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| 1 | 糖耐量低减和空腹血糖受损:定义及干预的现状显示文摘由国际糖尿病联盟 (IDF)召集的本次研讨会是为了考察有关糖耐量低减 (IGT)和空腹血糖受损 (IFG)相关的糖尿病和心血管疾病 (CVD)风险的最新文献 ,力图回答三个问题 :(1 )目前的IGT和IFG的定义是否合适 ;(2 )IFG和IGT是危险因子 (riskfactor)、危险标志 (riskmarker)还是疾病 (disease) ;(3)对 :IFG和IGT人群应该采取怎样的干预措施 (如果有的话 ) ?①引起空腹血糖 (FPG)和口服葡萄糖耐量试验(OGTT) 2h血糖 (2hPG)升高的因素并不相同 ,肝脏葡萄糖输出增加和早期胰岛素释放缺陷是前者的特点 ,而外周胰岛素抵抗是后者的显著特征。因此 ,IFG和IGT之间的一致性是有限的。迄今所有的患病率调查发现 ,只有不到一半的IFG人群有IGT ,更少的IGT人群 (2 0 %~ 30 % )有IFG。②大多数的人群研究表明 ,IGT的患病率远高于IFG ,二者的临床表现和性别分布也有差异。IFG在男性更为常见 ,IGT在女性稍微增多。IFG的患病率倾向在中年达到高峰 ,而IGT的患病率逐渐增加直到老龄。③IFG和IGT都与发生糖尿病的风险显著增加有关 ,而最大的风险在于同时具有IFG和IGT的人群。由于在多数人群IGT比IFG更常见 ,所以对于筛查糖尿病高危人群 ,IGT的敏感性较高 (特异性稍差 )。在多数人群 ,60 %的糖尿病人大约 5年前已有IGT或IFG ,另外 | Unwin N Shaw J Zimmet P Alberti KGMM 金文胜 潘长玉 | 2003 | 中华内分泌代谢杂志2003，19，1： | 92 |
| 2 | Meeting report:a hard look at the state of enamel research显示文摘The Encouraging Novel Amelogenesis Models and Ex vivo cell Lines(ENAMEL) Development workshop was held on 23 June 2017 at the Bethesda headquarters of the National Institute of Dental and Craniofacial Research(NIDCR). Discussion topics included model organisms, stem cells/cell lines, and tissues/3 D cell culture/organoids. Scientists from a number of disciplines,representing institutions from across the United States, gathered to discuss advances in our understanding of enamel, as well as future directions for the field. | ophir d klein olivier duverger wendy shaw rodrigo s lacruz derk joester janet moradian-oldak megan k pugach j timothy wright sarah e millar ashok b kulkarni john d bartlett thomas gh diekwisch pamela den besten james p simmer | 2017 | International Journal of Oral Science2017，9，4： | 3 |
| 3 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 4 | Molecular authentication of Panax species显示文摘 | Ngan F Shaw I C But P P H | 1999 | phytochemistry1999，50，5： | 1 |
| 5 | Frequent loss of heterozygosity for Rb, TP53, and chromosome arm 3p,but not NME1 in squamous cell carcinomas of the supraglottic larynx显示文摘 | SCHOLNICK S B SUN P C SHAW M E | 1994 | Cancer1994，73，： | 1 |
| 6 | Cloning of trichosanthin cDNA and its expression in Escherichia Ecoli显示文摘 | | 1991 | Gene1991，97，： | 1 |
| 7 | Ovary and ovulation:fresh and cryopreserved ovarian tissue samples from donors with lymphoma transmit the cancer to graft recipients显示文摘 | Shaw JM Bowles J Keopman P | 1996 | Hum Reprod1996，11，8： | 1 |
| 8 | Global and societal implications of the diabetes epidemic显示文摘 | Zimmet P Alberti KG Shaw J | 2001 | Nature2001，414，6865： | 1 |
| 9 | A novel role for the adaptor molecule CD2-associated protein in transforming growth factor-betainduced apoptosis显示文摘 | Schiffer M Mundel P Shaw AS | 2004 | J Biol Chem2004，279，37： | 1 |
| 10 | Predic- tors of laryngeal complications in patients implanted with the Cyberonics vagal nerve stimulator显示文摘 | SHAW G Y SECHTEM P SEARL J | 2006 | Ann Otol Rhinol Laryngol2006，115，： | 1 |
| 11 | Recent advances in trichosanthin,a ri- bosome - inactivating protein with multiple pharmacological properties 显示文摘 | Shaw P C Lee K M Wong K B | 2005 | Toxicon2005，45，： | 1 |
| 12 | Widely spread butyrylcholinesterase can hydrolyze acetylcholine in the normal and Alzheimer brain显示文摘 | MESULAM MM GUILLOZET A SHAW p | 2002 | Neurobiol Dis2002，9，： | 1 |
| 13 | Role of seed bank substrates in the revegetation of fly ash and gypsum in the Uuited Kingdom显示文摘 | SHAW P J A | 1996 | Restoration Ecology1996，，4： | 1 |
| 14 | Edible coatings for individual frozen meat portions显示文摘 | Shaw C P Secrist J L | 1977 | U S Army Natick Research & Development Command Food Engineering Laboratory Natick MA1977，，： | 1 |
| 15 | Effect of retinol palmitate on ovulation rate and embryo quality in superovulated cattle显示文摘 | Shaw DW Farin P W Washburn S P | 1995 | Theriogenology1995，44，： | 1 |
| 16 | A periodically forced Impact oscillator with large dissipation显示文摘 | Shaw S W Holmes P J | 1983 | Journal of Applied Mechanics1983，50，： | 1 |
| 17 | Phenotypic and genotypic diversity in Phytophthora infestans on potato in Great Britain, 1995-1998 显示文摘 | DAY J P WA271'IER R SHAW D S | 2004 | Plant Pathol2004，53，3： | 1 |
| 18 | Global and societal implications of the diabetes epidemic显示文摘 | Zimmet P Alberti KG Shaw J | | 0，，6865： | 1 |
| 19 | Forecasting Field Defect Rates Using a Combined Time-Based Approach:A Case Study ofOpenBSD 显示文摘 | L P L HERBSLEB J SHAW M | 2005 | Proc of the 16th Int''l Symp on Software Reliability Engineering2005，12，2： | 1 |
| 20 | Comparison of characteristics and outcomes of patients with heart failure preserved ejection fraction versus reduced left ventricular ejection fraction in an urban cohort显示文摘 | Quiroz R Doros G Shaw P | 2014 | Am J Cardiol2014，113，4： | 1 |
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