of General Internal Medicine1995，，10： | 2 |
| 9 | 微粒对多晶冰流变行为的影响——(Ⅱ)滞弹性行为显示文摘用反相直接加载的方法研究了微粒对多晶冰滞弹性的影响.结果表明:在较高频率时(1Hz和10-1Hz),滞弹性应变与应力峰值呈线性关系;在较低频率时(10-2Hz),其应力/应变偏离线性关系.微粒在高频时(1Hz)通过阻碍晶界滑移对晶界弛豫产生重要影响,增加了模量和降低了内耗.但微粒对低频时的位错弛豫没有明显的影响.通过滞弹性实验计算了非线性弛豫模型的两个重要参数,计算表明K值约为0.07Pa,α值约为0.54. | 宋旼 David M Cole Ian Baker | 2007 | 地球物理学报2007，50，4： | 2 |
| 10 | Specificity of choline metabolites for in vivo diagnosis of breast cancer using 1 H MRS at 1.5 T显示文摘 | Peter Stanwell Laurence Gluch David Clark Boguslaw Tomanek Luke Baker Bruno Giuffrè Cynthia Lean Peter Malycha Carolyn Mountford | 2005 | European Radiology2005，，5： | 2 |
| 11 | A global perspective on cadmium pollution and toxicity in non-occupationally exposed population显示文摘 | Soisungwan Satarug Jason R Baker Supanee Urbenjapol Melissa Haswell-Elkins Paul E.B Reilly David J Williams Michael R Moore | 2002 | Toxicology Letters2002，，1： | 2 |
| 12 | Ecological risk as- sessment of atrazine in North American surface waters 显示文摘 | Keith R Solomon David B Baker R Pe- ter Richards | 1996 | Environmental Toxi- cology and Chemistry1996，15，1： | 1 |
| 13 | Land cover changes and their biogeophysical effects on climate显示文摘 | Rezaul Mahmood Roger A. Pielke Kenneth G. Hubbard Dev Niyogi Paul A. Dirmeyer Clive McAlpine Andrew M. Carleton Robert Hale Samuel Gameda Adriana Beltrán‐Przekurat Bruce Baker Richard McNider David R. Legates Marshall Shepherd Jinyang Du Peter D. Blanken | 2014 | Int J Climatol2014，，4： | 1 |
| 14 | The Effect of Progressive, Reinforcing Telephone Education and Counseling Versus Brief Educational Intervention on Knowledge, Self-Care Behaviors and Heart Failure Symptoms显示文摘 | David W. Baker Darren A. DeWalt Dean Schillinger Victoria Hawk Bernice Ruo Kirsten Bibbins-Domingo Morris Weinberger Aurelia Macabasco-O’Connell Kathy L. Grady George M. Holmes Brian Erman Kimberly A. Broucksou Michael Pignone | 2011 | Journal of Cardiac Failure2011，，10： | 1 |
| 15 | Can fluorescence spectrometry be used as a surrogate for the Bio- chemical Oxygen Demand (BOD) test in water quality assess- ment? An example from South West England 显示文摘 | Naomi Hudson Andy Baker David Ward | 2008 | Science of The Total Environment2008，391，1： | 1 |
| 16 | Empathy and enduring depersonalization: The role of self-related processes显示文摘 | Lawrence E J Shaw P Baker D Patel M Sierra-Siegert M Medford N David A S | 2007 | Social Neuroscience2007，，2： | 1 |
| 17 | Effects of Resuscitation Fluid on Neurologic Physiology After Cerebral Trauma and Hemorrhage显示文摘 | Baker Andrew J Park Eugene Mazer David C | 2008 | Journal of Trauma-Injury Infection&Critical Care2008，64，2： | 1 |
| 18 | Metabolic implications of resistive force selection for oxidative stress and markers of muscle damage during 30?s of high-intensity exercise显示文摘 | Julien S. Baker Damian M. Bailey David Hullin Ian Young Bruce Davies | 2004 | European Journal of Applied Physiology2004，，3： | 1 |
| 19 | Genes, environment and sport performance: why the nature-nurture dualism is no longer relevant显示文摘 | DAVIDS K BAKER J | 2007 | Sports Medicine2007，37，11： | 1 |
| 20 | Severe Injury Is Associated With Insulin Resistance, Endoplasmic Reticulum Stress Response, and Unfolded Protein Response显示文摘 | Marc G. Jeschke Celeste C. Finnerty David N. Herndon Juquan Song Darren Boehning Ronald G. Tompkins Henry V. Baker Gerd G. Gauglitz | 2012 | Annals of Surgery2012，，2： | 1 |
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